Lista de obras - Jean-Luc Villeval - Dominio Público Uruguay

A monoclonal antibody against an erythrocyte ontogenic antigen identifies fetal and adult erythroid progenitors

artículo científico publicado en 1986

A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression.

artículo científico publicado en 2013

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

artículo científico publicado en 2003

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

artículo científico publicado en 2005

Activating mutations in human acute megakaryoblastic leukemia.

artículo científico publicado en 2008

Acute myelofibrosis in megakaryoblastic leukemia with translocation between chromosomes 8 and 14

artículo científico publicado en 1987

Adenoviral-mediated TGF-beta1 inhibition in a mouse model of myelofibrosis inhibit bone marrow fibrosis development

article

Aegyptin, a novel mosquito salivary gland protein, specifically binds to collagen and prevents its interaction with platelet glycoprotein VI, integrin alpha2beta1, and von Willebrand factor

artículo científico publicado en 2007

Anti GPVI human antibodies neutralizing collagen-induced platelet aggregation isolated from a combinatorial phage display library.

artículo científico publicado en 2002

Autocrine stimulation by erythropoietin (Epo) requires Epo secretion.

artículo científico publicado en 1994

Autocrine stimulation by erythropoietin and autonomous growth of human erythroid leukemic cells in vitro

artículo científico publicado en 1991

BCR-ABL1-positive CML and BCR-ABL1-negative chronic myeloproliferative disorders: some common and contrasting features

artículo científico publicado en 2008

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

artículo científico publicado en 2015

Carbonic anhydrase I is an early specific marker of normal human erythroid differentiation

scientific article published on 01 November 1985

Changes in hemopoietic and regulator levels in mice during fatal or nonfatal malarial infections. I. Erythropoietic populations

artículo científico publicado en 1990

Characterization of phorbol esters binding to K 562 cells

artículo científico publicado en 1984

Characterization of the blast cell population in two neonates with Down's syndrome and transient myeloproliferative disorder

scientific article published on 01 May 1987

Clinical studies with granulocyte colony stimulating factor (G-CSF) in patients receiving cytotoxic chemotherapy.

artículo científico publicado en 1988

Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily

artículo científico publicado en 2000

Cloning, expression, and function of BLAME, a novel member of the CD2 family.

artículo científico publicado en 2001

Co-targeting the PI3K/mTOR and JAK2 signalling pathways produces synergistic activity against myeloproliferative neoplasms

artículo científico publicado en 2013

Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors

artículo científico publicado en 2013

Comparison of endothelial promoter efficiency and specificity in mice reveals a subset of Pdgfb-positive hematopoietic cells

scientific article published on 24 March 2019

Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineage.

artículo científico publicado en 2008

Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis.

artículo científico publicado en 1996

Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis

scientific article published on 01 August 2007

Detection of cells of megakaryocyte lineage in haematological malignancies by immuno-alkaline phosphatase labelling cell smears with a panel of monoclonal antibodies

artículo científico publicado en 1987

Distinct effects of the soluble versus membrane-bound forms of the notch ligand delta-4 on human CD34+CD38low cell expansion and differentiation

artículo científico publicado en 2007

Early clinical trials with colony-stimulating factors.

artículo científico

Early erythroid markers as probes for normal and leukaemic erythroid differentiation

artículo científico publicado en 1987

Early expression of glycophorin C during normal and leukemic human erythroid differentiation

artículo científico publicado en 1989

Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease.

artículo científico publicado en 2002

Effect of recombinant human granulocyte-macrophage colony stimulating factor on progenitor cells in patients with advanced malignancies

artículo científico publicado en 1990

Effects of granulocyte-macrophage colony-stimulating factor and erythropoietin on leukemic erythroid colony formation in human early erythroblastic leukemias

scientific article published on 01 October 1987

Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients

artículo científico publicado en 1988

Endothelial-to-Mesenchymal Transition in Bone Marrow and Spleen of Primary Myelofibrosis.

artículo científico

Erythroid properties of K562 cells. Effect of hemin, butyrate and TPA induction

scientific article published on 01 July 1983

Erythropoietin gene transfer and expression in adult normal mice: use of an adenovirus vector

artículo científico publicado en 1994

Expression and function of the collagen receptor GPVI during megakaryocyte maturation.

artículo científico publicado en 2001

Expression of a foreign protein in human megakaryocytes and platelets by retrovirally mediated gene transfer.

artículo científico publicado en 1999

Expression of blood group A antigen during erythroid differentiation in A1 and A2 subjects

artículo científico publicado en 1987

Expression of osteoprotegerin mRNA and protein in murine megakaryocytes

scientific article published on 01 November 2003

Expression of platelet glycoproteins by erythroid blasts in four cases of trisomy 21

Fatal polycythemia induced in mice by dysregulated erythropoietin production by hematopoietic cells

artículo científico publicado en 1992

HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis.

artículo científico publicado en 2018

Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2.

artículo científico publicado en 2000

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm

artículo científico publicado en 2014

High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice

scientific article published on 01 December 1997

Human platelet alpha granules contain a nonspecific inhibitor of megakaryocyte colony formation: its relationship to type beta transforming growth factor (TGF-beta)

artículo científico publicado en 1988

Human platelet glycoprotein VI function is antagonized by monoclonal antibody-derived Fab fragments

artículo científico publicado en 2003

Identification of residues within human glycoprotein VI involved in the binding to collagen: evidence for the existence of distinct binding sites.

artículo científico publicado en 2004

Immunophenotype of leukemic blasts with small peroxidase-positive granules detected by electron microscopy

artículo científico publicado en 1988

Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation in JAK2V617F mutated cells through PP2A/CIP2A axis

artículo científico publicado en 2017

JAK2 inhibition has different therapeutic effects according to myeloproliferative neoplasm development in mice

artículo científico publicado en 2015

JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.

artículo científico publicado en 2008

JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα.

artículo científico publicado en 2013

JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.

artículo científico publicado en 2006

JAK2V⁶¹⁷F/TET2 mutations: does the order matter?

artículo científico publicado en 2011

Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity

artículo científico publicado en 2009

Limits of phenotypic markers for the diagnosis of megakaryoblastic leukemia

scientific article published on 01 January 1989

Major effects of TPO delivered by a single injection of a recombinant adenovirus on prevention of septicemia and anemia associated with myelosuppression in mice: risk of sustained expression inducing myelofibrosis due to immunosuppression

artículo científico publicado en 1998

Monocyte/macrophage dysfunctions do not impair the promotion of myelofibrosis by high levels of thrombopoietin

artículo científico publicado en 2006

Mpl ligand (thrombopoietin) and platelet regulation

artículo científico publicado en 1996

Mpl ligand or thrombopoietin: biological activities.

artículo científico publicado en 1998

Mutations in JAK2V617F homologous domain of JAK genes are uncommon in solid tumors

article

Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice.

artículo científico publicado en 2010

New insights into the pathogenesis of JAK2 V617F-positive myeloproliferative disorders and consequences for the management of patients.

artículo científico publicado en 2006

Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation.

artículo científico publicado en 2010

Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia.

artículo científico publicado en 2006

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia

scientific article published on 29 October 2019

Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2.

artículo científico publicado en 1999

Phenotype of early erythroblastic leukemias

artículo científico publicado en 1986

Platelet activation induces metalloproteinase-dependent GP VI cleavage to down-regulate platelet reactivity to collagen

scientific article published on 31 August 2004

Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice.

artículo científico publicado en 2007

Rare type 1-like and type 2-like calreticulin mutants induce similar myeloproliferative neoplasms as prevalent type 1 and 2 mutants in mice

artículo científico publicado en 2018

Regulation of megakaryocytopoiesis and platelet production: lessons from animal models.

artículo científico publicado en 1998

Retrovirus-mediated transfer of the erythropoietin gene in hematopoietic cells improves the erythrocyte phenotype in murine beta-thalassemia.

artículo científico publicado en 1994

Selective reduction of JAK2V617F-dependent cell growth by siRNA/shRNA and its reversal by cytokines.

artículo científico publicado en 2009

The cell cycle regulator CDC25A is a target for JAK2V617F oncogene.

artículo científico publicado en 2011

Thrombopoietin (TPO) knockout phenotype induced by cross-reactive antibodies against TPO following injection of mice with recombinant adenovirus encoding human TPO.

artículo científico publicado en 1998

Thrombopoietin does not induce lineage-restricted commitment of Mpl-R expressing pluripotent progenitors but permits their complete erythroid and megakaryocytic differentiation.

artículo científico publicado en 1997

Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes

scientific article published on 29 February 2012

Thrombospondin-1 is not the major activator of TGF-β1 in thrombopoietin-induced myelofibrosis

artículo científico publicado en 2010

Ultrastructural and cytochemical characterization of blasts from early erythroblastic leukemias

artículo científico publicado en 1987

Use of the 46/1 haplotype to model JAK2(V617F) clonal architecture in PV patients: clonal evolution and impact of IFNα treatment.

artículo científico publicado en 2013

Vascular endothelial cell expression of JAK2 is sufficient to promote a pro-thrombotic state due to increased P-selectin expression

artículo científico publicado en 2018

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

artículo científico publicado en 2007

[Physiopathologic and therapeutic importance of animal models of hemoglobinopathies]

scientific article published on 01 June 1993

p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging

artículo científico publicado en 2014

Lista de obras de Jean-Luc Villeval

A monoclonal antibody against an erythrocyte ontogenic antigen identifies fetal and adult erythroid progenitors

A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression.

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

Activating mutations in human acute megakaryoblastic leukemia.

Acute myelofibrosis in megakaryoblastic leukemia with translocation between chromosomes 8 and 14

Adenoviral-mediated TGF-beta1 inhibition in a mouse model of myelofibrosis inhibit bone marrow fibrosis development

Aegyptin, a novel mosquito salivary gland protein, specifically binds to collagen and prevents its interaction with platelet glycoprotein VI, integrin alpha2beta1, and von Willebrand factor

Anti GPVI human antibodies neutralizing collagen-induced platelet aggregation isolated from a combinatorial phage display library.

Autocrine stimulation by erythropoietin (Epo) requires Epo secretion.

Autocrine stimulation by erythropoietin and autonomous growth of human erythroid leukemic cells in vitro

BCR-ABL1-positive CML and BCR-ABL1-negative chronic myeloproliferative disorders: some common and contrasting features

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

Carbonic anhydrase I is an early specific marker of normal human erythroid differentiation

Changes in hemopoietic and regulator levels in mice during fatal or nonfatal malarial infections. I. Erythropoietic populations

Characterization of phorbol esters binding to K 562 cells

Characterization of the blast cell population in two neonates with Down's syndrome and transient myeloproliferative disorder

Clinical studies with granulocyte colony stimulating factor (G-CSF) in patients receiving cytotoxic chemotherapy.

Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily

Cloning, expression, and function of BLAME, a novel member of the CD2 family.

Co-targeting the PI3K/mTOR and JAK2 signalling pathways produces synergistic activity against myeloproliferative neoplasms

Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors

Comparison of endothelial promoter efficiency and specificity in mice reveals a subset of Pdgfb-positive hematopoietic cells

Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineage.

Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis.

Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis

Detection of cells of megakaryocyte lineage in haematological malignancies by immuno-alkaline phosphatase labelling cell smears with a panel of monoclonal antibodies

Distinct effects of the soluble versus membrane-bound forms of the notch ligand delta-4 on human CD34+CD38low cell expansion and differentiation

Early clinical trials with colony-stimulating factors.

Early erythroid markers as probes for normal and leukaemic erythroid differentiation

Early expression of glycophorin C during normal and leukemic human erythroid differentiation

Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease.

Effect of recombinant human granulocyte-macrophage colony stimulating factor on progenitor cells in patients with advanced malignancies

Effects of granulocyte-macrophage colony-stimulating factor and erythropoietin on leukemic erythroid colony formation in human early erythroblastic leukemias

Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients

Endothelial-to-Mesenchymal Transition in Bone Marrow and Spleen of Primary Myelofibrosis.

Erythroid properties of K562 cells. Effect of hemin, butyrate and TPA induction

Erythropoietin gene transfer and expression in adult normal mice: use of an adenovirus vector

Expression and function of the collagen receptor GPVI during megakaryocyte maturation.

Expression of a foreign protein in human megakaryocytes and platelets by retrovirally mediated gene transfer.

Expression of blood group A antigen during erythroid differentiation in A1 and A2 subjects

Expression of osteoprotegerin mRNA and protein in murine megakaryocytes

Expression of platelet glycoproteins by erythroid blasts in four cases of trisomy 21

Fatal polycythemia induced in mice by dysregulated erythropoietin production by hematopoietic cells

HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis.

Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2.

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm

High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice

Human platelet alpha granules contain a nonspecific inhibitor of megakaryocyte colony formation: its relationship to type beta transforming growth factor (TGF-beta)

Human platelet glycoprotein VI function is antagonized by monoclonal antibody-derived Fab fragments

Identification of residues within human glycoprotein VI involved in the binding to collagen: evidence for the existence of distinct binding sites.

Immunophenotype of leukemic blasts with small peroxidase-positive granules detected by electron microscopy

Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation in JAK2V617F mutated cells through PP2A/CIP2A axis

JAK2 inhibition has different therapeutic effects according to myeloproliferative neoplasm development in mice

JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.

JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα.

JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.

JAK2V⁶¹⁷F/TET2 mutations: does the order matter?

Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity

Limits of phenotypic markers for the diagnosis of megakaryoblastic leukemia

Major effects of TPO delivered by a single injection of a recombinant adenovirus on prevention of septicemia and anemia associated with myelosuppression in mice: risk of sustained expression inducing myelofibrosis due to immunosuppression

Monocyte/macrophage dysfunctions do not impair the promotion of myelofibrosis by high levels of thrombopoietin

Mpl ligand (thrombopoietin) and platelet regulation

Mpl ligand or thrombopoietin: biological activities.

Mutations in JAK2V617F homologous domain of JAK genes are uncommon in solid tumors

Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice.

New insights into the pathogenesis of JAK2 V617F-positive myeloproliferative disorders and consequences for the management of patients.

Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation.

Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia.

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia

Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2.

Phenotype of early erythroblastic leukemias

Platelet activation induces metalloproteinase-dependent GP VI cleavage to down-regulate platelet reactivity to collagen

Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice.

Rare type 1-like and type 2-like calreticulin mutants induce similar myeloproliferative neoplasms as prevalent type 1 and 2 mutants in mice

Regulation of megakaryocytopoiesis and platelet production: lessons from animal models.

Retrovirus-mediated transfer of the erythropoietin gene in hematopoietic cells improves the erythrocyte phenotype in murine beta-thalassemia.

Selective reduction of JAK2V617F-dependent cell growth by siRNA/shRNA and its reversal by cytokines.

The cell cycle regulator CDC25A is a target for JAK2V617F oncogene.