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Lista de obras de Mark W. Kieran

A POETIC Phase II study of continuous oral everolimus in recurrent, radiographically progressive pediatric low-grade glioma

artículo científico publicado en 2020

A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation-Positive Solid Tumors

scientific article published on 10 September 2019

A Phase II Study of Continuous Oral mTOR Inhibitor Everolimus for Recurrent, Radiographic-Progressive Neurofibromatosis Type 1-Associated Pediatric Low-Grade Glioma: A Neurofibromatosis Clinical Trials Consortium Study

artículo científico publicado en 2020

A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas.

artículo científico publicado en 2017

A feasibility trial of antiangiogenic (metronomic) chemotherapy in pediatric patients with recurrent or progressive cancer

artículo científico publicado en 2005

A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.

artículo científico publicado en 2014

A monoclonal antibody against chicken MHC class I (B-F) antigens

artículo científico publicado en 1985

A multi-disciplinary consensus statement concerning surgical approaches to low-grade, high-grade astrocytomas and diffuse intrinsic pontine gliomas in childhood (CPN Paris 2011) using the Delphi method

artículo científico publicado en 2013

A novel GIT2-BRAF fusion in pilocytic astrocytoma.

artículo científico publicado en 2017

A novel method for rapid molecular subgrouping of medulloblastoma.

artículo científico publicado en 2018

A pediatric trial of radiation/cetuximab followed by irinotecan/cetuximab in newly diagnosed diffuse pontine gliomas and high-grade astrocytomas: A Pediatric Oncology Experimental Therapeutics Investigators' Consortium study.

artículo científico publicado en 2017

A phase I and biology study of gefitinib and radiation in children with newly diagnosed brain stem gliomas or supratentorial malignant gliomas

artículo científico publicado en 2010

A phase I trial and PK study of cediranib (AZD2171), an orally bioavailable pan-VEGFR inhibitor, in children with recurrent or refractory primary CNS tumors

artículo científico publicado en 2015

A phase I trial of etanidazole and hyperfractionated radiotherapy in children with diffuse brainstem glioma

artículo científico publicado en 2003

A phase II trial of a multi-agent oral antiangiogenic (metronomic) regimen in children with recurrent or progressive cancer.

artículo científico publicado en 2013

A phase-1 pharmacokinetic optimal dosing study of intraventricular topotecan for children with neoplastic meningitis: a Pediatric Brain Tumor Consortium study

artículo científico publicado en 2012

A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase

artículo científico publicado en 2006

A prospective phase II trial of vinblastine and methotrexate in multivessel intraluminal pulmonary vein stenosis in infants and children

artículo científico publicado en 2011

A prospective study of radiographic manifestations in Hutchinson-Gilford progeria syndrome

artículo científico publicado en 2012

A prospective, blinded analysis of A-PROTEIN (recoverin or CAR protein) levels in pediatric patients with central nervous system tumors

artículo científico publicado en 2009

A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo

artículo científico publicado en 2011

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.

artículo científico publicado en 2003

AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant glioma

artículo científico publicado en 2006

ACCELERATE and European Medicines Agency Paediatric Strategy Forum for medicinal product development of checkpoint inhibitors for use in combination therapy in paediatric patients

scientific article published on 24 January 2020

Absence of oncogenic canonical pathway mutations in aggressive pediatric rhabdoid tumors.

artículo científico publicado en 2012

Adjunct Targeted Biologic Inhibition Agents to Treat Aggressive Multivessel Intraluminal Pediatric Pulmonary Vein Stenosis.

artículo científico publicado en 2018

Advances in pediatric neuro-oncology.

artículo científico publicado en 2000

An international study evaluating the epidemiology of intracranial germ cell tumors in the native versus immigrant Japanese populations: the need for an international registry

artículo científico publicado en 2022

Angiogenesis inhibitors and hypoxia

artículo científico publicado en 2003

Anti-angiogenic therapy in pediatric neuro-oncology.

artículo científico publicado en 2005

Anti-apoptosis mechanisms in malignant gliomas.

artículo científico publicado en 2008

Antiangiogenic (metronomic) chemotherapy for brain tumors: current and future perspectives.

