Lista de obras - Diana Conte Camerino - Dominio Público Uruguay

A large cohort of myotonia congenita probands: novel mutations and a high-frequency mutation region in exons 4 and 5 of the CLCN1 gene

artículo científico publicado en 2013

A multidisciplinary evaluation of the effectiveness of cyclosporine a in dystrophic mdx mice.

artículo científico publicado en 2005

Activation and inhibition of kidney CLC-K chloride channels by fenamates

artículo científico publicado en 2005

Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission

artículo científico publicado en 2012

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

artículo científico publicado en 2013

Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse

artículo científico publicado en 2002

Coexistence of CLCN1 and SCN4A mutations in one family suffering from myotonia.

artículo científico publicado en 2017

Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels

artículo científico publicado en 2013

Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents

artículo científico publicado en 2008

Decrease in resting calcium and calcium entry associated with slow-to-fast transition in unloaded rat soleus muscle

artículo científico publicado en 2003

Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders

artículo científico publicado en 2003

Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block

artículo científico publicado en 2003

Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance

artículo científico publicado en 2007

Dramatic improvement of myotonia permanens with flecainide: a two-case report of a possible bench-to-bedside pharmacogenetics strategy

artículo científico publicado en 2012

Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

artículo científico publicado en 2017

Dual response of the KATP channels to staurosporine: A novel role of SUR2B, SUR1 and Kir6.2 subunits in the regulation of the atrophy in different skeletal muscle phenotypes

scientific article published on 03 July 2014

Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1.

artículo científico publicado en 2003

Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone

artículo científico publicado en 2005

Fluvastatin and atorvastatin affect calcium homeostasis of rat skeletal muscle fibers in vivo and in vitro by impairing the sarcoplasmic reticulum/mitochondria Ca2+-release system

artículo científico publicado en 2007

Functional characterization of ClC-1 mutations from patients affected by recessive myotonia congenita presenting with different clinical phenotypes

artículo científico publicado en 2013

Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle

artículo científico publicado en 2008

Growth hormone secretagogues modulate the electrical and contractile properties of rat skeletal muscle through a ghrelin-specific receptor

artículo científico publicado en 2003

Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity

artículo científico publicado en 2010

In vivo evaluation of antimyotonic efficacy of β-adrenergic drugs in a rat model of myotonia

artículo científico publicado en 2012

In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: a new drug target for hypertension?

artículo científico publicado en 2012

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo

artículo científico publicado en 2001

Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.

artículo científico publicado en 2016

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile

artículo científico publicado en 2003

Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers

artículo científico publicado en 2004

Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb-unloaded mice

artículo científico publicado en 2009

Mechanisms of block of muscle type CLC chloride channels (Review).

artículo científico publicado en 2002

Molecular determinants of differential pore blocking of kidney CLC-K chloride channels

artículo científico publicado en 2004

Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials

artículo científico publicado en 2012

Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid

artículo científico publicado en 2002

Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies

artículo científico publicado en 2016

N-aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels

artículo científico publicado en 2014

New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function

artículo científico publicado en 2009

New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse

artículo científico publicado en 2004

On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles

artículo científico publicado en 2015

Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+Channels

Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels

artículo científico publicado en 2003

Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds

artículo científico publicado en 2003

Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: beneficial effect of pentoxifylline

artículo científico publicado en 2006

Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice

artículo científico publicado en 2013

Paving the way for Bartter syndrome type 3 drug discovery: a hope from basic research

artículo científico publicado en 2017

Pharmacology of CLC Chloride Channels and Transporters

scholarly article by Michael Pusch et al published 2006 in Advances in Molecular and Cell Biology

Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness

artículo científico publicado en 2002

Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide

artículo científico publicado en 2011

Splicing of the rSlo gene affects the molecular composition and drug response of Ca2+-activated K+ channels in skeletal muscle

artículo científico publicado en 2012

Statin or fibrate chronic treatment modifies the proteomic profile of rat skeletal muscle

artículo científico publicado en 2011

Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin

artículo científico publicado en 2016

Stereospecific synthesis of "para-hydroxymexiletine" and sodium channel blocking activity evaluation

artículo científico publicado en 2004

Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1.

artículo científico publicado en 2003

Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.

artículo científico publicado en 2010

Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels

artículo científico publicado en 2012

Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na(+) channels with increased potency and improved use-dependent activity.

artículo científico publicado en 2000

Taurine and skeletal muscle disorders

artículo científico publicado en 2004

Taurine: the appeal of a safe amino acid for skeletal muscle disorders

artículo científico publicado en 2015

Therapeutic approaches to ion channel diseases

artículo científico publicado en 2008

Lista de obras de Diana Conte Camerino

A large cohort of myotonia congenita probands: novel mutations and a high-frequency mutation region in exons 4 and 5 of the CLCN1 gene

A multidisciplinary evaluation of the effectiveness of cyclosporine a in dystrophic mdx mice.

Activation and inhibition of kidney CLC-K chloride channels by fenamates

Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse

Coexistence of CLCN1 and SCN4A mutations in one family suffering from myotonia.

Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels

Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents

Decrease in resting calcium and calcium entry associated with slow-to-fast transition in unloaded rat soleus muscle

Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders

Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block

Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance

Dramatic improvement of myotonia permanens with flecainide: a two-case report of a possible bench-to-bedside pharmacogenetics strategy

Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

Dual response of the KATP channels to staurosporine: A novel role of SUR2B, SUR1 and Kir6.2 subunits in the regulation of the atrophy in different skeletal muscle phenotypes

Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1.

Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone

Fluvastatin and atorvastatin affect calcium homeostasis of rat skeletal muscle fibers in vivo and in vitro by impairing the sarcoplasmic reticulum/mitochondria Ca2+-release system

Functional characterization of ClC-1 mutations from patients affected by recessive myotonia congenita presenting with different clinical phenotypes

Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle

Growth hormone secretagogues modulate the electrical and contractile properties of rat skeletal muscle through a ghrelin-specific receptor

Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity

In vivo evaluation of antimyotonic efficacy of β-adrenergic drugs in a rat model of myotonia

In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: a new drug target for hypertension?

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo

Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile

Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers

Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb-unloaded mice

Mechanisms of block of muscle type CLC chloride channels (Review).

Molecular determinants of differential pore blocking of kidney CLC-K chloride channels

Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials

Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid

Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies

N-aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels

New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function

New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse

On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles

Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+Channels

Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels

Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds

Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: beneficial effect of pentoxifylline

Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice

Paving the way for Bartter syndrome type 3 drug discovery: a hope from basic research

Pharmacology of CLC Chloride Channels and Transporters

Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness

Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide

Splicing of the rSlo gene affects the molecular composition and drug response of Ca2+-activated K+ channels in skeletal muscle

Statin or fibrate chronic treatment modifies the proteomic profile of rat skeletal muscle

Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin

Stereospecific synthesis of "para-hydroxymexiletine" and sodium channel blocking activity evaluation

Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1.

Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.

Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels

Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na(+) channels with increased potency and improved use-dependent activity.

Taurine and skeletal muscle disorders

Taurine: the appeal of a safe amino acid for skeletal muscle disorders

Therapeutic approaches to ion channel diseases