Lista de obras - Brian D Hudson - Dominio Público Uruguay

A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor

artículo científico publicado en 2016

A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias

artículo científico publicado en 2017

Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases

artículo científico publicado en 2015

Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4.

artículo científico publicado en 2015

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs.

artículo científico publicado en 2012

Chemogenetics defines receptor-mediated functions of short chain free fatty acids

artículo científico publicado en 2019

Comparison of immunomodulator mRNA and protein expression in the lungs of Stachybotrys chartarum spore-exposed mice

artículo científico publicado en 2005

Comparison of inflammatory and cytotoxic lung responses in mice after intratracheal exposure to spores of two different Stachybotrys chartarum strains

artículo científico publicado en 2004

Complex Pharmacology of Free Fatty Acid Receptors.

artículo científico publicado en 2016

Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands

artículo científico publicado en 2014

Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4

artículo científico publicado en 2014

Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

artículo científico publicado en 2013

Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43).

artículo científico publicado en 2017

Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer.

artículo científico publicado en 2016

Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes ⬇️

artículo científico publicado el 8 de abril de 2013

Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy.

artículo científico publicado en 2016

Discovery of a potent and selective GPR120 agonist.

artículo científico publicado en 2012

Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability.

artículo científico publicado en 2013

Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120.

artículo científico publicado en 2016

Drugs or diet?--Developing novel therapeutic strategies targeting the free fatty acid family of GPCRs

artículo científico publicado en 2013

Experimental challenges to targeting poorly characterized GPCRs: uncovering the therapeutic potential for free fatty acid receptors.

artículo científico publicado en 2011

Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.

artículo científico publicado en 2012

Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator

artículo científico publicado en 2011

FFA4/GPR120: Pharmacology and Therapeutic Opportunities.

artículo científico publicado en 2017

Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance

artículo científico publicado en 2017

Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties

artículo científico publicado en 2012

G-protein-coupled receptors for free fatty acids: nutritional and therapeutic targets

artículo científico publicado en 2014

Identification of novel competing β2AR phospho-extracellular signal regulated kinase 1/2 signaling pathways in human trabecular meshwork cells

artículo científico publicado en 2011

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

artículo científico publicado en 2010

Indirect sympatholytic actions at β-adrenoceptors account for the ocular hypotensive actions of cannabinoid receptor agonists

scientific article published on 01 September 2011

Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice

artículo científico publicado en 2014

Ligand- and heterodimer-directed signaling of the CB(1) cannabinoid receptor.

artículo científico publicado en 2009

Mechanism and function of Drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor

artículo científico publicado en 2012

Minireview: The effects of species ortholog and SNP variation on receptors for free fatty acids.

artículo científico publicado en 2013

Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity

artículo científico publicado en 2016

Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands.

artículo científico publicado en 2015

Physical and functional interaction between CB1 cannabinoid receptors and beta2-adrenoceptors

artículo científico publicado en 2010

Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4.

artículo científico publicado en 2017

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3

artículo científico publicado en 2011

The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35

scientific article published on 10 October 2013

The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120).

artículo científico publicado en 2014

The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism

artículo científico publicado en 2013

The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs.

artículo científico

Treatment of type 2 diabetes by free Fatty Acid receptor agonists

artículo científico

Using Biosensors to Study Free Fatty Acid Receptor Pharmacology and Function

artículo científico publicado en 2016

Lista de obras de Brian D Hudson

A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor

A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias

Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases

Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4.

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs.

Chemogenetics defines receptor-mediated functions of short chain free fatty acids

Comparison of immunomodulator mRNA and protein expression in the lungs of Stachybotrys chartarum spore-exposed mice

Comparison of inflammatory and cytotoxic lung responses in mice after intratracheal exposure to spores of two different Stachybotrys chartarum strains

Complex Pharmacology of Free Fatty Acid Receptors.

Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands

Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4

Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43).

Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer.

Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes ⬇️

Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy.

Discovery of a potent and selective GPR120 agonist.

Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability.

Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120.

Drugs or diet?--Developing novel therapeutic strategies targeting the free fatty acid family of GPCRs

Experimental challenges to targeting poorly characterized GPCRs: uncovering the therapeutic potential for free fatty acid receptors.

Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.

Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator

FFA4/GPR120: Pharmacology and Therapeutic Opportunities.

Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance

Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties

G-protein-coupled receptors for free fatty acids: nutritional and therapeutic targets

Identification of novel competing β2AR phospho-extracellular signal regulated kinase 1/2 signaling pathways in human trabecular meshwork cells

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

Indirect sympatholytic actions at β-adrenoceptors account for the ocular hypotensive actions of cannabinoid receptor agonists

Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice

Ligand- and heterodimer-directed signaling of the CB(1) cannabinoid receptor.

Mechanism and function of Drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor

Minireview: The effects of species ortholog and SNP variation on receptors for free fatty acids.

Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity

Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands.

Physical and functional interaction between CB1 cannabinoid receptors and beta2-adrenoceptors

Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4.

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3

The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35

The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120).

The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism

The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs.

Treatment of type 2 diabetes by free Fatty Acid receptor agonists

Using Biosensors to Study Free Fatty Acid Receptor Pharmacology and Function