Lista de obras - Peter Buchwald - Dominio Público Uruguay

A general bilinear model to describe growth or decline time profiles

artículo científico publicado en 2006

A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets

artículo científico publicado en 2011

A simple, predictive, structure-based skin permeability model.

artículo científico publicado en 2001

A three-parameter two-state model of receptor function that incorporates affinity, efficacy, and signal amplification

artículo científico publicado en 2017

Activity-limiting role of molecular size: size-dependency of maximum activity for P450 inhibition as revealed by qHTS data.

artículo científico publicado en 2014

An Open-Label, Single-Dose, Crossover Study of the Pharmacokinetics and Metabolism of Two Oral Formulations of 1-Octanol in Patients with Essential Tremor ⬇️

artículo científico publicado el 1 de octubre de 2011

Attempts of ranking in a series of synthetic nonpsychotropic cannabinoids

artículo científico publicado en 2001

Barriers to remember: brain-targeting chemical delivery systems and Alzheimer's disease.

artículo científico publicado en 2002

Bilinear Model for the Size-Dependency of the CYP3A4 Inhibitory Activity of Structurally Diverse Compounds

artículo científico publicado en 2013

Biphasic decline of β-cell function with age in euglycemic nonobese diabetic mice parallels diabetes onset

artículo científico publicado en 2015

Brain-Targeted Delivery of Estradiol

Brain-Targeting Chemical Delivery Systems and Their Cyclodextrin-Based Formulations in Light of the Contributions of Marcus E. Brewster.

artículo científico publicado en 2016

CD40-targeting KGYY15 peptides do not efficiently block the CD40-CD40L interaction

scientific article published on 09 September 2019

Cell length growth in fission yeast: an analysis of its bilinear character and the nature of its rate change transition

artículo científico publicado en 2013

Cell length growth patterns in fission yeast reveal a novel size control mechanism operating in late G2 phase

artículo científico publicado en 2016

Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours

artículo científico publicado en 2015

Choice of immunosuppression influences cytomegalovirus DNAemia in cynomolgus monkey (Macaca fascicularis) islet allograft recipients

artículo científico publicado en 2010

Comprehensive Metabolomics Study To Assess Longitudinal Biochemical Changes and Potential Early Biomarkers in Nonobese Diabetic Mice That Progress to Diabetes

artículo científico publicado en 2017

Computer-aided retrometabolic drug design: soft drugs ⬇️

artículo científico publicado el 1 de julio de 2007

Computer-assisted design of new drugs based on retrometabolic concepts.

artículo científico publicado en 1998

Controlled Release of Dexamethasone from Organosilicone Constructs for Local Modulation of Inflammation in Islet Transplantation

artículo científico publicado en 2015

Corticosteroid design for the treatment of asthma: structural insights and the therapeutic potential of soft corticosteroids

artículo científico publicado en 2006

Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40⁻CD154 Costimulatory Protein-Protein Interaction

artículo científico publicado en 2018

Designing safer (soft) drugs by avoiding the formation of toxic and oxidative metabolites.

artículo científico publicado en 2004

Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids.

artículo científico publicado en 2006

Drug targeting by retrometabolic design: soft drugs and chemical delivery systems ⬇️

artículo científico publicado el 1 de mayo de 2001

Drug targeting via retrometabolic approaches

artículo científico publicado en 1997

Effective and specific inhibition of the CD40-CD154 costimulatory interaction by a naphthalenesulphonic acid derivative

artículo científico publicado en 2010

Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cells

artículo científico publicado en 2014

Experimental evaluation and computational modeling of the effects of encapsulation on the time-profile of glucose-stimulated insulin release of pancreatic islets

artículo científico publicado en 2015

FEM-based oxygen consumption and cell viability models for avascular pancreatic islets.

artículo científico publicado en 2009

Feasibility of Localized Metabolomics in the Study of Pancreatic Islets and Diabetes

scientific article published on 29 September 2019

Glucocorticoid receptor binding: a biphasic dependence on molecular size as revealed by the bilinear LinBiExp model

artículo científico publicado en 2007

Glucose-stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets.

artículo científico publicado en 2017

High-throughput screening for human galactokinase inhibitors

artículo científico publicado en 2008

In vitro and in vivo evaluations of dihydroquinoline- and dihydroisoquinoline-based targetor moieties for brain-specific chemical delivery systems

artículo científico publicado en 2002

Influence of the N-acetylation polymorphism on the metabolism of talampanel: an investigation in fasted and fed subjects genotyped for NAT2 variants.

artículo científico publicado en 2006

Is there a universal rule for cellular growth?--Problems in studying and interpreting this phenomenon

artículo científico publicado en 2014

Local delivery of fingolimod from three-dimensional scaffolds impacts islet graft efficacy and microenvironment in a murine diabetic model

artículo científico publicado en 2017

Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets

artículo científico publicado en 2017

Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gbeta(5)-RGS7.

artículo científico publicado en 2010

Novel, cell-penetrating molecular transporters with flexible backbones and permanently charged side-chains

artículo científico publicado en 2007

Octanol-water partition of nonzwitterionic peptides: predictive power of a molecular size-based model

artículo científico publicado en 1998

Ophthalmic drug design based on the metabolic activity of the eye: soft drugs and chemical delivery systems.

artículo científico publicado en 2005

Organic dyes as small molecule protein-protein interaction inhibitors for the CD40-CD154 costimulatory interaction.

artículo científico publicado en 2010

Oscillatory dynamics of Cdc42 GTPase in the control of polarized growth. ⬇️

artículo científico publicado en 2012

Pharmacokinetic and pharmacodynamic evaluations of the zwitterionic metabolite of a new series of N-substituted soft anticholinergics

artículo científico publicado en 2005

Pharmacokinetics and delta1-cortienic acid excretion after intravenous administration of prednisolone and loteprednol etabonate in rats.

artículo científico publicado en 2010

Pharmacokinetics of the sequential metabolites of loteprednol etabonate in rats

artículo científico publicado en 2008

Pharmacological effects of some newly developed soft anticholinergics and a receptor-binding QSAR study.

artículo científico publicado en 2006

Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis

artículo científico publicado en 2015

Quantification of the islet product: presentation of a standardized current good manufacturing practices compliant system with minimal variability

artículo científico publicado en 2011

Quantitative assessment of islet cell products: estimating the accuracy of the existing protocol and accounting for islet size distribution.

artículo científico publicado en 2009

RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells

artículo científico publicado en 2022

Recent advances in retrometabolic drug design (RMDD) and development.

artículo científico publicado en 2010

Recent advances in the design and development of soft drugs

artículo científico publicado en 2014

Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets.

artículo científico publicado en 2017

Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction

artículo científico publicado en 2017

Small-molecule costimulatory blockade: organic dye inhibitors of the CD40-CD154 interaction

artículo científico publicado en 2009

Small-molecule modulators of the OX40-OX40 ligand co-stimulatory protein-protein interaction

artículo científico publicado en 2014

Small-molecule protein-protein interaction inhibitors: therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations.

artículo científico publicado en 2010

Soft corticosteroids for local immunosuppression: exploring the possibility for the use of loteprednol etabonate for islet transplantation

artículo científico publicado en 2008

Soft drugs: design principles, success stories, and future perspectives

artículo científico publicado en 2020

Soft quaternary anticholinergics: comprehensive quantitative structure-activity relationship (QSAR) with a linearized biexponential (LinBiExp) model

artículo científico publicado en 2006

Structural studies on the chiral selector capacity of cyclodextrin derivatives

artículo científico publicado en 2008

Structure-metabolism relationships: steric effects and the enzymatic hydrolysis of carboxylic esters.

artículo científico publicado en 2001

Suramin inhibits the CD40-CD154 costimulatory interaction: a possible mechanism for immunosuppressive effects

artículo científico publicado en 2009

Synthesis and pharmacological effects of new, N-substituted soft anticholinergics based on glycopyrrolate.

artículo científico publicado en 2005

The Effect of Recovery Warm-up Time Following Cold Storage on the Dynamic Glucose-stimulated Insulin Secretion of Isolated Human Islets

artículo científico publicado en 2020

The food colorant erythrosine is a promiscuous protein-protein interaction inhibitor

artículo científico publicado en 2011

The promiscuous protein binding ability of erythrosine B studied by metachromasy (metachromasia).

artículo científico publicado en 2013

The quantitative characterization of free radical sources and traps by electromigration applications.

artículo científico publicado en 2008

Unified pharmacogenetics-based parent-metabolite pharmacokinetic model incorporating acetylation polymorphism for talampanel in humans

artículo científico publicado en 2005

Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer

artículo científico publicado en 2016

Lista de obras de Peter Buchwald

A general bilinear model to describe growth or decline time profiles

A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets

A simple, predictive, structure-based skin permeability model.

A three-parameter two-state model of receptor function that incorporates affinity, efficacy, and signal amplification

Activity-limiting role of molecular size: size-dependency of maximum activity for P450 inhibition as revealed by qHTS data.

An Open-Label, Single-Dose, Crossover Study of the Pharmacokinetics and Metabolism of Two Oral Formulations of 1-Octanol in Patients with Essential Tremor ⬇️

Attempts of ranking in a series of synthetic nonpsychotropic cannabinoids

Barriers to remember: brain-targeting chemical delivery systems and Alzheimer's disease.

Bilinear Model for the Size-Dependency of the CYP3A4 Inhibitory Activity of Structurally Diverse Compounds

Biphasic decline of β-cell function with age in euglycemic nonobese diabetic mice parallels diabetes onset

Brain-Targeted Delivery of Estradiol

Brain-Targeting Chemical Delivery Systems and Their Cyclodextrin-Based Formulations in Light of the Contributions of Marcus E. Brewster.

