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Lista de obras de Sabine André

1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 31 kDa human galectin-7 (p53-induced gene 1) homodimer, a pro-apoptotic lectin

article

1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 36 proline-containing, full length 29 kDa human chimera-type galectin-3

article

A new combined computational and NMR-spectroscopical strategy for the identification of additional conformational constraints of the bound ligand in an aprotic solvent

artículo científico publicado en 2000

AB-type lectin (toxin/agglutinin) from mistletoe: differences in affinity of the two galactoside-binding Trp/Tyr-sites and regulation of their functionality by monomer/dimer equilibrium.

artículo científico

Activity-structure correlations in divergent lectin evolution: fine specificity of chicken galectin CG-14 and computational analysis of flexible ligand docking for CG-14 and the closely related CG-16.

artículo científico publicado en 2006

Adhesion/Growth-Regulatory Galectins: Insights into Their Ligand Selectivity Using Natural Glycoproteins and Glycotopes

artículo científico publicado en 2011

Adhesion/growth-regulatory galectins in the human eye: localization profiles and tissue reactivities as a standard to detect disease-associated alterations

artículo científico publicado en 2012

Adhesion/growth-regulatory tissue lectin galectin-1 in relation to angiogenesis/lymphocyte infiltration and prognostic relevance of stromal up-regulation in laryngeal carcinomas.

artículo científico publicado en 2009

Analysis of homodimeric avian and human galectins by two methods based on fluorescence spectroscopy: different structural alterations upon oxidation and ligand binding.

artículo científico publicado en 2012

Analysis of protein-carbohydrate interaction at the lower size limit of the protein part (15-mer peptide) by NMR spectroscopy, electrospray ionization mass spectrometry, and molecular modeling

artículo científico publicado en 2002

Analysis of selected blood and immune cell responses to carbohydrate-dependent surface binding of proto- and chimera-type galectins

artículo científico publicado en 2003

Are matrix-immobilized neoglycoproteins, plant and human lectins and carbohydrate--binding antibodies from human serum mediators of adhesion in vitro for carcinoma and lymphosarcoma cells?

artículo científico publicado en 1995

Assessing the inhibitory potency of galectin ligands identified from combinatorial (glyco)peptide libraries using surface plasmon resonance spectroscopy

artículo científico publicado en 2008

Association of concentration of asbestos and asbestos-like fibers with the patient's survival and the binding capacity of lung parenchyma to galectin-1 and natural alpha-galactoside- and alpha-mannoside-binding immunoglobulin G subfractions from huma

artículo científico publicado en 2000

Association of galectin-1- but not galectin-3-dependent parameters with proliferation activity in human neuroblastomas and small cell lung carcinomas

artículo científico publicado en 2002

Atypical adenomatous hyperplasia of lung: its incidence and analysis of clinical, glycohistochemical and structural features including newly defined growth regulators and vascularization

artículo científico publicado en 2003

Autoantibodies against galectin-2 peptides as biomarkers for the antiphospholipid syndrome

scientific article published on 01 June 2012

Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation

artículo científico publicado en 2009

Autoantibodies against galectins are associated with antiphospholipid syndrome in patients with systemic lupus erythematosus

scientific article published on 11 August 2012

Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1 [corrected].

artículo científico

Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins

artículo científico publicado en 2015

Bi- to tetravalent glycoclusters: synthesis, structure–activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity

artículo científico publicado en 2012

Binding capacities of two immunomodulatory lectins, carrier-immobilized glycoligands and steroid hormones in lung cancer and the concentration of nitrite/nitrate in pleural effusions

scientific article published on 01 February 1996

Binding studies of adhesion/growth-regulatory galectins with glycoconjugates monitored by surface plasmon resonance and NMR spectroscopy

scientific article published on 12 May 2010

Bioactive cell-like hybrids coassembled from (glyco)dendrimersomes with bacterial membranes

artículo científico publicado en 2016

Breaking pseudo-symmetry in multiantennary complex N-glycans using lanthanide-binding tags and NMR pseudo-contact shifts.

artículo científico publicado en 2013

CD4+CD7- leukemic T cells from patients with Sézary syndrome are protected from galectin-1-triggered T cell death.

artículo científico publicado en 2002

Calibration of Colorimetric Protein Assays for Quantitation of Plant AB Toxins

article

Calix[n]arene-based glycoclusters: bioactivity of thiourea-linked galactose/lactose moieties as inhibitors of binding of medically relevant lectins to a glycoprotein and cell-surface glycoconjugates and selectivity among human adhesion/growth-regula

artículo científico publicado en 2008

Carbohydrate chain of ganglioside GM1 as a ligand: identification of the binding strategies of three 15 mer peptides and their divergence from the binding modes of growth-regulatory galectin-1 and cholera toxin

artículo científico publicado en 2005

Carbohydrate specificity of chicken and human tandem-repeat-type galectins-8 in composition of cells.

artículo científico publicado en 2011

Carbohydrate-binding proteins (plant/human lectins and autoantibodies from human serum) as mediators of release of lysozyme, elastase, and myeloperoxidase from human neutrophils

article

Cell-type dependence of stability modulation of lectin-initiated contacts by impairment of multivalent carbohydrate binding and intracellular signaling

artículo científico

Cell-type-specific expression of murine multifunctional galectin-3 and its association with follicular atresia/luteolysis in contrast to pro-apoptotic galectins-1 and -7.

artículo científico publicado en 2008

Changes in Galectin-7 and Cytokeratin-19 Expression during the Progression of Malignancy in Thyroid Tumors: Diagnostic and Biological Implications

artículo científico publicado en 2002

Chemical biology of the sugar code

artículo científico publicado en 2004

Chromosomal aberrations, profiles of expression of growth-related markers including galectins and environmental hazards in relation to the incidence of chondroid pulmonary hamartomas

artículo científico publicado en 2003

Colonic carcinogenesis along different genetic routes: glycophenotyping of tumor cases separated by microsatellite instability/stability.

artículo científico publicado en 2012

Combined analysis of tumor growth pattern and expression of endogenous lectins as a prognostic tool in primary testicular cancer and its lung metastases

artículo científico publicado en 2003

Combining Crystallography and Hydrogen-Deuterium Exchange to Study Galectin-Ligand Complexes

artículo científico publicado en 2015

Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes

artículo científico publicado en 2011

Combining glycocluster synthesis with protein engineering: an approach to probe into the significance of linker length in a tandem-repeat-type lectin (galectin-4).

artículo científico publicado en 2014

Comparative analysis of the nuclear presence of adhesion/growth-regulatory galectins and reactivity in the nuclei of interphasic and mitotic cells.

artículo científico publicado en 2011

Comparative lectinology: Delineating glycan-specificity profiles of the chicken galectins using neoglycoconjugates in a cell assay.

artículo científico publicado en 2015

Comparative phenotypic characterization of keratinocytes originating from hair follicles.

artículo científico publicado en 2005

Comparative study of the glycan specificities of cell-bound human tandem-repeat-type galectin-4, -8 and -9.

artículo científico publicado en 2012

Comparison between intact and desialylated human serum amyloid P component by laser photo CIDNP (chemically induced dynamic nuclear polarization) technique: an indication for a conformational impact of sialic acid.

artículo científico publicado en 1997

Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile.

artículo científico publicado en 2009

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures

artículo científico publicado en 2001

Conformational selection in glycomimetics: human galectin-1 only recognizes syn-Ψ-type conformations of β-1,3-linked lactose and its C-glycosyl derivative.

artículo científico

Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target

artículo científico publicado en 2013

Correlation of expression of nuclear proteins pKi67 and p63 with lectin histochemical features in head and neck squamous cell cancer

artículo científico publicado en 2005

Craniopharyngioma: a case report and comparative galectin histochemical analysis.

artículo científico publicado en 2002

Decrease of nuclear reactivity to growth-regulatory galectin-1 in senescent human keratinocytes and detection of non-uniform staining profile alterations upon prolonged culture for galectin-1 and -3.

artículo científico publicado en 2004

Defining the glycophenotype of squamous epithelia using plant and mammalian lectins. Differentiation-dependent expression of alpha2,6- and alpha2,3-linked N-acetylneuraminic acid in squamous epithelia and carcinomas, and its differential effect on b

artículo científico publicado en 2002

Defining the potential of aglycone modifications for affinity/selectivity enhancement against medically relevant lectins: synthesis, activity screening, and HSQC-based NMR analysis.

artículo científico publicado en 2014

Delineating binding modes of Gal/GalNAc and structural elements of the molecular recognition of tumor-associated mucin glycopeptides by the human macrophage galactose-type lectin

artículo científico publicado en 2014

Describing Topology of Bound Ligand by Transferred Nuclear Overhauser Effect Spectroscopy and Molecular Modeling

scientific article published on 01 January 2003

Detection and chromatographic removal of lipopolysaccharide in preparations of multifunctional galectins.

artículo científico publicado en 2008

Detection of cell type and marker specificity of nuclear binding sites for anionic carbohydrate ligands.

artículo científico publicado en 2004

Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?

artículo científico publicado en 2009

Detection of ligand- and solvent-induced shape alterations of cell-growth-regulatory human lectin galectin-1 in solution by small angle neutron and x-ray scattering.

artículo científico publicado en 2003

Detection of new diagnostic markers in pathology by focus on growth-regulatory endogenous lectins. The case study of galectin-7 in squamous epithelia.

artículo científico publicado en 2005

Determination of modulation of ligand properties of synthetic complex-type biantennary N-glycans by introduction of bisecting GlcNAc in silico, in vitro and in vivo.

