Lista de obras - Laura De Luca - Dominio Público Uruguay

2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.

artículo científico publicado en 2010

3D Pharmacophore Models for 1,2,3,4-Tetrahydroisoquinoline Derivatives Acting as Anticonvulsant Agents

scientific article published on 01 July 2006

4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process

artículo científico publicado en 2011

6-Chloro-1-(3,5-dimethyl-phenyl-sulfon-yl)-1H-benzimidazol-2(3H)-one

artículo científico publicado en 2008

A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition

artículo científico publicado en 2014

A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series

artículo científico publicado en 2008

AMPA receptor antagonists as potential anticonvulsant drugs

artículo científico publicado en 2005

Analysis of the full-length integrase–DNA complex by a modified approach for DNA docking

article

Anti-HIV agents: design and discovery of new potent RT inhibitors

artículo científico publicado en 2003

Binding Mode Prediction of Strand Transfer HIV-1 Integrase Inhibitors Using Tn5 Transposase as a Plausible Surrogate Model for HIV-1 Integrase

article

Binding modes of noncompetitive AMPA antagonists: a computational approach

artículo científico publicado en 2003

Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms

artículo científico publicado en 2015

Chemical exploration of 4-(4-fluorobenzyl)piperidine fragment for the development of new tyrosinase inhibitors

artículo científico publicado en 2016

Combined strategies for the discovery of ionotropic glutamate receptor antagonists

artículo científico publicado en 2009

Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

artículo científico publicado en 2016

Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.

artículo científico publicado en 2005

Computational studies to discover a new NR2B/NMDA receptor antagonist and evaluation of pharmacological profile

artículo científico publicado en 2008

Correction to Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments

artículo científico publicado en 2019

Design and synthesis of N₁-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors

artículo científico publicado en 2013

Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain

artículo científico publicado en 2008

Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents

artículo científico publicado en 2002

Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process

artículo científico publicado en 2014

Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.

artículo científico publicado en 2001

Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist

artículo científico publicado en 2003

Discovery of benzimidazole-based L. mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis.

artículo científico publicado en 2018

Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions

artículo científico publicado en 2009

Efficient 3D database screening for novel HIV-1 IN inhibitors

artículo científico publicado en 2004

Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile

artículo científico publicado en 2019

Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety

artículo científico publicado en 2018

Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors

artículo científico publicado en 2012

Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping

artículo científico publicado en 2011

Fragmental modeling of human glutamate transporter EAAT1 and analysis of its binding modes by docking and pharmacophore mapping

artículo científico publicado en 2008

From NMDA receptor antagonists to discovery of selective σ₂ receptor ligands

artículo científico publicado en 2013

Graphene Quantum Dots Based Systems As HIV Inhibitors

scientific article published on 22 August 2018

HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation

artículo científico publicado en 2010

Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS

artículo científico publicado en 2007

Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies

artículo científico publicado en 2010

Identification of influenza PA-Nter endonuclease inhibitors using pharmacophore- and docking-based virtual screening

artículo científico publicado en 2018

Improvement of water solubility of non-competitive AMPA receptor antagonists by complexation with beta-cyclodextrin

artículo científico publicado en 2008

In Silico Insights towards the Identification of SARS-CoV-2 NSP13 Helicase Druggable Pockets

artículo científico publicado en 2022

Indole derivatives as dual-effective agents for the treatment of neurodegenerative diseases: synthesis, biological evaluation, and molecular modeling studies.

artículo científico publicado en 2013

Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors.

artículo científico publicado en 2009

Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases

artículo científico publicado en 2017

Insight into the fundamental interactions between LEDGF binding site inhibitors and integrase combining docking and molecular dynamics simulations.

artículo científico publicado en 2012

Investigation of the salicylaldehyde thiosemicarbazone scaffold for inhibition of influenza virus PA endonuclease

artículo científico publicado en 2015

In Vivo Evaluation of Selective Carbonic Anhydrase Inhibitors as Potential Anticonvulsant Agents

artículo científico publicado en 2016

Microwave assisted organic synthesis (MAOS) of small molecules as potential HIV-1 integrase inhibitors.

artículo científico publicado en 2011

Modeling of the intestinal peptide transporter hPepT1 and analysis of its transport capacities by docking and pharmacophore mapping

artículo científico publicado en 2008

Molecular dynamics studies of the full-length integrase-DNA complex

artículo científico publicado en 2005

N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes

artículo científico publicado en 2016

N-substituted isoquinoline derivatives as potential AChE inhibitors

New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors

artículo científico publicado en 2007

New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: virtual screening and activity assays

artículo científico publicado en 2013

New trends in the development of AMPA receptor antagonists

article

Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors

artículo científico publicado en 2008

Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton

artículo científico publicado en 2006

Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors

artículo científico publicado en 2015

Pharmacophore modeling as an efficient tool in the discovery of novel noncompetitive AMPA receptor antagonists

artículo científico publicado en 2003

Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors

artículo científico publicado en 2005

Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

artículo científico publicado en 2009

Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors

artículo científico publicado en 2008

Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides.

artículo científico publicado en 2017

QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor

artículo científico publicado en 2004

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein-protein Interaction Inhibitors

artículo científico publicado en 2016

Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson's disease

artículo científico publicado en 2020

Searching for indole derivatives as potential mushroom tyrosinase inhibitors

artículo científico publicado en 2015

Searching for novel N1-substituted benzimidazol-2-ones as non-nucleoside HIV-1 RT inhibitors

artículo científico publicado en 2017

Simulated human digestion of N1-aryl-2-arylthioacetamidobenzimidazoles and their activity against Herpes-simplex virus 1 in vitro

artículo científico publicado en 2019

Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor

artículo científico publicado en 2010

Structural Modification of Diketo Acid Portion in 1H-Benzylindole Derivatives HIV-1 Integrase Inhibitors

article

Structural optimization of N1-aryl-benzimidazoles for the discovery of new non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains

artículo científico publicado en 2017

Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors

artículo científico publicado en 2007

Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors

artículo científico publicado en 2013

Structure-guided design of new indoles as negative allosteric modulators (NAMs) of N-methyl-D-aspartate receptor (NMDAR) containing GluN2B subunit

artículo científico publicado en 2016

Synthesis and Biological Characterization of 3-Substituted 1H-Indoles as Ligands of GluN2B-Containing N-Methyl-d-aspartate Receptors. Part 2

scientific article published on 19 November 2012

Synthesis and anti-HIV activity of carboxylated and drug-conjugated multi-walled carbon nanotubes

article

Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists

artículo científico publicado en 2007

Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors

artículo científico publicado en 2011

Synthesis and biological evaluation of novel antiviral agents as protein-protein interaction inhibitors

artículo científico publicado en 2013

Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors

scientific article published on 12 October 2011

Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.

artículo científico publicado en 2009

Synthesis and structure-active relationship of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline anticonvulsants

artículo científico publicado en 2010

Synthesis of new pyridazine derivatives as potential anti-HIV-1 agents

article

Synthesis, computational studies and assessment of in vitro inhibitory activity of umbelliferon-based compounds against tumour-associated carbonic anhydrase isoforms IX and XII

artículo científico publicado en 2020

Synthesis, modelling and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-d-aspartate receptors

artículo científico publicado en 2013

Synthesis, resolution, stereochemistry, and molecular modeling of (R)- and (S)-2-acetyl-1-(4′-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline AMPAR antagonists

artículo científico publicado en 2007

Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors

artículo científico publicado en 2012

Targeting GluN2B-containing N-Methyl-D-aspartate receptors: design, synthesis, and binding affinity evaluation of novel 3-substituted indoles

artículo científico publicado en 2014

Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments.

artículo científico publicado en 2018

The link between the AMPK/SIRT1 axis and a flavonoid-rich extract of Citrus bergamia juice: A cell-free, in silico, and in vitro study

artículo científico publicado en 2019

Tn5 transposase as a useful platform to simulate HIV-1 integrase inhibitor binding mode

artículo científico publicado en 2007

Lista de obras de Laura De Luca

2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.

3D Pharmacophore Models for 1,2,3,4-Tetrahydroisoquinoline Derivatives Acting as Anticonvulsant Agents

4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process

6-Chloro-1-(3,5-dimethyl-phenyl-sulfon-yl)-1H-benzimidazol-2(3H)-one

A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition

A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series

AMPA receptor antagonists as potential anticonvulsant drugs

Analysis of the full-length integrase–DNA complex by a modified approach for DNA docking

Anti-HIV agents: design and discovery of new potent RT inhibitors

Binding Mode Prediction of Strand Transfer HIV-1 Integrase Inhibitors Using Tn5 Transposase as a Plausible Surrogate Model for HIV-1 Integrase

Binding modes of noncompetitive AMPA antagonists: a computational approach

Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms

Chemical exploration of 4-(4-fluorobenzyl)piperidine fragment for the development of new tyrosinase inhibitors

Combined strategies for the discovery of ionotropic glutamate receptor antagonists

Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.

Computational studies to discover a new NR2B/NMDA receptor antagonist and evaluation of pharmacological profile

Correction to Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments

Design and synthesis of N₁-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors

Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain

Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents

Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process

Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.

Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist

Discovery of benzimidazole-based L. mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis.

Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions

Efficient 3D database screening for novel HIV-1 IN inhibitors

Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile

Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety

Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors

Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping

Fragmental modeling of human glutamate transporter EAAT1 and analysis of its binding modes by docking and pharmacophore mapping

From NMDA receptor antagonists to discovery of selective σ₂ receptor ligands

Graphene Quantum Dots Based Systems As HIV Inhibitors

HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation

Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS

Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies

Identification of influenza PA-Nter endonuclease inhibitors using pharmacophore- and docking-based virtual screening

Improvement of water solubility of non-competitive AMPA receptor antagonists by complexation with beta-cyclodextrin

In Silico Insights towards the Identification of SARS-CoV-2 NSP13 Helicase Druggable Pockets

Indole derivatives as dual-effective agents for the treatment of neurodegenerative diseases: synthesis, biological evaluation, and molecular modeling studies.

Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors.

Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases

Insight into the fundamental interactions between LEDGF binding site inhibitors and integrase combining docking and molecular dynamics simulations.

Investigation of the salicylaldehyde thiosemicarbazone scaffold for inhibition of influenza virus PA endonuclease

In Vivo Evaluation of Selective Carbonic Anhydrase Inhibitors as Potential Anticonvulsant Agents

Microwave assisted organic synthesis (MAOS) of small molecules as potential HIV-1 integrase inhibitors.

Modeling of the intestinal peptide transporter hPepT1 and analysis of its transport capacities by docking and pharmacophore mapping

Molecular dynamics studies of the full-length integrase-DNA complex

N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes

N-substituted isoquinoline derivatives as potential AChE inhibitors

New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors

New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: virtual screening and activity assays

New trends in the development of AMPA receptor antagonists

Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors

Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton

Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors

Pharmacophore modeling as an efficient tool in the discovery of novel noncompetitive AMPA receptor antagonists

Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors

Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors

Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides.

QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein-protein Interaction Inhibitors

Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson's disease

Searching for indole derivatives as potential mushroom tyrosinase inhibitors

Searching for novel N1-substituted benzimidazol-2-ones as non-nucleoside HIV-1 RT inhibitors

Simulated human digestion of N1-aryl-2-arylthioacetamidobenzimidazoles and their activity against Herpes-simplex virus 1 in vitro

Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor

Structural Modification of Diketo Acid Portion in 1H-Benzylindole Derivatives HIV-1 Integrase Inhibitors

Structural optimization of N1-aryl-benzimidazoles for the discovery of new non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains

Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors

Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors

Structure-guided design of new indoles as negative allosteric modulators (NAMs) of N-methyl-D-aspartate receptor (NMDAR) containing GluN2B subunit

Synthesis and Biological Characterization of 3-Substituted 1H-Indoles as Ligands of GluN2B-Containing N-Methyl-d-aspartate Receptors. Part 2

Synthesis and anti-HIV activity of carboxylated and drug-conjugated multi-walled carbon nanotubes

Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists

Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors

Synthesis and biological evaluation of novel antiviral agents as protein-protein interaction inhibitors