Lista de obras - Vladimír Kryštof - Dominio Público Uruguay

2,6,8,9-tetrasubstituted purines as new CDK1 inhibitors.

artículo científico publicado en 2003

2,6,9-Trisubstituted purines as CRK3 kinase inhibitors with antileishmanial activity in vitro

artículo científico publicado en 2015

3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models

scientific article published on 17 April 2019

3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights

artículo científico publicado en 2019

4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects

artículo científico publicado en 2006

5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases.

artículo científico publicado en 2016

6-Substituted purines as ROCK inhibitors with anti-metastatic activity

scientific article published on 06 June 2019

8-Azapurines as new inhibitors of cyclin-dependent kinases

artículo científico publicado en 2005

A Stepwise Approach for the Synthesis of Folic Acid Conjugates with Protein Kinase Inhibitors

artículo científico publicado en 2017

A novel series of highly potent 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitors

artículo científico publicado en 2013

ALK5 kinase inhibitory activity and synthesis of 2,3,4-substituted 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles

artículo científico publicado en 2017

Activity of 2,6,9-trisubstituted purines as potent PDGFRα kinase inhibitors with antileukaemic activity

artículo científico publicado en 2019

Anti-angiogenic effects of novel cyclin-dependent kinase inhibitors with a pyrazolo[4,3-d]pyrimidine scaffold.

artículo científico publicado en 2016

Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases

scientific article published on 13 April 2011

Anti-leishmanial activity of disubstituted purines and related pyrazolo[4,3-d]pyrimidines.

artículo científico publicado en 2011

Anticancer activity of natural cytokinins: a structure-activity relationship study

artículo científico publicado en 2010

Antifungal activity of silver nanoparticles against Candida spp.

artículo científico publicado en 2009

Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor.

artículo científico publicado en 2005

Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves.

artículo científico publicado en 2012

Application of Pd-Catalyzed Cross-Coupling Reactions in the Synthesis of 5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles that Inhibit ALK5 Kinase.

artículo científico publicado en 2016

Arylazopyrazole AAP1742 inhibits CDKs and induces apoptosis in multiple myeloma cells via Mcl-1 downregulation.

artículo científico publicado en 2014

Biological Evaluation of Dipyrromethanes in Cancer Cell Lines: Antiproliferative and Pro-apoptotic Properties.

artículo científico publicado en 2017

Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells

artículo científico publicado en 2012

CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells

artículo científico publicado en 2020

Cdk2 inhibition prolongs G1 phase progression in mouse embryonic stem cells.

artículo científico publicado en 2010

Characterization of a Pyrazolo[4,3-d]pyrimidine Inhibitor of Cyclin-Dependent Kinases 2 and 5 and Aurora A With Pro-Apoptotic and Anti-Angiogenic Activity In Vitro

artículo científico publicado en 2015

Classical anticytokinins do not interact with cytokinin receptors but inhibit cyclin-dependent kinases.

artículo científico publicado en 2007

Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor

artículo científico publicado en 2018

Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis

artículo científico publicado en 2012

Cyclin-dependent kinase inhibitors as anticancer drugs.

artículo científico publicado en 2010

Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).

artículo científico

Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action

artículo científico publicado en 2015

Design, synthesis and antitrypanosomal activities of 2,6-disubstituted-4,5,7-trifluorobenzothiophenes

artículo científico publicado en 2015

Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl- N6-(4-morpholin-4-ylmethyl-phenyl)- 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations.

artículo científico publicado en 2018

Discovery of nitroaryl urea derivatives with antiproliferative properties

artículo científico publicado en 2015

Docking-Based Development of Purine-like Inhibitors of Cyclin-Dependent Kinase-2

artículo científico publicado en 2000

Dose and drug changes in chronic lymphocytic leukemia cell response in vitro: A comparison of standard therapy regimens with two novel cyclin‑dependent kinase inhibitors

artículo científico publicado en 2019

Effects of BP-14, a novel cyclin-dependent kinase inhibitor, on anaplastic thyroid cancer cells

artículo científico publicado en 2016

Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines.

artículo científico publicado en 2016

Exploitation of new structurally diverse d-glucuronamide-containing N-glycosyl compounds: synthesis and anticancer potential.

artículo científico publicado en 2017

How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?

artículo científico publicado en 2018

How selective are clinical CDK4/6 inhibitors?

scientific article published on 10 December 2020

Imidazo[1,2-c]pyrimidin-5(6H)-one as a novel core of cyclin-dependent kinase 2 inhibitors: Synthesis, activity measurement, docking, and quantum mechanical scoring.

artículo científico publicado en 2018

Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy

artículo científico publicado en 2014

LC-MS/MS method for determination of cyclin-dependent kinase inhibitors, BP-14 and BP-20, and its application in pharmacokinetic study in rat.

artículo científico publicado en 2018

New approaches to the synthesis of sildenafil analogues and their enzyme inhibitory activity

artículo científico publicado en 2015

Novel arylazopyrazole inhibitors of cyclin-dependent kinases.

artículo científico publicado en 2015

Novel inhibitors of cyclin-dependent kinases combat hepatocellular carcinoma without inducing chemoresistance.

artículo científico publicado en 2013

Novel modified leucine and phenylalanine dipeptides modulate viability and attachment of cancer cells

scientific article published on 07 January 2020

Novel potent pharmacological cyclin-dependent kinase inhibitors

artículo científico publicado en 2009

Outcome of treatment of human HeLa cervical cancer cells with roscovitine strongly depends on the dosage and cell cycle status prior to the treatment

artículo científico publicado en 2009

Perspective of cyclin-dependent kinase 9 (CDK9) as a drug target.

artículo científico publicado en 2012

Potential Clinical Uses of CDK Inhibitors: Lessons from Synthetic Lethality Screens

artículo científico

Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells

artículo científico publicado en 2005

Preparation, biological activity and endogenous occurrence of N6-benzyladenosines

artículo científico publicado en 2007

Preparation, physicochemical properties and biological activity of copper(II) complexes with 6-(2-chlorobenzylamino)purine (HL1) or 6-(3-chlorobenzylamino)purine (HL2). The single-crystal X-ray structure of.

artículo científico publicado en 2001

Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays

artículo científico publicado en 2019

Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity

artículo científico publicado en 2011

Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors.

artículo científico publicado en 2003

Roscovitine up-regulates p53 protein and induces apoptosis in human HeLaS(3) cervix carcinoma cells

artículo científico publicado en 2008

Selective inhibition reveals cyclin-dependent kinase 2 as another kinase that phosphorylates the androgen receptor at serine 81.

artículo científico publicado en 2017

Semisynthetic Esters of 17-Hydroxycativic Acid with in Vitro Cytotoxic Activity against Leukemia Cell Lines.

artículo científico publicado en 2017

Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC)

artículo científico publicado en 2019

Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles.

artículo científico publicado en 2017

Substituted 2-hydroxy-N-(arylalkyl)benzamide sensitizes cancer cells to metabolic stress by disrupting actin cytoskeleton and inhibiting autophagic flux

artículo científico publicado en 2016

Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines.

artículo científico publicado en 2013

Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines.

artículo científico publicado en 2018

Synthesis and antiproteasomal activity of novel O-benzyl salicylamide-based inhibitors built from leucine and phenylalanine

artículo científico publicado en 2017

Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin

artículo científico publicado en 2006

Synthesis and biological activity of olomoucine II.

artículo científico publicado en 2002

Synthesis and biological evaluation of guanidino analogues of roscovitine.

artículo científico publicado en 2013

Synthesis and in vitro biological evaluation of 2,6,9-trisubstituted purines targeting multiple cyclin-dependent kinases.

artículo científico publicado en 2012

Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines

artículo científico publicado en 2014

Synthesis of Novel N9-Substituted Purine Derivatives from Polymer Supported α-Amino Acids.

artículo científico publicado en 2015

Synthesis, Bacteriostatic and Anticancer Activity of Novel Phenanthridines Structurally Similar to Benzo[c]phenanthridine Alkaloids

artículo científico publicado en 2018

Synthesis, anticancer evaluation, and molecular docking studies of some novel 4,6-disubstituted pyrazolo[3,4-d]pyrimidines as cyclin-dependent kinase 2 (CDK2) inhibitors.

artículo científico publicado en 2018

Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors

artículo científico publicado en 2015

Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives

artículo científico publicado en 2009

The first iron(III) complexes with cyclin-dependent kinase inhibitors: Magnetic, spectroscopic (IR, ES+ MS, NMR, (57)Fe Mössbauer), theoretical, and biological activity studies.

artículo científico publicado en 2009

The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties.

artículo científico publicado en 2010

The selective P-TEFb inhibitor CAN508 targets angiogenesis.

artículo científico publicado en 2011

Trisubstituted purine inhibitors of PDGFRα and their antileukemic activity in the human eosinophilic cell line EOL-1.

artículo científico publicado en 2017

Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors

artículo científico publicado en 2013

Tumour suppressor PTEN regulates cell cycle and protein kinase B/Akt pathway in breast cancer cells.

artículo científico publicado en 2006

Zinc(II) complexes with potent cyclin-dependent kinase inhibitors derived from 6-benzylaminopurine: synthesis, characterization, X-ray structures and biological activity

artículo científico publicado en 2006

Lista de obras de Vladimír Kryštof

2,6,8,9-tetrasubstituted purines as new CDK1 inhibitors.

2,6,9-Trisubstituted purines as CRK3 kinase inhibitors with antileishmanial activity in vitro

3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models

3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights

4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects

5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases.

6-Substituted purines as ROCK inhibitors with anti-metastatic activity

8-Azapurines as new inhibitors of cyclin-dependent kinases

A Stepwise Approach for the Synthesis of Folic Acid Conjugates with Protein Kinase Inhibitors

A novel series of highly potent 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitors

ALK5 kinase inhibitory activity and synthesis of 2,3,4-substituted 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles

Activity of 2,6,9-trisubstituted purines as potent PDGFRα kinase inhibitors with antileukaemic activity

Anti-angiogenic effects of novel cyclin-dependent kinase inhibitors with a pyrazolo[4,3-d]pyrimidine scaffold.

Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases

Anti-leishmanial activity of disubstituted purines and related pyrazolo[4,3-d]pyrimidines.

Anticancer activity of natural cytokinins: a structure-activity relationship study

Antifungal activity of silver nanoparticles against Candida spp.

Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor.

Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves.

Application of Pd-Catalyzed Cross-Coupling Reactions in the Synthesis of 5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles that Inhibit ALK5 Kinase.

Arylazopyrazole AAP1742 inhibits CDKs and induces apoptosis in multiple myeloma cells via Mcl-1 downregulation.

Biological Evaluation of Dipyrromethanes in Cancer Cell Lines: Antiproliferative and Pro-apoptotic Properties.

Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells

CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells

Cdk2 inhibition prolongs G1 phase progression in mouse embryonic stem cells.

Characterization of a Pyrazolo[4,3-d]pyrimidine Inhibitor of Cyclin-Dependent Kinases 2 and 5 and Aurora A With Pro-Apoptotic and Anti-Angiogenic Activity In Vitro

Classical anticytokinins do not interact with cytokinin receptors but inhibit cyclin-dependent kinases.

Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor

Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis

Cyclin-dependent kinase inhibitors as anticancer drugs.

Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).

Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action

Design, synthesis and antitrypanosomal activities of 2,6-disubstituted-4,5,7-trifluorobenzothiophenes

Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl- N6-(4-morpholin-4-ylmethyl-phenyl)- 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations.

Discovery of nitroaryl urea derivatives with antiproliferative properties

Docking-Based Development of Purine-like Inhibitors of Cyclin-Dependent Kinase-2

Dose and drug changes in chronic lymphocytic leukemia cell response in vitro: A comparison of standard therapy regimens with two novel cyclin‑dependent kinase inhibitors

Effects of BP-14, a novel cyclin-dependent kinase inhibitor, on anaplastic thyroid cancer cells

Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines.

Exploitation of new structurally diverse d-glucuronamide-containing N-glycosyl compounds: synthesis and anticancer potential.

How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?

How selective are clinical CDK4/6 inhibitors?

Imidazo[1,2-c]pyrimidin-5(6H)-one as a novel core of cyclin-dependent kinase 2 inhibitors: Synthesis, activity measurement, docking, and quantum mechanical scoring.

Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy

LC-MS/MS method for determination of cyclin-dependent kinase inhibitors, BP-14 and BP-20, and its application in pharmacokinetic study in rat.

New approaches to the synthesis of sildenafil analogues and their enzyme inhibitory activity

Novel arylazopyrazole inhibitors of cyclin-dependent kinases.

Novel inhibitors of cyclin-dependent kinases combat hepatocellular carcinoma without inducing chemoresistance.

Novel modified leucine and phenylalanine dipeptides modulate viability and attachment of cancer cells

Novel potent pharmacological cyclin-dependent kinase inhibitors

Outcome of treatment of human HeLa cervical cancer cells with roscovitine strongly depends on the dosage and cell cycle status prior to the treatment

Perspective of cyclin-dependent kinase 9 (CDK9) as a drug target.

Potential Clinical Uses of CDK Inhibitors: Lessons from Synthetic Lethality Screens

Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells

Preparation, biological activity and endogenous occurrence of N6-benzyladenosines

Preparation, physicochemical properties and biological activity of copper(II) complexes with 6-(2-chlorobenzylamino)purine (HL1) or 6-(3-chlorobenzylamino)purine (HL2). The single-crystal X-ray structure of.

Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays

Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity

Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors.

Roscovitine up-regulates p53 protein and induces apoptosis in human HeLaS(3) cervix carcinoma cells

Selective inhibition reveals cyclin-dependent kinase 2 as another kinase that phosphorylates the androgen receptor at serine 81.

Semisynthetic Esters of 17-Hydroxycativic Acid with in Vitro Cytotoxic Activity against Leukemia Cell Lines.

Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC)

Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles.

Substituted 2-hydroxy-N-(arylalkyl)benzamide sensitizes cancer cells to metabolic stress by disrupting actin cytoskeleton and inhibiting autophagic flux

Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines.

Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines.

Synthesis and antiproteasomal activity of novel O-benzyl salicylamide-based inhibitors built from leucine and phenylalanine

Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin

Synthesis and biological activity of olomoucine II.

Synthesis and biological evaluation of guanidino analogues of roscovitine.

Synthesis and in vitro biological evaluation of 2,6,9-trisubstituted purines targeting multiple cyclin-dependent kinases.

Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines

Synthesis of Novel N9-Substituted Purine Derivatives from Polymer Supported α-Amino Acids.

Synthesis, Bacteriostatic and Anticancer Activity of Novel Phenanthridines Structurally Similar to Benzo[c]phenanthridine Alkaloids

Synthesis, anticancer evaluation, and molecular docking studies of some novel 4,6-disubstituted pyrazolo[3,4-d]pyrimidines as cyclin-dependent kinase 2 (CDK2) inhibitors.

Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors

Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives

The first iron(III) complexes with cyclin-dependent kinase inhibitors: Magnetic, spectroscopic (IR, ES+ MS, NMR, (57)Fe Mössbauer), theoretical, and biological activity studies.