Lista de obras - Carmen Méndez - Dominio Público Uruguay

A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis

artículo científico publicado en 2012

A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005. ⬇️

artículo científico publicado en 2005

A simple method to study colony development in Streptomyces

article

ABC transporters in antibiotic-producing actinomycetes

artículo científico publicado en 1998

Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus

artículo científico publicado en 2011

An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus

artículo científico publicado en 1996

An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tü57. ⬇️

artículo científico publicado en 2001

Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis

artículo científico publicado en 2009

Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster

artículo científico publicado en 2008

Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate ⬇️

artículo científico publicado en 2011

Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation

artículo científico publicado en 2004

Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues

artículo científico publicado en 2006

Biosynthesis pathways for deoxysugars in antibiotic-producing actinomycetes: isolation, characterization and generation of novel glycosylated derivatives

artículo científico publicado en 2005

Cellular response and activation of apoptosis by mithramycin SK in p21(WAF1)-deficient HCT116 human colon carcinoma cells

artículo científico publicado en 2009

Chapter 11. Sugar biosynthesis and modification

artículo científico publicado en 2009

Characterization of the terminal activation step catalyzed by oxygenase CmmOIV of the chromomycin biosynthetic pathway from Streptomyces griseus ⬇️

artículo científico publicado en 2011

Cloning and disruption of a fragment of Streptomyces halstedii DNA involved in the biosynthesis of a spore pigment

artículo científico publicado el 1 de marzo de 1992

Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses

artículo científico publicado en 2006

Combinatorial biosynthesis of antitumor indolocarbazole compounds

artículo científico publicado en 2005

Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

artículo científico publicado en 2005

DNA binding characteristics of mithramycin and chromomycin analogues obtained by combinatorial biosynthesis

artículo científico publicado en 2010

Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives

artículo científico publicado en 2009

Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species

artículo científico publicado en 2006

Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase

artículo científico publicado en 2005

Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity ⬇️

artículo científico publicado en 2006

Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern

artículo científico publicado en 2008

Differential inhibition of restriction enzyme cleavage by chromophore-modified analogues of the antitumour antibiotics mithramycin and chromomycin reveals structure-activity relationships

artículo científico publicado en 2010

Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT.

artículo científico publicado en 2002

Discovery of cryptic largimycins in Streptomyces reveals novel biosynthetic avenues enriching the structural diversity of the leinamycin family

scientific article published on 20 April 2020

Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity ⬇️

scientific article published on January 2009

Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.

artículo científico publicado en 2005

Engineered Biosynthesis of Gilvocarcin Analogues with Altered Deoxyhexopyranose Moieties ⬇️

artículo científico publicado el 12 de noviembre de 2010

Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin.

artículo científico publicado en 2004

Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives

artículo científico publicado en 2006

Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds

artículo científico publicado en 2002

Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase

artículo científico publicado en 2002

Engineering the glycosylation of natural products in actinomycetes

artículo científico publicado en 2007

Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences

artículo científico publicado en 2007

Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus ⬇️

artículo científico publicado en 2001

Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis

artículo científico publicado en 2008

Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus

artículo científico publicado en 2004

Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles

artículo científico publicado en 2009

Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891.

artículo científico publicado en 2004

Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity

artículo científico publicado en 2008

Glycosyltransferases, important tools for drug design

artículo científico publicado en 2008

Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin

scientific article published on 24 May 2020

Hybridization and DNA sequence analyses suggest an early evolutionary divergence of related biosynthetic gene sets encoding polyketide antibiotics and spore pigments in Streptomyces spp.

artículo científico publicado en 1993

Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus

artículo científico publicado en 2000

Identification of a growth phase-dependent promoter in the rplJL operon of Streptomyces coelicolor A3(2)

artículo científico publicado en 2001

Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycin ⬇️

artículo científico publicado en 2005

Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya

artículo científico publicado en 2008

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

artículo científico publicado en 2008

Indolocarbazole antitumour compounds by combinatorial biosynthesis

artículo científico publicado en 2009

Indolocarbazole natural products: occurrence, biosynthesis, and biological activity

artículo científico publicado en 2006

Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes

artículo científico publicado en 2006

Involvement of a chromomycin ABC transporter system in secretion of a deacetylated precursor during chromomycin biosynthesis

artículo científico publicado en 2007

Involvement of the beta subunit of RNA polymerase in resistance to streptolydigin and streptovaricin in the producer organisms Streptomyces lydicus and Streptomyces spectabilis ⬇️

artículo científico publicado en 2010

Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin

artículo científico publicado en 2006

Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal nov ⬇️

artículo científico publicado en 2002

Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512.

artículo científico publicado en 2006

Mithramycin SK modulates polyploidy and cell death in colon carcinoma cells

artículo científico publicado en 2008

Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces argillaceus through Combinatorial Biosynthesis ⬇️

artículo científico publicado el 14 de mayo de 2003

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity ⬇️

artículo científico publicado en 2008

Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis

artículo científico publicado en 2009

Molecular insights on the biosynthesis of antitumour compounds by actinomycetes

artículo científico publicado en 2010

Mutational Analysis of the Thienamycin Biosynthetic Gene Cluster from Streptomyces cattleya ⬇️

artículo científico publicado el 24 de enero de 2011

Novel Hybrid Tetracenomycins through Combinatorial Biosynthesis Using a Glycosyltransferase Encoded by theelmGenes in Cosmid 16F4 and Which Shows a Broad Sugar Substrate Specificity

article

Novel compounds produced by Streptomyces lydicus NRRL 2433 engineered mutants altered in the biosynthesis of streptolydigin ⬇️

artículo científico publicado en 2012

Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea

artículo científico publicado en 2002

Participation of putative glycoside hydrolases SlgC1 and SlgC2 in the biosynthesis of streptolydigin in Streptomyces lydicus ⬇️

artículo científico publicado en 2012

Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

artículo científico publicado en 2010

Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways

artículo científico publicado en 2002

Reactome array: forging a link between metabolome and genome

artículo científico publicado en 2009

Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis.

artículo científico publicado en 2006

Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain

artículo científico publicado en 2006

Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A by Streptomyces griseus ssp. griseus ⬇️

artículo científico publicado en 2004

The Biosynthesis of Aureolic Acid Group Antibiotics

The Biosynthetic Gene Cluster for the β-Lactam Carbapenem Thienamycin in Streptomyces cattleya ⬇️

artículo científico publicado el 1 de abril de 2003

The Structure of Mithramycin Reinvestigated

artículo científico publicado en 1999

The Volatile Organic Compounds of Streptomyces spp.: An In-Depth Analysis of Their Antifungal Properties

artículo científico publicado en 2023

The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives

artículo científico publicado en 2006

The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives

artículo científico publicado en 2002

The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin

artículo científico publicado en 2010

The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties

artículo científico publicado en 2001

Three pathway-specific regulators control streptolydigin biosynthesis in Streptomyces lydicus.

artículo científico publicado en 2012

Topological studies of the membrane component of the OleC ABC transporter involved in oleandomycin resistance in Streptomyces antibioticus.

artículo científico publicado en 1996

Transcriptional organization of ThnI-regulated thienamycin biosynthetic genes in Streptomyces cattleya.

artículo científico publicado en 2010

Uncovering production of specialized metabolites by Streptomyces argillaceus: Activation of cryptic biosynthesis gene clusters using nutritional and genetic approaches. ⬇️

artículo científico publicado en 2018

Lista de obras de Carmen Méndez

A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis

A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005. ⬇️

A simple method to study colony development in Streptomyces

ABC transporters in antibiotic-producing actinomycetes

Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus

An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus

An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tü57. ⬇️

Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis

Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster

Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate ⬇️

Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation

Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues

Biosynthesis pathways for deoxysugars in antibiotic-producing actinomycetes: isolation, characterization and generation of novel glycosylated derivatives

Cellular response and activation of apoptosis by mithramycin SK in p21(WAF1)-deficient HCT116 human colon carcinoma cells

Chapter 11. Sugar biosynthesis and modification

Characterization of the terminal activation step catalyzed by oxygenase CmmOIV of the chromomycin biosynthetic pathway from Streptomyces griseus ⬇️

Cloning and disruption of a fragment of Streptomyces halstedii DNA involved in the biosynthesis of a spore pigment

Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses

Combinatorial biosynthesis of antitumor indolocarbazole compounds

Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

DNA binding characteristics of mithramycin and chromomycin analogues obtained by combinatorial biosynthesis

Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives

Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species

Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase

Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity ⬇️

Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern

Differential inhibition of restriction enzyme cleavage by chromophore-modified analogues of the antitumour antibiotics mithramycin and chromomycin reveals structure-activity relationships

Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT.

Discovery of cryptic largimycins in Streptomyces reveals novel biosynthetic avenues enriching the structural diversity of the leinamycin family

Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity ⬇️

Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.

Engineered Biosynthesis of Gilvocarcin Analogues with Altered Deoxyhexopyranose Moieties ⬇️

Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin.

Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives

Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds

Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase

Engineering the glycosylation of natural products in actinomycetes

Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences

Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus ⬇️

Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis

Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus

Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles

Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891.

Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity

Glycosyltransferases, important tools for drug design

Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin

Hybridization and DNA sequence analyses suggest an early evolutionary divergence of related biosynthetic gene sets encoding polyketide antibiotics and spore pigments in Streptomyces spp.

Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus

Identification of a growth phase-dependent promoter in the rplJL operon of Streptomyces coelicolor A3(2)

Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycin ⬇️

Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

Indolocarbazole antitumour compounds by combinatorial biosynthesis

Indolocarbazole natural products: occurrence, biosynthesis, and biological activity

Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes

Involvement of a chromomycin ABC transporter system in secretion of a deacetylated precursor during chromomycin biosynthesis

Involvement of the beta subunit of RNA polymerase in resistance to streptolydigin and streptovaricin in the producer organisms Streptomyces lydicus and Streptomyces spectabilis ⬇️

Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin

Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal nov ⬇️

Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512.

Mithramycin SK modulates polyploidy and cell death in colon carcinoma cells

Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces argillaceus through Combinatorial Biosynthesis ⬇️

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity ⬇️

Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis

Molecular insights on the biosynthesis of antitumour compounds by actinomycetes

Mutational Analysis of the Thienamycin Biosynthetic Gene Cluster from Streptomyces cattleya ⬇️

Novel Hybrid Tetracenomycins through Combinatorial Biosynthesis Using a Glycosyltransferase Encoded by theelmGenes in Cosmid 16F4 and Which Shows a Broad Sugar Substrate Specificity

Novel compounds produced by Streptomyces lydicus NRRL 2433 engineered mutants altered in the biosynthesis of streptolydigin ⬇️

Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea

Participation of putative glycoside hydrolases SlgC1 and SlgC2 in the biosynthesis of streptolydigin in Streptomyces lydicus ⬇️

Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways

Reactome array: forging a link between metabolome and genome

Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis.

Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain

Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A by Streptomyces griseus ssp. griseus ⬇️

The Biosynthesis of Aureolic Acid Group Antibiotics

The Biosynthetic Gene Cluster for the β-Lactam Carbapenem Thienamycin in Streptomyces cattleya ⬇️

The Structure of Mithramycin Reinvestigated