Lista de obras - Brian J. Smith - Dominio Público Uruguay

1H, 13C, and 15N resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP.

artículo científico publicado en 2005

A Critical Region in the Mineralocorticoid Receptor for Aldosterone Binding and Activation by Cortisol: Evidence for a Common Mechanism Governing Ligand Binding Specificity in Steroid Hormone Receptors

article

A common cross-species function for the double epidermal growth factor-like modules of the highly divergent plasmodium surface proteins MSP-1 and MSP-8.

artículo científico publicado en 2004

A constricted opening in Kir channels does not impede potassium conduction

artículo científico publicado en 2020

A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol).

artículo científico publicado en 2003

A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion

artículo científico publicado en 2008

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

artículo científico publicado en 2016

A newly discovered protein export machine in malaria parasites

artículo científico publicado en 2009

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

artículo científico publicado en 2020

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

artículo científico publicado en 2015

Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum

artículo científico publicado en 2009

Anticonvulsant Met-enkephalin analogues containing backbone spacers reveal alternative non-opioid signaling in the brain

artículo científico publicado en 2009

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

artículo científico publicado en 2014

Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.

artículo científico publicado en 2014

Author Correction: A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

artículo científico publicado en 2020

BAK core dimers bind lipids and can be bridged by them

scientific article published on 14 September 2020

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

artículo científico publicado en 2015

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

artículo científico publicado en 2013

BioPPSy: An Open-Source Platform for QSAR/QSPR Analysis

artículo científico publicado en 2016

Can thioglycosides imitate the oxonium intermediate in glycosyl hydrolases?

artículo científico publicado en 2003

Catalytic mechanism and cofactor preference of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus

artículo científico publicado en 2011

Catalytic mechanisms and reaction intermediates along the hydrolytic pathway of a plant beta-D-glucan glucohydrolase

artículo científico publicado en 2001

Characterization of the two fundamental conformations of benzoylureas and elucidation of the factors that facilitate their conformational interchange

artículo científico publicado en 2009

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

artículo científico publicado en 2009

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

artículo científico publicado en 2018

Conotoxins containing nonnatural backbone spacers: cladistic-based design, chemical synthesis, and improved analgesic activity

artículo científico publicado en 2007

Consequences of two different amino-acid substitutions at the same codon in KRT14 indicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis

artículo científico publicado en 2011

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

artículo científico publicado en 2017

Cortisol resistance in the New World revisited

artículo científico publicado en 2004

Crystal structure and immunological properties of the first annexin from Schistosoma mansoni: insights into the structural integrity of the schistosomal tegument

artículo científico publicado en 2014

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

artículo científico publicado en 2007

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

artículo científico publicado en 2014

Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins

artículo científico publicado en 2011

De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization

artículo científico publicado en 2014

Determinants of spironolactone binding specificity in the mineralocorticoid receptor

artículo científico publicado en 2003

Development of recombinant protein-based influenza vaccine. Expression and affinity purification of H1N1 influenza virus neuraminidase

artículo científico publicado en 2006

Differences in the determinants of eplerenone, spironolactone and aldosterone binding to the mineralocorticoid receptor

artículo científico publicado en 2004

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

artículo científico publicado en 2005

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

artículo científico publicado en 2014

Discovery of inhibitors of lupin diadenosine 5',5'''-P(1),P(4)-tetraphosphate hydrolase by virtual screening.

artículo científico publicado en 2009

Diverse Reactions of PhI(OTf)2 with Common 2-Electron Ligands: Complex Formation, Oxidation, and Oxidative Coupling

artículo científico publicado en 2012

Diversity in the intrinsic apoptosis pathway of nematodes

artículo científico publicado en 2020

Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels

artículo científico publicado en 2010

Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking

artículo científico

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

artículo científico publicado en 2012

Evolution of the thyroid hormone distributor protein transthyretin in microbes, C. elegans, and vertebrates

artículo científico publicado en 2005

Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.

artículo científico publicado en 2016

Further Insights into the Effects of Pre-organizing the BimBH3 Helix

artículo científico publicado en 2014

Gaussian-theory predictions of proton transfer to water of phenol and 3-chlorophenol: resolution of an apparent difficulty

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

artículo científico publicado en 2009

Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain

artículo científico publicado en 2016

How insulin engages its primary binding site on the insulin receptor

artículo científico publicado en 2013

Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening

artículo científico publicado en 2014

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites

artículo científico publicado en 2014

Insight into the self-association of key enzymes from pathogenic species.

artículo científico publicado en 2005

Insights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparum

artículo científico publicado en 2012

Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor

artículo científico publicado en 2016

Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease

artículo científico publicado en 2013

Ion currents through Kir potassium channels are gated by anionic lipids

artículo científico publicado en 2022

Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA

artículo científico publicado en 2011

Leishmania major CorA-like magnesium transporters play a critical role in parasite development and virulence

artículo científico publicado en 2008

Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation.

artículo científico publicado en 2016

Modelling the structure of the fusion protein from human respiratory syncytial virus

artículo científico publicado en 2002

Modulation of voltage-gated K+ channels by the sodium channel β1 subunit

artículo científico publicado en 2012

N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.

artículo científico publicado en 2015

Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels

artículo científico publicado en 2005

PS – a program for the analysis of helix geometry ⬇️

artículo científico publicado el 6 de diciembre de 2011

Physiological restraint of Bak by Bcl-xL is essential for cell survival

artículo científico publicado en 2016

Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparum

artículo científico publicado en 2009

Predicting the Enthalpy and Gibbs Energy of Sublimation by QSPR Modeling

artículo científico publicado en 2018

Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana

artículo científico publicado en 2004

Protective hinge in insulin opens to enable its receptor engagement

artículo científico publicado en 2014

Pseudohypoaldosteronism type 1: the index case revisited

artículo científico publicado en 2011

Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex

artículo científico publicado en 2011

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

artículo científico publicado en 2011

Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding

artículo científico publicado en 2017

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change

artículo científico publicado en 2009

Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity

artículo científico publicado en 2013

Structural Basis for Broad Substrate Specificity in Higher Plant beta-D-Glucan Glucohydrolases

artículo científico publicado en 2002

Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design

artículo científico publicado en 2011

Structural analysis of bioinspired nano materials with synchrotron far IR spectroscopy

artículo científico publicado en 2016

Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels

artículo científico publicado en 2006

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

artículo científico publicado en 2015

Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1

artículo científico publicado en 2019

Structural insights into the degradation of Mcl-1 induced by BH3 domains

artículo científico publicado en 2007

Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine

artículo científico publicado en 2009

Structural rationale for low-nanomolar binding of transition state mimics to a family GH3 beta-D-glucan glucohydrolase from barley

artículo científico publicado en 2005

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

artículo científico publicado en 2010

Structural studies of the resistance of influenza virus neuramindase to inhibitors

artículo científico publicado en 2002

Structure and mechanism of a sub-family of enzymes related to N-acetylneuraminate lyase

artículo científico publicado en 1997

Structure of Leishmania mexicana Phosphomannomutase Highlights Similarities with Human Isoforms

artículo científico publicado en 2006

Structure of a calcium-deficient form of influenza virus neuraminidase: implications for substrate binding

artículo científico publicado en 2006

Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum

artículo científico publicado en 2005

Structure of the Plasmodium falciparum PfSERA5 pseudo-zymogen

scientific article published on 21 September 2020

Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion

artículo científico publicado en 2009

Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins

artículo científico publicado en 2013

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L

artículo científico publicado en 2014

Structure-guided design of a novel class of benzyl-sulfonate inhibitors for influenza virus neuraminidase

artículo científico publicado en 2006

Structure-guided design of a selective BCL-X(L) inhibitor

artículo científico publicado en 2013

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

artículo científico publicado en 2007

Substrate-Assisted Catalysis in Sialic Acid Aldolase

artículo científico publicado en 1999

Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site.

artículo científico publicado en 2018

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production

artículo científico publicado en 2006

The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation

artículo científico publicado en 2008

The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues

artículo científico publicado en 2005

The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion

artículo científico publicado en 2001

The trypanosomal trans-sialidase: two catalytic functions associated with one catalytic site

artículo científico publicado en 2002

Three-dimensional structure of the barley beta-D-glucan glucohydrolase in complex with a transition state mimic

artículo científico publicado en 2004

Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.

artículo científico publicado en 2018

Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax

artículo científico publicado en 2014

Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion.

artículo científico publicado en 2016

Two Essential Light Chains Regulate the MyoA Lever Arm To Promote Toxoplasma Gliding Motility

artículo científico publicado en 2015

α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells

artículo científico publicado en 2015

Lista de obras de Brian J. Smith

1H, 13C, and 15N resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP.

A Critical Region in the Mineralocorticoid Receptor for Aldosterone Binding and Activation by Cortisol: Evidence for a Common Mechanism Governing Ligand Binding Specificity in Steroid Hormone Receptors

A common cross-species function for the double epidermal growth factor-like modules of the highly divergent plasmodium surface proteins MSP-1 and MSP-8.

A constricted opening in Kir channels does not impede potassium conduction

A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol).

A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

A newly discovered protein export machine in malaria parasites

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum

Anticonvulsant Met-enkephalin analogues containing backbone spacers reveal alternative non-opioid signaling in the brain

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.

Author Correction: A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

BAK core dimers bind lipids and can be bridged by them

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

BioPPSy: An Open-Source Platform for QSAR/QSPR Analysis

Can thioglycosides imitate the oxonium intermediate in glycosyl hydrolases?

Catalytic mechanism and cofactor preference of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus

Catalytic mechanisms and reaction intermediates along the hydrolytic pathway of a plant beta-D-glucan glucohydrolase

Characterization of the two fundamental conformations of benzoylureas and elucidation of the factors that facilitate their conformational interchange

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

Conotoxins containing nonnatural backbone spacers: cladistic-based design, chemical synthesis, and improved analgesic activity

Consequences of two different amino-acid substitutions at the same codon in KRT14 indicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

Cortisol resistance in the New World revisited

Crystal structure and immunological properties of the first annexin from Schistosoma mansoni: insights into the structural integrity of the schistosomal tegument

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins

De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization

Determinants of spironolactone binding specificity in the mineralocorticoid receptor

Development of recombinant protein-based influenza vaccine. Expression and affinity purification of H1N1 influenza virus neuraminidase

Differences in the determinants of eplerenone, spironolactone and aldosterone binding to the mineralocorticoid receptor

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

Discovery of inhibitors of lupin diadenosine 5',5'''-P(1),P(4)-tetraphosphate hydrolase by virtual screening.

Diverse Reactions of PhI(OTf)2 with Common 2-Electron Ligands: Complex Formation, Oxidation, and Oxidative Coupling

Diversity in the intrinsic apoptosis pathway of nematodes

Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels

Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

Evolution of the thyroid hormone distributor protein transthyretin in microbes, C. elegans, and vertebrates

Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.

Further Insights into the Effects of Pre-organizing the BimBH3 Helix

Gaussian-theory predictions of proton transfer to water of phenol and 3-chlorophenol: resolution of an apparent difficulty

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain

How insulin engages its primary binding site on the insulin receptor

Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites

Insight into the self-association of key enzymes from pathogenic species.

Insights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparum

Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor

Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease

Ion currents through Kir potassium channels are gated by anionic lipids

Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA

Leishmania major CorA-like magnesium transporters play a critical role in parasite development and virulence

Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation.

Modelling the structure of the fusion protein from human respiratory syncytial virus

Modulation of voltage-gated K+ channels by the sodium channel β1 subunit

N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.

Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels

PS – a program for the analysis of helix geometry ⬇️

Physiological restraint of Bak by Bcl-xL is essential for cell survival

Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparum

Predicting the Enthalpy and Gibbs Energy of Sublimation by QSPR Modeling

Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana

Protective hinge in insulin opens to enable its receptor engagement

Pseudohypoaldosteronism type 1: the index case revisited

Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change

Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity

Structural Basis for Broad Substrate Specificity in Higher Plant beta-D-Glucan Glucohydrolases