Lista de obras - Stuart J. Conway - Dominio Público Uruguay

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands

artículo científico publicado en 2011

A Single-Stranded DNA-Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks

artículo científico publicado en 2020

A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction

artículo científico publicado en 2014

Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System. ⬇️

artículo científico publicado en 2017

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability

artículo científico publicado en 2018

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.

artículo científico publicado en 2004

Bifunctional Molecules beyond PROTACs

scientific article published on 11 March 2020

Biology-enabling inositol phosphates, phosphatidylinositol phosphates and derivatives

artículo científico publicado en 2007

Bromodomains: are readers right for epigenetic therapy?

artículo científico publicado en 2012

Bürgenstock 2012: Reflections on stereochemistry

scientific article published on 01 February 2013

CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora A.

artículo científico publicado en 2013

CYP450 Enzymes Effect Oxygen-Dependent Reduction of Azide-Based Fluorogenic Dyes

artículo científico publicado en 2017

Caged AG10: new tools for spatially predefined mitochondrial uncoupling

artículo científico publicado en 2009

Chemical Epigenetics: The Impact of Chemical and Chemical Biology Techniques on Bromodomain Target Validation

artículo científico publicado en 2019

Co-incident signalling between mu-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3 receptor sensitization

artículo científico publicado en 2003

Correction to Small Molecule Inhibitors of Bromodomain-Acetyl-lysine Interactions.

artículo científico publicado en 2016

Defective chemoattractant-induced calcium signalling in S100A9 null neutrophils

artículo científico publicado en 2006

Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs.

artículo científico publicado en 2016

Development of inositol-based antagonists for thed-myo-inositol 1,4,5-trisphosphate receptor

artículo científico publicado en 2011

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

artículo científico publicado en 2014

Engineering transkingdom signalling in plants to control gene expression in rhizosphere bacteria

artículo científico publicado en 2019

Epigenetics 2.0: Special Issue on Epigenetics-Call for Papers

scientific article published on 22 October 2020

Epigenetics: Novel Therapeutics Targeting Epigenetics

scientific article published on 29 January 2016

Epigenetics: novel therapeutics targeting epigenetics

scientific article published on 22 December 2014

Facile one-pot synthesis of 5-substituted hydantoins

artículo científico publicado en 2008

Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruzi

artículo científico publicado en 2020

Hypoxia-Activated, Small-Molecule-Induced Gene Expression

artículo científico publicado en 2018

In vitro photo-release of a TRPV1 agonist

artículo científico publicado en 2005

Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes

scientific article published on 01 August 2006

Isoxazole-Derived Amino Acids are Bromodomain-Binding Acetyl-Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3.

artículo científico publicado en 2016

KefF, the regulatory subunit of the potassium efflux system KefC, shows quinone oxidoreductase activity.

artículo científico

Mechanism of ligand-gated potassium efflux in bacterial pathogens

artículo científico publicado en 2010

Mitochondrial β-amyloid in Alzheimer's disease.

artículo científico publicado en 2011

NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing

artículo científico publicado en 2012

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

artículo científico publicado en 2013

Phenotypic screening and fragment-based approaches to the discovery of small-molecule bromodomain ligands.

artículo científico

Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals.

artículo científico publicado en 2003

Production and characterization of reduced NAADP (nicotinic acid-adenine dinucleotide phosphate).

artículo científico publicado en 2004

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions

artículo científico publicado en 2012

Purinergic receptor-stimulated IP3-mediated Ca2+ release enhances neuroprotection by increasing astrocyte mitochondrial metabolism during aging.

artículo científico publicado en 2007

Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms

artículo científico publicado en 2016

Quantitative hopanoid analysis enables robust pattern detection and comparison between laboratories

artículo científico publicado en 2015

Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins

artículo científico publicado en 2004

Selective fragments for the CREBBP bromodomain identified from an Encoded Self-Assembly Chemical Library

artículo científico publicado en 2020

Small molecule inhibitors of bromodomain-acetyl-lysine interactions

artículo científico publicado en 2015

Small molecules as tools to study the chemical epigenetics of lysine acetylation

artículo científico publicado en 2018

Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate.

artículo científico publicado en 2007

Synthesis and biological evaluation of a novel cardiolipin affinity matrix

artículo científico publicado en 2009

Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes

artículo científico publicado en 2009

Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors

artículo científico publicado en 2001

Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists

artículo científico publicado en 2009

TRPing the switch on pain: an introduction to the chemistry and biology of capsaicin and TRPV1.

artículo científico publicado en 2008

Temporal changes in atrial EC-coupling during prolonged stimulation with endothelin-1

scientific article published on 14 June 2007

The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains

artículo científico publicado en 2013

The photochemical thiol-ene reaction as a versatile method for the synthesis of glutathione S-conjugates targeting the bacterial potassium efflux system Kef.

artículo científico publicado en 2016

The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis

artículo científico publicado en 2007

The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction

artículo científico publicado en 2004

Understanding the structural requirements for activators of the Kef bacterial potassium efflux system.

artículo científico publicado en 2014

Wavelength-orthogonal photolysis of neurotransmitters in vitro

artículo científico publicado en 2011

Lista de obras de Stuart J. Conway

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands

A Single-Stranded DNA-Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks

A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction

Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System. ⬇️

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.

Bifunctional Molecules beyond PROTACs

Biology-enabling inositol phosphates, phosphatidylinositol phosphates and derivatives

Bromodomains: are readers right for epigenetic therapy?

Bürgenstock 2012: Reflections on stereochemistry

CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora A.

CYP450 Enzymes Effect Oxygen-Dependent Reduction of Azide-Based Fluorogenic Dyes

Caged AG10: new tools for spatially predefined mitochondrial uncoupling

Chemical Epigenetics: The Impact of Chemical and Chemical Biology Techniques on Bromodomain Target Validation

Co-incident signalling between mu-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3 receptor sensitization

Correction to Small Molecule Inhibitors of Bromodomain-Acetyl-lysine Interactions.

Defective chemoattractant-induced calcium signalling in S100A9 null neutrophils

Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs.

Development of inositol-based antagonists for thed-myo-inositol 1,4,5-trisphosphate receptor

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

Engineering transkingdom signalling in plants to control gene expression in rhizosphere bacteria

Epigenetics 2.0: Special Issue on Epigenetics-Call for Papers

Epigenetics: Novel Therapeutics Targeting Epigenetics

Epigenetics: novel therapeutics targeting epigenetics

Facile one-pot synthesis of 5-substituted hydantoins

Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruzi

Hypoxia-Activated, Small-Molecule-Induced Gene Expression

In vitro photo-release of a TRPV1 agonist

Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes

Isoxazole-Derived Amino Acids are Bromodomain-Binding Acetyl-Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3.

KefF, the regulatory subunit of the potassium efflux system KefC, shows quinone oxidoreductase activity.

Mechanism of ligand-gated potassium efflux in bacterial pathogens

Mitochondrial β-amyloid in Alzheimer's disease.

NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

Phenotypic screening and fragment-based approaches to the discovery of small-molecule bromodomain ligands.

Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals.

Production and characterization of reduced NAADP (nicotinic acid-adenine dinucleotide phosphate).

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions

Purinergic receptor-stimulated IP3-mediated Ca2+ release enhances neuroprotection by increasing astrocyte mitochondrial metabolism during aging.

Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms

Quantitative hopanoid analysis enables robust pattern detection and comparison between laboratories

Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins

Selective fragments for the CREBBP bromodomain identified from an Encoded Self-Assembly Chemical Library

Small molecule inhibitors of bromodomain-acetyl-lysine interactions

Small molecules as tools to study the chemical epigenetics of lysine acetylation

Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate.

Synthesis and biological evaluation of a novel cardiolipin affinity matrix

Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes

Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors

Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists

TRPing the switch on pain: an introduction to the chemistry and biology of capsaicin and TRPV1.

Temporal changes in atrial EC-coupling during prolonged stimulation with endothelin-1

The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains

The photochemical thiol-ene reaction as a versatile method for the synthesis of glutathione S-conjugates targeting the bacterial potassium efflux system Kef.

The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis

The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction

Understanding the structural requirements for activators of the Kef bacterial potassium efflux system.

Wavelength-orthogonal photolysis of neurotransmitters in vitro