artículo científico publicado en 2004

Determination of structural and functional overlap/divergence of five proto-type galectins by analysis of the growth-regulatory interaction with ganglioside GM1 in silico and in vitro on human neuroblastoma cells

artículo científico publicado en 2005

Differences in zero-force and force-driven kinetics of ligand dissociation from beta-galactoside-specific proteins (plant and animal lectins, immunoglobulin G) monitored by plasmon resonance and dynamic single molecule force microscopy.

artículo científico publicado en 2000

Differential binding of two chicken beta-galactoside-specific lectins to homologous lymphocyte subpopulations and evidence for inhibitor activity of the dimeric lectin on stimulated T cells

artículo científico publicado en 1995

Differential regulation of galectin expression/reactivity during wound healing in porcine skin and in cultures of epidermal cells with functional impact on migration

article

Differential response of the epidermal growth factor receptor tyrosine kinase activity to several plant and mammalian lectins

article

Differential stimulation of VEGF-C production by adhesion/growth-regulatory galectins and plant lectins in human breast cancer cells.

artículo científico publicado en 2010

Diffusion nuclear magnetic resonance spectroscopy detects substoichiometric concentrations of small molecules in protein samples

artículo científico publicado en 2009

Discovery of galectin ligands in fully randomized combinatorial one-bead-one-compound (glyco)peptide libraries

artículo científico publicado en 2006

Dissecting molecular aspects of cell interactions using glycodendrimersomes with programmable glycan presentation and engineered human lectins.

artículo científico publicado en 2015

Domain versatility in plant AB-toxins: evidence for a local, pH-dependent rearrangement in the 2gamma lectin site of the mistletoe lectin by applying ligand derivatives and modelling

artículo científico publicado en 2008

Down-regulation of the epidermal growth factor receptor by altering N-glycosylation: emerging role of β1,4-galactosyltransferases.

artículo científico publicado en 2012

Duodenal phytohaemagglutinin (red kidney bean lectin) stimulates gallbladder contraction in humans

artículo científico publicado en 2008

Early stages of trachea healing process: (immuno/lectin) histochemical monitoring of selected markers and adhesion/growth-regulatory endogenous lectins

artículo científico publicado en 2012

Effect of enzymatic desialylation of human serum amyloid P component on surface exposure of laser photo CIDNP (chemically induced dynamic nuclear polarization)--reactive histidine, tryptophan and tyrosine residues

artículo científico publicado en 1995

Effects of polyvalency of glycotopes and natural modifications of human blood group ABH/Lewis sugars at the Galβ1-terminated core saccharides on the binding of domain-I of recombinant tandem-repeat-type galectin-4 from rat gastrointestinal tract (G4

artículo científico publicado en 2004

Emerging role of tissue lectins as microenvironmental effectors in tumors and wounds.

artículo científico publicado en 2014

Endogenous lectins as targets for drug delivery

artículo científico publicado en 2000

Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity

artículo científico publicado en 2015

Enhanced signal dispersion in saturation transfer difference experiments by conversion to a 1D-STD-homodecoupled spectrum

artículo científico publicado en 2006

Evidence for lectin activity of a plant receptor-like protein kinase by application of neoglycoproteins and bioinformatic algorithms

artículo científico publicado en 2005

Evidence for stimulation of tumor proliferation in cell lines and histotypic cultures by clinically relevant low doses of the galactoside-binding mistletoe lectin, a component of proprietary extracts

artículo científico publicado en 2001

Expression of endogenous lectins (galectins, receptors for ABH-epitopes) and the MIB-1 antigen in esophageal carcinomas and their syntactic structure analysis in relation to post-surgical tumor stage and lymph node involvement

artículo científico publicado en 2001

Extracellular matrix of galectin-1-exposed dermal and tumor-associated fibroblasts favors growth of human umbilical vein endothelial cells in vitro: a short report

Fine specificity of domain-I of recombinant tandem-repeat-type galectin-4 from rat gastrointestinal tract (G4-N)

artículo científico publicado en 2002

Fine-tuning of prototype chicken galectins: structure of CG-2 and structure-activity correlations

artículo científico publicado en 2013

First demonstration of differential inhibition of lectin binding by synthetic tri- and tetravalent glycoclusters from cross-coupling of rigidified 2-propynyl lactoside.

artículo científico publicado en 2003

Fluorinated Carbohydrates as Lectin Ligands: (19)F-Based Direct STD Monitoring for Detection of Anomeric Selectivity.

artículo científico publicado en 2015

Fluorinated carbohydrates as lectin ligands: versatile sensors in 19F-detected saturation transfer difference NMR spectroscopy.

artículo científico publicado en 2009

From lectin structure to functional glycomics: principles of the sugar code.

artículo científico publicado en 2011

From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans

scientific article published on July 2009

Functional interplay between ganglioside GM1 and cross-linking galectin-1 induces axon-like neuritogenesis via integrin-based signaling and TRPC5-dependent Ca²⁺ influx

artículo científico publicado en 2015

Galectin 7 (p53-induced gene 1): a new prognostic predictor of recurrence and survival in stage IV hypopharyngeal cancer.

artículo científico publicado en 2006

Galectin fingerprinting by immuno- and lectin histochemistry in cutaneous lymphoma

artículo científico publicado en 2001

Galectin fingerprinting in Warthin's tumors: lectin-based approach to trace its origin?

artículo científico publicado en 2010

Galectin-1 Couples Glycobiology to Inflammation in Osteoarthritis through the Activation of an NF-κB-Regulated Gene Network

artículo científico

Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation

artículo científico publicado en 2014

Galectin-1 interacts with the {alpha}5{beta}1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27.

artículo científico publicado en 2005

Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancer.

artículo científico publicado en 2008

Galectin-1 sensitizes carcinoma cells to anoikis via the fibronectin receptor α5β1-integrin.

artículo científico publicado en 2010

Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP.

artículo científico publicado en 2004

Galectin-3 Upregulation During Tumor Progression in Head and Neck Cancer

artículo científico publicado en 2008

Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction

artículo científico publicado en 2004

Galectin-3 – an emerging prognostic indicator in advanced head and neck carcinoma

artículo científico publicado en 2004

Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells

artículo científico publicado en 2005

Galectin-4-regulated delivery of glycoproteins to the brush border membrane of enterocyte-like cells

artículo científico publicado en 2009

Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

artículo científico publicado en 2009

Galectin-7: will the lectin's activity establish clinical correlations in head and neck squamous cell and basal cell carcinomas?

artículo científico publicado en 2009

Galectin-8 up-regulation during hypopharyngeal and laryngeal tumor progression and comparison with galectin-1, -3 and -7.

artículo científico

Galectins promote the interaction of influenza virus with its target cell

artículo científico publicado en 2011

Galectins-1 and -3 and their ligands in tumor biology. Non-uniform properties in cell-surface presentation and modulation of adhesion to matrix glycoproteins for various tumor cell lines, in biodistribution of free and liposome-bound galectins and i

artículo científico publicado en 1999

Ganglioside GM1/galectin-dependent growth regulation in human neuroblastoma cells: special properties of bivalent galectin-4 and significance of linker length for ligand selection.

artículo científico publicado en 2012

Gene-expression signature of adhesion/growth-regulatory tissue lectins (galectins) in transitional cell cancer and its prognostic relevance

article

Generation of H2O2 by human neutrophils and changes of cytosolic Ca2+ and pH of rat thymocytes in response to galactoside-binding proteins (lectins or immunoglobulins)

artículo científico publicado en 1997

Glycan tagging to produce bioactive ligands for a surface plasmon resonance study via immobilization on different surfaces.

artículo científico publicado en 2009

Glyco- and immunohistochemical refinement of the differential diagnosis between mesothelioma and metastatic carcinoma and survival analysis of patients

artículo científico publicado en 2001

Glycocluster design for improved avidity and selectivity in blocking human lectin/plant toxin binding to glycoproteins and cells.

artículo científico publicado en 2010

Glycodendrimersomes from Sequence-Defined Janus Glycodendrimers Reveal High Activity and Sensor Capacity for the Agglutination by Natural Variants of Human Lectins.

artículo científico publicado en 2015

Glycomic profiling of developmental changes in bovine testis by lectin histochemistry and further analysis of the most prominent alteration on the level of the glycoproteome by lectin blotting and lectin affinity chromatography.

artículo científico publicado en 2004

Glycophenotype of psoriatic skin

artículo científico publicado en 2006

Glycophenotyping of osteoarthritic cartilage and chondrocytes by RT-qPCR, mass spectrometry, histochemistry with plant/human lectins and lectin localization with a glycoprotein

artículo científico publicado en 2013

Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking

artículo científico publicado en 2009

Glycosyldisulfides from dynamic combinatorial libraries as O-glycoside mimetics for plant and endogenous lectins: their reactivities in solid-phase and cell assays and conformational analysis by molecular dynamics simulations

artículo científico publicado en 2006

Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding

artículo científico publicado en 2004

High level of galectin-1 expression is a negative prognostic predictor of recurrence in laryngeal squamous cell carcinomas

scientific article published on 01 May 2007

Homodimeric chicken galectin CG-1B (C-14): Crystal structure and detection of unique redox-dependent shape changes involving inter- and intrasubunit disulfide bridges by gel filtration, ultracentrifugation, site-directed mutagenesis, and [...]

artículo científico publicado en 2009

Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells

artículo científico publicado en 2003

Human Galectins Induce Conversion of Dermal Fibroblasts into Myofibroblasts and Production of Extracellular Matrix: Potential Application in Tissue Engineering and Wound Repair

article

Human chimera-type galectin-3: defining the critical tail length for high-affinity glycoprotein/cell surface binding and functional competition with galectin-1 in neuroblastoma cell growth regulation

artículo científico publicado en 2014

Human galectin-2: expression profiling by RT-PCR/immunohistochemistry and its introduction as a histochemical tool for ligand localization.

artículo científico publicado en 2005

Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation

artículo científico publicado en 2004

Human galectin-2: nuclear presence in vitro and its modulation by quiescence/stress factors.

artículo científico publicado en 2008

Human galectin-3 (Mac-2 antigen): defining molecular switches of affinity to natural glycoproteins, structural and dynamic aspects of glycan binding by flexible ligand docking and putative regulatory sequences in the proximal promoter region

artículo científico publicado en 2010

Human galectins as sensors for apoptosis/necrosis-associated surface changes of granulocytes and lymphocytes

artículo científico publicado en 2008

Human osteoarthritic knee cartilage: fingerprinting of adhesion/growth-regulatory galectins in vitro and in situ indicates differential upregulation in severe degeneration

artículo científico publicado en 2014

Hydrodynamic properties of human adhesion/growth-regulatory galectins studied by fluorescence correlation spectroscopy

artículo científico publicado en 2010

Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes

artículo científico publicado en 2010

Identification of matrix metalloproteinase-9 as an independent prognostic marker in laryngeal and hypopharyngeal cancer with opposite correlations to adhesion/growth-regulatory galectins-1 and -7.

artículo científico publicado en 2009

Identification of peptide ligands for malignancy- and growth-regulating galectins using random phage-display and designed combinatorial peptide libraries.

artículo científico publicado en 2005

Immunohistochemical fingerprinting of the network of seven adhesion/growth-regulatory lectins in human skin and detection of distinct tumour-associated alterations.

artículo científico publicado en 2009

Impact of sodium butyrate on the network of adhesion/growth-regulatory galectins in human colon cancer in vitro.

artículo científico publicado en 2014

Increased expression and altered intracellular distribution of adhesion/growth-regulatory lectins galectins-1 and -7 during tumour progression in hypopharyngeal and laryngeal squamous cell carcinomas

scientific article published on 01 March 2008

Increased expression of macrophage migration inhibitory factor during progression to hypopharyngeal squamous cell carcinoma

artículo científico publicado en 2010

Increased galectin-3 expression and intra-epithelial neutrophils in small airways in severe COPD

artículo científico publicado en 2007

Inhibition of human retinal pigment epithelial cell attachment, spreading, and migration by the human lectin galectin-1.

scientific article published on 23 October 2009

Inhibitory potential of chemical substitutions at bioinspired sites of β-d-galactopyranose on neoglycoprotein/cell surface binding of two classes of medically relevant lectins ⬇️

artículo científico publicado el 30 de marzo de 2011

Interaction profile of galectin-5 with free saccharides and mammalian glycoproteins: probing its fine specificity and the effect of naturally clustered ligand presentation.

artículo científico

Interference of the galactose-dependent binding of lectins by novel pentapeptide ligands

artículo científico publicado en 2004

Intra- and intermolecular interactions of human galectin-3: assessment by full-assignment-based NMR

artículo científico publicado en 2016

Labeled neoglycoproteins and human lectins as diagnostic and potential functional markers in salivary glands of patients with Sjögren's syndrome

scientific article published on 01 August 2000

Lactose binding to human galectin-7 (p53-induced gene 1) induces long-range effects through the protein resulting in increased dimer stability and evidence for positive cooperativity

artículo científico publicado en 2013

Lanthanide-chelating carbohydrate conjugates are useful tools to characterize carbohydrate conformation in solution and sensitive sensors to detect carbohydrate-protein interactions.

artículo científico

Lectin-based drug design: combined strategy to identify lead compounds using STD NMR spectroscopy, solid-phase assays and cell binding for a plant toxin model.

artículo científico

Lectin-mediated drug targeting: selection of valency, sugar type (Gal/Lac), and spacer length for cluster glycosides as parameters to distinguish ligand binding to C-type asialoglycoprotein receptors and galectins.

artículo científico

Lectins: getting familiar with translators of the sugar code

artículo científico publicado en 2015

Ligands for Viscum album agglutinin and galectin-1 in human lung cancer: is there any prognostic relevance?

artículo científico publicado en 1999

Localized fibrous tumors (LFTs) of the pleura: clinical data, asbestos burden, and syntactic structure analysis applied to newly defined angiogenic/growth-regulatory effectors.

artículo científico publicado en 2005

Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas

artículo científico publicado en 2012

Low-dose intragastric administration of Phaseolus vulgaris agglutinin (PHA) does not induce immunoglobulin E (IgE) production in Sprague-Dawley rats

scientific article published on 01 April 2001

Mammalian lectin as tool in glycochemistry and histochemistry with relevance for diagnostic procedure

artículo científico publicado en 2008

Marker profiling of normal keratinocytes identifies the stroma from squamous cell carcinoma of the oral cavity as a modulatory microenvironment in co-culture

article

Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context

artículo científico publicado el 9 de noviembre de 2015

Mimicking Biological Membranes with Programmable Glycan Ligands Self-Assembled from Amphiphilic Janus Glycodendrimers

artículo científico publicado en 2014

Modification of the functional activity of neutrophils treated with acute phase response proteins.

artículo científico publicado en 1998

Molecular Recognition of the Thomsen-Friedenreich Antigen–Threonine Conjugate by Adhesion/Growth Regulatory Galectin-3: Nuclear Magnetic Resonance Studies and Molecular Dynamics Simulations

artículo científico publicado en 2012

Molecular biological fingerprinting of human lectin expression by RT-PCR.

artículo científico publicado en 2003

Molecular recognition of complex-type biantennary N-glycans by protein receptors: a three-dimensional view on epitope selection by NMR.

artículo científico publicado en 2013

Monitoring the expression profiles of integrins and adhesion/growth-regulatory galectins in adamantinomatous craniopharyngiomas: their ability to regulate tumor adhesiveness to surrounding tissue and their contribution to prognosis

artículo científico publicado en 2005

Monomer/dimer equilibrium of the AB-type lectin from mistletoe enables combination of toxin/agglutinin activities in one protein: analysis of native and citraconylated proteins by ultracentrifugation/gel filtration and cell biological consequences o

artículo científico publicado en 2005

Murine homodimeric adhesion/growth-regulatory galectins-1, -2 and -7: comparative profiling of gene/ promoter sequences by database mining, of expression by RT-PCR/immunohistochemistry and of contact sites for carbohydrate ligands by computational c

artículo científico publicado en 2007

N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin

artículo científico publicado en 2009

N-domain of human adhesion/growth-regulatory galectin-9: preference for distinct conformers and non-sialylated N-glycans and detection of ligand-induced structural changes in crystal and solution

artículo científico publicado en 2010

NMR investigations of protein-carbohydrate interactions: insights into the topology of the bound conformation of a lactose isomer and beta-galactosyl xyloses to mistletoe lectin and galectin-1.

artículo científico publicado en 2001

NO-dependent regulation of lectin- and menadione-induced H2O2 production by cells from pleural effusions of lung cancer patients and by immune cells

artículo científico publicado en 1999

Natural single amino acid polymorphism (F19Y) in human galectin-8: detection of structural alterations and increased growth-regulatory activity on tumor cells

artículo científico publicado en 2014

Negative regulation of RPE cell attachment by carbohydrate-dependent cell surface binding of galectin-3 and inhibition of the ERK–MAPK pathway

artículo científico publicado en 2010

Neoglycoproteins with the synthetic complex biantennary nonasaccharide or its alpha 2,3/alpha 2,6-sialylated derivatives: their preparation, assessment of their ligand properties for purified lectins, for tumor cells in vitro, and in tissue sections

artículo científico publicado en 1997

Neuronal Galectin-4 is required for axon growth and for the organization of axonal membrane L1 delivery and clustering

artículo científico publicado en 2013

New aspects of galectin functionality in nuclei of cultured bone marrow stromal and epidermal cells: biotinylated galectins as tool to detect specific binding sites

artículo científico publicado en 2003

Nitric oxide changes distinct aspects of the glycophenotype of human neuroblastoma NB69 cells.

artículo científico publicado en 2010

Non-synonymous single nucleotide polymorphisms in genes for immunoregulatory galectins: association of galectin-8 (F19Y) occurrence with autoimmune diseases in a Caucasian population.

artículo científico publicado en 2012

Nuclear presence of adhesion-/growth-regulatory galectins in normal/malignant cells of squamous epithelial origin.

artículo científico publicado en 2005

Onion-like glycodendrimersomes from sequence-defined Janus glycodendrimers and influence of architecture on reactivity to a lectin

artículo científico publicado en 2016

Peptides derived from human galectin-3 N-terminal tail interact with its carbohydrate recognition domain in a phosphorylation-dependent manner.

artículo científico publicado en 2013

Persubstituted cyclodextrin-based glycoclusters as inhibitors of protein-carbohydrate recognition using purified plant and mammalian lectins and wild-type and lectin-gene-transfected tumor cells as targets

artículo científico publicado en 2004

Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing

artículo científico publicado en 2015

Phenotype-associated lectin-binding profiles of normal and transformed blood cells: a comparative analysis of mannose- and galactose-binding lectins from plants and human serum/placenta

artículo científico publicado en 1994

Phenotypic characterization of human keratinocytes in coculture reveals differential effects of fibroblasts from benign fibrous histiocytoma (dermatofibroma) as compared to cells from its malignant form and to normal fibroblasts

artículo científico publicado en 2009

Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles

artículo científico publicado en 2009

Phosphorylated human galectin-3: facile large-scale preparation of active lectin and detection of structural changes by CD spectroscopy.

artículo científico publicado en 2008

Phosphorylation of adhesion- and growth-regulatory human galectin-3 leads to the induction of axonal branching by local membrane L1 and ERM redistribution

artículo científico publicado en 2010

Phosphorylation of multifunctional galectins by protein kinases CK1, CK2, and PKA.

artículo científico publicado en 2013

Photoderivatized polymer thin films at quartz crystal microbalance surfaces: sensors for carbohydrate-protein interactions

artículo científico publicado en 2007

Preliminary X-ray crystallographic analysis of an engineered variant of human chimera-type galectin-3 with a shortened N-terminal domain.

artículo científico publicado en 2015

Preneoplasia-associated expression of calcyclin and of binding sites for synthetic blood group A/H trisaccharide--exposing neoglycoconjugates in human lung.

artículo científico

Primary colorectal carcinomas and their intrapulmonary metastases: Clinical, glyco-, immuno- and lectin histochemical, nuclear and syntactic structure analysis with emphasis on correlation with period of occurrence of metastases and survival

artículo científico publicado en 2002

Prognostic stratification of Dukes B colon cancer by a neoglycoprotein.

artículo científico publicado en 2004

Prototype chicken galectins revisited: characterization of a third protein with distinctive hydrodynamic behaviour and expression pattern in organs of adult animals

artículo científico publicado en 2008

Quantitative immunohistochemical fingerprinting of adhesion/growth-regulatory galectins in salivary gland tumours: divergent profiles with diagnostic potential

scientific article published on 01 March 2011

Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting

artículo científico publicado en 2003

Regulation of expression of galectin-7 in human nasal polyps by budesonide

artículo científico publicado en 2005

Regulatory Impact of Amniotic Membrane Transplantation on Presence of Adhesion/Growth-Regulatory Galectins-1 and -7 in Corneal Explants from Acanthamoeba Keratitis Patients: Clinical Note.

artículo científico publicado en 2015

Rho GTPase Rac1: molecular switch within the galectin network and for N-glycan α2,6-sialylation/O-glycan core 1 sialylation in colon cancer in vitro

artículo científico publicado en 2014

Rigidified multivalent lactose molecules and their interactions with mammalian galectins: a route to selective inhibitors.

artículo científico publicado en 2003

Sensing ligand binding to a clinically relevant lectin by tryptophan fluorescence anisotropy

artículo científico publicado en 2011

Serum Galectin-1 and Galectin-3 Levels in Benign and Malignant Nodular Thyroid Disease

scientific article published on 01 July 2008

Simultaneous detection of endogenous lectins and their binding capacity at the single-cell level--a technical note.

artículo científico publicado en 1999

Single-site mutational engineering and following monoPEGylation of the human lectin galectin-2: effects on ligand binding, functional aspects, and clearance from serum.

artículo científico publicado en 2013

Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: Increased expression of galectin-1 and induction of poor prognosis factors

artículo científico publicado en 2012

Solid phase measurements of antibody and lectin binding to xenogenic carbohydrate antigens

artículo científico publicado en 2004

Solid-phase assays for study of carbohydrate specificity of galectins

artículo científico publicado en 2010

Stromal fibroblasts from basal cell carcinoma affect phenotype of normal keratinocytes

artículo científico publicado en 2007

Structural aspects of binding of α-linked digalactosides to human galectin-1

artículo científico publicado en 2011

Structural significance of galectin design: impairment of homodimer stability by linker insertion and partial reversion by ligand presence.

artículo científico publicado en 2015

Structure-activity profiles of complex biantennary glycans with core fucosylation and with/without additional alpha 2,3/alpha 2,6 sialylation: synthesis of neoglycoproteins and their properties in lectin assays, cell binding, and organ uptake

artículo científico publicado en 2002

Studies on Unprocessed and Acid-Treated Arabinogalactan from Larch as an Inhibitor of Glycan Binding of a Plant Toxin and Biomedically Relevant Human Lectins

article

Studies related to Norway spruce galactoglucomannans: chemical synthesis, conformation analysis, NMR spectroscopic characterization, and molecular recognition of model compounds

artículo científico publicado en 2012

Substitutions in theN-Glycan Core as Regulators of Biorecognition: The Case of Core-Fucose and Bisecting GlcNAc Moieties†

artículo científico publicado en 2007

Suitability of binary mixtures of water with aprotic solvents to turn hydroxyl protons of carbohydrate ligands into conformational sensors in NOE and transferred NOE experiments

artículo científico publicado en 2003

Symmetric dithiodigalactoside: strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins.

artículo científico publicado en 2011

Synthesis and conformational analysis of (alpha-D-galactosyl)phenylmethane and alpha-,beta-difluoromethane analogues: interactions with the plant lectin viscumin

artículo científico publicado en 2009

Synthesis of bivalent lactosides and their activity as sensors for differences between lectins in inter- and intrafamily comparisons

artículo científico publicado en 2011

Synthesis of bivalent lactosides based on terephthalamide, N,N'-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins.

artículo científico publicado en 2009

Synthetic polyamine BPA-C8 inhibits TGF-β1-mediated conversion of human dermal fibroblast to myofibroblasts and establishment of galectin-1-rich extracellular matrix in vitro

artículo científico publicado en 2014

Targeting Matrix Metalloproteinases: Design of a Bifunctional Inhibitor for Presentation by Tumour-Associated Galectins

artículo científico publicado en 2012

Temperature dependence of ligand–protein complex formation as reflected by saturation transfer difference NMR experiments

article

The amino-acid sequence of the abalone (Haliotis laevigata) nacre protein perlucin

artículo científico publicado en 2000

The application of neoglycopeptides in the development of sensitive surface plasmon resonance-based biosensors

artículo científico publicado en 2008

The conformation of the C-glycosyl analogue of N-acetyl-lactosamine in the free state and bound to a toxic plant agglutinin and human adhesion/growth-regulatory galectin-1.

artículo científico

The glycobiology of the CD system: a dictionary for translating marker designations into glycan/lectin structure and function

artículo científico

The growing galectin network in colon cancer and clinical relevance of cytoplasmic galectin-3 reactivity

artículo científico publicado en 2013

The sugar code: functional lectinomics

artículo científico publicado en 2002

The third dimension of reading the sugar code by lectins: design of glycoclusters with cyclic scaffolds as tools with the aim to define correlations between spatial presentation and activity.

artículo científico

The tumor-associated antigen 90K/Mac-2-binding protein secreted by human colon carcinoma cells enhances extracellular levels of promatrilysin and is a novel substrate of matrix metalloproteinases-2, -7 (matrilysin) and -9: Implications of proteolyti

artículo científico publicado en 2009

Thermodynamic Switch in Binding of Adhesion/Growth Regulatory Human Galectin-3 to Tumor-Associated TF Antigen (CD176) and MUC1 Glycopeptides.

artículo científico publicado en 2015

Thio- and selenoglycosides as ligands for biomedically relevant lectins: valency-activity correlations for benzene-based dithiogalactoside clusters and first assessment for (di)selenodigalactosides.

artículo científico publicado en 2014

Toward comprehensive analysis of the galectin network in chicken: unique diversity of galectin-3 and comparison of its localization profile in organs of adult animals to the other four members of this lectin family.

artículo científico publicado en 2011

Towards dissecting molecular routes of intercellular communication in the tumour microenvironment: phenotypic plasticity of stem cell-associated markers in co-culture (carcinoma cell/fibroblast) systems

artículo científico publicado en 2014

Towards functional glycomics by localization of binding sites for tissue lectins: lectin histochemical reactivity for galectins during diethylstilbestrol-induced kidney tumorigenesis in male Syrian hamster.

artículo científico

Tumor galectinology: insights into the complex network of a family of endogenous lectins

artículo científico publicado en 2004

Tumor suppressor p16 INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model.

artículo científico publicado en 2010

Tumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells

artículo científico

Tumour suppressor p16(INK4a) - anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model.

artículo científico publicado en 2012

Tyramine-containing poly(4-nitrophenylacrylate) as iodinatable ligand carrier in biodistribution analysis

artículo científico

Unique chicken tandem-repeat-type galectin: implications of alternative splicing and a distinct expression profile compared to those of the three proto-type proteins

artículo científico publicado en 2009

Unique conformer selection of human growth-regulatory lectin galectin-1 for ganglioside GM1 versus bacterial toxins

artículo científico

Unique sequence and expression profiles of rat galectins-5 and -9 as a result of species-specific gene divergence

article

Unraveling functional significance of natural variations of a human galectin by glycodendrimersomes with programmable glycan surface

artículo científico publicado en 2015

Versatile strategy for the synthesis of biotin-labelled glycans, their immobilization to establish a bioactive surface and interaction studies with a lectin on a biochip

artículo científico publicado en 2008

WITHDRAWN: Corrigendum to "A lectin from the Chinese bird-hunting spider binds sialic acids"

retracted scientific article published on 20 February 2010

Wedgelike glycodendrimers as inhibitors of binding of mammalian galectins to glycoproteins, lactose maxiclusters, and cell surface glycoconjugates

artículo científico publicado en 2001

X-ray reflectivity and grazing incidence diffraction studies of interaction between human adhesion/growth-regulatory galectin-1 and DPPE-GM1 lipid monolayer at an air/water interface

artículo científico publicado en 2015

[4] Detection and quantification of carbohydrate-binding sites on cell surfaces and in tissue sections by neoglycoproteins

artículo científico publicado en 1994

[The mistletoe myth--claims, reality and provable perspectives]

artículo científico publicado en 1996

alpha2,6-Sialylation promotes binding of placental protein 14 via its Ca2+-dependent lectin activity: insights into differential effects on CD45RO and CD45RA T cells

artículo científico publicado en 2005

α-N-Linked glycopeptides: conformational analysis and bioactivity as lectin ligands

artículo científico publicado en 2012

α-O-Linked Glycopeptide Mimetics: Synthesis, Conformation Analysis, and Interactions with Viscumin, a Galactoside-Binding Model Lectin

article

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