Lista de obras - Mar Cuadrado-Tejedor - Dominio Público Uruguay

A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice.

artículo científico publicado en 2016

Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.

artículo científico publicado en 2004

Advanced Assay Monitoring APP-Carboxyl-Terminal Fragments as Markers of APP Processing in Alzheimer Disease Mouse Models

artículo científico publicado en 2016

Age-related mitochondrial alterations without neuronal loss in the hippocampus of a transgenic model of Alzheimer's disease.

artículo científico publicado en 2013

Changes in cytoskeletal gene expression linked to MPTP-treatment in Mice

artículo científico publicado en 2005

Chronic Mild Stress Assay Leading to Early Onset and Propagation of Alzheimer's Disease Phenotype in Mouse Models

artículo científico publicado en 2016

Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice

artículo científico publicado en 2012

Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation.

artículo científico publicado en 2011

Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer's disease

artículo científico publicado en 2015

Current animal models of Alzheimer's disease: challenges in translational research

artículo científico publicado en 2014

Decreased levels of guanosine 3', 5'-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease

artículo científico publicado en 2015

Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.

artículo científico publicado en 2016

Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors

scientific article published on 21 December 2018

Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease.

artículo científico publicado en 2009

Enhanced expression of the voltage-dependent anion channel 1 (VDAC1) in Alzheimer's disease transgenic mice: an insight into the pathogenic effects of amyloid-β.

artículo científico publicado en 2011

Epigenetic drugs in Alzheimer's disease

artículo científico publicado en 2013

GLUT12 Expression in Brain of Mouse Models of Alzheimer's Disease

artículo científico publicado en 2019

Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer's Disease

artículo científico publicado en 2016

Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice

artículo científico publicado en 2014

La proteína priónica celular en el sistema nervioso central de mamíferos. Correlatos anatomoclínicos

artículo científico publicado en 2010

Long-term phenylbutyrate administration prevents memory deficits in Tg2576 mice by decreasing Abeta

artículo científico publicado en 2011

Multitarget Approach for the Treatment of Alzheimer's Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles

scientific article published on 04 September 2019

Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels.

artículo científico publicado en 2008

Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels

artículo científico publicado en 2015

Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model

artículo científico publicado en 2009

Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model

artículo científico publicado en 2013

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

artículo científico publicado en 2010

Phosphodiesterase inhibition in cognitive decline

artículo científico publicado en 2014

Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology

artículo científico publicado en 2010

Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF.

artículo científico publicado en 2010

Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.

artículo científico publicado en 2011

Synthesis and evaluation of (13)N-labelled azo compounds for β-amyloid imaging in mice

artículo científico publicado en 2013

Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD.

artículo científico publicado en 2012

The cellular prion protein and its role in Alzheimer disease

artículo científico publicado en 2009

Lista de obras de Mar Cuadrado-Tejedor

A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice.

Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.

Advanced Assay Monitoring APP-Carboxyl-Terminal Fragments as Markers of APP Processing in Alzheimer Disease Mouse Models

Age-related mitochondrial alterations without neuronal loss in the hippocampus of a transgenic model of Alzheimer's disease.

Changes in cytoskeletal gene expression linked to MPTP-treatment in Mice

Chronic Mild Stress Assay Leading to Early Onset and Propagation of Alzheimer's Disease Phenotype in Mouse Models

Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice

Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation.

Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer's disease

Current animal models of Alzheimer's disease: challenges in translational research

Decreased levels of guanosine 3', 5'-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease

Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.

Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors

Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease.

Enhanced expression of the voltage-dependent anion channel 1 (VDAC1) in Alzheimer's disease transgenic mice: an insight into the pathogenic effects of amyloid-β.

Epigenetic drugs in Alzheimer's disease

GLUT12 Expression in Brain of Mouse Models of Alzheimer's Disease

Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer's Disease

Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice

La proteína priónica celular en el sistema nervioso central de mamíferos. Correlatos anatomoclínicos

Long-term phenylbutyrate administration prevents memory deficits in Tg2576 mice by decreasing Abeta

Multitarget Approach for the Treatment of Alzheimer's Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles

Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels.

Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels

Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model

Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

Phosphodiesterase inhibition in cognitive decline

Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology

Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF.

Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.

Synthesis and evaluation of (13)N-labelled azo compounds for β-amyloid imaging in mice

Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD.

The cellular prion protein and its role in Alzheimer disease