Lista de obras - Matthew P Blakeley - Dominio Público Uruguay

"To Be or Not to Be" Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation.

artículo científico publicado en 2018

A molecular mechanism for transthyretin amyloidogenesis

scientific article published on 25 February 2019

A preliminary neutron crystallographic study of an A-DNA crystal.

artículo científico publicado en 2009

A preliminary neutron crystallographic study of proteinase K at pD 6.5.

artículo científico publicado en 2009

A preliminary neutron diffraction study of rasburicase, a recombinant urate oxidase enzyme, complexed with 8-azaxanthin

artículo científico publicado en 2006

An extended N-H bond, driven by a conserved second-order interaction, orients the flavin N5 orbital in cholesterol oxidase

artículo científico publicado en 2017

Back-exchange of deuterium in neutron crystallography: characterization by IR spectroscopy.

artículo científico publicado en 2017

Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein

artículo científico publicado en 2014

Catalytically important damage-free structures of a copper nitrite reductase obtained by femtosecond X-ray laser and room-temperature neutron crystallography

scientific article published on 23 June 2019

Combined neutron and X-ray diffraction studies of DNA in crystals and solutions

article

Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase–inhibitor complex

artículo científico publicado en 2006

Direct visualization of a Fe(IV)-OH intermediate in a heme enzyme

artículo científico publicado en 2016

Direct visualization of critical hydrogen atoms in a pyridoxal 5'-phosphate enzyme

artículo científico publicado en 2017

Elucidation of hydrogen bonding patterns in ligand-free, lactose- and glycerol-bound galectin-3C by neutron crystallography to guide drug design.

artículo científico publicado en 2018

Heme enzymes. Neutron cryo-crystallography captures the protonation state of ferryl heme in a peroxidase

artículo científico publicado en 2014

Heme peroxidase-Trapping intermediates by cryo neutron crystallography

artículo científico publicado en 2020

High-resolution neutron and X-ray diffraction room-temperature studies of an H-FABP-oleic acid complex: study of the internal water cluster and ligand binding by a transferred multipolar electron-density distribution

artículo científico publicado en 2016

High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase.

artículo científico publicado en 2005

Identification of the elusive hydronium ion exchanging roles with a proton in an enzyme at lower pH values

artículo científico publicado en 2011

Incorporation of methyl-protonated valine and leucine residues into deuterated ocean pout type III antifreeze protein: expression, crystallization and preliminary neutron diffraction studies.

artículo científico publicado en 2010

Inorganic pyrophosphatase crystals from Thermococcus thioreducensfor X-ray and neutron diffraction

artículo científico publicado en 2012

L-Arabinose binding, isomerization, and epimerization by D-xylose isomerase: X-ray/neutron crystallographic and molecular simulation study

artículo científico publicado en 2014

Large crystal growth by thermal control allows combined X-ray and neutron crystallographic studies to elucidate the protonation states in Aspergillus flavus urate oxidase.

artículo científico publicado en 2009

Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site

artículo científico publicado en 2016

Metal Ion Roles and the Movement of Hydrogen during Reaction Catalyzed by D-Xylose Isomerase: A Joint X-Ray and Neutron Diffraction Study

artículo científico publicado en 2010

Near-atomic resolution neutron crystallography on perdeuterated Pyrococcus furiosus rubredoxin: implication of hydronium ions and protonation state equilibria in redox changes

artículo científico publicado en 2013

Neutron Crystallography Detects Differences in Protein Dynamics: Structure of the PKG II Cyclic Nucleotide Binding Domain in Complex with an Activator.

artículo científico publicado en 2018

Neutron Laue macromolecular crystallography.

artículo científico publicado en 2006

Neutron crystallography aids in drug design

artículo científico publicado en 2016

Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding

artículo científico publicado en 2022

Neutron crystallography: opportunities, challenges, and limitations

artículo científico publicado en 2008

Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: insights for cGMP-dependent protein kinase agonist design.

artículo científico publicado en 2014

Neutron diffraction studies of a class A beta-lactamase Toho-1 E166A/R274N/R276N triple mutant

artículo científico publicado en 2010

Neutron macromolecular crystallography with LADI-III.

artículo científico publicado en 2010

Neutron structures of <i>Leishmania mexicana</i> triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps

artículo científico publicado en 2021

Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C

artículo científico publicado en 2016

Perdeuteration, large crystal growth and neutron data collection of Leishmania mexicana triose-phosphate isomerase E65Q variant

artículo científico publicado en 2019

Perdeuteration, purification, crystallization and preliminary neutron diffraction of an ocean pout type III antifreeze protein.

artículo científico publicado en 2009

Perdeuteration: improved visualization of solvent structure in neutron macromolecular crystallography

artículo científico publicado en 2014

Production of perdeuterated fucose from glyco-engineered bacteria

artículo científico publicado en 2020

Production, crystallization and neutron diffraction of fully deuterated human myelin peripheral membrane protein P2.

artículo científico publicado en 2015

Protein kinase A in the neutron beam: Insights for catalysis from directly observing protons

artículo científico publicado en 2020

Proton transfer and drug binding details revealed in neutron diffraction studies of wild-type and drug resistant HIV-1 protease

artículo científico publicado en 2020

Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase

artículo científico publicado en 2008

Rapid visualization of hydrogen positions in protein neutron crystallographic structures

artículo científico publicado en 2012

Room Temperature Neutron Crystallography of Drug Resistant HIV-1 Protease Uncovers Limitations of X-ray Structural Analysis at 100 K.

artículo científico publicado en 2017

Sub-atomic resolution X-ray crystallography and neutron crystallography: promise, challenges and potential

artículo científico publicado en 2015

Sweet neutron crystallography

artículo científico publicado el 20 de octubre de 2010

Synchrotron and neutron techniques in biological crystallography.

artículo científico publicado en 2004

Temperature-Induced Replacement of Phosphate Proton with Metal Ion Captured in Neutron Structures of A-DNA

scientific article published on 20 September 2018

The active site protonation states of perdeuterated Toho-1 β-lactamase determined by neutron diffraction support a role for Glu166 as the general base in acylation

artículo científico publicado en 2011

The neutron structure of urate oxidase resolves a long-standing mechanistic conundrum and reveals unexpected changes in protonation

artículo científico publicado en 2014

Unambiguous determination of H-atom positions: comparing results from neutron and high-resolution X-ray crystallography

artículo científico publicado en 2010

Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative

artículo científico publicado en 2019

Visualizing the protons in a metalloenzyme electron proton transfer pathway

scientific article published on 09 March 2020

Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex

scientific article published on 20 March 2019

Lista de obras de Matthew P Blakeley

"To Be or Not to Be" Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation.

A molecular mechanism for transthyretin amyloidogenesis

A preliminary neutron crystallographic study of an A-DNA crystal.

A preliminary neutron crystallographic study of proteinase K at pD 6.5.

A preliminary neutron diffraction study of rasburicase, a recombinant urate oxidase enzyme, complexed with 8-azaxanthin

An extended N-H bond, driven by a conserved second-order interaction, orients the flavin N5 orbital in cholesterol oxidase

Back-exchange of deuterium in neutron crystallography: characterization by IR spectroscopy.

Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein

Catalytically important damage-free structures of a copper nitrite reductase obtained by femtosecond X-ray laser and room-temperature neutron crystallography

Combined neutron and X-ray diffraction studies of DNA in crystals and solutions

Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase–inhibitor complex

Direct visualization of a Fe(IV)-OH intermediate in a heme enzyme

Direct visualization of critical hydrogen atoms in a pyridoxal 5'-phosphate enzyme

Elucidation of hydrogen bonding patterns in ligand-free, lactose- and glycerol-bound galectin-3C by neutron crystallography to guide drug design.

Heme enzymes. Neutron cryo-crystallography captures the protonation state of ferryl heme in a peroxidase

Heme peroxidase-Trapping intermediates by cryo neutron crystallography

High-resolution neutron and X-ray diffraction room-temperature studies of an H-FABP-oleic acid complex: study of the internal water cluster and ligand binding by a transferred multipolar electron-density distribution

High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase.

Identification of the elusive hydronium ion exchanging roles with a proton in an enzyme at lower pH values

Incorporation of methyl-protonated valine and leucine residues into deuterated ocean pout type III antifreeze protein: expression, crystallization and preliminary neutron diffraction studies.

Inorganic pyrophosphatase crystals from Thermococcus thioreducensfor X-ray and neutron diffraction

L-Arabinose binding, isomerization, and epimerization by D-xylose isomerase: X-ray/neutron crystallographic and molecular simulation study

Large crystal growth by thermal control allows combined X-ray and neutron crystallographic studies to elucidate the protonation states in Aspergillus flavus urate oxidase.

Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site

Metal Ion Roles and the Movement of Hydrogen during Reaction Catalyzed by D-Xylose Isomerase: A Joint X-Ray and Neutron Diffraction Study

Near-atomic resolution neutron crystallography on perdeuterated Pyrococcus furiosus rubredoxin: implication of hydronium ions and protonation state equilibria in redox changes

Neutron Crystallography Detects Differences in Protein Dynamics: Structure of the PKG II Cyclic Nucleotide Binding Domain in Complex with an Activator.

Neutron Laue macromolecular crystallography.

Neutron crystallography aids in drug design

Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding

Neutron crystallography: opportunities, challenges, and limitations

Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: insights for cGMP-dependent protein kinase agonist design.

Neutron diffraction studies of a class A beta-lactamase Toho-1 E166A/R274N/R276N triple mutant

Neutron macromolecular crystallography with LADI-III.

Neutron structures of <i>Leishmania mexicana</i> triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps

Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C

Perdeuteration, large crystal growth and neutron data collection of Leishmania mexicana triose-phosphate isomerase E65Q variant

Perdeuteration, purification, crystallization and preliminary neutron diffraction of an ocean pout type III antifreeze protein.

Perdeuteration: improved visualization of solvent structure in neutron macromolecular crystallography

Production of perdeuterated fucose from glyco-engineered bacteria

Production, crystallization and neutron diffraction of fully deuterated human myelin peripheral membrane protein P2.

Protein kinase A in the neutron beam: Insights for catalysis from directly observing protons

Proton transfer and drug binding details revealed in neutron diffraction studies of wild-type and drug resistant HIV-1 protease

Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase

Rapid visualization of hydrogen positions in protein neutron crystallographic structures

Room Temperature Neutron Crystallography of Drug Resistant HIV-1 Protease Uncovers Limitations of X-ray Structural Analysis at 100 K.

Sub-atomic resolution X-ray crystallography and neutron crystallography: promise, challenges and potential

Sweet neutron crystallography

Synchrotron and neutron techniques in biological crystallography.

Temperature-Induced Replacement of Phosphate Proton with Metal Ion Captured in Neutron Structures of A-DNA

The active site protonation states of perdeuterated Toho-1 β-lactamase determined by neutron diffraction support a role for Glu166 as the general base in acylation

The neutron structure of urate oxidase resolves a long-standing mechanistic conundrum and reveals unexpected changes in protonation

Unambiguous determination of H-atom positions: comparing results from neutron and high-resolution X-ray crystallography

Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative

Visualizing the protons in a metalloenzyme electron proton transfer pathway

Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex