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Lista de obras de Annalisa De Silvestri

A Systematic Review and Meta-Analysis of Ginkgo biloba in Neuropsychiatric Disorders: From Ancient Tradition to Modern-Day Medicine

artículo científico publicado en 2013

A Trained Pulmonologist Can Reliably Assess Endosonography-Derived Lymph Node Samples during Rapid On-Site Evaluation

scientific article published on 12 April 2019

A case report on filamin A gene mutation and progressive pulmonary disease in an infant: A lung tissued derived mesenchymal stem cell study

article

A family based linkage analysis of HLA and 5-HTTLPR gene polymorphisms in Sardinian children with autism spectrum disorder

artículo científico publicado en 2006

A meta-analysis of remote monitoring of heart failure patients

scientific article published on October 2009

A proposal for a semiquantitative scoring system for lymphedema using Non-contrast Magnetic Resonance Lymphography (NMRL): Reproducibility among readers and correlation with clinical grading

artículo científico publicado en 2020

A shared protocol for porcine surfactant use in pediatric acute respiratory distress syndrome: a feasibility study.

artículo científico publicado en 2019

Accuracy of a Wrist-Worn Heart Rate Sensing Device during Elective Pediatric Surgical Procedures.

artículo científico publicado en 2018

Adenoidectomy: Anatomical variables as predictive factors of intraoperative adenoid residues

artículo científico publicado en 2020

Adherence to quality criteria improves concordance between transient elastography and ElastPQ for liver stiffness assessment-A multicenter retrospective study.

artículo científico publicado en 2018

Aetiology and outcome of pneumoniae in HIV-positive patients in the antiretroviral era.

artículo científico publicado en 2016

Agreement Between an Automated Volume Breast Scanner and Handheld Ultrasound for Diagnostic Breast Examinations.

artículo científico publicado en 2017

An historical approach to the genetic distribution of KIR and HLA ligands in Eastern Sicilians compared to modern descendants of their invaders.

artículo científico publicado en 2017

An immune-molecular hypothesis supporting infectious aetiopathogenesis of Kawasaki disease in children.

artículo científico publicado en 2017

Antibodies to wheat high-molecular-weight glutenin subunits in patients with celiac disease

artículo científico publicado en 2012

Antigen-specific T cell response in infants after recombinant hepatitis B virus vaccination at birth: evaluation of T helper lymphocyte diversity.

artículo científico publicado en 2003

Autoimmune Thyroid Diseases in Children and Adolescents with Maturity Onset Diabetes of the Young Type 2

scientific article published on 04 September 2019

BNP concentrations and cardiovascular adaptation in preterm and fullterm newborn infants

artículo científico publicado en 2010

Barbed suture in minimally invasive hysterectomy: a systematic review and meta-analysis.

artículo científico publicado en 2015

Baseline Amino Acid Substitutions in the NS5A ISDR and PKR Binding Domain of Hepatitis C and Different Fibrosis Levels and Levels of Development of Hepatocellular Carcinoma in Patients Treated with DAAs

scientific article published on 25 February 2020

Bioequivalence of a New Oral Levosulpiride Formulation Compared With a Standard One in Healthy Volunteers.

artículo científico publicado en 2017

Birth-weight as a risk factor for cancer in adulthood: the stem cell perspective.

artículo científico publicado en 2011

CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer

artículo científico publicado en 2003

Can High-Flow Oxygen Overstep Low-Flow Oxygen Therapy in Weaning From Noninvasive Ventilation in Patients With Acute Respiratory Failure Due to Chronic Obstructive Pulmonary Disease Exacerbation?

artículo científico publicado en 2020

Cardiac Adaptation to Severe Congenital Diaphragmatic Hernia

artículo científico publicado en 2015

Case-finding for alpha1-antitrypsin deficiency in Kazakh patients with COPD.

artículo científico publicado en 2017

Catabolism of C1 inhibitor influences the response to replacement therapy in hereditary angioedema.

artículo científico publicado en 2016

Celiac disease in children with autoimmune thyroid disease

artículo científico publicado en 2001

Changes in Proteinuria and Side Effects of Corticosteroids Alone or in Combination with Azathioprine at Different Stages of IgA Nephropathy.

artículo científico publicado en 2016

Children with recurrent otitis show defective IFNγ-producing cells in adenoids

scientific article published on 06 February 2008

Circulating endothelial progenitor cells in preterm infants with bronchopulmonary dysplasia

artículo científico publicado en 2009

Clinical audit improves hypertension control in hemodialysis patients.

artículo científico publicado en 2013

Codon 72 polymorphism of P53 gene does not affect the risk of cirrhosis and hepatocarcinoma in HCV-infected patients.

artículo científico publicado en 2004

Comparison of the Diagnostic Accuracy of Three Rapid Tests for the Serodiagnosis of Hepatic Cystic Echinococcosis in Humans.

artículo científico publicado en 2016

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

artículo científico publicado en 2016

Complement receptor 1 gene polymorphisms are associated with idiopathic pulmonary fibrosis

artículo científico publicado en 2003

Comprehensive characterization of mesenchymal stromal cells from patients with Fanconi anaemia

artículo científico publicado en 2015

Continuous wound infusion with chloroprocaine in a pig model of surgical lesion: drug absorption and effects on inflammatory response

artículo científico publicado en 2017

Cord blood, perinatal BNP values in term and preterm newborns

artículo científico publicado en 2010

Correlation between HLA-DQB1*06:02 and narcolepsy with and without cataplexy: approving a safe and sensitive genetic test in four major ethnic groups. A systematic meta-analysis

artículo científico publicado en 2018

Correlation of serum sHLA-G levels with cyst stage in patients with cystic echinococcosis: is it an immune evasion strategy?

artículo científico publicado en 2016

Corticosteroid Treatment Influences TA-Proteinuria and Renal Survival in IgA Nephropathy

artículo científico publicado en 2016

Critical evaluation of the variants influencing the clinical response of vitiligo: study of 60 cases treated with ultraviolet B narrow-band phototherapy.

artículo científico publicado en 2007

Cytokine genetic profile in Whipple’s disease

artículo científico publicado en 2012

Decline of maternal hepatitis A virus antibody levels in infants

artículo científico publicado en 2002

Detection of Liver Steatosis With a Novel Ultrasound-Based Technique: A Pilot Study Using MRI-Derived Proton Density Fat Fraction as the Gold Standard

artículo científico publicado en 2019

Diabetes Type 2 in Neurologically Impaired Children and Adolescents Without Obesity: A New Emerging Entity?

artículo científico publicado en 2019

Diagnostic Performance and Accuracy of the 3 Interpreting Methods of Breast Strain Elastography: A Systematic Review and Meta-analysis

scientific article published on 09 November 2018

Diagnostic Performances of Commercial ELISA, Indirect Hemagglutination, and Western Blot in Differentiation of Hepatic Echinococcal and Non-Echinococcal Lesions: A Retrospective Analysis of Data from a Single Referral Centre

scientific article published on 01 December 2019

Differences in implementation of HIV/AIDS clinical research in developed versus developing world: an evidence-based review on protease inhibitor use among women and minorities.

artículo científico publicado en 2012

Disorders of Puberty in Severely Neurologically Impaired Children: Is Delayed Puberty an Underestimated Problem?

scientific article published on 14 November 2019

Does a research group increase impact on the scientific community or general public discussion? Alternative metric-based evaluation

artículo científico publicado en 2016

Economic impact of remote patient monitoring: an integrated economic model derived from a meta-analysis of randomized controlled trials in heart failure

artículo científico publicado en 2010

Effect of telemonitoring of cardiac implantable electronic devices on healthcare utilization: a meta-analysis of randomized controlled trials in patients with heart failure.

artículo científico publicado en 2016

Effectiveness of aromatase inhibitors in the treatment of advanced endometrial adenocarcinoma

artículo científico

Effectiveness of complex interventions focused on quality-of-life assessment to improve palliative care patients' outcomes: a systematic review

artículo científico publicado en 2014

Effects of Simvastatin on Fetal Cardiac Impairment in the Diaphragmatic Experimental Hernia Model

artículo científico publicado en 2018

Efficacy of low-dose rituximab for the treatment of mixed cryoglobulinemia vasculitis: Phase II clinical trial and systematic review

artículo científico

Emerging mutations at virological failure of HAART combinations containing tenofovir and lamivudine or emtricitabine

artículo científico publicado en 2010

Endobronchial ultrasound-guided transbronchial needle aspiration for diagnosis of sarcoidosis in clinically unselected study populations

artículo científico publicado en 2015

Epicardial Fat Thickness in Non-Obese Neurologically Impaired Children: Association with Unfavorable Cardiometabolic Risk Profile

artículo científico publicado en 2018

Epidemiological characteristics of bloodstream infections in patients with different degrees of liver disease.

artículo científico publicado en 2015

Epidemiology of Nonesophageal Eosinophilic Gastrointestinal Diseases in Symptomatic Patients: A Systematic Review and Meta-Analysis

artículo científico publicado en 2020

Erratum to: Inter-device reproducibility of retrobulbar blood flow velocity measurements in healthy subjects using color Doppler imaging.

artículo científico publicado en 2017

Esophageal Atresia: Nutritional Status and Energy Metabolism to Maximize Growth Outcome

artículo científico publicado en 2020

Evaluation of Allostatic Load as a Marker of Chronic Stress in Children and the Importance of Excess Weight

artículo científico publicado en 2019

Evaluation of Inter-System Variability in Liver Stiffness Measurements.

artículo científico publicado en 2018

Evaluation of the Active Melioidosis Detect™ test as a point-of-care tool for the early diagnosis of melioidosis: a comparison with culture in Laos

artículo científico publicado en 2019

Excess of activating killer cell immunoglobulin‑like receptors and lack of HLA-Bw4 ligands: A two‑edged weapon in chronic fatigue syndrome

article

Extracellular vesicles derived from mesenchymal cells: perspective treatment for cutaneous wound healing in pediatrics

artículo científico publicado en 2018

Factors Influencing the Serological Response in Hepatic Echinococcus granulosus Infection.

artículo científico publicado en 2015

Family study of non-responsiveness to hepatitis B vaccine confirms the importance of HLA class III C4A locus

article

Fetal Cardiac Impairment in Nitrofen-Induced Congenital Diaphragmatic Hernia: Postmortem Microcomputed Tomography Imaging Study.

artículo científico publicado en 2017

Fetal surgery and maternal cortisol response to stress. The myelomeningocele sheep model.

artículo científico publicado en 2015

Functional and social limitations after facial palsy: expanded and independent validation of the Italian version of the facial disability index

artículo científico publicado en 2014

Gender-based differences in the clustering of metabolic syndrome factors in children and adolescents

artículo científico publicado en 2020

Genetic epistasis between killer immunoglobulin-like receptors and human leukocyte antigens in Kawasaki disease susceptibility.

artículo científico publicado en 2015

Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients.

artículo científico publicado en 2003

Genomic alterations in human umbilical cord-derived mesenchymal stromal cells call for stringent quality control before any possible therapeutic approach

artículo científico publicado en 2013

Genotyping in patients affected by HLA-related diseases. App development for diagnostic support

artículo científico publicado en 2018

HLA and hypocomplementemia: the disadvantage of carrying the HLA-B35 and the silent alleles of the C4 complement component.

artículo científico publicado en 2004

HLA genes and surnames show a similar genetic structure in Lombardy: does this reflect part of the history of the region?

artículo científico publicado en 2007

HLA haplotypes and birth weight variation: is your future going to be light or heavy?

artículo científico publicado en 2009

HLA polymorphisms in Italian children with autism spectrum disorders: results of a family based linkage study

artículo científico publicado en 2010

HLA-A*01 is associated with late onset of Alzheimer's disease in Italian patients.

artículo científico publicado en 2009

HLA-A, -B and -C genotyping and haplotype frequencies in a population of 50 healthy unrelated Bone Marrow donors from Eastern Sicily

artículo científico publicado en 2017

HLA-A, -B, -DRB1 allele and haplotype frequencies of 674 cord blood donors from North Italy

artículo científico publicado en 2017

HLA-DQ genetics in children with Celiac disease: A meta-analysis suggesting a two-step genetic screening procedure starting with HLA-DQ β chains.

artículo científico publicado en 2017

HLA-DRB1 alleles and juvenile idiopathic arthritis: Diagnostic clues emerging from a meta-analysis

artículo científico publicado en 2017

Halo nevus, rather than vitiligo, is a typical dermatologic finding of Turner's syndrome: Clinical, genetic, and immunogenetic study in 72 patients

scientific article published on 01 September 2004

Helicobacter pyloriInfection and Autoimmune Thyroid Disease in Young Patients: The Disadvantage of Carrying the Human Leukocyte Antigen-DRB1*0301 Allele

artículo científico publicado en 2005

Hepatitis C infection in Italian psoriatic patients: prevalence and correlation with patient age and psoriasis severity

artículo científico publicado en 2011

Human Cytomegalovirus-Specific Memory CD4+ T-Cell Response and Its Correlation With Virus Transmission to the Fetus in Pregnant Women With Primary Infection

artículo científico publicado en 2017

Human colostrum T lymphocytes and their effector cytokines actively aid the development of the newborn immune system.

artículo científico publicado en 2008

Human cystic echinococcosis in Morocco: Ultrasound screening in the Mid Atlas through an Italian-Moroccan partnership

artículo científico publicado en 2017

Humoral response to recombinant hepatitis B virus vaccine at birth: role of HLA and beyond.

artículo científico publicado en 2000

Immunogenetic factors in mycosis fungoides: can the HLA system influence the susceptibility and prognosis of the disease? Long-term follow-up study of 46 patients

artículo científico publicado en 2014

Immunogenicity of a three-component acellular pertussis vaccine administered at birth

artículo científico publicado en 2003

Immunogenicity of hepatitis A-inactivated vaccine administered to seronegative infants, and serological follow-up 12 months after second dose.

artículo científico publicado en 2006

Immunoglobulin E levels in the 1st year of life

artículo científico publicado en 2008

Improved metabolic and cardiorespiratory fitness during a recreational training program in obese children

article

In vitro megakaryocyte differentiation and proplatelet formation in Ph-negative classical myeloproliferative neoplasms: distinct patterns in the different clinical phenotypes.

artículo científico publicado en 2011

Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis

artículo científico publicado en 2006

Increment of recombinant hepatitis B surface antigen-specific T-cell precursors after revaccination of slow responder children

artículo científico publicado en 2001

Infective endocarditis in patients with hepatic diseases.

artículo científico publicado en 2015

Inferior vena cava, abdominal aorta, and IVC-to-aorta ratio in healthy Caucasian children: Ultrasound Z-scores according to BSA and age

artículo científico publicado en 2019

Inflammation and atherosclerosis: the role of TNF and TNF receptors polymorphisms in coronary artery disease

artículo científico publicado en 2007

Influence of HLA-DQ2 and DQ8 on severity in celiac Disease.

artículo científico publicado en 2012

Inter-device reproducibility of retrobulbar blood flow velocity measurements in healthy subjects using color Doppler imaging

artículo científico publicado en 2016

Interobserver reproducibility in pathologist interpretation of columnar-lined esophagus

artículo científico publicado en 2015

Intragenomic conflict of maternal HLA haplotypes: A potential link between vigorous intrauterine growth and risk of autoimmunity in adulthood

artículo científico publicado en 2011

Kinetic and Angiogenic Activity of Circulating Endothelial Colony Forming Cells in Patients with Infantile Haemangioma Receiving Propranolol

artículo científico publicado en 2019

Kinetics of T-lymphocyte subsets and posttransplant opportunistic infections in heart and kidney transplant recipients

artículo científico publicado en 2012

Laparoscopy in children and its impact on brain oxygenation during routine inguinal hernia repair.

artículo científico publicado en 2017

Limited sampling strategy for the estimation of systemic exposure to the protease inhibitor nelfinavir

artículo científico publicado en 2005

Management of mineral metabolism in hemodialysis patients: discrepancy between interventions and perceived causes of failure

scientific article published on 08 May 2014

Maternal and neonatal outcomes in pregnant women with autoimmune diseases in Pavia, Italy

artículo científico publicado en 2015

Matrix metalloproteinase 2 may be a marker of microangiopathy in children and adolescents with type 1 diabetes

artículo científico publicado en 2004

Matrix metalloproteinase 2 may be a marker of microangiopathy in children and adolescents with type 1 diabetes mellitus

scientific article published on 18 April 2005

Medical treatment versus "Watch and Wait" in the clinical management of CE3b echinococcal cysts of the liver

artículo científico publicado en 2014

Mesenchymal stromal cells for cutaneous wound healing in a rabbit model: pre-clinical study applicable in the pediatric surgical setting.

artículo científico publicado en 2015

Meticillin-resistant Staphylococcus aureus control in an intensive care unit: a 10 year analysis.

artículo científico publicado en 2007

Microbiological sentinel events at a neurological hospital: a retrospective cohort study.

artículo científico publicado en 2016

Microbiota in Clostridioides difficile-Associated Diarrhea: Comparison in Recurrent and Non-Recurrent Infections

scientific article published on 08 September 2020

Minimum biopsy set for HER2 evaluation in gastric and gastro-esophageal junction cancer

artículo científico publicado en 2015

Molecular study of receptor for advanced glycation endproduct gene promoter and identification of specific HLA haplotypes possibly involved in chronic fatigue syndrome

artículo científico publicado en 2009

Monitoring of Busulphan Concentrations in Children Undergone Hematopoietic Stem Cell Transplantation: Unicentric Experience over 10 years.

artículo científico publicado en 2017

Mycosis fungoides: association of KIR ligands and HLA-DQB1*05 with bad prognosis of the disease

artículo científico publicado en 2015

Neonatal outcome in patients with rheumatic disease

artículo científico publicado en 2004

Neoplasia in Turner syndrome. The importance of clinical and screening practices during follow-up

artículo científico publicado en 2016

Non classical HLA genes and non-HLA genes in a population of infants at familial risk of atopy

artículo científico publicado en 2006

Noninvasive assessment of liver steatosis in children: the clinical value of controlled attenuation parameter.

artículo científico publicado en 2017

Novel bibliometric scores for evaluating research quality and output: a correlation study with established indexes

artículo científico publicado en 2016

Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell-therapy approaches: further insights in the search for a fetal calf serum substitute.

artículo científico publicado en 2007

Optimizing allergic disease prevention screening in newborns

scientific article published on 01 December 2006

Oral valganciclovir treatment in newborns with symptomatic congenital cytomegalovirus infection.

artículo científico publicado en 2009

PROTEIN C CONCENTRATE AS ADJUVANT TREATMENT IN NEONATES WITH SEPSIS-INDUCED COAGULOPATHY

artículo científico publicado en 2010

Pediatric Laparoscopy and Adaptive Oxygenation and Hemodynamic Changes.

artículo científico publicado en 2017

Pediatric anesthesia practice in Italy: a multicenter national prospective observational study derived from the APRICOT Trial

scientific article published on 09 December 2019

Pegvisomant-primed growth hormone (GH) stimulation test is useful in identifying true GH deficient children

artículo científico publicado en 2017

Percutaneous Coronary Intervention Techniques for Bifurcation Disease: Network Meta-analysis Reveals Superiority of Double-Kissing Crush

scientific article published on 09 September 2019

Personality traits in childhood and adolescent headache

artículo científico publicado en 2001

Plasma from donors recovered from the new Coronavirus 2019 as therapy for critical patients with COVID-19 (COVID-19 plasma study): a multicentre study protocol

artículo científico publicado en 2020

Plasma lactoferrin levels in newborn preterm infants with sepsis.

artículo científico publicado en 2016

Polymorphisms of microsomal epoxide hydrolase gene and severity of HCV-related liver disease

artículo científico publicado en 2002

Preliminary assessment of the diagnostic performances of a new rapid diagnostic test for the serodiagnosis of human cystic echinococcosis

artículo científico publicado en 2018

Prevalence and epidemiological correlates and treatment outcome of HCV infection in an Italian prison setting

artículo científico publicado en 2013

Prevalence, severity and clinical features of psoriasis in fingernails and toenails in adult patients: Italian experience

article

Psychological correlates of decision-making during prenatal diagnosis: a prospective study

artículo científico publicado en 2013

Radiation-induced circulating miRNA expression in blood of head and neck cancer patients

artículo científico publicado en 2020

Relevance of HLA-DQB1*02 Allele in the Genetic Predisposition of Children with Celiac Disease: Additional Cues from a Meta-Analysis

artículo científico publicado en 2019

Reproducibility of retrobulbar blood flow velocity measurements in normal subjects using two different CDI devices

artículo científico publicado en 2015

Response to antiretroviral treatment after failure of NNRTI plus NRTIs-based therapy. Data from the ARCA collaborative group.

artículo científico publicado en 2012

Role of endobronchial ultrasound strain elastography in the identification of fibrotic lymph nodes in sarcoidosis: A pilot study

scientific article published on 12 July 2020

Ruling-in and Ruling-out Significant Fibrosis and Cirrhosis in Patients with Chronic Hepatitis C Using a Shear Wave Measurement Method.

artículo científico publicado en 2017

Serum Calprotectin Level in Children: Marker of Obesity and its Metabolic Complications

artículo científico publicado en 2018

Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis.

artículo científico publicado en 2015

Specific polymorphisms of cytokine genes are associated with different risks to develop single-system or multi-system childhood Langerhans cell histiocytosis

artículo científico publicado en 2006

Stress Measured by Allostatic Load in Neurologically Impaired Children: The Importance of Nutritional Status.

artículo científico

Surnames, HLA genes and ancient migrations in the Po Valley (Italy)

artículo científico publicado el 1 de mayo de 1998

Sézary Syndrome: a clinico-pathological study of 9 cases and review of the literature

artículo científico publicado en 2020

T-lymphocyte subsets in lung transplant recipients: association between nadir CD4 T-cell count and viral infections after transplantation

artículo científico publicado en 2015

Targeting the immunogenetic diseases with the appropriate HLA molecular typing: critical appraisal on 2666 patients typed in one single centre.

artículo científico publicado en 2013

Th17 and Treg Balance in Children With Obesity and Metabolically Altered Status

artículo científico publicado en 2020

The HLA alleles DRB1*13 and DQB1*06 are associated to Whipple's disease

artículo científico publicado en 2009

The Immunosignature of Mother/Fetus Couples in Gestational Diabetes Mellitus: Role of HLA-G 14 bp ins/del and PAPP-A A/C Polymorphisms in the Uterine Inflammatory Milieu

artículo científico publicado en 2017

The Involvement of HLA Class II Alleles in Multiple Sclerosis: A Systematic Review with Meta-analysis

artículo científico publicado en 2019

The Role of Staphylococcus aureus in Mastitis: A Multidisciplinary Working Group Experience

artículo científico publicado en 2019

The clinical value of controlled attenuation parameter for the noninvasive assessment of liver steatosis

artículo científico publicado en 2016

The duration of clinical remission of photochemotherapy and narrow-band UV-B phototherapy in the treatment of psoriasis: a retrospective study

artículo científico publicado en 2008

The evolving landscape of human papillomavirus-related oropharyngeal squamous cell carcinoma at a single institution in Northern Italy

article

The impact of covid-19 pandemic on urgent endoscopy in Italy: a nation-wide multicenter study

artículo científico publicado en 2020

Thrombophilic screening in Turner syndrome.

artículo científico publicado en 2011

Timing, prevalence, and dynamics of thyroid disorders in children and adolescents affected with Down syndrome

artículo científico publicado en 2020

Triglyceride Glucose Index as a Surrogate Measure of Insulin Sensitivity in a Caucasian Pediatric Population

artículo científico publicado en 2019

Twenty Years Later: the Recent Trends of HIV-infection – Evidence from an Italian Region

article

Under-recognized post-stroke acute kidney injury: risk factors and relevance for stroke outcome of a frequent comorbidity

scientific article published on 20 June 2019

Update on α-antitrypsin deficiency

scientific article published on 01 June 2018

Use of IVUS guided coronary stenting with drug eluting stent: a systematic review and meta-analysis of randomized controlled clinical trials and high quality observational studies.

artículo científico

Validation of the Italian version of the Sunnybrook Facial Grading System.

artículo científico publicado en 2012

Waveform parameters of retrobulbar vessels in glaucoma patients with different demographics and disease severity

artículo científico publicado en 2019

What Is the Role of Barbed Suture in Laparoscopic Myomectomy? A Meta-Analysis and Pregnancy Outcome Evaluation

scientific article published on 12 April 2018