Lista de obras - Daniele Passarella - Dominio Público Uruguay

'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells.

artículo científico publicado en 2012

4-(1,2-diarylbut-1-en-1-yl)isobutyranilide derivatives as inhibitors of topoisomerase II.

artículo científico publicado en 2016

9-Fluorenone-2-Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds

artículo científico publicado en 2013

A convenient synthesis of delta(7,8)-morphinan-6-one and its direct oxidation to 14-hydroxy-delta(7,8)-morphinan-6-one

artículo científico publicado en 2002

A highly enantioselective synthesis of (−)-antirhine by chemo-enzymatic approach

article published in 1994

A small library of chalcones induce liver cancer cell death through Akt phosphorylation inhibition

artículo científico publicado en 2020

Access to Pyrrolo- and Pyrido[1,2-a]indole Derivatives by Intramolecular Nitrone Cycloadditions. Effect of Steric Factors on the Regioselective Product Formation

artículo científico publicado en 2000

An efficient chemo-enzymatic approach to (+)-meroquinene

Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: cytological studies and chemical investigations. ⬇️

artículo científico publicado en 2014

Aspidosperma alkaloids cyclization of secodine intermediate: Synthesis of (±)-3-oxovincadifformine ethyl ester

Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2.

artículo científico publicado en 2015

Bruno Danieli (1939–2014).

artículo científico publicado en 2015

Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation

artículo científico publicado en 2012

Can we use the epigenetic bioactivity of caloric restriction and phytochemicals to promote healthy ageing?

Cannabidiol as the Substrate in Acid-Catalyzed Intramolecular Cyclization

scientific article published on 29 September 2020

Catalytic C3 aza-alkylation of indoles

artículo científico publicado en 2020

Chalcone Derivatives Activate and Desensitize the Transient Receptor Potential Ankyrin 1 Cation Channel, Subfamily A, Member 1 TRPA1 Ion Channel: Structure-Activity Relationships in vitro and Anti-Nociceptive and Anti-inflammatory Activity in vivo.

artículo científico publicado en 2016

Chemical approaches to targeting drug resistance in cancer stem cells.

artículo científico publicado en 2014

Chiral flavanones from Amygdalus lycioides Spach: structural elucidation and identification of TNFalpha inhibitors by bioactivity-guided fractionation ⬇️

artículo científico publicado en 2012

Combinatorial solid-phase synthesis of 6-hydroxy-1,2,3,4-tetrahydro-beta-carbolines from l-5-hydroxytryptophan.

artículo científico publicado en 2005

Combined drug action of 2-phenylimidazo[2,1-b]benzothiazole derivatives on cancer cells according to their oncogenic molecular signatures

artículo científico publicado en 2012

Comparative phytochemical and morphological analyses of three Italian Primula species

artículo científico publicado en 2007

Concise total synthesis of (+/-)-aloperine and 6-epi-aloperine

scientific article published on 01 August 2002

Covalent Nucleoside Adducts of Aspidosperma Alkaloids

Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels

artículo científico publicado en 2014

Efficient continuous flow synthesis of hydroxamic acids and suberoylanilide hydroxamic acid preparation

artículo científico publicado en 2009

Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors

scientific article published on 11 July 2020

Enantiopure 2-piperidylacetaldehyde as a useful building block in the diversity-oriented synthesis of polycyclic piperidine derivatives

Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis

artículo científico publicado en 2016

Exploiting enzymatic regioselectivity: a facile methodology for the synthesis of polyhydroxylated hybrid compounds

scientific article published on 30 September 2010

Farinose alpine Primula species: phytochemical and morphological investigations.

artículo científico publicado en 2013

Functionalization at C-17 of an Eburnea-Aspidosperma Binary Alkaloid as a Model to Study Modified Vinblastine-type Antitumor Alkaloids

Histone deacetylase and microtubules as targets for the synthesis of releasable conjugate compounds

artículo científico publicado en 2009

Histone demethylating agents as potential S-adenosyl-l-methionine-competitors

Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

artículo científico publicado en 2003

Identification of new aminoacid amides containing the imidazo[2,1-b]benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling ⬇️

artículo científico publicado el 4 de noviembre de 2011

Microwave-assisted, solid-phase synthesis of a chiral 1,2,3,4-tetrahydro-quinoline library.

artículo científico publicado en 2006

N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl.

artículo científico publicado en 2011

Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers

artículo científico publicado en 2019

Natural Products and Cancer Stem Cells.

artículo científico

Nature-inspired indolyl-2-azabicyclo[2.2.2]oct-7-ene derivatives as promising agents for the attenuation of withdrawal symptoms: synthesis of 20-desethyl-20-hydroxymethyl-11-demethoxyibogaine

artículo científico publicado en 2006

New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A.

artículo científico publicado en 2014

New flavonol glycosides from Aconitum burnatii Gáyer and Aconitum variegatum L.

artículo científico publicado en 2010

Novel chemical probes for the investigation of nonribosomal peptide assembly.

artículo científico publicado en 2017

Preparation of Fluorescent Tubulin Binders

Probing the binding site of abl tyrosine kinase using in situ click chemistry.

artículo científico publicado en 2013

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

artículo científico publicado en 2013

Remote stereocenter discrimination in the enzymatic resolution of piperidine-2-ethanol. Short enantioselective synthesis of sedamine and allosedamine.

artículo científico publicado en 2003

Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks

artículo científico publicado en 2017

Self-assembly drug conjugates for anticancer treatment

artículo científico publicado en 2016

Synthesis and biological evaluation of epothilone A dimeric compounds.

artículo científico publicado en 2009

Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors

artículo científico publicado en 2011

Synthesis and biological evaluation of new camptothecin derivatives obtained by modification of position 20.

artículo científico publicado en 2010

Synthesis and biological evaluation of novel tamoxifen analogues

artículo científico publicado en 2013

Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates.

artículo científico publicado en 2009

Synthesis and biological evaluation of paclitaxel-thiocolchicine hybrids

artículo científico publicado en 2004

Synthesis and biological evaluation of pyrroloiminoquinone derivatives

artículo científico publicado en 2007

Synthesis of (+)-dumetorine and congeners by using flow chemistry technologies

scientific article published on 19 April 2011

Synthesis of Pironetin-Dumetorine Hybrids as Tubulin Binders

article published in 2016

Synthesis of Thicolchicine-Based Conjugates: Investigation towards Bivalent Tubulin/Microtubules Binders

artículo científico publicado en 2019

Synthetic studies on indole alxaloids. A stereocontrolled entry to the cuanzine structural unit

Thiocolchicine-podophyllotoxin conjugates: dynamic libraries based on disulfide exchange reaction.

artículo científico publicado en 2006

Tools for the rational design of bivalent microtubule-targeting drugs.

artículo científico publicado en 2016

Total Synthesis of (-)-Anaferine: A Further Ramification in a Diversity-Oriented Approach

artículo científico publicado en 2020

Total enantioselective synthesis of (-)-cytisine

scientific article published on 01 February 2004

trans-6-Aminocyclohept-3-enols, a new designed polyfunctionalized chiral building block for the asymmetric synthesis of 2-substituted-4-hydroxypiperidines

artículo científico publicado en 2002

Lista de obras de Daniele Passarella

'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells.

4-(1,2-diarylbut-1-en-1-yl)isobutyranilide derivatives as inhibitors of topoisomerase II.

9-Fluorenone-2-Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds

A convenient synthesis of delta(7,8)-morphinan-6-one and its direct oxidation to 14-hydroxy-delta(7,8)-morphinan-6-one

A highly enantioselective synthesis of (−)-antirhine by chemo-enzymatic approach

A small library of chalcones induce liver cancer cell death through Akt phosphorylation inhibition

Access to Pyrrolo- and Pyrido[1,2-a]indole Derivatives by Intramolecular Nitrone Cycloadditions. Effect of Steric Factors on the Regioselective Product Formation

An efficient chemo-enzymatic approach to (+)-meroquinene

Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: cytological studies and chemical investigations. ⬇️

Aspidosperma alkaloids cyclization of secodine intermediate: Synthesis of (±)-3-oxovincadifformine ethyl ester

Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2.

Bruno Danieli (1939–2014).

Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation

Can we use the epigenetic bioactivity of caloric restriction and phytochemicals to promote healthy ageing?

Cannabidiol as the Substrate in Acid-Catalyzed Intramolecular Cyclization

Catalytic C3 aza-alkylation of indoles

Chalcone Derivatives Activate and Desensitize the Transient Receptor Potential Ankyrin 1 Cation Channel, Subfamily A, Member 1 TRPA1 Ion Channel: Structure-Activity Relationships in vitro and Anti-Nociceptive and Anti-inflammatory Activity in vivo.

Chemical approaches to targeting drug resistance in cancer stem cells.

Chiral flavanones from Amygdalus lycioides Spach: structural elucidation and identification of TNFalpha inhibitors by bioactivity-guided fractionation ⬇️

Combinatorial solid-phase synthesis of 6-hydroxy-1,2,3,4-tetrahydro-beta-carbolines from l-5-hydroxytryptophan.

Combined drug action of 2-phenylimidazo[2,1-b]benzothiazole derivatives on cancer cells according to their oncogenic molecular signatures

Comparative phytochemical and morphological analyses of three Italian Primula species

Concise total synthesis of (+/-)-aloperine and 6-epi-aloperine

Covalent Nucleoside Adducts of Aspidosperma Alkaloids

Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels

Efficient continuous flow synthesis of hydroxamic acids and suberoylanilide hydroxamic acid preparation

Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors

Enantiopure 2-piperidylacetaldehyde as a useful building block in the diversity-oriented synthesis of polycyclic piperidine derivatives

Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis

Exploiting enzymatic regioselectivity: a facile methodology for the synthesis of polyhydroxylated hybrid compounds

Farinose alpine Primula species: phytochemical and morphological investigations.

Functionalization at C-17 of an Eburnea-Aspidosperma Binary Alkaloid as a Model to Study Modified Vinblastine-type Antitumor Alkaloids

Histone deacetylase and microtubules as targets for the synthesis of releasable conjugate compounds

Histone demethylating agents as potential S-adenosyl-l-methionine-competitors

Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

Identification of new aminoacid amides containing the imidazo[2,1-b]benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling ⬇️

Microwave-assisted, solid-phase synthesis of a chiral 1,2,3,4-tetrahydro-quinoline library.

N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl.

Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers

Natural Products and Cancer Stem Cells.

Nature-inspired indolyl-2-azabicyclo[2.2.2]oct-7-ene derivatives as promising agents for the attenuation of withdrawal symptoms: synthesis of 20-desethyl-20-hydroxymethyl-11-demethoxyibogaine

New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A.

New flavonol glycosides from Aconitum burnatii Gáyer and Aconitum variegatum L.

Novel chemical probes for the investigation of nonribosomal peptide assembly.

Preparation of Fluorescent Tubulin Binders

Probing the binding site of abl tyrosine kinase using in situ click chemistry.

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

Remote stereocenter discrimination in the enzymatic resolution of piperidine-2-ethanol. Short enantioselective synthesis of sedamine and allosedamine.

Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks

Self-assembly drug conjugates for anticancer treatment

Synthesis and biological evaluation of epothilone A dimeric compounds.

Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors

Synthesis and biological evaluation of new camptothecin derivatives obtained by modification of position 20.

Synthesis and biological evaluation of novel tamoxifen analogues

Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates.

Synthesis and biological evaluation of paclitaxel-thiocolchicine hybrids

Synthesis and biological evaluation of pyrroloiminoquinone derivatives

Synthesis of (+)-dumetorine and congeners by using flow chemistry technologies

Synthesis of Pironetin-Dumetorine Hybrids as Tubulin Binders

Synthesis of Thicolchicine-Based Conjugates: Investigation towards Bivalent Tubulin/Microtubules Binders

Synthetic studies on indole alxaloids. A stereocontrolled entry to the cuanzine structural unit

Thiocolchicine-podophyllotoxin conjugates: dynamic libraries based on disulfide exchange reaction.

Tools for the rational design of bivalent microtubule-targeting drugs.

Total Synthesis of (-)-Anaferine: A Further Ramification in a Diversity-Oriented Approach

Total enantioselective synthesis of (-)-cytisine

trans-6-Aminocyclohept-3-enols, a new designed polyfunctionalized chiral building block for the asymmetric synthesis of 2-substituted-4-hydroxypiperidines