Lista de obras - Christopher J. Moody - Dominio Público Uruguay

19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity

artículo científico publicado en 2014

5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo

artículo científico publicado en 2006

7-Deazapurine biosynthesis: NMR study of toyocamycin biosynthesis in Streptomyces rimosus using 2-13C-7-15N-adenine

artículo científico publicado en 2011

A Concise Route to Pyridines from Hydrazides by Metal Carbene N−H Insertion, 1,2,4-Triazine Formation, and Diels−Alder Reaction

artículo científico publicado en 2009

A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity

artículo científico publicado en 2015

A new protecting-group strategy for indoles

A new route to α-carbolines based on 6π-electrocyclization of indole-3-alkenyl oximes

artículo científico publicado en 2013

A short synthesis of the triazolopyrimidine antibiotic essramycin

artículo científico publicado en 2010

A two step route to indoles from haloarenes—a versatile variation on the Fischer indole synthesis ⬇️

artículo científico publicado el 22 de noviembre de 2010

Alkyl Halide-Free Heteroatom Alkylation and Epoxidation Facilitated by a Recyclable Polymer-Supported Oxidant for the In-Flow Preparation of Diazo Compounds

artículo científico publicado en 2015

Amination of heteroaryl chlorides: palladium catalysis or SN Ar in green solvents?

artículo científico publicado en 2013

Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A.

artículo científico publicado en 2013

An Exploration of Ferrocenyl Ureas as Enantioselective Electrochemical Sensors for Chiral Carboxylate Anions

artículo científico publicado en 2008

An Improved Synthesis of Resorcylic Acid Macrolactone Inhibitors of Hsp90

An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration

artículo científico publicado en 2013

Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin reductase and activation of redox signaling

artículo científico publicado en 2011

Antitumour indolequinones: synthesis and activity against human pancreatic cancer cells

artículo científico publicado en 2014

Asymmetric Synthesis of 2-Substituted Piperidines. Synthesis of the Alkaloids (−)-Coniine and (+)-Pseudoconhydrine

artículo científico publicado en 1997

Asymmetric Synthesis of Chiral α-Ferrocenylalkylamines and Their Use in the Preparation of Chiral Redox-Active Receptors

artículo científico publicado en 2002

Asymmetric synthesis of N-protected amino acids by the addition of organolithium carboxyl synthons to ROPHy/SOPHy-derived aldoximes and ketoximes

artículo científico publicado en 2003

Asymmetric synthesis of the central tryptophan residue of stephanotic acid

artículo científico publicado en 2004

Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.

artículo científico publicado en 2007

Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1

artículo científico publicado en 2013

Benzofuranquinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis and biological evaluation.

artículo científico publicado en 2014

Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, in cellular systems

artículo científico publicado en 2003

Biomimetic Synthesis of the Apoptosis-Inducing Thiazinoquinone Thiaplidiaquinone A

artículo científico publicado en 2012

Biomimetic approaches to diazonamide A. Direct synthesis of the indole bis-oxazole fragment by oxidation of a TyrValTrpTrp tetrapeptide

scientific article published on 09 May 2006

C-H Insertion as a Key Step to Spiro-Oxetanes, Scaffolds for Drug Discovery

artículo científico publicado en 2017

Carbene reactivity of 4-diazo-4H-imidazoles toward nucleophiles and aromatic compounds

artículo científico publicado en 2009

Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches

artículo científico publicado en 2001

Chiral oxime ethers in asymmetric synthesis. O-(1-Phenylbutyl)benzyloxyacetaldoxime, a versatile reagent for the asymmetric synthesis of protected 1,2-aminoalcohols, alpha-amino acid derivatives, and 2-hydroxymethyl nitrogen heterocycles including i

artículo científico publicado en 2005

Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents

artículo científico publicado en 2002

Competition between planar and central chiral control elements in nucleophilic addition to ferrocenyl imine derivatives.

artículo científico publicado en 2008

Construction of macrocyclic thiodepsipeptides: synthesis of a nosiheptide 'southern hemisphere' model system

artículo científico publicado en 2007

Control of competing N-H insertion and Wolff rearrangement in dirhodium(II)-catalyzed reactions of 3-indolyl diazoketoesters. synthesis of a potential precursor to the marine 5-(3-indolyl)oxazole martefragin A.

artículo científico publicado en 2005

Copper(II)-Mediated Synthesis of Indolequinones from Bromoquinones and Enamines

artículo científico publicado en 2013

Cyclopropamitosenes, Novel Bioreductive Anticancer Agents. Synthesis, Electrochemistry, and Biological Activity of 7-Substituted Cyclopropamitosenes and Related Indolequinones

artículo científico publicado en 1994

Delivery of Temozolomide and N3-Propargyl Analog to Brain Tumors Using an Apoferritin Nanocage

scientific article published on 04 March 2020

Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells

artículo científico publicado en 2007

Diastereoselective Synthesis of Highly Substituted, Amino- and Pyrrolidino-Tetrahydrofurans as Lead-like Molecular Scaffolds.

artículo científico publicado en 2018

Dirhodium(II) carboxylate-catalysed oxidation of allylic and benzylic alcohols

Dirhodium(II) tetraacetate catalysed reactions of diazo thioamides: isolation and cycloaddition of anhydro-4-hydroxy-1,3-thiazolium hydroxides (thioisomünchnones), an approach to analogues of dehydrogliotoxin

artículo científico publicado en 2003

Diverse Trifluoromethyl Heterocycles from a Single Precursor

scientific article published on 20 January 2012

Enantioselective insertion of metal carbenes into N-H bonds: a potentially versatile route to chiral amine derivatives.

artículo científico publicado en 2007

Experimental Organic Chemistry: Principles and Practice ⬇️

Book

First Synthesis of the Naturally Occurring Diazocarbonyl Compound Cremeomycin

article published in 2008

First syntheses of 2,2-dimethyl-7-(2'-methylbut-3'-en-2'-yl)-2H-chromen-6-ol and 2-(3'-methylbut-2'-enyl)-5-(2'-methylbut-3'-en-2'-yl)-1,4-benzoquinone, novel prenylated quinone derivatives from the New Zealand brown alga Perithalia capillaris

artículo científico publicado en 2008

First synthesis of N-(3-carboxylpropyl)-5-amino-2-hydroxy-3- tridecyl-1,4-benzoquinone, an unusual quinone isolated from Embelia ribes.

artículo científico publicado en 2007

Formal Total Synthesis of Diazonamide A by Indole Oxidative Rearrangement

artículo científico publicado en 2016

From amino acids to heteroaromatics--thiopeptide antibiotics, nature's heterocyclic peptides

artículo científico publicado en 2007

Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines

artículo científico publicado en 2016

Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo.

artículo científico publicado en 2004

Heat shock protein 90 controls HIV-1 reactivation from latency

artículo científico publicado en 2014

Indolequinone Antitumor Agents: Correlation between Quinone Structure, Rate of Metabolism by Recombinant Human NAD(P)H:Quinone Oxidoreductase, and in Vitro Cytotoxicity1

artículo científico publicado en 1998

Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro

artículo científico publicado en 1998

Indolequinone antitumor agents: Relationship between quinone structure and rate of metabolism by recombinant human NQO1

artículo científico publicado en 1998

Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2.

artículo científico publicado en 2001

Indolequinone antitumour agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase.

artículo científico publicado en 2007

Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems

artículo científico publicado en 2011

Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies

artículo científico publicado en 2010

Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol

artículo científico publicado en 2006

Keap calm, and carry on covalently

artículo científico publicado en 2013

Learning from nature: advances in geldanamycin- and radicicol-based inhibitors of Hsp90.

artículo científico publicado en 2013

Ligand effects in the metal catalysed reactions of N-aryldiazoamides: Ylide formation vs. insertion reactions

Mechanism-Based Inhibition of Quinone Reductase 2 (NQO2): Selectivity for NQO2 over NQO1 and Structural Basis for Flavoprotein Inhibition

artículo científico publicado en 2011

Microwave-mediated Claisen rearrangement followed by phenol oxidation: a simple route to naturally occurring 1,4-benzoquinones. The first syntheses of verapliquinones A and B and panicein A.

artículo científico publicado en 2005

Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: a key factor in controlling hypoxia-selective drug release

artículo científico publicado en 2002

Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential

artículo científico publicado en 2007

Natural products containing a diazo group

scientific article published on 18 May 2011

Novel quinolinequinone antitumor agents: Structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1)

artículo científico publicado en 1999

Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1).

artículo científico publicado en 2004

Nucleophilic fluorination of β-ketoester derivatives with HBF4

artículo científico publicado en 2012

N–H Insertion reactions of rhodium carbenoids. Part 5: A convenient route to 1,3-azoles

Origin of the Thiopyrone CTP-431 “Unexpectedly” Isolated from the Marine Sponge Cacospongia mycofijiensis

scientific article published on 02 August 2018

Oxidative Rearrangement of Indoles: A New Approach to the EFHG-Tetracyclic Core of Diazonamide A

artículo científico publicado en 2007

Oxidative Routes to the Heterocyclic Cores of Benzothiazole Natural Products

Oxidative activation of antioxidant defence

artículo científico publicado en 2005

Potassium N-iodo p-toluenesulfonamide (TsNIK, Iodamine-T): a new reagent for the oxidation of hydrazones to diazo compounds

artículo científico publicado en 2014

Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target

artículo científico publicado en 2009

Preparation of tetrahydrobenz[cd]indoles from 1-tetralones

article

Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I.

artículo científico publicado en 2003

Quinones as dienophiles in the Diels-Alder reaction: history and applications in total synthesis

artículo científico publicado en 2014

Rapid access to α-alkoxy and α-amino acid derivatives through safe continuous-flow generation of diazoesters.

artículo científico publicado en 2011

Regioselectivity of the Claisen rearrangement in meta-allyloxy aryl ketones: an experimental and computational study, and application in the synthesis of (R)-(-)-pestalotheol D.

artículo científico publicado en 2011

Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones

artículo científico publicado en 2001

Rhodium carbene routes to oxazoles and thiazoles. Catalyst effects in the synthesis of oxazole and thiazole carboxylates, phosphonates, and sulfones

artículo científico publicado en 2010

Rhodium carbenoid mediated cyclisations. Part 6. Synthesis of cyclic sulphoxonium ylides

scholarly article by Christopher J. Moody & Roger J. Taylor published January 1990 in Tetrahedron

Seven-membered ring scaffolds for drug discovery: Access to functionalised azepanes and oxepanes through diazocarbonyl chemistry

artículo científico publicado en 2015

Solar photochemical oxidation of alcohols using catalytic hydroquinone and copper nanoparticles under oxygen: oxidative cleavage of lignin models

artículo científico publicado en 2014

Solar photochemical oxidations of benzylic and allylic alcohols using catalytic organo-oxidation with DDQ: application to lignin models.

artículo científico publicado en 2014

Solution structures of thiopeptide antibiotics

artículo científico publicado en 2006

Stereoselective Synthesis of Functionalized Pyrrolidines by the Diverted N-H Insertion Reaction of Metallocarbenes with β-Aminoketone Derivatives.

artículo científico publicado en 2016

Stereoselective Synthesis of Highly Substituted Tetrahydrofurans through Diverted Carbene O-H Insertion Reaction.

artículo científico publicado en 2015

Synthesis and Intracellular Redox Cycling of Natural Quinones and Their Analogues and Identification of Indoleamine-2,3-dioxygenase (IDO) as Potential Target for Anticancer Activity

artículo científico publicado en 2015

Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity

artículo científico publicado en 2007

Synthesis and evaluation of prodrugs for anti-angiogenic pyrrolylmethylidenyl oxindoles

artículo científico publicado en 2007

Synthesis and growth-inhibitory activities of imidazo[5,1-]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position

article

Synthesis and solid state structures of N,N′-linked carbazoles and indoles

Synthesis of (+/-)-likonide B (smenochromene D) using a regioselective Claisen rearrangement, separation of the enantiomers and stereochemical assignment.

artículo científico publicado en 2009

Synthesis of (±)-Smenochromene D (Likonide B) Using a Regioselective Claisen Rearrangement

Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90

artículo científico publicado en 2013

Synthesis of 3-(carboxyarylalkyl)imidazo[2,1-f][1,2,4]triazines as potential inhibitors of AMP deaminase.

artículo científico publicado en 2008

Synthesis of Indolequinones from Bromoquinones and Enamines Mediated by Cu(OAc)2·H2O

artículo científico publicado en 2010

Synthesis of Ptaeroxylin (Desoxykarenin): An Unusual Chromone from the Sneezewood TreePtaeroxylon obliquum

Synthesis of Spirotetramates via a Diels−Alder Approach

artículo científico publicado en 2011

Synthesis of amino-1,4-benzoquinones and their use in Diels-Alder approaches to the aminonaphthoquinone antibiotics.

artículo científico publicado en 2011

Synthesis of an achiral isomer of lipoic acid as an anchor group for SAM formation on gold surfaces

artículo científico publicado en 2010

Synthesis of balsaminone A, a naturally occurring pentacyclic dinaphthofuran quinone.

artículo científico publicado en 2011

Synthesis of cyclic ethers by rhodium carbenoid cyclisation

scholarly article by Julie C Heslin et al published January 1986 in Tetrahedron Letters

Synthesis of highly substituted 1,2-diazetidin-3-ones, small ring scaffolds for drug discovery.

artículo científico publicado en 2018

Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90

artículo científico publicado en 2014

Synthesis of parvistemin A via biomimetic oxidative dimerization.

artículo científico publicado en 2011

Synthesis of the 2,3,4-trisubstituted indole fragments of nosiheptide and glycothiohexide

artículo científico publicado en 2004

Synthesis of the Reported Structure of Crassiflorone, a Pentacyclic Naphthoquinone Isolated from the African Ebony Diospyros crassiflora

Synthesis of the Reported Structure of the Bisbenzoquinone Lanciaquinone, Isolated from Maesa lanceolata

artículo científico publicado en 2008

Synthesis of the combined centre- and right-hand section of the antitumour agent CC-1065

Synthesis of the oxepinochromone natural products ptaeroxylin (desoxykarenin), ptaeroxylinol, and eranthin

artículo científico publicado en 2010

Synthesis of the reported structure of crassiflorone, a naturally occurring quinone isolated from the African ebony Diospyros crassiflora, and regioisomeric pentacyclic furocoumarin naphthoquinones

artículo científico publicado en 2011

Synthesis of the ‘Northern-Hemisphere’ Fragments of the Thiopeptide Antibiotic Nosiheptide

Synthesis of β-keto esters in-flow and rapid access to substituted pyrimidines

artículo científico publicado en 2010

Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin

artículo científico publicado en 2007

Targeting the Hsp90 chaperone: synthesis of novel resorcylic acid macrolactone inhibitors of Hsp90.

artículo científico publicado en 2010

Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies

artículo científico publicado en 2011

Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes.

artículo científico publicado en 2010

The design of a new group of angiotensin-converting enzyme inhibitors

artículo científico publicado en 1982

The diazo route to diazonamide A. Studies on the indole bis-oxazole fragment

artículo científico publicado en 2005

The diazo route to diazonamide A: studies on the tyrosine-derived fragment

artículo científico publicado en 2005

The effect of central and planar chirality on the electrochemical and chiral sensing properties of ferrocenyl urea H-bonding receptors

artículo científico publicado en 2015

The remarkable effect of the 7-substituent in the diastereoselective oxidative rearrangement of indoles: Asymmetric synthesis of 3,3-disubstituted oxindoles

artículo científico publicado en 2006

The rhodium carbene route to oxazoles: a remarkable catalyst effect.

artículo científico publicado en 2009

The synthetic challenge of diazonamide A, a macrocyclic indole bis-oxazole marine natural product

artículo científico publicado en 2008

The total synthesis of siphonazole, a structurally unusual bis-oxazole natural product.

artículo científico publicado en 2007

Total Synthesis of (±)-Distomadines A and B

artículo científico publicado en 2014

Total Synthesis of Stephanotic Acid Methyl Ester

scientific article published on 01 May 2006

Total Synthesis of the Cyclic Dodecapeptides Wewakazole and Wewakazole B.

artículo científico publicado en 2017

Total Synthesis of the Post-translationally Modified Polyazole Peptide Antibiotic Goadsporin

artículo científico publicado en 2017

Total Synthesis of the Posttranslationally Modified Polyazole Peptide Antibiotic Plantazolicin A.

artículo científico publicado en 2015

Total synthesis of mevashuntin.

artículo científico publicado en 2012

Total synthesis of siphonazole and its O-methyl derivative, structurally unusual bis-oxazole natural products

artículo científico publicado en 2008

Total synthesis of the thiopeptide antibiotic amythiamicin D.

artículo científico publicado en 2005

Toward the Total Synthesis of Hygrocin B and Divergolide C: Construction of the Naphthoquinone–Azepinone Core

artículo científico publicado en 2014

Two approaches to the aromatic core of the aminonaphthoquinone antibiotics.

artículo científico publicado en 2013

Two-step route to indoles and analogues from haloarenes: a variation on the Fischer indole synthesis

artículo científico publicado en 2011

Lista de obras de Christopher J. Moody

19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity

5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo

7-Deazapurine biosynthesis: NMR study of toyocamycin biosynthesis in Streptomyces rimosus using 2-13C-7-15N-adenine

A Concise Route to Pyridines from Hydrazides by Metal Carbene N−H Insertion, 1,2,4-Triazine Formation, and Diels−Alder Reaction

A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity

A new protecting-group strategy for indoles

A new route to α-carbolines based on 6π-electrocyclization of indole-3-alkenyl oximes

A short synthesis of the triazolopyrimidine antibiotic essramycin

A two step route to indoles from haloarenes—a versatile variation on the Fischer indole synthesis ⬇️

Alkyl Halide-Free Heteroatom Alkylation and Epoxidation Facilitated by a Recyclable Polymer-Supported Oxidant for the In-Flow Preparation of Diazo Compounds

Amination of heteroaryl chlorides: palladium catalysis or SN Ar in green solvents?

Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A.

An Exploration of Ferrocenyl Ureas as Enantioselective Electrochemical Sensors for Chiral Carboxylate Anions

An Improved Synthesis of Resorcylic Acid Macrolactone Inhibitors of Hsp90

An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration

Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin reductase and activation of redox signaling

Antitumour indolequinones: synthesis and activity against human pancreatic cancer cells

Asymmetric Synthesis of 2-Substituted Piperidines. Synthesis of the Alkaloids (−)-Coniine and (+)-Pseudoconhydrine

Asymmetric Synthesis of Chiral α-Ferrocenylalkylamines and Their Use in the Preparation of Chiral Redox-Active Receptors

Asymmetric synthesis of N-protected amino acids by the addition of organolithium carboxyl synthons to ROPHy/SOPHy-derived aldoximes and ketoximes

Asymmetric synthesis of the central tryptophan residue of stephanotic acid

Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.

Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1

Benzofuranquinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis and biological evaluation.

Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, in cellular systems

Biomimetic Synthesis of the Apoptosis-Inducing Thiazinoquinone Thiaplidiaquinone A

Biomimetic approaches to diazonamide A. Direct synthesis of the indole bis-oxazole fragment by oxidation of a TyrValTrpTrp tetrapeptide

C-H Insertion as a Key Step to Spiro-Oxetanes, Scaffolds for Drug Discovery

Carbene reactivity of 4-diazo-4H-imidazoles toward nucleophiles and aromatic compounds

Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches

Chiral oxime ethers in asymmetric synthesis. O-(1-Phenylbutyl)benzyloxyacetaldoxime, a versatile reagent for the asymmetric synthesis of protected 1,2-aminoalcohols, alpha-amino acid derivatives, and 2-hydroxymethyl nitrogen heterocycles including i

Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents

Competition between planar and central chiral control elements in nucleophilic addition to ferrocenyl imine derivatives.

Construction of macrocyclic thiodepsipeptides: synthesis of a nosiheptide 'southern hemisphere' model system

Control of competing N-H insertion and Wolff rearrangement in dirhodium(II)-catalyzed reactions of 3-indolyl diazoketoesters. synthesis of a potential precursor to the marine 5-(3-indolyl)oxazole martefragin A.

Copper(II)-Mediated Synthesis of Indolequinones from Bromoquinones and Enamines

Cyclopropamitosenes, Novel Bioreductive Anticancer Agents. Synthesis, Electrochemistry, and Biological Activity of 7-Substituted Cyclopropamitosenes and Related Indolequinones

Delivery of Temozolomide and N3-Propargyl Analog to Brain Tumors Using an Apoferritin Nanocage

Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells

Diastereoselective Synthesis of Highly Substituted, Amino- and Pyrrolidino-Tetrahydrofurans as Lead-like Molecular Scaffolds.

Dirhodium(II) carboxylate-catalysed oxidation of allylic and benzylic alcohols

Dirhodium(II) tetraacetate catalysed reactions of diazo thioamides: isolation and cycloaddition of anhydro-4-hydroxy-1,3-thiazolium hydroxides (thioisomünchnones), an approach to analogues of dehydrogliotoxin

Diverse Trifluoromethyl Heterocycles from a Single Precursor

Enantioselective insertion of metal carbenes into N-H bonds: a potentially versatile route to chiral amine derivatives.

Experimental Organic Chemistry: Principles and Practice ⬇️

First Synthesis of the Naturally Occurring Diazocarbonyl Compound Cremeomycin

First syntheses of 2,2-dimethyl-7-(2'-methylbut-3'-en-2'-yl)-2H-chromen-6-ol and 2-(3'-methylbut-2'-enyl)-5-(2'-methylbut-3'-en-2'-yl)-1,4-benzoquinone, novel prenylated quinone derivatives from the New Zealand brown alga Perithalia capillaris

First synthesis of N-(3-carboxylpropyl)-5-amino-2-hydroxy-3- tridecyl-1,4-benzoquinone, an unusual quinone isolated from Embelia ribes.

Formal Total Synthesis of Diazonamide A by Indole Oxidative Rearrangement

From amino acids to heteroaromatics--thiopeptide antibiotics, nature's heterocyclic peptides

Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines

Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo.

Heat shock protein 90 controls HIV-1 reactivation from latency

Indolequinone Antitumor Agents: Correlation between Quinone Structure, Rate of Metabolism by Recombinant Human NAD(P)H:Quinone Oxidoreductase, and in Vitro Cytotoxicity1

Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro

Indolequinone antitumor agents: Relationship between quinone structure and rate of metabolism by recombinant human NQO1

Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2.

Indolequinone antitumour agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase.

Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems

Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies

Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol

Keap calm, and carry on covalently

Learning from nature: advances in geldanamycin- and radicicol-based inhibitors of Hsp90.

Ligand effects in the metal catalysed reactions of N-aryldiazoamides: Ylide formation vs. insertion reactions

Mechanism-Based Inhibition of Quinone Reductase 2 (NQO2): Selectivity for NQO2 over NQO1 and Structural Basis for Flavoprotein Inhibition

Microwave-mediated Claisen rearrangement followed by phenol oxidation: a simple route to naturally occurring 1,4-benzoquinones. The first syntheses of verapliquinones A and B and panicein A.

Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: a key factor in controlling hypoxia-selective drug release

Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential

Natural products containing a diazo group

Novel quinolinequinone antitumor agents: Structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1)

Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1).

Nucleophilic fluorination of β-ketoester derivatives with HBF4

N–H Insertion reactions of rhodium carbenoids. Part 5: A convenient route to 1,3-azoles

Origin of the Thiopyrone CTP-431 “Unexpectedly” Isolated from the Marine Sponge Cacospongia mycofijiensis

Oxidative Rearrangement of Indoles: A New Approach to the EFHG-Tetracyclic Core of Diazonamide A

Oxidative Routes to the Heterocyclic Cores of Benzothiazole Natural Products

Oxidative activation of antioxidant defence

Potassium N-iodo p-toluenesulfonamide (TsNIK, Iodamine-T): a new reagent for the oxidation of hydrazones to diazo compounds

Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target