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Lista de obras de Rafael Franco

A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice.

artículo científico publicado en 2016

A computer program for enzyme kinetics that combines model discrimination, parameter refinement and sequential experimental design.

artículo científico publicado en 1986

A hybrid indoloquinolizidine peptide as allosteric modulator of dopamine D1 receptors

artículo científico publicado en 2009

A method for binding parameters estimation of A1 adenosine receptor subtype: a practical approach

artículo científico publicado en 1990

A model for adenosine transport and metabolism

artículo científico publicado en 1992

A model of the pentose phosphate pathway in rat liver cells.

artículo científico publicado en 1995

A new strategy for the evaluation of force parameters from quantum mechanical computations

A program for the numerical integration of enzyme kinetic equations using small computers.

artículo científico publicado en 1984

A quantum chemical study of the enzymatic deamination of benzoadenine derivatives. A theoretical model of the interactions occurring between nucleosides and the active site of adenosine deaminase.

artículo científico publicado en 1990

A role for interleukin-12 in the regulation of T cell plasma membrane compartmentation

artículo científico publicado en 2003

A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation

artículo científico publicado en 2003

A1 adenosine receptors can occur manifesting two kinetic components of 8-cyclopentyl-1,3-[3H]dipropylxanthine ([3H]DPCPX) binding

artículo científico publicado en 1994

A1R-A2AR heteromers coupled to Gs and G i/0 proteins modulate GABA transport into astrocytes.

artículo científico publicado en 2013

A2A Receptor Homodimer-Disrupting Sequence Efficiently Delivered by a Protease-Resistant, Cyclic CPP Vector

artículo científico publicado en 2019

A2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase

artículo científico publicado en 2011

A2A and A2B adenosine receptors: The extracellular loop 2 determines high (A2A) or low affinity (A2B) for adenosine

artículo científico publicado en 2019

ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors

scientific journal article

Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease

artículo científico publicado en 2006

Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors.

artículo científico publicado en 2010

Actin-binding protein alpha-actinin-1 interacts with the metabotropic glutamate receptor type 5b and modulates the cell surface expression and function of the receptor

artículo científico publicado en 2007

Adenine nucleotides and adenosine metabolism in pig kidney proximal tubule membranes

artículo científico publicado en 1993

Adenosine (Ado) uptake in brush-border membrane vesicles from rat kidney (BBM)

artículo científico publicado en 1991

Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function

artículo científico publicado en 2011

Adenosine A1 Receptor in Cultured Neurons from Rat Cerebral Cortex

artículo científico publicado en 2000

Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease

scientific article published on 26 April 2020

Adenosine A2A and A3 Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling

scientific article published on 17 July 2020

Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function

artículo científico publicado en 2005

Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes

artículo científico publicado en 2005

Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia

artículo científico publicado en 2005

Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers

artículo científico publicado en 2009

Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release.

artículo científico publicado en 2006

Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

artículo científico publicado en 2003

Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders

artículo científico publicado en 2004

Adenosine A2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells

artículo científico publicado en 2001

Adenosine deaminase affects ligand-induced signalling by interacting with cell surface adenosine receptors

artículo científico publicado en 1996

Adenosine deaminase and A1 adenosine receptors internalize together following agonist-induced receptor desensitization

artículo científico publicado en 1998

Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles

artículo científico publicado en 1997

Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV.

artículo científico publicado en 2009

Adenosine deaminase enhances the immunogenicity of human dendritic cells from healthy and HIV-infected individuals

artículo científico publicado en 2012

Adenosine deaminase interacts with A1 adenosine receptors in pig brain cortical membranes

artículo científico publicado en 1996

Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells.

artículo científico publicado en 2010

Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1.

artículo científico publicado en 2015

Adenosine metabolism in kidney slices under normoxic conditions.

artículo científico publicado en 1990

Adenosine receptor heteromers and their integrative role in striatal function

artículo científico publicado en 2007

Adenosine receptor-dopamine receptor interactions in the basal ganglia and their relevance for brain function.

artículo científico publicado en 2007

Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation

artículo científico publicado en 2004

Adenosine receptors in myelin fractions and subfractions: the effect of the agonist (R)-phenylisopropyladenosine on myelin membrane microviscosity

artículo científico publicado en 1991

Adenosine-cannabinoid receptor interactions. Implications for striatal function

artículo científico publicado en 2010

Adenosine-glutamate receptor-receptor interactions in the central nervous system

Adenosine/dopamine receptor-receptor interactions in the central nervous system

scholarly article by Rafael Franco et al published January 2001 in Drug Development Research

Adreno-melatonin receptor complexes control ion homeostasis and intraocular pressure - their disruption contributes to hypertensive glaucoma

artículo científico publicado en 2020

Age-related mitochondrial alterations without neuronal loss in the hippocampus of a transgenic model of Alzheimer's disease.

artículo científico publicado en 2013

Allosteric modulation of dopamine D2 receptors by homocysteine

artículo científico publicado en 2006

Alternatively activated microglia and macrophages in the central nervous system.

artículo científico

Ammonium toxicity in different cell lines

article

An improved method for the preparation of rat brain microsomes

artículo científico publicado en 1986

An old enzyme for current needs: adenosine deaminase and a dendritic cell vaccine for HIV.

artículo científico publicado en 2011

Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis

artículo científico publicado en 2008

Antioxidant Defense Mechanisms in Erythrocytes and in the Central Nervous System

artículo científico publicado en 2019

Antioxidants versus Food Antioxidant Additives and Food Preservatives

artículo científico publicado en 2019

Aspects of the general biology of adenosine A2A signaling.

artículo científico publicado en 2007

Association of adenosine deaminase with erythrocyte and platelet plasma membrane: an immunological study using light and electron microscopy

artículo científico publicado en 1990

Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization

artículo científico publicado en 2016

Basic concepts in G-protein-coupled receptor homo- and heterodimerization.

artículo científico publicado en 2007

Biochemical systems theory: increasing predictive power by using second-order derivatives measurements.

artículo científico publicado en 1991

Biotin Ergopeptide Probes for Dopamine Receptors ⬇️

artículo científico publicado el 31 de enero de 2011

Bridging the gap

Building a new conceptual framework for receptor heteromers

artículo científico publicado en 2009

CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum

artículo científico publicado en 2014

CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients

artículo científico publicado en 2012

CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface

artículo científico publicado en 2014

CD26 and Adenosine Deaminase Interaction: Its Role in the Fusion Between Horse Membrane Vesicles and Spermatozoa1

artículo científico publicado en 1999

CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse.

artículo científico publicado en 2005

Calcium mobilization in Jurkat cells via A2b adenosine receptors

artículo científico publicado en 1997

Calcium-mediated modulation of the quaternary structure and function of adenosine A2A-dopamine D2 receptor heteromers

artículo científico publicado en 2009

Cannabinoid receptors CB1 and CB2 form functional heteromers in brain

artículo científico publicado en 2012

Cell surface adenosine deaminase: much more than an ectoenzyme.

artículo científico publicado en 1997

Challenges in the development of heteromer-GPCR-based drugs

artículo científico

Characterization of adenosine receptors in brush-border membranes from pig kidney

artículo científico publicado en 1992

Characterization of the GTP/GDP binding site in the murine CD3-zeta polypeptide chain.

artículo científico publicado en 1994

Chemical rules on the assessment of antioxidant potential in food and food additives aimed at reducing oxidative stress and neurodegeneration

artículo científico publicado en 2017

Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis

artículo científico publicado en 2016

Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice

artículo científico publicado en 2012

Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation.

artículo científico publicado en 2011

Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland

artículo científico publicado en 2012

Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors

artículo científico publicado en 2002

Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors

artículo científico publicado en 2018

Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers

artículo científico publicado en 2013

Cocaine produces D2R-mediated conformational changes in the adenosine A(2A)R-dopamine D2R heteromer

artículo científico publicado en 2010

Cocaine self-administration markedly increases dopamine D2 receptor negative cooperativity for dopamine binding: A receptor dimer-based analysis

artículo científico publicado en 2010

Coffee and cancer

artículo científico publicado en 2008

Coffee and mental health

artículo científico publicado en 2009

Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors

artículo científico publicado en 2004

Comodulation of CXCR4 and CD26 in human lymphocytes

artículo científico publicado en 2001

Computer simulation of purine metabolism ⬇️

artículo científico publicado el 15 de octubre de 1984

Computer-based learning of cooperativity and allostery.

artículo científico publicado en 1985

Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer's disease

artículo científico publicado en 2015

Control analysis of systems having two steps catalyzed by the same protein molecule in unbranched chains

artículo científico publicado en 1990

Control analysis of transition times. Extension of analysis and matrix method.

artículo científico publicado en 1991

Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain.

artículo científico publicado en 2018

Cytokines regulate membrane adenosine deaminase on human activated lymphocytes

artículo científico publicado en 2001

Decreased levels of guanosine 3', 5'-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease

artículo científico publicado en 2015

Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease.

artículo científico

Degradation of adenosine by extracellular adenosine deaminase in the rat duodenum.

artículo científico publicado en 1988

Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism

artículo científico publicado en 2014

Detection of heteromerization of more than two proteins by sequential BRET-FRET.

artículo científico publicado en 2008

Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer.

artículo científico publicado en 2008

Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology

artículo científico publicado en 2013

Determination of the characteristics, properties and homogeneity of rat brain microsomes. Binding of lactate dehydrogenase, malate dehydrogenase and 5' nucleotidase to microsomal membranes

artículo científico publicado en 1988

Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine

artículo científico publicado en 2014

Dimer-based model for heptaspanning membrane receptors

scientific article published on 01 July 2005

Dipropylcyclopentylxanthine triggers apoptosis in Jurkat T cells by a receptor-independent mechanism

artículo científico publicado en 1997

Dipropylcyclopentylxanthine triggers apoptosis in cells from patients with myeloid leukaemia

artículo científico publicado en 1998

Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine

artículo científico publicado en 2010

Disruption of a dopamine receptor complex amplifies the actions of cocaine

artículo científico publicado en 2016

Distribution of A1-adenosine receptors, adenosine deaminase and 5'-nucleotidase in brain and other tissues of the pig.

artículo científico publicado en 1990

Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway

artículo científico publicado en 2010

Dopamine D2 and angiotensin II type 1 receptors form functional heteromers in rat striatum.

artículo científico publicado en 2015

Dopamine receptor heteromeric complexes and their emerging functions

artículo científico publicado en 2014

Dopamine-galanin receptor heteromers modulate cholinergic neurotransmission in the rat ventral hippocampus.

artículo científico publicado en 2011

Dynamic Regulation of CXCR1 and CXCR2 Homo- and Heterodimers

scientific article published on 04 November 2009

Ecto-ADA in the development of theimmune system

article

Effect of Endogenous Phospholipids on the [3H]R-Pia Binding to A1Adenosine Receptors from PIG Cerebral Cortex

Effect of phospholipases and proteases on the [3H]N6-(R)-phenylisopropyladenosine ([3H]R-PIA) binding to A1 adenosine receptors from pig cerebral cortex

artículo científico publicado en 1991

Energy gradients for VT-signal migration in the CNS: studies on melanocortin receptors, mitochondrial uncoupling proteins and food intake.

artículo científico publicado en 2004

Enhancing cognition before clinical symptoms of dementia.

artículo científico publicado en 2014

Enzymatic and extraenzymatic role of adenosine deaminase 1 in T-cell-dendritic cell contacts and in alterations of the immune function.

scientific article published on January 2007

Enzymatic and extraenzymatic role of ecto-adenosine deaminase in lymphocytes

artículo científico publicado en 1998

Enzyme kinetic studies from progress curves.

artículo científico publicado en 1986

Enzymes of the purine metabolism in rat brain microsomes

artículo científico publicado en 1986

Epidermal growth factor (EGF)-induced up-regulation and agonist- and antagonist-induced desensitization and internalization of A1 adenosine receptors in a pituitary-derived cell line.

artículo científico publicado en 1999

Epigenetic drugs in Alzheimer's disease

artículo científico publicado en 2013

Expression of A2B adenosine receptors in human lymphocytes: their role in T cell activation

artículo científico publicado en 1999

Expression of GPR55 and either cannabinoid CB1 or CB2 heteroreceptor complexes in the caudate, putamen, and accumbens nuclei of control, parkinsonian, and dyskinetic non-human primates

artículo científico publicado en 2020

Expression of Melatonin and Dopamine D3 Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension

scientific article published on 08 January 2020

Expression of cannabinoid CB1 R-GPR55 heteromers in neuronal subtypes of the Macaca fascicularis striatum

artículo científico publicado en 2020

Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule

artículo científico publicado en 1995

Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis

artículo científico publicado en 2010

Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease.

artículo científico publicado en 2016

Fitting integrated enzyme rate equations to progress curves with the use of a weighting matrix

artículo científico publicado en 1991

Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue

artículo científico publicado en 2020

Functional relevance of neurotransmitter receptor heteromers in the central nervous system.

artículo científico publicado en 2007

Further characterization of adenosine transport in renal brush-border membranes

artículo científico publicado en 1990

G protein-coupled receptor heteromers as new targets for drug development

artículo científico publicado en 2010

G-protein-coupled receptor heteromers as key players in the molecular architecture of the central nervous system.

artículo científico

G-protein-coupled receptor heteromers: function and ligand pharmacology

artículo científico publicado en 2008

GPCR homomers and heteromers: a better choice as targets for drug development than GPCR monomers?

artículo científico publicado en 2009

GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells

artículo científico publicado en 2014

Gi protein coupling to adenosine A1-A2A receptor heteromers in human brain caudate nucleus.

artículo científico publicado en 2010

Glutamate Released by Dendritic Cells as a Novel Modulator of T Cell Activation

artículo científico publicado en 2006

Graphical analysis of data from pharmacology experiments

artículo científico publicado en 1992

HIV-1 Envelope gp120 and Viral Particles Block Adenosine Deaminase Binding to Human CD26 ⬇️

artículo científico publicado el 1 de enero de 1997

Health benefits of methylxanthines in cacao and chocolate

artículo científico publicado en 2013

Health benefits of methylxanthines in neurodegenerative diseases

artículo científico publicado en 2017

Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins: focus on adenosine, dopamine, and metabotropic glutamate receptor function

artículo científico publicado en 2005

Heterodimeric adenosine receptors: a device to regulate neurotransmitter release.

artículo científico publicado en 2006

Heterogeneity of the gradients performed by the freeze-thaw method

artículo científico publicado en 1989

Heterogeneous localization of some purine enzymes in subcellular fractions of rat brain and cerebellum.

artículo científico publicado en 1986

Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine release.

artículo científico publicado en 2006

Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signalling

artículo científico publicado en 2014

Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer's Disease

artículo científico publicado en 2016

Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum.

artículo científico publicado en 2015

Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

artículo científico publicado en 2004

Hormetic and Mitochondria-Related Mechanisms of Antioxidant Action of Phytochemicals

artículo científico publicado en 2019

How calmodulin interacts with the adenosine A(2A) and the dopamine D(2) receptors

artículo científico publicado en 2008

Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages.

artículo científico publicado en 2010

Human adenosine deaminase as an allosteric modulator of human A(1) adenosine receptor: abolishment of negative cooperativity for [H](R)-pia binding to the caudate nucleus

artículo científico publicado en 2008

IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation

artículo científico publicado en 1999

Identification and rejection of outliers in enzyme kinetics.

artículo científico publicado en 1988

Identification of a Tool Compound to Study the Mechanisms of Functional Selectivity between D2 and D3 Dopamine Receptors

scholarly article by Irene Reyes-Resina et al published 14 December 2018 in ACS Omega

Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum

artículo científico publicado en 2008

Immunodensity and mRNA expression of A2A adenosine, D2 dopamine, and CB1 cannabinoid receptors in postmortem frontal cortex of subjects with schizophrenia: effect of antipsychotic treatment

artículo científico publicado en 2009

Immunolocalization of A1 Adenosine Receptors in Mammalian Spermatozoa

scientific article published on 01 September 2000

Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activation.

artículo científico publicado en 2009

Immunological identification of A1adenosine receptors in brain cortex

scientific article published on 01 December 1995

Increase in A2A receptors in the nucleus accumbens after extended cocaine self-administration and its disappearance after cocaine withdrawal

artículo científico publicado en 2007

Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression

artículo científico publicado en 2010

Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4(+) T-cell activation and dendritic cell maturation.

artículo científico publicado en 2016

Indoloquinolizidine-peptide hybrids as multiple agonists for D1 and D2 dopamine receptors.

artículo científico publicado en 2009

Interaction of trans-acting factors with the proximal promoter of the mouse alpha-fetoprotein gene

artículo científico publicado en 1992

Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors

artículo científico publicado en 2009

Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function

artículo científico publicado en 2008

Interactions between intracellular domains as key determinants of the quaternary structure and function of receptor heteromers

artículo científico publicado en 2010

Interdependence between cooperativity and control coefficients.

artículo científico publicado en 1989

Intramembrane receptor-receptor interactions: a novel principle in molecular medicine.

artículo científico publicado en 2006

Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine

artículo científico publicado en 2006

Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line

artículo científico publicado en 2001

Is adenosine deaminase involved in adenosine transport?

artículo científico publicado en 1990

Kinetics of the 5'-nucleotidase and the adenosine deaminase in subcellular fractions of rat brain

artículo científico publicado en 1986

L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies

artículo científico publicado en 2014

L-DOPA-treatment in primates disrupts the expression of A(2A) adenosine-CB(1) cannabinoid-D(2) dopamine receptor heteromers in the caudate nucleus

artículo científico publicado en 2013

Lessons on Differential Neuronal-Death-Vulnerability from Familial Cases of Parkinson's and Alzheimer's Diseases

artículo científico publicado en 2019

Ligand-Induced Phosphorylation, Clustering, and Desensitization of A1Adenosine Receptors

scientific article published on 01 November 1997

Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling

artículo científico publicado en 2003

Light resonance energy transfer-based methods in the study of G protein-coupled receptor oligomerization

artículo científico publicado en 2008

Loss of parvalbumin-positive neurons from the globus pallidus in animal models of Parkinson disease

artículo científico publicado en 2012

MECHANISMS OF CD26/DIPEPTIDYL PEPTIDASE IV CYTOKINE-DEPENDENT REGULATION ON HUMAN ACTIVATED LYMPHOCYTES

artículo científico publicado en 2000

Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors

artículo científico publicado en 2009

Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors.

artículo científico publicado en 2013

Metabotropic glutamate 1alpha and adenosine A1 receptors assemble into functionally interacting complexes.

artículo científico publicado en 2001

Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions

artículo científico publicado en 2003

Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration.

artículo científico publicado en 2016

Modulation of GABA transport by adenosine A1R-A2AR heteromers, which are coupled to both Gs- and G(i/o)-proteins

scientific article published on 01 November 2011

Modulation of adenosine agonist [3H]N6-(R)-phenylisopropyladenosine binding to pig brain cortical membranes by changes of membrane fluidity and of medium physicochemical characteristics.

artículo científico publicado en 1992

Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons.

artículo científico publicado en 2003

Molecular mechanisms involved in the adenosine A and A receptor-induced neuronal differentiation in neuroblastoma cells and striatal primary cultures

artículo científico publicado en 2005

Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model

artículo científico publicado en 2014

Mutual regulation between metabotropic glutamate type 1alpha receptor and caveolin proteins: from traffick to constitutive activity

artículo científico publicado en 2004

N-Methyl-D-aspartate (NMDA) and cannabinoid CB<sub>2</sub> receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors

artículo científico publicado en 2021

N-ethylmaleimide affects agonist binding to A1 adenosine receptors differently in the presence than in the absence of ligand

artículo científico publicado en 1991

Natural Compounds as Guides for the Discovery of Drugs Targeting G-Protein-Coupled Receptors

artículo científico publicado en 2020

Neurochemical evidence supporting dopamine D1-D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation

artículo científico publicado en 2016

Neuroprotective Effect of JZL184 in MPP(+)-Treated SH-SY5Y Cells Through CB2 Receptors

artículo científico publicado en 2015

Neuroprotective effect of L-DOPA co-administered with the adenosine A2A receptor agonist CGS 21680 in an animal model of Parkinson's disease

artículo científico publicado en 2004

Neuroprotective potential of adenosine A2A and cannabinoid CB1 receptor antagonists in an animal model of Parkinson disease.

artículo científico publicado en 2014

Neurotransmitter receptor heteromers and their integrative role in 'local modules': the striatal spine module.

artículo científico publicado en 2007

Neurotransmitter receptor heteromers in neurodegenerative diseases and neural plasticity.

artículo científico publicado en 2008

Neutralizing antibodies against the V3 loop of human immunodeficiency virus type 1 gp120 block the CD4-dependent and -independent binding of virus to cells.

artículo científico publicado en 1997

New methods to evaluate colocalization of fluorophores in immunocytochemical preparations as exemplified by a study on A2A and D2 receptors in Chinese hamster ovary cells

artículo científico publicado en 2005

New possibilities in the therapy of immunodeficiency diseases

artículo científico publicado en 1991

Novel Interactions Involving the Mas Receptor Show Potential of the Renin-Angiotensin system in the Regulation of Microglia Activation: Altered Expression in Parkinsonism and Dyskinesia

artículo científico publicado en 2021

Novel ergopeptides as dual ligands for adenosine and dopamine receptors

artículo científico publicado en 2007

Novel pharmacological targets based on receptor heteromers

artículo científico publicado en 2008

Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index.

artículo científico publicado en 2007

On the molecular basis of the receptor mosaic hypothesis of the engram

artículo científico publicado en 2004

Optimal association-saturation procedure for estimating association and dissociation rate parameters in receptor studies. Application to solubilized A1 adenosine receptors.

artículo científico publicado en 1992

Partners for adenosine A1 receptors

artículo científico publicado en 2005

Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease.

artículo científico publicado en 2011

Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels

artículo científico publicado en 2015

Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease

artículo científico publicado en 2016

Phenyl acyl acids attenuate the unfolded protein response in tunicamycin-treated neuroblastoma cells

artículo científico publicado en 2013

Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model

artículo científico publicado en 2013

Phosphodiesterase inhibition in cognitive decline

artículo científico publicado en 2014

Phosphorylation of adenosine in renal brush-border membrane vesicles by an exchange reaction catalysed by adenosine kinase

artículo científico publicado en 1994

Plasma membrane diffusion of G protein-coupled receptor oligomers

artículo científico publicado en 2008

Platforms for the identification of GPCR targets, and of orthosteric and allosteric modulators.

artículo científico

Possible role of intramembrane receptor-receptor interactions in memory and learning via formation of long-lived heteromeric complexes: focus on motor learning in the basal ganglia.

artículo científico publicado en 2003

Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease

artículo científico publicado en 2017

Potential of caveolae in the therapy of cardiovascular and neurological diseases

artículo científico publicado en 2014

Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists

scientific article published on 19 August 2019

Preparative purification of adenosine deaminase from human erythrocytes by affinity chromatography

Presence of adenosine deaminase on the surface of mononuclear blood cells: immunochemical localization using light and electron microscopy

artículo científico publicado en 1991

Presynaptic P2X1-3 and α3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus.

artículo científico publicado en 2016

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers

artículo científico publicado en 2006

Purification and partial characterization of brain adenosine deaminase: inhibition by purine compounds and by drugs

artículo científico publicado en 1988

Purification of Adenosine Deaminase from Chicken-Egg Yolk by Affinity Column Chromatography

artículo científico publicado en 1990

Purinergic signaling in Parkinson's disease. Relevance for treatment

artículo científico

Quantum Chemical Study of the Electronic and Conformational Characteristics of Adenosine and 8-Substituted Derivatives: Functional Implications in the Mechanism of Reaction of Adenosine Deaminase

artículo científico publicado en 1990

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.

artículo científico publicado en 2016

Real-time G-protein-coupled receptor imaging to understand and quantify receptor dynamics.

artículo científico publicado en 2011

Receptor-receptor interactions involving adenosine A1 or dopamine D1 receptors and accessory proteins.

artículo científico publicado en 2006

Regulation of L-type calcium channels in GH4 cells via A1 adenosine receptors

artículo científico publicado en 1997

Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction

artículo científico publicado en 2002

Regulation of heptaspanning-membrane-receptor function by dimerization and clustering

artículo científico publicado en 2003

Regulation of nitrobenzylthioninosine-sensitive adenosine uptake by cultured kidney cells.

artículo científico publicado en 1994

Reinforcing and neurochemical effects of cannabinoid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonist

artículo científico publicado en 2010

Release of adenosine deaminase from rat intestinal mucosa

artículo científico publicado en 1990

Resveratrol and Related Stilbenoids, Nutraceutical/Dietary Complements with Health-Promoting Actions: Industrial Production, Safety, and the Search for Mode of Action

article

Role of adenosine in the control of homosynaptic plasticity in striatal excitatory synapses.

artículo científico publicado en 2005

Role of electrostatic interaction in receptor-receptor heteromerization

artículo científico publicado en 2005

Role of glutamate on T-cell mediated immunity.

artículo científico publicado en 2007

Role of histidine residues in agonist and antagonist binding sites of A1 adenosine receptor.

artículo científico publicado en 1993

SARS-CoV-2 as a Factor to Disbalance the Renin-Angiotensin System: A Suspect in the Case of Exacerbated IL-6 Production

artículo científico publicado en 2020

SIMCODE: A program for simulating point mutations in genomic DNA

Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.

artículo científico publicado en 2011

Simulation of the purine nucleotide cycle as an anaplerotic process in skeletal muscle.

artículo científico publicado en 1987

Slight differences between adenosine deaminases from different species an immunochemical study

artículo científico publicado en 1990

Solubilization and molecular characterization of the nitrobenzylthioinosine binding sites from pig kidney brush-border membranes

artículo científico

Solubilization of A1adenosine receptor from pig brain: Characterization and evidence of the role of the cell membrane on the coexistence of high- and low-affinity states

artículo científico publicado en 1990

Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids

scientific journal article

Striatal plasticity at the network level. Focus on adenosine A2A and D2 interactions in models of Parkinson's Disease

artículo científico publicado en 2004

Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists

artículo científico publicado en 2011

Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia

artículo científico publicado en 2014

Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins

artículo científico publicado en 2015

Studies on homocysteine plasma levels in Alzheimer's patients. Relevance for neurodegeneration

artículo científico publicado en 2004

Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?

artículo científico publicado en 2014

Suggesting a Way to Understand the Actual Potential of Anti-Alzheimer's Disease Drugs That Show Promise in Transgenic Mouse Models

artículo científico publicado en 2015

Surface adenosine deaminase. A novel B-cell marker in chronic lymphocytic leukemia

artículo científico publicado en 1995

Surface expression of adenosine deaminase in mitogen-stimulated lymphocytes

scientific article published on 01 August 1993

Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.

artículo científico publicado en 2002

Synthesis and evaluation of (13)N-labelled azo compounds for β-amyloid imaging in mice

artículo científico publicado en 2013

Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD.

artículo científico publicado en 2012

Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

artículo científico publicado en 2016

The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression

artículo científico publicado en 2000

The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin

scientific journal article

The adenosine receptors present on the plasma membrane of chromaffin cells are of the A2b subtype

artículo científico publicado en 1992

The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function

artículo científico publicado en 2009

The binding of [3H]R-PIA to A1 adenosine receptors produces a conversion of the high- to the low-affinity state.

artículo científico publicado en 1991

The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors

artículo científico publicado en 2012

The cluster-arranged cooperative model: a model that accounts for the kinetics of binding to A1 adenosine receptors

artículo científico publicado en 1996

The emergence of neurotransmitters as immune modulators.

artículo científico publicado en 2007

The heat shock cognate protein hsc73 assembles with A(1) adenosine receptors to form functional modules in the cell membrane

scientific journal article

The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor

artículo científico publicado en 2007

The potential of methylxanthine-based therapies in pediatric respiratory tract diseases

artículo científico publicado en 2016

The relevance of theobromine for the beneficial effects of cocoa consumption

artículo científico publicado en 2015

The two-state dimer receptor model: a general model for receptor dimers

artículo científico publicado en 2006

Theoretical Approximation to the Reaction Mechanism of Adenosine Deaminase

Theoretical study about the variability of the genome of foot-and-mouth disease viruses

artículo científico publicado en 1992

Theoretical study of the acidic strength of amino acid side chains

Theoretical study of the protonation and tautomerization of adenosine, formycin, and their 2-NH2 and 2-F derivatives: functional implications in the mechanism of reaction of adenosine deaminase.

artículo científico publicado en 1989

Thermodynamic analysis of agonist and antagonist binding to membrane-bound and solubilized A1 adenosine receptors

artículo científico publicado en 1993

Trafficking of adenosine A2A and dopamine D2 receptors

artículo científico publicado en 2005

Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression

artículo científico publicado en 2012

Two Affinity Sites of the Cannabinoid Subtype 2 Receptor Identified by a Novel Homogeneous Binding Assay.

artículo científico publicado en 2016

Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes

artículo científico publicado en 2016

Understanding the added value of g-protein-coupled receptor heteromers.

artículo científico

Unmasking adenosine 2A receptors (A2ARs) in monkey basal ganglia output neurons using cholera toxin subunit B (CTB).

artículo científico publicado en 2012

Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease.

artículo científico publicado en 2004

Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist-antagonist binding modulation.

artículo científico publicado en 2009

Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain

artículo científico publicado en 2006

[Purine catabolism in rat brain (author's transl)]

artículo científico publicado en 1981

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