Lista de obras - Jonas Abrahamsson - Dominio Público Uruguay

A glycosylation-dependent CD45RB epitope defines previously unacknowledged CD27⁻IgM(high) B cell subpopulations enriched in young children and after hematopoietic stem cell transplantation.

artículo científico publicado en 2013

Accurate and sensitive analysis of minimal residual disease in acute myeloid leukemia using deep sequencing of single nucleotide variations

artículo científico publicado en 2018

Acute Myeloid Leukemia in Adolescents and Young Adults Treated in Pediatric and Adult Departments in the Nordic Countries.

artículo científico publicado en 2015

Acute leukaemia in children with Down syndrome: a population-based Nordic study

artículo científico publicado en 2005

Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19: Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature.

artículo científico publicado en 2018

Antiarrhythmic effects of magnesium sulphate. Report of three cases

artículo científico publicado en 1995

Appearance of the novel activating F1174S ALK mutation in neuroblastoma correlates with aggressive tumor progression and unresponsiveness to therapy

artículo científico publicado en 2010

Ara-C fever and infections after high-dose ara-C treatment in pediatric lymphoid malignancies

artículo científico publicado en 2005

Asparaginase-associated pancreatitis in children with acute lymphoblastic leukaemia in the NOPHO ALL2008 protocol

artículo científico publicado en 2014

Asparaginase-associated pancreatitis: a study on phenotype and genotype in the NOPHO ALL2008 protocol

artículo científico publicado en 2016

Associations between neutrophil recovery time, infections and relapse in pediatric acute myeloid leukemia.

artículo científico publicado en 2018

Avidity of tetanus and Hib antibodies after childhood acute lymphoblastic leukaemia - implications for vaccination strategies

scientific article published on 01 June 2006

Bone marrow fibrosis and radiological changes of the long bones in children with acute megakaryocytic leukaemia

scientific article published on 01 October 1998

Bone marrow immunoglobulin-secreting cells are not reduced in children with leukaemia as compared to children with solid tumours

artículo científico publicado en 1997

CD27 expression and its association with clinical outcome in children and adults with pro-B acute lymphoblastic leukemia.

artículo científico publicado en 2017

Characteristics and outcome in patients with central nervous system involvement treated in European pediatric acute myeloid leukemia study groups.

artículo científico publicado en 2017

Children with low-risk acute lymphoblastic leukemia are at highest risk of second cancers.

artículo científico publicado en 2017

Cholesteryl sulphate and phosphate in the solid state and in aqueous systems

artículo científico publicado en 1977

Clinical features and early treatment response of central nervous system involvement in childhood acute lymphoblastic leukemia

artículo científico publicado en 2014

Complying with the European Clinical Trials directive while surviving the administrative pressure - an alternative approach to toxicity registration in a cancer trial.

artículo científico publicado en 2013

Comprehensive SNP array study of frequently used neuroblastoma cell lines; copy neutral loss of heterozygosity is common in the cell lines but uncommon in primary tumors

artículo científico publicado en 2011

DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia

artículo científico publicado en 2015

Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes

artículo científico publicado en 2016

Determination of blood cell subtype concentrations from frozen whole blood samples using TruCount beads.

artículo científico publicado en 2016

Differences in infection prophylaxis measures between paediatric acute myeloid leukaemia study groups within the international Berlin-Frankfürt-Münster (I-BFM) study group

artículo científico publicado en 2018

Effect of age and body weight on toxicity and survival in pediatric acute myeloid leukemia: results from NOPHO-AML 2004.

artículo científico publicado en 2016

Effects of epinephrine and norepinephrine on hemodynamic parameters and arrhythmias during a continuous infusion of amitriptyline in rats

scientific article published on 01 January 1993

Effects of epinephrine, norepinephrine, magnesium sulfate, and milrinone on survival and the occurrence of arrhythmias in amitriptyline poisoning in the rat.

artículo científico publicado en 1994

Effects of magnesium sulfate and lidocaine in the treatment of ventricular arrhythmias in experimental amitriptyline poisoning in the rat.

artículo científico publicado en 1994

Efficacy and Toxicity of Intrathecal Liposomal Cytarabine in First-line Therapy of Childhood Acute Lymphoblastic Leukemia.

artículo científico publicado en 2016

Emergence of new ALK mutations at relapse of neuroblastoma

artículo científico publicado en 2014

Epinephrine and sodium bicarbonate independently and additively increase survival in experimental amitriptyline poisoning

artículo científico publicado en 1997

Extramedullary leukemia in children with acute myeloid leukemia: A population-based cohort study from the Nordic Society of Pediatric Hematology and Oncology (NOPHO).

artículo científico publicado en 2017

High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: four cases of homozygous deletions of the CDKN2A gene

artículo científico publicado en 2008

High-resolution copy number array in the molecular cytogenetic diagnostics of pediatric malignant hematological disorders

artículo científico publicado en 2012

Hyperleucocytosis in paediatric acute myeloid leukaemia - the challenge of white blood cell counts above 200 × 109 /l. The NOPHO experience 1984-2014.

artículo científico publicado en 2017

Immune reconstitution after childhood acute lymphoblastic leukemia is most severely affected in the high risk group.

artículo científico publicado en 2005

Immunoglobulin levels and lymphocyte response to mitogenic stimulation in children with malignant disease during treatment and follow-up

artículo científico publicado en 1995

Improved outcome after relapse in children with acute myeloid leukaemia

artículo científico publicado en 2007

In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia

artículo científico publicado en 2008

Individualized 6-mercaptopurine increments in consolidation treatment of childhood acute lymphoblastic leukemia: A NOPHO randomized controlled trial

artículo científico publicado en 2017

Individualized toxicity-titrated 6-mercaptopurine increments during high-dose methotrexate consolidation treatment of lower risk childhood acute lymphoblastic leukaemia. A Nordic Society of Paediatric Haematology and Oncology (NOPHO) pilot study

artículo científico publicado en 2011

Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia

scientific article published on 14 September 2018

Intensive treatment for childhood acute lymphoblastic leukemia reduces immune responses to diphtheria, tetanus, and Haemophilus influenzae type b.

artículo científico publicado en 2004

Interferon gamma and tumour necrosis factor alpha in relation to anaemia and prognosis in childhood cancer

artículo científico publicado en 2005

Interleukin 6, but not tumour necrosis factor-alpha, is a good predictor of severe infection in febrile neutropenic and non-neutropenic children with malignancy.

artículo científico publicado en 1997

Intragenic anaplastic lymphoma kinase (ALK) rearrangements: translocations as a novel mechanism of ALK activation in neuroblastoma tumors.

artículo científico publicado en 2014

Leukemic blasts are present at low levels in spinal fluid in one-third of childhood acute lymphoblastic leukemia cases

artículo científico publicado en 2016

Liver transplantation after stem cell transplantation with the same living donor in a monozygotic twin with acute myeloid leukemia

article

Long-term health outcomes in survivors of childhood AML treated with allogeneic HSCT: a NOPHO-AML Study

artículo científico publicado en 2018

Long-term results in children with AML: NOPHO-AML Study Group--report of three consecutive trials

artículo científico publicado en 2005

MYCN amplicon junctions as tumor-specific targets for minimal residual disease detection in neuroblastoma.

artículo científico publicado en 2011

Magnesium sulphate in the treatment of ventricular fibrillation in amitriptyline poisoning

artículo científico publicado en 1997

Management of neutropenic enterocolitis in children with cancer

artículo científico publicado en 2011

Methotrexate polyglutamate levels and co-distributions in childhood acute lymphoblastic leukemia maintenance therapy

artículo científico publicado en 2018

Minimal residual disease assessment in childhood acute lymphoblastic leukaemia: a Swedish multi-centre study comparing real-time polymerase chain reaction and multicolour flow cytometry.

artículo científico publicado en 2011

Minimal residual disease monitoring in childhood B lymphoblastic leukemia with t(12;21)(p13;q22); ETV6-RUNX1: concordant results using quantitation of fusion transcript and flow cytometry

artículo científico publicado en 2016

Mjältsekvestrering hos barn med sicklecellanemi - Akut livshotande komplikation, snabb behandling är avgörande

artículo científico publicado en 2016

Multiple lymph node metastases in a boy with primary testicular carcinoid, despite negative preoperative imaging procedures.

artículo científico publicado en 2005

Multivariate analysis of the relation between immune dysfunction and treatment intensity in children with acute lymphoblastic leukemia.

artículo científico publicado en 2011

Myeloid leukemia in children 4 years or older with Down syndrome often lacks GATA1 mutation and cytogenetics and risk of relapse are more akin to sporadic AML

artículo científico publicado en 2007

Myelotoxicity after high-dose methotrexate in childhood acute leukemia is influenced by 6-mercaptopurine dosing but not by intermediate thiopurine methyltransferase activity

artículo científico publicado en 2014

NESP55, a novel chromogranin-like peptide, is expressed in endocrine tumours of the pancreas and adrenal medulla but not in ileal carcinoids.

artículo científico publicado en 2003

NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia

artículo científico publicado en 2018

No disadvantage in outcome of using matched unrelated donors as compared with matched sibling donors for bone marrow transplantation in children with acute lymphoblastic leukemia in second remission

artículo científico publicado en 2001

Outcome after intensive reinduction therapy and allogeneic stem cell transplant in paediatric relapsed acute myeloid leukaemia.

artículo científico publicado en 2017

Outcome of poor response paediatric AML using early SCT

artículo científico publicado en 2013

PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers.

artículo científico publicado en 2018

PAX5-ESRRB is a recurrent fusion gene in B-cell precursor pediatric acute lymphoblastic leukemia

artículo científico publicado en 2015

PEG-asparaginase allergy in children with acute lymphoblastic leukemia in the NOPHO ALL2008 protocol

scientific article published on 21 November 2014

Parents' and Adolescents' Preferences for Intensified or Reduced Treatment in Randomized Lymphoblastic Leukemia Trials

artículo científico publicado en 2015

Patient-tailored analysis of minimal residual disease in acute myeloid leukemia using next-generation sequencing

artículo científico publicado en 2016

Pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia: influence on cure rates and risk of second cancer.

artículo científico publicado en 2014

Pharmacokinetics of doxorubicin in children with acute lymphoblastic leukemia: multi-institutional collaborative study

artículo científico publicado en 2002

Ploidy and clinical characteristics of childhood acute myeloid leukemia: A NOPHO-AML study

artículo científico publicado en 2014

Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia

artículo científico publicado en 2011

Presenting features and imaging in childhood acute myeloid leukemia with central nervous system involvement.

artículo científico publicado en 2017

Prevalence and characteristics of survivors from acute myeloid leukemia in Sweden

artículo científico publicado en 2016

Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents

artículo científico publicado en 2015

Prognostic impact of t(16;21)(p11;q22) and t(16;21)(q24;q22) in pediatric AML: a retrospective study by the I-BFM Study Group

scientific article published on 27 August 2018

Prognostic implications of mutations in NOTCH1 and FBXW7 in childhood T-ALL treated according to the NOPHO ALL-1992 and ALL-2000 protocols

artículo científico publicado en 2013

Proinflammatory cytokines mediate the systemic inflammatory response associated with high-dose cytarabine treatment in children.

artículo científico publicado en 2001

Re-immunisations after childhood leukaemia

artículo científico publicado en 2005

Residual disease detected by flow cytometry is an independent predictor of survival in childhood acute myeloid leukaemia; results of the NOPHO-AML 2004 study.

artículo científico publicado en 2016

Response-guided induction therapy in pediatric acute myeloid leukemia with excellent remission rate

scientific article published on 13 December 2010

Results of NOPHO ALL2008 treatment for patients aged 1-45 years with acute lymphoblastic leukemia

artículo científico publicado en 2017

Risk group assignment differs for children and adults 1-45 yr with acute lymphoblastic leukemia treated by the NOPHO ALL-2008 protocol

artículo científico publicado en 2013

Role of neuroimaging in children with acute lymphoblastic leukemia and central nervous system involvement at diagnosis

artículo científico publicado en 2016

Safe administration of oral BU twice daily during conditioning for stem cell transplantation in a paediatric population: a comparative study between the standard 4-dose and a 2-dose regimen.

artículo científico publicado en 2007

Serum antibody levels and avidities to Escherichia coli O antigens and poliovirus type 1 antigen are increased in children treated for malignant disease

artículo científico publicado en 1999

The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia

artículo científico publicado en 2016

The applicability of the WHO classification in paediatric AML. A NOPHO-AML study

artículo científico publicado en 2015

The experience of therapeutic support groups by siblings of children with cancer

scientific article published on 01 November 2010

The mutational landscape in pediatric acute lymphoblastic leukemia deciphered by whole genome sequencing

artículo científico publicado en 2015

The paediatric cytarabine syndrome can be viewed as a drug-induced cytokine release syndrome.

artículo científico publicado en 2004

The prognostic significance of early treatment response in pediatric relapsed acute myeloid leukemia: results of the international study Relapsed AML 2001/01

artículo científico publicado en 2014

The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation

artículo científico publicado en 2014

Toxicity profile and treatment delays in NOPHO ALL2008-comparing adults and children with Philadelphia chromosome-negative acute lymphoblastic leukemia.

artículo científico publicado en 2015

Transcriptome sequencing in pediatric acute lymphoblastic leukemia identifies fusion genes associated with distinct DNA methylation profiles

artículo científico

Treatment stratification based on initial in vivo response in acute myeloid leukaemia in children without Down's syndrome: results of NOPHO-AML trials

artículo científico publicado en 2003

Trisomy 8 in pediatric acute myeloid leukemia: A NOPHO-AML study

artículo científico publicado en 2016

Tumor necrosis factor-alpha in malignant disease

scientific article published on 01 November 1993

Twenty-three deaths with gamma-hydroxybutyrate overdose in western Sweden between 2000 and 2007.

artículo científico publicado en 2010

Use of intrathecal chemoprophylaxis in children after SCT and the risk of central nervous system relapse

artículo científico publicado en 2010

Vincristine in childhood leukaemia: no pharmacokinetic rationale for dose reduction in adolescents

artículo científico publicado en 2003

Vincristine pharmacokinetics is related to clinical outcome in children with standard risk acute lymphoblastic leukemia

artículo científico publicado en 2008

Lista de obras de Jonas Abrahamsson

A glycosylation-dependent CD45RB epitope defines previously unacknowledged CD27⁻IgM(high) B cell subpopulations enriched in young children and after hematopoietic stem cell transplantation.

Accurate and sensitive analysis of minimal residual disease in acute myeloid leukemia using deep sequencing of single nucleotide variations

Acute Myeloid Leukemia in Adolescents and Young Adults Treated in Pediatric and Adult Departments in the Nordic Countries.

Acute leukaemia in children with Down syndrome: a population-based Nordic study

Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19: Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature.

Antiarrhythmic effects of magnesium sulphate. Report of three cases

Appearance of the novel activating F1174S ALK mutation in neuroblastoma correlates with aggressive tumor progression and unresponsiveness to therapy

Ara-C fever and infections after high-dose ara-C treatment in pediatric lymphoid malignancies

Asparaginase-associated pancreatitis in children with acute lymphoblastic leukaemia in the NOPHO ALL2008 protocol

Asparaginase-associated pancreatitis: a study on phenotype and genotype in the NOPHO ALL2008 protocol

Associations between neutrophil recovery time, infections and relapse in pediatric acute myeloid leukemia.

Avidity of tetanus and Hib antibodies after childhood acute lymphoblastic leukaemia - implications for vaccination strategies

Bone marrow fibrosis and radiological changes of the long bones in children with acute megakaryocytic leukaemia

Bone marrow immunoglobulin-secreting cells are not reduced in children with leukaemia as compared to children with solid tumours

CD27 expression and its association with clinical outcome in children and adults with pro-B acute lymphoblastic leukemia.

Characteristics and outcome in patients with central nervous system involvement treated in European pediatric acute myeloid leukemia study groups.

Children with low-risk acute lymphoblastic leukemia are at highest risk of second cancers.

Cholesteryl sulphate and phosphate in the solid state and in aqueous systems

Clinical features and early treatment response of central nervous system involvement in childhood acute lymphoblastic leukemia

Complying with the European Clinical Trials directive while surviving the administrative pressure - an alternative approach to toxicity registration in a cancer trial.

Comprehensive SNP array study of frequently used neuroblastoma cell lines; copy neutral loss of heterozygosity is common in the cell lines but uncommon in primary tumors

DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia

Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes

Determination of blood cell subtype concentrations from frozen whole blood samples using TruCount beads.

Differences in infection prophylaxis measures between paediatric acute myeloid leukaemia study groups within the international Berlin-Frankfürt-Münster (I-BFM) study group

Effect of age and body weight on toxicity and survival in pediatric acute myeloid leukemia: results from NOPHO-AML 2004.

Effects of epinephrine and norepinephrine on hemodynamic parameters and arrhythmias during a continuous infusion of amitriptyline in rats

Effects of epinephrine, norepinephrine, magnesium sulfate, and milrinone on survival and the occurrence of arrhythmias in amitriptyline poisoning in the rat.

Effects of magnesium sulfate and lidocaine in the treatment of ventricular arrhythmias in experimental amitriptyline poisoning in the rat.

Efficacy and Toxicity of Intrathecal Liposomal Cytarabine in First-line Therapy of Childhood Acute Lymphoblastic Leukemia.

Emergence of new ALK mutations at relapse of neuroblastoma

Epinephrine and sodium bicarbonate independently and additively increase survival in experimental amitriptyline poisoning

Extramedullary leukemia in children with acute myeloid leukemia: A population-based cohort study from the Nordic Society of Pediatric Hematology and Oncology (NOPHO).

High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: four cases of homozygous deletions of the CDKN2A gene

High-resolution copy number array in the molecular cytogenetic diagnostics of pediatric malignant hematological disorders

Hyperleucocytosis in paediatric acute myeloid leukaemia - the challenge of white blood cell counts above 200 × 109 /l. The NOPHO experience 1984-2014.

Immune reconstitution after childhood acute lymphoblastic leukemia is most severely affected in the high risk group.

Immunoglobulin levels and lymphocyte response to mitogenic stimulation in children with malignant disease during treatment and follow-up

Improved outcome after relapse in children with acute myeloid leukaemia

In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia

Individualized 6-mercaptopurine increments in consolidation treatment of childhood acute lymphoblastic leukemia: A NOPHO randomized controlled trial

Individualized toxicity-titrated 6-mercaptopurine increments during high-dose methotrexate consolidation treatment of lower risk childhood acute lymphoblastic leukaemia. A Nordic Society of Paediatric Haematology and Oncology (NOPHO) pilot study

Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia

Intensive treatment for childhood acute lymphoblastic leukemia reduces immune responses to diphtheria, tetanus, and Haemophilus influenzae type b.

Interferon gamma and tumour necrosis factor alpha in relation to anaemia and prognosis in childhood cancer

Interleukin 6, but not tumour necrosis factor-alpha, is a good predictor of severe infection in febrile neutropenic and non-neutropenic children with malignancy.

Intragenic anaplastic lymphoma kinase (ALK) rearrangements: translocations as a novel mechanism of ALK activation in neuroblastoma tumors.

Leukemic blasts are present at low levels in spinal fluid in one-third of childhood acute lymphoblastic leukemia cases

Liver transplantation after stem cell transplantation with the same living donor in a monozygotic twin with acute myeloid leukemia

Long-term health outcomes in survivors of childhood AML treated with allogeneic HSCT: a NOPHO-AML Study

Long-term results in children with AML: NOPHO-AML Study Group--report of three consecutive trials

MYCN amplicon junctions as tumor-specific targets for minimal residual disease detection in neuroblastoma.

Magnesium sulphate in the treatment of ventricular fibrillation in amitriptyline poisoning

Management of neutropenic enterocolitis in children with cancer

Methotrexate polyglutamate levels and co-distributions in childhood acute lymphoblastic leukemia maintenance therapy

Minimal residual disease assessment in childhood acute lymphoblastic leukaemia: a Swedish multi-centre study comparing real-time polymerase chain reaction and multicolour flow cytometry.

Minimal residual disease monitoring in childhood B lymphoblastic leukemia with t(12;21)(p13;q22); ETV6-RUNX1: concordant results using quantitation of fusion transcript and flow cytometry

Mjältsekvestrering hos barn med sicklecellanemi - Akut livshotande komplikation, snabb behandling är avgörande

Multiple lymph node metastases in a boy with primary testicular carcinoid, despite negative preoperative imaging procedures.

Multivariate analysis of the relation between immune dysfunction and treatment intensity in children with acute lymphoblastic leukemia.

Myeloid leukemia in children 4 years or older with Down syndrome often lacks GATA1 mutation and cytogenetics and risk of relapse are more akin to sporadic AML

Myelotoxicity after high-dose methotrexate in childhood acute leukemia is influenced by 6-mercaptopurine dosing but not by intermediate thiopurine methyltransferase activity

NESP55, a novel chromogranin-like peptide, is expressed in endocrine tumours of the pancreas and adrenal medulla but not in ileal carcinoids.

NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia

No disadvantage in outcome of using matched unrelated donors as compared with matched sibling donors for bone marrow transplantation in children with acute lymphoblastic leukemia in second remission

Outcome after intensive reinduction therapy and allogeneic stem cell transplant in paediatric relapsed acute myeloid leukaemia.

Outcome of poor response paediatric AML using early SCT

PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers.

PAX5-ESRRB is a recurrent fusion gene in B-cell precursor pediatric acute lymphoblastic leukemia

PEG-asparaginase allergy in children with acute lymphoblastic leukemia in the NOPHO ALL2008 protocol

Parents' and Adolescents' Preferences for Intensified or Reduced Treatment in Randomized Lymphoblastic Leukemia Trials

Patient-tailored analysis of minimal residual disease in acute myeloid leukemia using next-generation sequencing

Pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia: influence on cure rates and risk of second cancer.

Pharmacokinetics of doxorubicin in children with acute lymphoblastic leukemia: multi-institutional collaborative study

Ploidy and clinical characteristics of childhood acute myeloid leukemia: A NOPHO-AML study

Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia

Presenting features and imaging in childhood acute myeloid leukemia with central nervous system involvement.

Prevalence and characteristics of survivors from acute myeloid leukemia in Sweden

Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents