Lista de obras - Michael O Hottiger - Dominio Público Uruguay

A Novel Spectral Annotation Strategy Streamlines Reporting of Mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-γ

scientific article published on 28 September 2021

A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function

artículo científico publicado en 2014

A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation

artículo científico publicado en 2019

A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions ⬇️

artículo científico publicado en 2016

A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation

artículo científico publicado en 2000

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

artículo científico publicado en 2009

A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation

artículo científico publicado en 1999

ADP-ribosylation of histones by ARTD1: an additional module of the histone code?

scientific article published on 21 March 2011

ARTD1 Suppresses Interleukin 6 Expression by Repressing MLL1-Dependent Histone H3 Trimethylation.

artículo científico publicado en 2015

ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation

artículo científico publicado en 2012

ARTD1 in Myeloid Cells Controls the IL-12/18-IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer

scientific article published on 23 January 2019

ARTD1 regulates cyclin E expression and consequently cell-cycle re-entry and G1/S progression in T24 bladder carcinoma cells.

artículo científico publicado en 2016

ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchange

artículo científico publicado en 2014

ARTD2 activity is stimulated by RNA.

artículo científico publicado en 2014

Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation

artículo científico publicado en 2010

Absent in Melanoma 2 (AIM2) limits pro-inflammatory cytokine transcription in cardiomyocytes by inhibiting STAT1 phosphorylation.

artículo científico publicado en 2016

Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression

artículo científico publicado en 2010

Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription

artículo científico publicado en 2005

Acetylation regulates the DNA end-trimming activity of DNA polymerase beta

artículo científico publicado en 2002

Analysis of Chromatin ADP-Ribosylation at the Genome-wide Level and at Specific Loci by ADPr-ChAP.

artículo científico publicado en 2016

Arginine methylation regulates DNA polymerase beta

artículo científico publicado en 2006

Artd1/Parp1 regulates reprogramming by transcriptional regulation of Fgf4 via Sox2 ADP-ribosylation

artículo científico publicado en 2013

CARM1 but not its enzymatic activity is required for transcriptional coactivation of NF-kappaB-dependent gene expression

artículo científico publicado en 2009

Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells

artículo científico publicado en 2011

Chemoselective Dimerization of Phosphates

artículo científico publicado en 2016

Combining Higher-Energy Collision Dissociation and Electron-Transfer/Higher-Energy Collision Dissociation Fragmentation in a Product-Dependent Manner Confidently Assigns Proteomewide ADP-Ribose Acceptor Sites

artículo científico publicado en 2016

Comprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site

artículo científico publicado en 2018

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

artículo científico publicado en 2016

Differential discrimination of DNA polymerase for variants of the non-standard nucleobase pair between xanthosine and 2,4-diaminopyrimidine, two components of an expanded genetic alphabet.

artículo científico publicado en 1996

Discovery of Compounds Inhibiting the ADP-Ribosyltransferase Activity of Pertussis Toxin

artículo científico publicado en 2020

Ecto-ADP-ribosyltransferase ARTC2.1 functionally modulates FcγR1 and FcγR2B on murine microglia

artículo científico publicado en 2017

Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

scientific article published on 15 October 2020

Enhancement of the efficiency of non-viral gene delivery by application of pulsed magnetic field

artículo científico publicado en 2006

Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage

artículo científico publicado en 2017

Epstein-Barr virus nuclear antigen 3C and prothymosin alpha interact with the p300 transcriptional coactivator at the CH1 and CH3/HAT domains and cooperate in regulation of transcription and histone acetylation.

artículo científico publicado en 2002

Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling

artículo científico publicado en 2014

Functional genomics in HIV-1 virus replication: protein-protein interactions as a basis for recruiting the host cell machinery for viral propagation.

artículo científico publicado en 2001

Gas-Phase Fragmentation of ADP-Ribosylated Peptides: Arginine-Specific Side-Chain Losses and Their Implication in Database Searches

artículo científico publicado en 2020

Gene expression in synovial membrane cells after intraarticular delivery of plasmid-linked superparamagnetic iron oxide particles--a preliminary study in sheep

artículo científico publicado en 2006

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells

scientific article published on 01 November 2018

HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination

artículo científico publicado en 2011

HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator

artículo científico publicado en 1998

HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other

artículo científico publicado en 2001

Histone ADP-ribosylation in DNA repair, replication and transcription.

artículo científico publicado en 2011

Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways

scientific article published on 22 August 2013

Identification of distinct amino acids as ADP-ribose acceptor sites by mass spectrometry

artículo científico publicado en 2011

Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation.

artículo científico publicado en 2008

Identification of novel and cell type enriched cofactors of the transcription activation domain of RelA (p65 NF-kappaB).

artículo científico publicado en 2005

Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS

artículo científico publicado en 2008

Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes.

artículo científico publicado en 2012

Inheritance of silent rDNA chromatin is mediated by PARP1 via noncoding RNA.

artículo científico publicado en 2012

Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia.

artículo científico publicado en 2010

Isolation, establishment, and characterization of ex vivo equine melanoma cell cultures

artículo científico publicado en 2008

Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo

artículo científico publicado en 2017

Liposome-mediated gene transfer into human basal cell carcinoma

artículo científico publicado en 1999

Localized insulin-like growth factor I delivery to enhance new bone formation

artículo científico publicado en 2003

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

artículo científico publicado en 2014

Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.

artículo científico publicado en 2013

Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300.

artículo científico publicado en 1998

NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells

artículo científico publicado en 2005

New Quantitative Mass Spectrometry Approaches Reveal Different ADP-ribosylation Phases Dependent On the Levels of Oxidative Stress.

artículo científico publicado en 2017

New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy

artículo científico publicado en 2020

Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics.

artículo científico publicado en 2015

Optimization of LTQ-Orbitrap Mass Spectrometer Parameters for the Identification of ADP-Ribosylation Sites.

artículo científico publicado en 2015

PARP-1 and gene regulation: progress and puzzles.

artículo científico

PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase

artículo científico publicado en 2003

PARP1 ADP-ribosylates lysine residues of the core histone tails

artículo científico publicado en 2010

PARP1 is required for adhesion molecule expression in atherogenesis

artículo científico publicado en 2007

PKC signaling prevents irradiation-induced apoptosis of primary human fibroblasts

artículo científico publicado en 2013

PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation

artículo científico publicado en 2016

Peroxynitrite induces gene expression in intervertebral disc cells

artículo científico publicado en 2009

Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding

scientific journal article

Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression

artículo científico publicado en 2008

Poly(ADP-ribose) polymerase inhibitor therapeutic effect: are we just scratching the surface?

artículo científico publicado en 2015

Poly(ADP-ribose) polymerase-1 protects from oxidative stress induced endothelial dysfunction

artículo científico publicado en 2011

Poly(ADP-ribosyl)ation of Methyl CpG Binding Domain Protein 2 Regulates Chromatin Structure.

artículo científico publicado en 2016

Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation

artículo científico publicado en 2016

Progress in the function and regulation of ADP-Ribosylation

artículo científico publicado en 2011

Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1.

artículo científico publicado en 2008

Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses

artículo científico publicado en 2013

Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue.

scientific article published on 30 September 2016

Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase

artículo científico publicado en 2017

Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation

artículo científico publicado en 2016

Regulation of beta -catenin transformation by the p300 transcriptional coactivator.

artículo científico publicado en 2000

SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress

artículo científico publicado en 2013

SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance

artículo científico publicado en 2011

SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1

artículo científico publicado en 2009

SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310

artículo científico publicado en 2010

Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission

artículo científico publicado en 2016

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1

artículo científico publicado en 2020

SnapShot: ADP-Ribosylation Signaling

artículo científico publicado en 2015

Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

artículo científico publicado en 2008

Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function.

artículo científico publicado en 2009

Systemic distribution and elimination of plain and with Cy3.5 functionalized poly(vinyl alcohol) coated superparamagnetic maghemite nanoparticles after intraarticular injection in sheep in vivo

artículo científico publicado en 2006

Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death

artículo científico publicado en 2022

The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

artículo científico publicado en 2014

The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.

artículo científico publicado en 2012

The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.

artículo científico publicado en 2008

The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity.

artículo científico publicado en 2005

Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

artículo científico publicado en 2010

Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis

artículo científico publicado en 2001

Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1.

artículo científico publicado en 2003

Uptake and biocompatibility of functionalized poly(vinylalcohol) coated superparamagnetic maghemite nanoparticles by synoviocytes in vitro.

artículo científico publicado en 2006

WNT/β-catenin signaling inhibits CBP-mediated RelA acetylation and expression of proinflammatory NF-κB target genes.

artículo científico publicado en 2015

p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization.

artículo científico publicado en 2009

p65 controls NF-κB activity by regulating cellular localization of IκBβ

artículo científico publicado en 2011

Lista de obras de Michael O Hottiger

A Novel Spectral Annotation Strategy Streamlines Reporting of Mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-γ

A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function

A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation

A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions ⬇️

A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation

ADP-ribosylation of histones by ARTD1: an additional module of the histone code?

ARTD1 Suppresses Interleukin 6 Expression by Repressing MLL1-Dependent Histone H3 Trimethylation.

ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation

ARTD1 in Myeloid Cells Controls the IL-12/18-IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer

ARTD1 regulates cyclin E expression and consequently cell-cycle re-entry and G1/S progression in T24 bladder carcinoma cells.

ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchange

ARTD2 activity is stimulated by RNA.

Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation

Absent in Melanoma 2 (AIM2) limits pro-inflammatory cytokine transcription in cardiomyocytes by inhibiting STAT1 phosphorylation.

Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression

Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription

Acetylation regulates the DNA end-trimming activity of DNA polymerase beta

Analysis of Chromatin ADP-Ribosylation at the Genome-wide Level and at Specific Loci by ADPr-ChAP.

Arginine methylation regulates DNA polymerase beta

Artd1/Parp1 regulates reprogramming by transcriptional regulation of Fgf4 via Sox2 ADP-ribosylation

CARM1 but not its enzymatic activity is required for transcriptional coactivation of NF-kappaB-dependent gene expression

Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells

Chemoselective Dimerization of Phosphates

Combining Higher-Energy Collision Dissociation and Electron-Transfer/Higher-Energy Collision Dissociation Fragmentation in a Product-Dependent Manner Confidently Assigns Proteomewide ADP-Ribose Acceptor Sites

Comprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

Differential discrimination of DNA polymerase for variants of the non-standard nucleobase pair between xanthosine and 2,4-diaminopyrimidine, two components of an expanded genetic alphabet.

Discovery of Compounds Inhibiting the ADP-Ribosyltransferase Activity of Pertussis Toxin

Ecto-ADP-ribosyltransferase ARTC2.1 functionally modulates FcγR1 and FcγR2B on murine microglia

Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

Enhancement of the efficiency of non-viral gene delivery by application of pulsed magnetic field

Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage

Epstein-Barr virus nuclear antigen 3C and prothymosin alpha interact with the p300 transcriptional coactivator at the CH1 and CH3/HAT domains and cooperate in regulation of transcription and histone acetylation.

Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling

Functional genomics in HIV-1 virus replication: protein-protein interactions as a basis for recruiting the host cell machinery for viral propagation.

Gas-Phase Fragmentation of ADP-Ribosylated Peptides: Arginine-Specific Side-Chain Losses and Their Implication in Database Searches

Gene expression in synovial membrane cells after intraarticular delivery of plasmid-linked superparamagnetic iron oxide particles--a preliminary study in sheep

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells

HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination

HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator

HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other

Histone ADP-ribosylation in DNA repair, replication and transcription.

Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways

Identification of distinct amino acids as ADP-ribose acceptor sites by mass spectrometry

Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation.

Identification of novel and cell type enriched cofactors of the transcription activation domain of RelA (p65 NF-kappaB).

Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS

Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes.

Inheritance of silent rDNA chromatin is mediated by PARP1 via noncoding RNA.

Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia.

Isolation, establishment, and characterization of ex vivo equine melanoma cell cultures

Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo

Liposome-mediated gene transfer into human basal cell carcinoma

Localized insulin-like growth factor I delivery to enhance new bone formation

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.

Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300.

NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells

New Quantitative Mass Spectrometry Approaches Reveal Different ADP-ribosylation Phases Dependent On the Levels of Oxidative Stress.

New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy

Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics.

Optimization of LTQ-Orbitrap Mass Spectrometer Parameters for the Identification of ADP-Ribosylation Sites.

PARP-1 and gene regulation: progress and puzzles.

PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase

PARP1 ADP-ribosylates lysine residues of the core histone tails

PARP1 is required for adhesion molecule expression in atherogenesis

PKC signaling prevents irradiation-induced apoptosis of primary human fibroblasts

PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation

Peroxynitrite induces gene expression in intervertebral disc cells

Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding

Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression

Poly(ADP-ribose) polymerase inhibitor therapeutic effect: are we just scratching the surface?

Poly(ADP-ribose) polymerase-1 protects from oxidative stress induced endothelial dysfunction

Poly(ADP-ribosyl)ation of Methyl CpG Binding Domain Protein 2 Regulates Chromatin Structure.

Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation

Progress in the function and regulation of ADP-Ribosylation

Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1.