CD40-targeting KGYY15 peptides do not efficiently block the CD40-CD40L interaction

Cell length growth in fission yeast: an analysis of its bilinear character and the nature of its rate change transition

Cell length growth patterns in fission yeast reveal a novel size control mechanism operating in late G2 phase

Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours

Choice of immunosuppression influences cytomegalovirus DNAemia in cynomolgus monkey (Macaca fascicularis) islet allograft recipients

Comprehensive Metabolomics Study To Assess Longitudinal Biochemical Changes and Potential Early Biomarkers in Nonobese Diabetic Mice That Progress to Diabetes

Computer-aided retrometabolic drug design: soft drugs ⬇️

Computer-assisted design of new drugs based on retrometabolic concepts.

Controlled Release of Dexamethasone from Organosilicone Constructs for Local Modulation of Inflammation in Islet Transplantation

Corticosteroid design for the treatment of asthma: structural insights and the therapeutic potential of soft corticosteroids

Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40⁻CD154 Costimulatory Protein-Protein Interaction

Designing safer (soft) drugs by avoiding the formation of toxic and oxidative metabolites.

Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids.

Drug targeting by retrometabolic design: soft drugs and chemical delivery systems ⬇️

Drug targeting via retrometabolic approaches

Effective and specific inhibition of the CD40-CD154 costimulatory interaction by a naphthalenesulphonic acid derivative

Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cells

Experimental evaluation and computational modeling of the effects of encapsulation on the time-profile of glucose-stimulated insulin release of pancreatic islets

FEM-based oxygen consumption and cell viability models for avascular pancreatic islets.

Feasibility of Localized Metabolomics in the Study of Pancreatic Islets and Diabetes

Glucocorticoid receptor binding: a biphasic dependence on molecular size as revealed by the bilinear LinBiExp model

Glucose-stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets.

High-throughput screening for human galactokinase inhibitors

In vitro and in vivo evaluations of dihydroquinoline- and dihydroisoquinoline-based targetor moieties for brain-specific chemical delivery systems

Influence of the N-acetylation polymorphism on the metabolism of talampanel: an investigation in fasted and fed subjects genotyped for NAT2 variants.

Is there a universal rule for cellular growth?--Problems in studying and interpreting this phenomenon

Local delivery of fingolimod from three-dimensional scaffolds impacts islet graft efficacy and microenvironment in a murine diabetic model

Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets

Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gbeta(5)-RGS7.

Novel, cell-penetrating molecular transporters with flexible backbones and permanently charged side-chains

Octanol-water partition of nonzwitterionic peptides: predictive power of a molecular size-based model

Ophthalmic drug design based on the metabolic activity of the eye: soft drugs and chemical delivery systems.

Organic dyes as small molecule protein-protein interaction inhibitors for the CD40-CD154 costimulatory interaction.

Oscillatory dynamics of Cdc42 GTPase in the control of polarized growth. ⬇️

Pharmacokinetic and pharmacodynamic evaluations of the zwitterionic metabolite of a new series of N-substituted soft anticholinergics

Pharmacokinetics and delta1-cortienic acid excretion after intravenous administration of prednisolone and loteprednol etabonate in rats.

Pharmacokinetics of the sequential metabolites of loteprednol etabonate in rats

Pharmacological effects of some newly developed soft anticholinergics and a receptor-binding QSAR study.

Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis

Quantification of the islet product: presentation of a standardized current good manufacturing practices compliant system with minimal variability

Quantitative assessment of islet cell products: estimating the accuracy of the existing protocol and accounting for islet size distribution.

RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells

Recent advances in retrometabolic drug design (RMDD) and development.

Recent advances in the design and development of soft drugs

Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets.

Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction

Small-molecule costimulatory blockade: organic dye inhibitors of the CD40-CD154 interaction

Small-molecule modulators of the OX40-OX40 ligand co-stimulatory protein-protein interaction

Small-molecule protein-protein interaction inhibitors: therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations.

Soft corticosteroids for local immunosuppression: exploring the possibility for the use of loteprednol etabonate for islet transplantation

Soft drugs: design principles, success stories, and future perspectives

Soft quaternary anticholinergics: comprehensive quantitative structure-activity relationship (QSAR) with a linearized biexponential (LinBiExp) model

Structural studies on the chiral selector capacity of cyclodextrin derivatives

Structure-metabolism relationships: steric effects and the enzymatic hydrolysis of carboxylic esters.

Suramin inhibits the CD40-CD154 costimulatory interaction: a possible mechanism for immunosuppressive effects

Synthesis and pharmacological effects of new, N-substituted soft anticholinergics based on glycopyrrolate.

The Effect of Recovery Warm-up Time Following Cold Storage on the Dynamic Glucose-stimulated Insulin Secretion of Isolated Human Islets

The food colorant erythrosine is a promiscuous protein-protein interaction inhibitor

The promiscuous protein binding ability of erythrosine B studied by metachromasy (metachromasia).

The quantitative characterization of free radical sources and traps by electromigration applications.

Unified pharmacogenetics-based parent-metabolite pharmacokinetic model incorporating acetylation polymorphism for talampanel in humans

Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer