Lista de obras -

A nested gene in Streptomyces bacteria encodes a protein involved in quaternary complex formation

artículo científico publicado en 2007

A pharmaceutical model for the molecular evolution of microbial natural products

artículo científico publicado en 2019

Activation of microbial secondary metabolic pathways: Avenues and challenges

scientific article published on 12 September 2018

Artificial Reconstruction of Two Cryptic Angucycline Antibiotic Biosynthetic Pathways

artículo científico publicado en 2007

Biosynthesis of pyranonaphthoquinone polyketides reveals diverse strategies for enzymatic carbon-carbon bond formation

artículo científico

Biosynthetic conclusions from the functional dissection of oxygenases for biosynthesis of actinorhodin and related Streptomyces antibiotics.

artículo científico publicado en 2013

Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage

artículo científico publicado en 2012

Characterization and overproduction of cell-associated cholesterol oxidase ChoD from Streptomyces lavendulae YAKB-15

scientific article published on 14 August 2019

Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin ⬇️

scientific article published on 20 June 2019

Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.

artículo científico publicado en 2008

Characterization of the two-component monooxygenase system AlnT/AlnH reveals early timing of quinone formation in alnumycin biosynthesis

artículo científico publicado en 2012

Chemoenzymatic synthesis of novel C-ribosylated naphthoquinones

artículo científico publicado en 2013

Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater ⬇️

artículo científico publicado en 2012

Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis

artículo científico publicado en 2007

Discovery of a two-component monooxygenase SnoaW/SnoaL2 involved in nogalamycin biosynthesis

artículo científico publicado en 2012

Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics

artículo científico publicado en 2017

Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis

artículo científico publicado en 2015

Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway

artículo científico publicado en 2016

Effective Antibiofilm Polyketides against Staphylococcus aureus from the Pyranonaphthoquinone Biosynthetic Pathways of Streptomyces Species ⬇️

artículo científico publicado en 2015

Engineering Anthracycline Biosynthesis toward Angucyclines

artículo científico publicado en 2003

Engineering anthracycline biosynthesis toward angucyclines

artículo científico publicado en 2003

Enzymatic Synthesis of the C-Glycosidic Moiety of Nogalamycin R

artículo científico publicado en 2018

Evolution inspired engineering of antibiotic biosynthesis enzymes.

artículo científico publicado en 2017

Evolution-guided engineering of non-heme iron enzymes involved in nogalamycin biosynthesis

artículo científico publicado en 2019

Evolution-inspired engineering of anthracycline methyltransferases

Evolutionary Trajectories for the Functional Diversification of Anthracycline Methyltransferases

artículo científico publicado en 2019

Flavoprotein hydroxylase PgaE catalyzes two consecutive oxygen-dependent tailoring reactions in angucycline biosynthesis

artículo científico publicado en 2011

Formation of 5-Hydroxy-3-methoxy-1,4-naphthoquinone and 8-Hydroxy-4-methoxy-1,2-naphthoquinone from Juglone

artículo científico publicado en 2012

Functional and structural insights into a novel promiscuous ketoreductase of the lugdunomycin biosynthetic pathway

artículo científico publicado en 2020

Genotyping-Guided Discovery of Persiamycin A From Sponge-Associated Halophilic Streptomonospora sp. PA3 ⬇️

artículo científico publicado en 2020

Identification of Late-Stage Glycosylation Steps in the Biosynthetic Pathway of the Anthracycline Nogalamycin

scientific article published on 25 November 2011

Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE.

artículo científico publicado en 2016

Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives.

artículo científico publicado en 2008

Laboratory course on Streptomyces genetics and secondary metabolism

artículo científico publicado en 2016

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

artículo científico publicado en 2024

Minimum Information about a Biosynthetic Gene cluster.

artículo científico publicado en 2015

Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces species

artículo científico publicado en 2002

Molecular evolution of the bacterial pseudouridine-5'-phosphate glycosidase protein family

artículo científico publicado en 2014

Oxazinomycin arrests RNA polymerase at the polythymidine sequences

scientific article published on 01 November 2019

Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.

artículo científico publicado en 2004

Pathway engineering of anthracyclines: Blazing trails in natural product glycodiversification

scientific article published on 16 September 2020

Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products

artículo científico publicado en 2021

Sequential action of two flavoenzymes, PgaE and PgaM, in angucycline biosynthesis: chemoenzymatic synthesis of gaudimycin C.

artículo científico publicado en 2008

Single cell mutant selection for metabolic engineering of actinomycetes

scholarly article

Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis

artículo científico publicado en 2013

Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway

artículo científico publicado en 2013

Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis

artículo científico publicado en 2020

Structure-based engineering of angucyclinone 6-ketoreductases

artículo científico publicado en 2014

Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities

artículo científico publicado en 2013

Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.

artículo científico publicado en 2012

Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection

artículo científico publicado en 2014

The Rieske Oxygenase SnoT Catalyzes 2''-Hydroxylation of l-Rhodosamine in Nogalamycin Biosynthesis

scientific article published on 17 June 2020

The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases

scientific article published on 04 February 2021

Tracing the evolution of angucyclinone monooxygenases: structural determinants for C-12b hydroxylation and substrate inhibition in PgaE

artículo científico publicado en 2013

Lista de obras de

A nested gene in Streptomyces bacteria encodes a protein involved in quaternary complex formation

A pharmaceutical model for the molecular evolution of microbial natural products

Activation of microbial secondary metabolic pathways: Avenues and challenges

Artificial Reconstruction of Two Cryptic Angucycline Antibiotic Biosynthetic Pathways

Biosynthesis of pyranonaphthoquinone polyketides reveals diverse strategies for enzymatic carbon-carbon bond formation

Biosynthetic conclusions from the functional dissection of oxygenases for biosynthesis of actinorhodin and related Streptomyces antibiotics.

Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage

Characterization and overproduction of cell-associated cholesterol oxidase ChoD from Streptomyces lavendulae YAKB-15

Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin ⬇️

Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.

Characterization of the two-component monooxygenase system AlnT/AlnH reveals early timing of quinone formation in alnumycin biosynthesis

Chemoenzymatic synthesis of novel C-ribosylated naphthoquinones

Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater ⬇️

Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis

Discovery of a two-component monooxygenase SnoaW/SnoaL2 involved in nogalamycin biosynthesis

Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics

Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis

Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway

Effective Antibiofilm Polyketides against Staphylococcus aureus from the Pyranonaphthoquinone Biosynthetic Pathways of Streptomyces Species ⬇️

Engineering Anthracycline Biosynthesis toward Angucyclines

Engineering anthracycline biosynthesis toward angucyclines

Enzymatic Synthesis of the C-Glycosidic Moiety of Nogalamycin R

Evolution inspired engineering of antibiotic biosynthesis enzymes.

Evolution-guided engineering of non-heme iron enzymes involved in nogalamycin biosynthesis

Evolution-inspired engineering of anthracycline methyltransferases

Evolutionary Trajectories for the Functional Diversification of Anthracycline Methyltransferases

Flavoprotein hydroxylase PgaE catalyzes two consecutive oxygen-dependent tailoring reactions in angucycline biosynthesis

Formation of 5-Hydroxy-3-methoxy-1,4-naphthoquinone and 8-Hydroxy-4-methoxy-1,2-naphthoquinone from Juglone

Functional and structural insights into a novel promiscuous ketoreductase of the lugdunomycin biosynthetic pathway

Genotyping-Guided Discovery of Persiamycin A From Sponge-Associated Halophilic Streptomonospora sp. PA3 ⬇️

Identification of Late-Stage Glycosylation Steps in the Biosynthetic Pathway of the Anthracycline Nogalamycin

Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE.

Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives.

Laboratory course on Streptomyces genetics and secondary metabolism

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

Minimum Information about a Biosynthetic Gene cluster.

Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces species

Molecular evolution of the bacterial pseudouridine-5'-phosphate glycosidase protein family

Oxazinomycin arrests RNA polymerase at the polythymidine sequences

Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.

Pathway engineering of anthracyclines: Blazing trails in natural product glycodiversification

Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products

Sequential action of two flavoenzymes, PgaE and PgaM, in angucycline biosynthesis: chemoenzymatic synthesis of gaudimycin C.

Single cell mutant selection for metabolic engineering of actinomycetes

Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis

Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway

Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis

Structure-based engineering of angucyclinone 6-ketoreductases

Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities

Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.

Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection

The Rieske Oxygenase SnoT Catalyzes 2''-Hydroxylation of l-Rhodosamine in Nogalamycin Biosynthesis

The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases

Tracing the evolution of angucyclinone monooxygenases: structural determinants for C-12b hydroxylation and substrate inhibition in PgaE