Lista de obras - Jan Weber - Dominio Público Uruguay

A novel TaqMan real-time PCR assay to estimate ex vivo human immunodeficiency virus type 1 fitness in the era of multi-target (pol and env) antiretroviral therapy

artículo científico publicado en 2003

A picomolar inhibitor of resistant strains of human immunodeficiency virus protease identified by a combinatorial approach.

artículo científico publicado en 2000

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

artículo científico publicado en 2017

Configurations of diastereomeric hydroxyethylene isosteres strongly affect biological activities of a series of specific inhibitors of human-immunodeficiency-virus proteinase

artículo científico publicado en 1997

Contribution of human immunodeficiency virus type 1 minority variants to reduced drug susceptibility in patients on an integrase strand transfer inhibitor-based therapy

artículo científico publicado en 2014

Design, Synthesis, and Biological Evaluation of Isothiosemicarbazones with Antimycobacterial Activity

artículo científico publicado en 2017

Development of 5' LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals

artículo científico publicado en 2016

Diminished replicative fitness of primary human immunodeficiency virus type 1 isolates harboring the K65R mutation

artículo científico publicado en 2005

Does BCA3 Play a Role in the HIV-1 Replication Cycle?

artículo científico publicado en 2018

Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells

artículo científico publicado en 2016

Expression of TIM-3 on Plasmacytoid Dendritic Cells as a Predictive Biomarker of Decline in HIV-1 RNA Level during ART.

artículo científico publicado en 2018

Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination

artículo científico publicado en 2020

Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action

artículo científico publicado en 2015

Highly functionalized and potent antiviral cyclopentane derivatives formed by a tandem process consisting of organometallic, transition-metal-catalyzed, and radical reaction steps.

artículo científico publicado en 2014

Human Immunodeficiency Virus Type 1 Resistance or Cross-Resistance to Nonnucleoside Reverse Transcriptase Inhibitors Currently under Development as Microbicides

scientific article published in 2011

Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication

artículo científico publicado en 2003

Human immunodeficiency virus type 1 resistance or cross-resistance to nonnucleoside reverse transcriptase inhibitors currently under development as microbicides

artículo científico publicado en 2011

Identification of low-molecular weight inhibitors of HIV-1 reverse transcriptase using a cell-based high-throughput screening system.

artículo científico publicado en 2011

Impact on replicative fitness of the G48E substitution in the protease of HIV-1: an in vitro and in silico evaluation

artículo científico publicado en 2008

Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals

artículo científico publicado en 2017

Increased levels of human beta-defensins mRNA in sexually HIV-1 exposed but uninfected individuals

artículo científico publicado en 2008

Inhibition of the precursor and mature forms of HIV-1 protease as a tool for drug evaluation.

artículo científico publicado en 2018

Insertions in the reverse transcriptase increase both drug resistance and viral fitness in a human immunodeficiency virus type 1 isolate harboring the multi-nucleoside reverse transcriptase inhibitor resistance 69 insertion complex mutation

artículo científico publicado en 2002

Novel influenza inhibitors designed to target PB1 interactions with host importin RanBP5

artículo científico publicado en 2019

Novel method for simultaneous quantification of phenotypic resistance to maturation, protease, reverse transcriptase, and integrase HIV inhibitors based on 3'Gag(p2/p7/p1/p6)/PR/RT/INT-recombinant viruses: a useful tool in the multitarget era of ant

artículo científico publicado en 2011

Novel recombinant virus assay for measuring susceptibility of human immunodeficiency virus type 1 group M subtypes to clinically approved drugs

scientific article published on 29 April 2009

PRMT5: A novel regulator of Hepatitis B virus replication and an arginine methylase of HBV core

artículo científico publicado en 2017

Protective hybrid coating containing silver, copper and zinc cations effective against human immunodeficiency virus and other enveloped viruses

artículo científico publicado en 2016

Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors

artículo científico publicado en 2016

Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology

artículo científico publicado en 2016

Resistance mutations outside the integrase coding region have an effect on human immunodeficiency virus replicative fitness but do not affect its susceptibility to integrase strand transfer inhibitors

artículo científico publicado en 2013

Role of Baseline pol Genotype in HIV-1 Fitness Evolution

artículo científico publicado en 2003

Role of the human immunodeficiency virus type 1 envelope gene in viral fitness.

artículo científico publicado en 2003

Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis and Candida lusitaniae. Inhibition with peptidomimetic inhibitors

artículo científico publicado en 2001

Sensitive cell-based assay for determination of human immunodeficiency virus type 1 coreceptor tropism.

artículo científico publicado en 2013

Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido[4,5-b]indole ribonucleosides.

artículo científico publicado en 2013

Synthesis and biological profiling of 6- or 7-(het)aryl-7-deazapurine 4'-C-methylribonucleosides.

artículo científico publicado en 2015

Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly

artículo científico publicado en 2016

The MEK1/2-ERK Pathway Inhibits Type I IFN Production in Plasmacytoid Dendritic Cells.

artículo científico publicado en 2018

Toll-like receptor dual-acting agonists are potent inducers of PBMC-produced cytokines that inhibit hepatitis B virus production in primary human hepatocytes

artículo científico publicado en 2020

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor

artículo científico publicado en 2015

Unusual binding mode of an HIV-1 protease inhibitor explains its potency against multi-drug-resistant virus strains

artículo científico publicado en 2002

Upregulation of mRNA Expression of ADGRD1/GPR133 and ADGRG7/GPR128 in SARS-CoV-2-Infected Lung Adenocarcinoma Calu-3 Cells

Use of a novel assay based on intact recombinant viruses expressing green (EGFP) or red (DsRed2) fluorescent proteins to examine the contribution of pol and env genes to overall HIV-1 replicative fitness

artículo científico publicado en 2006

Use of four next-generation sequencing platforms to determine HIV-1 coreceptor tropism

artículo científico publicado en 2012

Viral drug resistance and fitness.

artículo científico publicado en 2008

Viral fitness: relation to drug resistance mutations and mechanisms involved: nucleoside reverse transcriptase inhibitor mutations.

scientific article published on March 2007

Lista de obras de Jan Weber

A novel TaqMan real-time PCR assay to estimate ex vivo human immunodeficiency virus type 1 fitness in the era of multi-target (pol and env) antiretroviral therapy

A picomolar inhibitor of resistant strains of human immunodeficiency virus protease identified by a combinatorial approach.

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

Configurations of diastereomeric hydroxyethylene isosteres strongly affect biological activities of a series of specific inhibitors of human-immunodeficiency-virus proteinase

Contribution of human immunodeficiency virus type 1 minority variants to reduced drug susceptibility in patients on an integrase strand transfer inhibitor-based therapy

Design, Synthesis, and Biological Evaluation of Isothiosemicarbazones with Antimycobacterial Activity

Development of 5' LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals

Diminished replicative fitness of primary human immunodeficiency virus type 1 isolates harboring the K65R mutation

Does BCA3 Play a Role in the HIV-1 Replication Cycle?

Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells

Expression of TIM-3 on Plasmacytoid Dendritic Cells as a Predictive Biomarker of Decline in HIV-1 RNA Level during ART.

Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination

Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action

Highly functionalized and potent antiviral cyclopentane derivatives formed by a tandem process consisting of organometallic, transition-metal-catalyzed, and radical reaction steps.

Human Immunodeficiency Virus Type 1 Resistance or Cross-Resistance to Nonnucleoside Reverse Transcriptase Inhibitors Currently under Development as Microbicides

Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication

Human immunodeficiency virus type 1 resistance or cross-resistance to nonnucleoside reverse transcriptase inhibitors currently under development as microbicides

Identification of low-molecular weight inhibitors of HIV-1 reverse transcriptase using a cell-based high-throughput screening system.

Impact on replicative fitness of the G48E substitution in the protease of HIV-1: an in vitro and in silico evaluation

Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals

Increased levels of human beta-defensins mRNA in sexually HIV-1 exposed but uninfected individuals

Inhibition of the precursor and mature forms of HIV-1 protease as a tool for drug evaluation.

Insertions in the reverse transcriptase increase both drug resistance and viral fitness in a human immunodeficiency virus type 1 isolate harboring the multi-nucleoside reverse transcriptase inhibitor resistance 69 insertion complex mutation

Novel influenza inhibitors designed to target PB1 interactions with host importin RanBP5

Novel method for simultaneous quantification of phenotypic resistance to maturation, protease, reverse transcriptase, and integrase HIV inhibitors based on 3'Gag(p2/p7/p1/p6)/PR/RT/INT-recombinant viruses: a useful tool in the multitarget era of ant

Novel recombinant virus assay for measuring susceptibility of human immunodeficiency virus type 1 group M subtypes to clinically approved drugs

PRMT5: A novel regulator of Hepatitis B virus replication and an arginine methylase of HBV core

Protective hybrid coating containing silver, copper and zinc cations effective against human immunodeficiency virus and other enveloped viruses

Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors

Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology

Resistance mutations outside the integrase coding region have an effect on human immunodeficiency virus replicative fitness but do not affect its susceptibility to integrase strand transfer inhibitors

Role of Baseline pol Genotype in HIV-1 Fitness Evolution

Role of the human immunodeficiency virus type 1 envelope gene in viral fitness.

Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis and Candida lusitaniae. Inhibition with peptidomimetic inhibitors

Sensitive cell-based assay for determination of human immunodeficiency virus type 1 coreceptor tropism.

Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido[4,5-b]indole ribonucleosides.

Synthesis and biological profiling of 6- or 7-(het)aryl-7-deazapurine 4'-C-methylribonucleosides.

Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly

The MEK1/2-ERK Pathway Inhibits Type I IFN Production in Plasmacytoid Dendritic Cells.

Toll-like receptor dual-acting agonists are potent inducers of PBMC-produced cytokines that inhibit hepatitis B virus production in primary human hepatocytes

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor

Unusual binding mode of an HIV-1 protease inhibitor explains its potency against multi-drug-resistant virus strains

Upregulation of mRNA Expression of ADGRD1/GPR133 and ADGRG7/GPR128 in SARS-CoV-2-Infected Lung Adenocarcinoma Calu-3 Cells

Use of a novel assay based on intact recombinant viruses expressing green (EGFP) or red (DsRed2) fluorescent proteins to examine the contribution of pol and env genes to overall HIV-1 replicative fitness

Use of four next-generation sequencing platforms to determine HIV-1 coreceptor tropism

Viral drug resistance and fitness.

Viral fitness: relation to drug resistance mutations and mechanisms involved: nucleoside reverse transcriptase inhibitor mutations.