Lista de obras - Boris Schmidt - Dominio Público Uruguay

2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer's disease

artículo científico publicado en 2012

3-[2,6-Bis(diethylcarbamoyl)pyridin-4-yl]-N-(tert-butoxycarbonyl)alanine methyl ester: a chiral tridentate ligand that causes a diastereomeric excess of its lanthanide complexes in solution.

artículo científico publicado en 2003

A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells

artículo científico publicado en 2009

A frame shifted disulfide bridged analogue of angiotensin II

scientific article published on 01 March 2003

An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin

artículo científico publicado en 2012

Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.

artículo científico publicado en 2003

Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite EXP3179.

artículo científico publicado en 2002

Angiotensin receptor type 1 blockade in astroglia decreases hypoxia-induced cell damage and TNF alpha release

artículo científico publicado en 2007

Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model

artículo científico publicado en 2014

Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models

artículo científico publicado en 2012

Cell-Based Optimization of Covalent Reversible Ketoamide Inhibitors Bridging the Unprimed to the Primed Site of the Proteasome β5 Subunit

scientific article published on 12 November 2019

Combined effect of proteasome and calpain inhibition on cisplatin-resistant human melanoma cells

artículo científico publicado en 2006

Complexation of copper(II)-Chelidamate: A multifrequency-pulsed electron paramagnetic resonance and electron nuclear double resonance analysis

scientific article published on 01 October 2006

Computational & experimental evaluation of the structure/activity relationship of β-carbolines as DYRK1A inhibitors.

artículo científico publicado en 2014

Computer-guided design, synthesis, and biological evaluation of quinoxalinebisarylureas as FLT3 inhibitors

artículo científico publicado en 2015

Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor.

artículo científico publicado en 2007

Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain

artículo científico publicado en 2004

Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms

artículo científico publicado en 2009

Curcumin derivatives inhibit or modulate beta-amyloid precursor protein metabolism.

artículo científico publicado en 2007

Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease?

artículo científico publicado en 2008

DOCKTITE-a highly versatile step-by-step workflow for covalent docking and virtual screening in the molecular operating environment

artículo científico publicado en 2015

Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium.

artículo científico publicado en 2013

Determinants of steady-state torasemide pharmacokinetics: impact of pharmacogenetic factors, gender and angiotensin II receptor blockers

artículo científico publicado en 2008

Development and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's disease

artículo científico publicado en 2013

Development of tau aggregation inhibitors for Alzheimer's disease

artículo científico publicado en 2009

Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.

artículo científico publicado en 2017

Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors.

artículo científico publicado en 2018

Drug development and PET-diagnostics for Alzheimer's disease.

artículo científico publicado en 2005

Dysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer's Disease Model.

artículo científico publicado en 2016

EXP3179 inhibits collagen-dependent platelet activation via glycoprotein receptor-VI independent of AT1-receptor antagonism: potential impact on atherothrombosis

artículo científico publicado en 2007

Elastase-like Activity Is Dominant to Chymotrypsin-like Activity in 20S Proteasome's β5 Catalytic Subunit

artículo científico publicado en 2016

Elucidation of the α‐Keto‐Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition ⬇️

artículo científico publicado el 10 de enero de 2011

Ensemble-Docking Approach on BACE-1: Pharmacophore Perception and Guidelines for Drug Design

scholarly article by Vittorio Limongelli et al published 11 June 2007 in ChemMedChem

Ensemble-docking approach on BACE-1: pharmacophore perception and guidelines for drug design

artículo científico publicado en 2007

Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa

scientific article published on 12 November 2018

Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains.

artículo científico publicado en 2013

Fmoc protected peptide mimetic based on a cyclohexane framework and incorporation into angiotensin II

Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions

artículo científico publicado en 2012

Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α.

artículo científico publicado en 2012

Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model

artículo científico publicado en 2014

Improved synthesis of ADAM10 inhibitor GI254023X.

artículo científico publicado en 2010

In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques.

artículo científico publicado en 2014

Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta.

artículo científico publicado en 2010

Inhibitors and modulators of beta- and gamma-secretase

artículo científico publicado en 2006

Lipid bilayer position and orientation of novel carprofens, modulators of γ-secretase in Alzheimer's disease

artículo científico publicado en 2018

Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice

artículo científico publicado en 2012

Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation.

artículo científico publicado en 2013

Membrane anchoring γ-secretase modulators with terpene-derived moieties

artículo científico publicado en 2013

Memory trace interference impairs recall in a mouse model of Alzheimer's disease

artículo científico publicado en 2020

Methyltrioxorhenium - from oxidation and cyclopropanation to metathesis

Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3.

artículo científico publicado en 2012

Modulators and inhibitors of gamma- and beta-secretases.

artículo científico publicado en 2006

Mutation-specific dual potentiators maximize rescue of CFTR gating mutants

scientific article published on 30 October 2019

N'-benzylidene-benzohydrazides as novel and selective tau-PHF ligands

artículo científico publicado en 2011

NSAID-derived gamma-secretase modulators. Part III: Membrane anchoring.

artículo científico publicado en 2009

NSAID-derived γ-secretase modulation requires an acidic moiety on the carbazole scaffold.

artículo científico publicado en 2011

Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells

artículo científico publicado en 2007

Regulation of peroxisome proliferator-activated receptor gamma activity by losartan metabolites

artículo científico publicado en 2005

Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping

artículo científico publicado en 2007

Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models.

artículo científico publicado en 2012

Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models

artículo científico publicado en 2012

Soluble CD23 controls IgE synthesis and homeostasis in human B cells.

artículo científico publicado en 2012

Structure-based optimization of oxadiazole-based GSK-3 inhibitors.

artículo científico publicado en 2012

Substrate-targeting gamma-secretase modulators

artículo científico publicado en 2008

Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas.

artículo científico publicado en 2011

Synthesis of methoxy-X04 derivatives and their evaluation in Alzheimer's disease pathology.

artículo científico publicado en 2013

Synthesis of tetramic and tetronic acids as beta-secretase inhibitors.

artículo científico publicado en 2006

Therapeutic effects of angiotensin (AT1) receptor antagonists: potential contribution of mechanisms other than AT1 receptor blockade

artículo científico publicado en 2004

Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations

scientific article published on 25 February 2019

Lista de obras de Boris Schmidt

2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer's disease

3-[2,6-Bis(diethylcarbamoyl)pyridin-4-yl]-N-(tert-butoxycarbonyl)alanine methyl ester: a chiral tridentate ligand that causes a diastereomeric excess of its lanthanide complexes in solution.

A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells

A frame shifted disulfide bridged analogue of angiotensin II

An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin

Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.

Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite EXP3179.

Angiotensin receptor type 1 blockade in astroglia decreases hypoxia-induced cell damage and TNF alpha release

Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model

Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models

Cell-Based Optimization of Covalent Reversible Ketoamide Inhibitors Bridging the Unprimed to the Primed Site of the Proteasome β5 Subunit

Combined effect of proteasome and calpain inhibition on cisplatin-resistant human melanoma cells

Complexation of copper(II)-Chelidamate: A multifrequency-pulsed electron paramagnetic resonance and electron nuclear double resonance analysis

Computational & experimental evaluation of the structure/activity relationship of β-carbolines as DYRK1A inhibitors.

Computer-guided design, synthesis, and biological evaluation of quinoxalinebisarylureas as FLT3 inhibitors

Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor.

Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain

Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms

Curcumin derivatives inhibit or modulate beta-amyloid precursor protein metabolism.

Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease?

DOCKTITE-a highly versatile step-by-step workflow for covalent docking and virtual screening in the molecular operating environment

Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium.

Determinants of steady-state torasemide pharmacokinetics: impact of pharmacogenetic factors, gender and angiotensin II receptor blockers

Development and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's disease

Development of tau aggregation inhibitors for Alzheimer's disease

Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.

Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors.

Drug development and PET-diagnostics for Alzheimer's disease.

Dysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer's Disease Model.

EXP3179 inhibits collagen-dependent platelet activation via glycoprotein receptor-VI independent of AT1-receptor antagonism: potential impact on atherothrombosis

Elastase-like Activity Is Dominant to Chymotrypsin-like Activity in 20S Proteasome's β5 Catalytic Subunit

Elucidation of the α‐Keto‐Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition ⬇️

Ensemble-Docking Approach on BACE-1: Pharmacophore Perception and Guidelines for Drug Design

Ensemble-docking approach on BACE-1: pharmacophore perception and guidelines for drug design

Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa

Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains.

Fmoc protected peptide mimetic based on a cyclohexane framework and incorporation into angiotensin II

Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions

Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α.

Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model

Improved synthesis of ADAM10 inhibitor GI254023X.

In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques.

Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta.

Inhibitors and modulators of beta- and gamma-secretase

Lipid bilayer position and orientation of novel carprofens, modulators of γ-secretase in Alzheimer's disease

Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice

Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation.

Membrane anchoring γ-secretase modulators with terpene-derived moieties

Memory trace interference impairs recall in a mouse model of Alzheimer's disease

Methyltrioxorhenium - from oxidation and cyclopropanation to metathesis

Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3.

Modulators and inhibitors of gamma- and beta-secretases.

Mutation-specific dual potentiators maximize rescue of CFTR gating mutants

N'-benzylidene-benzohydrazides as novel and selective tau-PHF ligands

NSAID-derived gamma-secretase modulators. Part III: Membrane anchoring.

NSAID-derived γ-secretase modulation requires an acidic moiety on the carbazole scaffold.

Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells

Regulation of peroxisome proliferator-activated receptor gamma activity by losartan metabolites

Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping

Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models.

Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models

Soluble CD23 controls IgE synthesis and homeostasis in human B cells.

Structure-based optimization of oxadiazole-based GSK-3 inhibitors.

Substrate-targeting gamma-secretase modulators

Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas.

Synthesis of methoxy-X04 derivatives and their evaluation in Alzheimer's disease pathology.

Synthesis of tetramic and tetronic acids as beta-secretase inhibitors.

Therapeutic effects of angiotensin (AT1) receptor antagonists: potential contribution of mechanisms other than AT1 receptor blockade

Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations