Lista de obras - Scott D Gray-Owen - Dominio Público Uruguay

A Slam-dependent hemophore contributes to heme acquisition in the bacterial pathogen Acinetobacter baumannii

artículo científico publicado en 2021

A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin

artículo científico publicado en 2007

A comparative, cross-species investigation of the properties and roles of transferrin- and lactoferrin-binding protein B from pathogenic bacteria

artículo científico publicado en 2016

A native outer membrane vesicle vaccine confers protection against meningococcal colonization in human CEACAM1 transgenic mice

artículo científico publicado en 2015

Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease

artículo científico publicado en 2011

Adherent-invasive Escherichia coli blocks interferon-γ-induced signal transducer and activator of transcription (STAT)-1 in human intestinal epithelial cells

artículo científico publicado en 2012

Adherent-invasive Escherichia coli target the epithelial barrier

artículo científico publicado en 2010

Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epithelia

artículo científico publicado en 2009

Alternate synthesis to d-glycero-β-d-manno-heptose 1,7-biphosphate.

artículo científico publicado en 2017

Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2.

artículo científico publicado en 2007

Association of Neisseria gonorrhoeae Opa(CEA) with dendritic cells suppresses their ability to elicit an HIV-1-specific T cell memory response

artículo científico publicado en 2013

Bacterial transferrin and lactoferrin receptors

artículo científico publicado en 1996

Bcl10 synergistically links CEACAM3 and TLR-dependent inflammatory signalling

artículo científico publicado en 2017

CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes ⬇️

artículo científico publicado el 16 de junio de 1997

CEACAM1 (CD66a) promotes human monocyte survival via a phosphatidylinositol 3-kinase- and AKT-dependent pathway

artículo científico publicado en 2006

CEACAM1 as a multi-purpose target for cancer immunotherapy

artículo científico publicado en 2017

Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1.

artículo científico publicado en 2005

Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells.

artículo científico publicado en 2000

Characterization of aferric-binding proteinmutant inHaemophilus influenzae

artículo científico publicado en 1997

Characterization of the Moraxella catarrhalis opa-like protein, OlpA, reveals a phylogenetically conserved family of outer membrane proteins

artículo científico publicado en 2006

Characterization of transferrin binding proteins 1 and 2 in invasive type b and nontypeable strains of Haemophilus influenzae.

artículo científico publicado en 1995

Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment.

artículo científico publicado en 2018

Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae.

artículo científico publicado en 2011

Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity

artículo científico publicado en 2016

Differential Opa specificities for CD66 receptors influence tissue interactions and cellular response to Neisseria gonorrhoeae

artículo científico publicado en 1997

Differential response of primary and immortalized CD4+ T cells to Neisseria gonorrhoeae-induced cytokines determines the effect on HIV-1 replication.

artículo científico publicado en 2011

Discordant Effects of Licensed Meningococcal Serogroup B Vaccination on Invasive Disease and Nasal Colonization in a Humanized Mouse Model

artículo científico publicado en 2017

Endometrial epithelial cell responses to coinfecting viral and bacterial pathogens in the genital tract can activate the HIV-1 LTR in an NF{kappa}B-and AP-1-dependent manner

artículo científico publicado en 2011

Engulfment of Neisseria gonorrhoeae: revealing distinct processes of bacterial entry by individual carcinoembryonic antigen-related cellular adhesion molecule family receptors.

artículo científico publicado en 2004

Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation

artículo científico publicado en 2010

Expression and translocation of fluorescent-tagged p21-activated kinase-binding domain and PH domain of protein kinase B during murine neutrophil chemotaxis

artículo científico publicado en 2007

Genome-based Definition of an Inflammatory Bowel Disease-associated Adherent-Invasive Escherichia coli Pathovar

artículo científico publicado en 2015

Global analysis of neutrophil responses to Neisseria gonorrhoeae reveals a self-propagating inflammatory program

artículo científico publicado en 2014

Helicobacter pylori induces but survives the extracellular release of oxygen radicals from professional phagocytes using its catalase activity

article

Helicobacter pylori inhibits phagocytosis by professional phagocytes involving type IV secretion components

artículo científico publicado en 2000

Heptose Sounds the Alarm: Innate Sensing of a Bacterial Sugar Stimulates Immunity

artículo científico publicado en 2016

High Density or Urban Sprawl: What Works Best in Biology?

artículo científico publicado en 2017

High-Throughput Screening Identifies Genes Required for Induction of Macrophage Pyroptosis

article

Host cell invasion by pathogenic Neisseriae.

artículo científico publicado en 2000

INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity.

artículo científico publicado en 2015

Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor.

artículo científico publicado en 2003

Impact of the Listeria monocytogenes Protein InlC on Infection in Mice ⬇️

artículo científico publicado el 12 de febrero de 2013

In vivo adaptation and persistence of Neisseria meningitidis within the nasopharyngeal mucosa.

artículo científico publicado en 2013

Induction of antigen-specific TH 9 immunity accompanied by mast cell activation blocks tumor cell engraftment

artículo científico publicado en 2016

Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway.

artículo científico publicado en 2017

Inside-out signaling promotes dynamic changes in the carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) oligomeric state to control its cell adhesion properties.

artículo científico publicado en 2013

Interaction of ruminant transferrins with transferrin receptors in bovine isolates of Pasteurella haemolytica and Haemophilus somnus ⬇️

artículo científico publicado el 1 de julio de 1992

Invasive potential of nonencapsulated disease isolates of Neisseria meningitidis.

artículo científico publicado en 2012

Metagenomics-Based, Strain-Level Analysis of Escherichia coli From a Time-Series of Microbiome Samples From a Crohn's Disease Patient

artículo científico publicado en 2018

Modeling Neisseria meningitidis Infection in Mice: Methods and Logistical Considerations for Nasal Colonization and Invasive Disease

artículo científico publicado en 2019

Modular arrangement of allelic variants explains the divergence in Moraxella catarrhalis UspA protein function.

artículo científico publicado en 2008

Moraxella catarrhalis binding to host cellular receptors is mediated by sequence-specific determinants not conserved among all UspA1 protein variants

artículo científico publicado en 2008

Mucosal Neisseria gonorrhoeae coinfection during HIV acquisition is associated with enhanced systemic HIV-specific CD8 T-cell responses

artículo científico publicado en 2008

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

artículo científico publicado en 2021

Murine Plasmodium chabaudi malaria increases mucosal immune activation and the expression of putative HIV susceptibility markers in the gut and genital mucosae

artículo científico publicado en 2014

Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases

article

Neisseria gonorrhoeae co-infection exacerbates vaginal HIV shedding without affecting systemic viral loads in human CD34+ engrafted mice

artículo científico publicado en 2018

Neisseria gonorrhoeae effectively blocks HIV-1 replication by eliciting a potent TLR9-dependent interferon-α response from plasmacytoid dendritic cells

article

Neisseria gonorrhoeae infects the heterogeneous epithelia of the human cervix using distinct mechanisms

scientific article published on 02 December 2019

Neisseria gonorrhoeae selectively suppresses the development of Th1 and Th2 cells, and enhances Th17 cell responses, through TGF-β-dependent mechanisms.

artículo científico publicado en 2012

Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression

artículo científico publicado en 2013

Neisserial Opa proteins: impact on colonization, dissemination and immunity.

artículo científico publicado en 2003

Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes

artículo científico publicado en 2002

Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function.

artículo científico publicado en 2007

Opa binding to cellular CD66 receptors mediates the transcellular traversal of Neisseria gonorrhoeae across polarized T84 epithelial cell monolayers.

artículo científico publicado en 1998

Opa proteins and CEACAMs: pathways of immune engagement for pathogenic Neisseria

artículo científico publicado en 2011

Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients

artículo científico publicado en 2020

Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae.

artículo científico publicado en 2003

Progress Toward a Gonococcal Vaccine: The Way Forward

artículo científico publicado en 2019

Redefined nomenclature for members of the carcinoembryonic antigen family

artículo científico publicado en 1999

Reverse vaccinology-based identification of a novel surface lipoprotein that is an effective vaccine antigen against bovine infections caused by Pasteurella multocida ⬇️

artículo científico publicado en 2023

Selection for a CEACAM receptor-specific binding phenotype during Neisseria gonorrhoeae infection of the human genital tract.

artículo científico publicado en 2015

Shikimate Induced Transcriptional Activation of Protocatechuate Biosynthesis Genes by QuiR, a LysR-Type Transcriptional Regulator, in Listeria monocytogenes

artículo científico publicado en 2018

Slam is an outer membrane protein that is required for the surface display of lipidated virulence factors in Neisseria

artículo científico publicado en 2016

Specific binding to differentially-expressed human CEACAMs determines the outcome of Neisseria gonorrhoeae infections along the female reproductive tract

artículo científico publicado en 2018

Sterilizing immunity elicited by Neisseria meningitidis carriage shows broader protection than predicted by serum antibody cross-reactivity in CEACAM1-humanized mice.

artículo científico publicado en 2014

Summary and Recommendations from the National Institute of Allergy and Infectious Diseases (NIAID) Workshop "Gonorrhea Vaccines: the Way Forward".

artículo científico publicado en 2016

TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection

artículo científico publicado en 2017

The HopQ-CEACAM Interaction Controls CagA Translocation, Phosphorylation, and Phagocytosis of Helicobacter pylori in Neutrophils

scientific article published on 04 February 2020

The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria.

artículo científico publicado en 2009

The global roadmap for advancing development of vaccines against sexually transmitted infections: Update and next steps.

artículo científico publicado en 2016

The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling

artículo científico publicado en 2019

The interaction of primate transferrins with receptors on bacteria pathogenic to humans

artículo científico publicado en 1993

The molecular mechanism of Zinc acquisition by the neisserial outer-membrane transporter ZnuD.

artículo científico publicado en 2015

The reproductive cycle is a pathogenic determinant during gonococcal pelvic inflammatory disease in mice.

scientific article published on 23 December 2015

The specific innate immune receptor CEACAM3 triggers neutrophil bactericidal activities via a Syk kinase-dependent pathway

artículo científico publicado en 2007

The structural basis of CEACAM-receptor targeting by neisserial Opa proteins.

artículo científico publicado en 2000

Total synthesis and antibacterial testing of the A54556 cyclic acyldepsipeptides isolated from Streptomyces hawaiiensis.

artículo científico publicado en 2014

Utility of Hybrid Transferrin Binding Protein Antigens for Protection Against Pathogenic Neisseria Species

scientific article published on 19 February 2019

Vigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeae

artículo científico publicado en 2012

Whole-Genome Sequencing Reveals the Origin and Rapid Evolution of an Emerging Outbreak Strain of Streptococcus pneumoniae 12F.

artículo científico publicado en 2016

d-Glycero-β-d-Manno-Heptose 1-Phosphate and d-Glycero-β-d-Manno-Heptose 1,7-Biphosphate Are Both Innate Immune Agonists

scholarly article by Itunuoluwa A Adekoya et al published 15 October 2018 in Journal of Immunology

Lista de obras de Scott D Gray-Owen

A Slam-dependent hemophore contributes to heme acquisition in the bacterial pathogen Acinetobacter baumannii

A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin

A comparative, cross-species investigation of the properties and roles of transferrin- and lactoferrin-binding protein B from pathogenic bacteria

A native outer membrane vesicle vaccine confers protection against meningococcal colonization in human CEACAM1 transgenic mice

Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease

Adherent-invasive Escherichia coli blocks interferon-γ-induced signal transducer and activator of transcription (STAT)-1 in human intestinal epithelial cells

Adherent-invasive Escherichia coli target the epithelial barrier

Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epithelia

Alternate synthesis to d-glycero-β-d-manno-heptose 1,7-biphosphate.

Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2.

Association of Neisseria gonorrhoeae Opa(CEA) with dendritic cells suppresses their ability to elicit an HIV-1-specific T cell memory response

Bacterial transferrin and lactoferrin receptors

Bcl10 synergistically links CEACAM3 and TLR-dependent inflammatory signalling

CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes ⬇️

CEACAM1 (CD66a) promotes human monocyte survival via a phosphatidylinositol 3-kinase- and AKT-dependent pathway

CEACAM1 as a multi-purpose target for cancer immunotherapy

Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1.

Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells.

Characterization of aferric-binding proteinmutant inHaemophilus influenzae

Characterization of the Moraxella catarrhalis opa-like protein, OlpA, reveals a phylogenetically conserved family of outer membrane proteins

Characterization of transferrin binding proteins 1 and 2 in invasive type b and nontypeable strains of Haemophilus influenzae.

Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment.

Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae.

Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity

Differential Opa specificities for CD66 receptors influence tissue interactions and cellular response to Neisseria gonorrhoeae

Differential response of primary and immortalized CD4+ T cells to Neisseria gonorrhoeae-induced cytokines determines the effect on HIV-1 replication.

Discordant Effects of Licensed Meningococcal Serogroup B Vaccination on Invasive Disease and Nasal Colonization in a Humanized Mouse Model

Endometrial epithelial cell responses to coinfecting viral and bacterial pathogens in the genital tract can activate the HIV-1 LTR in an NF{kappa}B-and AP-1-dependent manner

Engulfment of Neisseria gonorrhoeae: revealing distinct processes of bacterial entry by individual carcinoembryonic antigen-related cellular adhesion molecule family receptors.

Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation

Expression and translocation of fluorescent-tagged p21-activated kinase-binding domain and PH domain of protein kinase B during murine neutrophil chemotaxis

Genome-based Definition of an Inflammatory Bowel Disease-associated Adherent-Invasive Escherichia coli Pathovar

Global analysis of neutrophil responses to Neisseria gonorrhoeae reveals a self-propagating inflammatory program

Helicobacter pylori induces but survives the extracellular release of oxygen radicals from professional phagocytes using its catalase activity

Helicobacter pylori inhibits phagocytosis by professional phagocytes involving type IV secretion components

Heptose Sounds the Alarm: Innate Sensing of a Bacterial Sugar Stimulates Immunity

High Density or Urban Sprawl: What Works Best in Biology?

High-Throughput Screening Identifies Genes Required for Induction of Macrophage Pyroptosis

Host cell invasion by pathogenic Neisseriae.

INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity.

Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor.

Impact of the Listeria monocytogenes Protein InlC on Infection in Mice ⬇️

In vivo adaptation and persistence of Neisseria meningitidis within the nasopharyngeal mucosa.

Induction of antigen-specific TH 9 immunity accompanied by mast cell activation blocks tumor cell engraftment

Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway.

Inside-out signaling promotes dynamic changes in the carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) oligomeric state to control its cell adhesion properties.

Interaction of ruminant transferrins with transferrin receptors in bovine isolates of Pasteurella haemolytica and Haemophilus somnus ⬇️

Invasive potential of nonencapsulated disease isolates of Neisseria meningitidis.

Metagenomics-Based, Strain-Level Analysis of Escherichia coli From a Time-Series of Microbiome Samples From a Crohn's Disease Patient

Modeling Neisseria meningitidis Infection in Mice: Methods and Logistical Considerations for Nasal Colonization and Invasive Disease

Modular arrangement of allelic variants explains the divergence in Moraxella catarrhalis UspA protein function.

Moraxella catarrhalis binding to host cellular receptors is mediated by sequence-specific determinants not conserved among all UspA1 protein variants

Mucosal Neisseria gonorrhoeae coinfection during HIV acquisition is associated with enhanced systemic HIV-specific CD8 T-cell responses

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

Murine Plasmodium chabaudi malaria increases mucosal immune activation and the expression of putative HIV susceptibility markers in the gut and genital mucosae

Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases

Neisseria gonorrhoeae co-infection exacerbates vaginal HIV shedding without affecting systemic viral loads in human CD34+ engrafted mice

Neisseria gonorrhoeae effectively blocks HIV-1 replication by eliciting a potent TLR9-dependent interferon-α response from plasmacytoid dendritic cells

Neisseria gonorrhoeae infects the heterogeneous epithelia of the human cervix using distinct mechanisms

Neisseria gonorrhoeae selectively suppresses the development of Th1 and Th2 cells, and enhances Th17 cell responses, through TGF-β-dependent mechanisms.

Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression

Neisserial Opa proteins: impact on colonization, dissemination and immunity.

Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes

Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function.

Opa binding to cellular CD66 receptors mediates the transcellular traversal of Neisseria gonorrhoeae across polarized T84 epithelial cell monolayers.

Opa proteins and CEACAMs: pathways of immune engagement for pathogenic Neisseria

Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients

Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae.

Progress Toward a Gonococcal Vaccine: The Way Forward

Redefined nomenclature for members of the carcinoembryonic antigen family

Reverse vaccinology-based identification of a novel surface lipoprotein that is an effective vaccine antigen against bovine infections caused by Pasteurella multocida ⬇️

Selection for a CEACAM receptor-specific binding phenotype during Neisseria gonorrhoeae infection of the human genital tract.

Shikimate Induced Transcriptional Activation of Protocatechuate Biosynthesis Genes by QuiR, a LysR-Type Transcriptional Regulator, in Listeria monocytogenes

Slam is an outer membrane protein that is required for the surface display of lipidated virulence factors in Neisseria

Specific binding to differentially-expressed human CEACAMs determines the outcome of Neisseria gonorrhoeae infections along the female reproductive tract

Sterilizing immunity elicited by Neisseria meningitidis carriage shows broader protection than predicted by serum antibody cross-reactivity in CEACAM1-humanized mice.

Summary and Recommendations from the National Institute of Allergy and Infectious Diseases (NIAID) Workshop "Gonorrhea Vaccines: the Way Forward".

TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection

The HopQ-CEACAM Interaction Controls CagA Translocation, Phosphorylation, and Phagocytosis of Helicobacter pylori in Neutrophils