artículo científico publicado en 2009

Antiangiogenic metronomic therapy for children with recurrent embryonal brain tumors

artículo científico publicado en 2011

Aspirin-triggered proresolving mediators stimulate resolution in cancer

artículo científico publicado en 2019

Association of Lonafarnib Treatment vs No Treatment With Mortality Rate in Patients With Hutchinson-Gilford Progeria Syndrome.

artículo científico publicado en 2018

Association of rapidly progressive moyamoya syndrome with bevacizumab treatment for glioblastoma in a child with neurofibromatosis type 1.

artículo científico publicado en 2010

Automated Processing of Dynamic Contrast-Enhanced MRI: Correlation of Advanced Pharmacokinetic Metrics with Tumor Grade in Pediatric Brain Tumors.

artículo científico publicado en 2016

BET bromodomain inhibition of MYC-amplified medulloblastoma.

artículo científico publicado en 2013

Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth.

artículo científico publicado en 2008

Biological modification strategies following marrow ablative, high-dose chemotherapy (HDCT) with autologous hematopoietic stem cell rescue (AHSCR) for pediatric brain tumors.

artículo científico publicado en 2010

Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summary.

artículo científico publicado en 2003

Biopsy for diffuse intrinsic pontine glioma: a reappraisal

artículo científico publicado en 2016

Bone density in post-pubertal adolescent survivors of childhood brain tumors.

artículo científico publicado en 2011

Brain tumors: from childhood through adolescence into adulthood

scientific article published on 10 May 2010

Brainstem lesions in neurofibromatosis type 1.

artículo científico publicado en 2007

CRAN-11. MULTIPLEXED IMMUNOFLUORESCENCE REVEALS POTENTIAL PD-1/PD-L1 PATHWAY VULNERABILITIES IN CRANIOPHARYNGIOMA

Cardiac Abnormalities in Patients With Hutchinson-Gilford Progeria Syndrome.

artículo científico publicado en 2018

Central Versus Extraventricular Neurocytoma in Children: A Clinicopathologic Comparison and Review of the Literature

artículo científico publicado en 2016

Challenges to curing primary brain tumours

scientific article published on 01 August 2019

Challenges with defining response to antitumor agents in pediatric neuro-oncology: A report from the response assessment in pediatric neuro-oncology (RAPNO) working group

article

Characteristics of children ≤36 months of age with DIPG: A report from the international DIPG registry

scientific article published in 2022

Chemotherapy for progressive low-grade gliomas in children older than ten years: the Dana-Farber experience

artículo científico publicado en 2003

Chemotherapy-generated cell debris stimulates colon carcinoma tumor growth via osteopontin

artículo científico publicado en 2018

Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome

artículo científico publicado en 2016

Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: A population-based study

artículo científico publicado en 2016

Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.

artículo científico publicado en 2017

Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome

artículo científico publicado en 2012

Clinical, Pathological, and Molecular Characterization of Infant Medulloblastomas Treated with Sequential High-Dose Chemotherapy

artículo científico publicado en 2016

Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.

artículo científico publicado en 2018

Clinicopathologic study of glioblastoma in children with neurofibromatosis type 1.

artículo científico publicado en 2010

Concomitant Use of Panobinostat and Reirradiation in Progressive DIPG: Report of 2 Cases

artículo científico publicado en 2017

Continuous remission of newly diagnosed and relapsed central nervous system atypical teratoid/rhabdoid tumor

artículo científico publicado en 2005

Contribution of bone microenvironment to leukemogenesis and leukemia progression

artículo científico publicado en 2009

Contributors

Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples

Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples.

artículo científico publicado en 2010

Correlation of erythrocytic peripheral blood chimaerism and putative bone marrow precursors bearing erythroid differentiation (B-G) antigens using monoclonal antibodies immobilized on fluorescent latex spheres

artículo científico publicado en 1984

Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma

artículo científico publicado en 2011

Cutaneous reactions to targeted therapies in children with CNS tumors: A cross-sectional study

scientific article published on 28 February 2019

Cutaneovisceral angiomatosis with thrombocytopenia

artículo científico publicado en 2005

DIPG-02. TRANSLATIONAL MR IMAGING CORRELATES FOR MOLECULAR ANALYSES IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

artículo científico publicado en 2019

DIPG-06. REDEFINING THE CELLULAR ARCHITECTURE OF DIFFUSE MIDLINE GLIOMAS WITH H3 K27M MUTATIONS THROUGH LARGE-SCALE SINGLE-CELL ANALYSES.

artículo científico publicado en 2017

DIPG-29. GENOMIC LANDSCAPE OF DIFFUSE INTRINSIC PONTINE GLIOMA: AN ANALYSIS OF THE DIPG-BATS COHORT.

artículo científico publicado en 2017

DIPG-39. UNCOUPLING CAR T CELL RECOGNITION FROM TUMOR KILLING FOR DIPG THERAPY.

artículo científico publicado en 2018

DIPG-69. CHARACTERISTICS OF PATIENTS ≥ 10 YEARS OF AGE WITH DIFFUSE INTRINSIC PONTINE GLIOMA: A REPORT FROM THE INTERNATIONAL DIPG REGISTRY

DIPG-70. CLINICAL, RADIOLOGICAL, PATHOLOGICAL AND MOLECULAR CHARACTERISTICS OF CHILDREN <3 YEARS WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG): A REPORT FROM THE INTERNATIONAL DIPG REGISTRY

DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues

artículo científico publicado en 2012

DTI assessment of the brainstem white matter tracts in pediatric BSG before and after therapy: a report from the Pediatric Brain Tumor Consortium.

artículo científico publicado en 2010

Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas.

artículo científico publicado en 2011

Development of a parent-report cognitive function item bank using item response theory and exploration of its clinical utility in computerized adaptive testing

artículo científico publicado en 2011

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.

artículo científico publicado en 2018

Diencephalic syndrome: a cause of failure to thrive and a model of partial growth hormone resistance.

artículo científico publicado en 2005

Differences in molecular genetics between pediatric and adult malignant astrocytomas: age matters.

artículo científico publicado en 2012

Differences in vasculature between pilocytic and anaplastic astrocytomas of childhood

artículo científico publicado en 2003

Diffuse intrinsic pontine glioma: a reassessment

artículo científico

Disease progression in Hutchinson-Gilford progeria syndrome: impact on growth and development.

artículo científico publicado en 2007

Disseminated glioneuronal tumors occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation.

artículo científico publicado en 2016

Distinct patterns of primary and motile cilia in Rathke's cleft cysts and craniopharyngioma subtypes

artículo científico publicado en 2016

Don't throw out the baby with the bathwater!

artículo científico publicado en 2005

Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis

artículo científico publicado en 2014

EPIDEMIOLOGY

scholarly article by A. P.-Y. Liu et al published 1 June 2014 in Neuro-Oncology

EPN-14PEDIATRIC EPENDYMOMA: MULTI-INSTITUTIONAL EXPERIENCE REVEALS POOR LONG-TERM OVERALL SURVIVAL DESPITE FAVORABLE FIVE-YEAR OUTCOMES.

artículo científico publicado en 2016

EPT-14PHASE I STUDY OF GENE MEDIATED CYTOTOXIC IMMUNOTHERAPY WITH AdV-tk AS ADJUVANT TO SURGERY AND RADIATION THERAPY FOR PEDIATRIC MALIGNANT GLIOMA AND RECURRENT EPENDYMOMA.

artículo científico publicado en 2016

EPT-20CLINICAL TARGETED EXOME-BASED SEQUENCING IN COMBINATION WITH GENOME WIDE COPY NUMBER PROFILING: A CLIA CERTIFIED APPROACH FOR PRECISION MEDICINE IN 203 PEDIATRIC BRAIN TUMOR PATIENTS.

artículo científico publicado en 2016

Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation-Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study

artículo científico publicado en 2019

Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells

artículo científico publicado en 2008

Epigenetics in clinical management of children and adolescents with brain tumors

artículo científico publicado en 2017

Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis

artículo científico publicado en 2013

Epoxyeicosanoids promote organ and tissue regeneration.

artículo científico publicado en 2013

Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice

artículo científico publicado en 2011

Everyday cognitive function after craniopharyngioma in childhood.

artículo científico publicado en 2006

Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas

artículo científico publicado en 2014

Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma

artículo científico publicado en 2010

Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype

artículo científico publicado en 2015

Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome

scientific article published on 08 May 2019

FINAL RESULTS OF A PROSPECTIVE MULTI-INSTITUTIONAL PHASE II STUDY OF EVEROLIMUS (RAD001), AN MTOR INHIBITOR, IN PEDIATRIC PATIENTS WITH RECURRENT OR PROGRESSIVE LOW-GRADE GLIOMA. A POETIC CONSORTIUM TRIAL.

artículo científico publicado en 2014

Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors

artículo científico publicado en 2005

Future Clinical Trials in DIPG: Bringing Epigenetics to the Clinic

artículo científico publicado en 2015

Future of clinical genomics in pediatric oncology.

artículo científico

GE-02CLINICAL TARGETED EXOME-BASED SEQUENCING FOR CHILDREN DIAGNOSED WITH BRAIN TUMORS: INITIAL RESULTS OF AN INSTITUTE-WIDE PROJECT ON PERSONALIZED MEDICINE.

artículo científico publicado en 2014

GE-05EXOME SEQUENCING REVEALS BRAF MUTATIONS IN PAPILLARY CRANIOPHARYNGIOMAS.

artículo científico publicado en 2014

GENE-07. LIQUID BIOPSY DETECTION OF GENOMIC ALTERATIONS IN PEDIATRIC BRAIN TUMORS FROM CELL-FREE DNA IN PERIPHERAL BLOOD, CSF, AND URINE

artículo científico publicado en 2019

GENE-09. PRECISION MEDICINE ANALYSIS OF 203 PEDIATRIC BRAIN TUMORS REVEALS CLINICALLY RELEVANT GENOMIC ALTERATIONS.

artículo científico publicado en 2017

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

artículo científico publicado en 2014

Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1

artículo científico publicado en 2013

Gliomatosis cerebri: A consensus summary report from the First International Gliomatosis cerebri Group Meeting, March 26-27, 2015, Paris, France

artículo científico publicado en 2016

HG-109CONTEMPORARY SURVIVAL ENDPOINTS: AN INTERNATIONAL DIFFUSE INTRINSIC PONTINE GLIOMA REGISTRY STUDY.

artículo científico publicado en 2016

HG-110SINGLE-CELL TRANSCRIPTOME ANALYSIS IN PEDIATRIC HEMISPHERIC AND MIDLINE HIGH-GRADE GLIOMAS.

artículo científico publicado en 2016

HG-73SAFETY AND FEASIBILITY OF A MULTI-INSTITUTIONAL PHASE II TRIAL INCOPORATING BIOPSY AND MOLECULARLY DETERMINED TREATMENT OF CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPG).

artículo científico publicado en 2016

HG-75CLINICAL, RADIOLOGICAL, AND HISTO-GENETIC CHARACTERISTICS OF LONG-TERM SURVIVORS OF DIFFUSE INTRINSIC PONTINE GLIOMA: A COLLABORATIVE REPORT FROM THE INTERNATIONAL AND SIOP-E DIPG REGISTRIES.

artículo científico publicado en 2016

HG-93CONCURRENT USE OF PANOBINOSTAT AND RE-IRRADIATION IN CHILDREN WITH PROGRESSIVE DIPG: REPORT OF 2 CASES. ⬇️

artículo científico publicado en 2016

Hutchinson-Gilford progeria is a skeletal dysplasia

artículo científico publicado en 2011

IMMU-04. IMMUNOPHENOTYPING OF PEDIATRIC BRAIN TUMORS: CORRELATING IMMUNE INFILTRATE WITH HISTOLOGY, MUTATIONAL LOAD, AND SURVIVAL AND ASSESSING CLONAL T CELL RESPONSE

IMMU-08. IMMUNOPHENOTYPING OF PEDIATRIC BRAIN TUMORS: CORRELATING IMMUNE INFILTRATE WITH HISTOLOGY, MUTATIONAL LOAD, AND SURVIVAL.

artículo científico publicado en 2017

IMMU-13. A FAILURE TO RESOLVE INFLAMMATION: ROLE OF RESOLVINS IN THE TREATMENT OF PEDIATRIC CNS TUMORS.

artículo científico publicado en 2018

IMMU-23. IMMUNOPHENOTYPING OF PEDIATRIC BRAIN TUMORS: CORRELATING IMMUNE INFILTRATE WITH HISTOLOGY, MUTATIONAL LOAD, AND SURVIVAL AND ASSESSING CLONAL T CELL RESPONSE.

artículo científico publicado en 2017

INNV-22. LIQUID BIOPSY DETECTION OF GENOMIC ALTERATIONS IN PEDIATRIC BRAIN TUMORS FROM CELL FREE DNA IN PERIPHERAL BLOOD, CSF, AND URINE

Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity

artículo científico publicado en 2008

Identification of fibroblast heterogeneity in the tumor microenvironment

artículo científico publicado en 2006

Identification of novel biologic targets in the treatment of newly diagnosed diffuse intrinsic pontine glioma

artículo científico publicado en 2012

Immunophenotyping of pediatric brain tumors: correlating immune infiltrate with histology, mutational load, and survival and assessing clonal T cell response.

artículo científico publicado en 2018

Impact of farnesylation inhibitors on survival in Hutchinson-Gilford progeria syndrome.

artículo científico publicado en 2014

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

artículo científico publicado en 2014

Increasing value of autopsies in patients with brain tumors in the molecular era

scientific article published on 30 September 2019

Inhibition of neuroblastoma cell proliferation with omega-3 fatty acids and treatment of a murine model of human neuroblastoma using a diet enriched with omega-3 fatty acids in combination with sunitinib.

artículo científico publicado en 2011

Inhibition of tumor angiogenesis by oral etoposide.

artículo científico publicado en 2010

Initial cutaneous manifestations of Hutchinson-Gilford progeria syndrome

artículo científico publicado en 2014

Innovative therapies for pediatric brain tumors

artículo científico publicado en 1999

Intensive Multimodality Treatment for Children With Newly Diagnosed CNS Atypical Teratoid Rhabdoid Tumor

artículo científico publicado en 2009

LG-02MYB-QKI REARRANGEMENTS IN ANGIOCENTRIC GLIOMA DRIVE TUMORIGENICITY THROUGH A TRIPARTITE MECHANISM.

artículo científico publicado en 2016

LG-03RADIATION THERAPY IS ASSOCIATED WITH INCREASED LATE MORTALITY IN LONG-TERM ADULT SURVIVORS OF CHILDHOOD LOW GRADE GLIOMA: A POPULATION BASED STUDY.

artículo científico publicado en 2015

LG-46INFERIOR OUTCOME AND POOR RESPONSE TO CONVENTIONAL THERAPIES IN PEDIATRIC LOW-GRADE GLIOMAS HARBORING THE BRAF V600E MUTATION.

artículo científico publicado en 2016

LG-47TYPE II RAF INHIBITORS INHIBIT BRAF MUTATIONS AND TRUNCATED FUSIONS IN PEDIATRIC LOW-GRADE GLIOMAS.

artículo científico publicado en 2016

LG-66CLINICAL AND TREATMENT FACTORS DETERMINING LONG-TERM OUTCOMES FOR ADULT SURVIVORS OF CHILDHOOD LOW-GRADE GLIOMA: A POPULATION-BASED STUDY.

artículo científico publicado en 2016

LGG-05. SINGLE CELL RNA SEQUENCING REVEALS MITOGENIC AND PROGENITOR GENE PROGRAMS IN BRAF-REARRANGED PILOCYTIC ASTROCYTOMAS

artículo científico publicado en 2019

LGG-05. SINGLE-CELL RNA SEQUENCING OF PEDIATRIC LOW-GRADE GLIOMAS REVEALS INTRATUMORAL HETEROGENEITY.

artículo científico publicado en 2017

LGG-13. RESOLVING TRANSCRIPTIONAL PROFILES IN BRAF-REARRANGED PILOCYTIC ASTROCYTOMA USING SINGLE CELL RNA SEQUENCING

artículo científico publicado en 2018

LGG-26. TYPE II BRAF INHIBITOR TAK-580 SHOWS PROMISE FOR UPCOMING CLINAL TRIAL AS EVIDENCED BY SINGLE PATIENT IND STUDY

artículo científico publicado en 2018

LGG-44. A PHASE I DOSE ESCALATION TRIAL OF THE MEK1/2 INHIBITOR MEK162 (BINIMETINIB) IN CHILDREN WITH LOW-GRADE GLIOMAS AND OTHER RAS/RAF PATHWAY-ACTIVATED TUMORS

LGG-46. TRAMETINIB THERAPY IN PEDIATRIC PATIENTS WITH LOW-GRADE GLIOMAS (LGG) WITH BRAF GENE FUSION; A DISEASE-SPECIFIC COHORT IN THE FIRST PEDIATRIC TESTING OF TRAMETINIB

LOW GRADE GLIOMAS

Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas

artículo científico publicado en 2011

Long-term clinical outcomes following treatment of childhood craniopharyngioma.

artículo científico publicado en 2010

Long-term neuropsychological follow-up of young children with medulloblastoma treated with sequential high-dose chemotherapy and irradiation sparing approach

artículo científico publicado en 2017

Long-term outcome of 4,040 children diagnosed with pediatric low-grade gliomas: an analysis of the Surveillance Epidemiology and End Results (SEER) database

artículo científico publicado en 2014

Long-term visual outcomes of optic pathway gliomas in pediatric patients without neurofibromatosis type 1.

artículo científico publicado en 2016

Lymphocyte homing.

artículo científico publicado en 1989

MB-52RESPONSE ASSESSMENT IN PEDIATRIC NEURO-ONCOLOGY (RAPNO) COMMITTEE GUIDELINES FOR RESPONSE ASSESSMENT IN MEDULLOBLASTOMA AND OTHER LEPTOMENINGEAL SEEDING TUMORS.

artículo científico publicado en 2016

MB-66PILOT STUDY OF A SURGERY AND CHEMOTHERAPY-ONLY APPROACH IN THE UPFRONT THERAPY OF CHLDREN WITH Wnt POSITIVE STANDARD RISK MEDULLOBLASTOMA.

artículo científico publicado en 2016

MB-70MEMMAT - A PHASE II STUDY OF METRONOMIC AND TARGETED ANTI-ANGIOGENESIS THERAPY FOR CHILDREN WITH RECURRENT/PROGRESSIVE MEDULLOBLASTOMA.

artículo científico publicado en 2016

MBCL-02. CURRENT ISSUES IN THE MANAGEMENT OF DESMOPLASTIC NODULAR MEDULLOBLASTOMA IN YOUNG CHILDREN

MEDICAL AND NEURO-ONCOLOGY

artículo científico publicado en 2011

MEDU-37. NEURONAL DIFFERENTIATION AND CELL-CYCLE PROGRAMS MEDIATE RESPONSE AND RESISTANCE TO BET-BROMODOMAIN INHIBITION IN MYC-DRIVEN MEDULLOBLASTOMA

MEDULLOBLASTOMA

MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma

scientific article published on 07 May 2020

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

artículo científico publicado en 2016

Marked regression of metastatic pilocytic astrocytoma during treatment with imatinib mesylate (STI-571, Gleevec): a case report and laboratory investigation

artículo científico publicado en 2003

Mechanism of pulmonary vein stenosis in infants with normally connected veins

artículo científico publicado en 2000

Mechanisms of premature vascular aging in children with Hutchinson-Gilford progeria syndrome

artículo científico publicado en 2011

Medical, psychological, cognitive and educational late-effects in pediatric low-grade glioma survivors treated with surgery only.

scientific article published on September 2009

Metachronous mediastinal seminoma occurring after intracranial germinoma in an adolescent

artículo científico publicado en 2009

Metronomic antiangiogenic therapy in children with recurrent brain tumours of different histologies

Microbiome at sites of gingival recession in children with Hutchinson-Gilford progeria syndrome

artículo científico publicado en 2018

Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells

artículo científico publicado en 2019

Molecular aspects, clinical aspects and possible treatment modalities for Costello syndrome: Proceedings from the 1st International Costello Syndrome Research Symposium 2007

artículo científico publicado en 2008

Moving forward with metronomic chemotherapy: meeting report of the 2nd International Workshop on Metronomic and Anti-Angiogenic Chemotherapy in Paediatric Oncology.

artículo científico publicado en 2011

Moyamoya following cranial irradiation for primary brain tumors in children.

artículo científico publicado en 2007

Multiparametric Analysis of Permeability and ADC Histogram Metrics for Classification of Pediatric Brain Tumors by Tumor Grade.

artículo científico publicado en 2018

Multiplexed Immunofluorescence Reveals Potential PD-1/PD-L1 Pathway Vulnerabilities in Craniopharyngioma.

artículo científico publicado en 2018

Myelopoiesis in the zebrafish, Danio rerio.

artículo científico publicado en 2001

Myxopapillary ependymomas in children: imaging, treatment and outcomes

artículo científico

NF1 plexiform neurofibroma growth rate by volumetric MRI: relationship to age and body weight.

artículo científico publicado en 2007

NS-26THE ROLE OF SURGERY IN NON-NF-ASSOCIATED PEDIATRIC OPTIC PATHWAY GLIOMAS (OPG) - IS THERE A NEW PARADIGM?

artículo científico publicado en 2016

Neurologic features of Hutchinson-Gilford progeria syndrome after lonafarnib treatment

artículo científico publicado en 2013

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

artículo científico publicado en 2019

Neuropsychological functioning after surgery in children treated for brain tumor

artículo científico publicado en 2003

Neutralization of Circulating Vascular Endothelial Growth Factor (VEGF) by Anti-VEGF Antibodies and Soluble VEGF Receptor 1 (sFlt-1) Induces Proteinuria

scientific article published in Journal of Biological Chemistry

New Classification for Central Nervous System Tumors: Implications for Diagnosis and Therapy

artículo científico publicado en 2017

New approaches to progeria

artículo científico publicado en 2007

New strategies in pediatric gliomas: molecular advances in pediatric low-grade gliomas as a model

artículo científico publicado en 2013

Next generation metronomic chemotherapy-report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6-8 May 2016, Mumbai.

artículo científico publicado en 2016

Ophthalmologic Features of Progeria

artículo científico publicado en 2017

Outcome of pediatric pineoblastoma after surgery, radiation and chemotherapy.

artículo científico publicado en 2008

PATH-17. INCREASING VALUE OF AUTOPSIES IN PATIENTS WITH BRAIN TUMORS IN THE MOLECULAR ERA

PCLN-07. A 3D HYDROGEL CULTURE SYSTEM FACILITATES STUDY OF PRIMARY PEDIATRIC LOW-GRADE GLIOMA CELLS IN VITRO

artículo científico publicado en 2018

PDCT-03. PHASE 1 STUDY OF Ad-RTS-hIL-12 + VELEDIMEX IN PEDIATRIC BRAIN TUMORS

PDCT-20. FEASIBILITY AND SAFETY OF SURGICAL BIOPSY FOR PATIENTS WITH DIPG: PRELIMINARY RESULTS FROM DIPG-BATS

artículo científico publicado en 2017

PDCT-24. A PHASE I DOSE ESCALATION TRIAL OF THE MEK1/2 INHIBITOR MEK162 (BINIMETINIB) IN CHILDREN WITH LOW-GRADE GLIOMAS AND OTHER RAS-RAF PATHWAY-ACTIVATED TUMORS: INITIAL REPORT

PDTM-04. REDEFINING THE CELLULAR ARCHITECTURE OF DIFFUSE MIDLINE GLIOMAS WITH H3 K27M MUTATIONS THROUGH LARGE-SCALE SINGLE-CELL ANALYSES

PDTM-06. ALK AMPLIFICATION AND REARRANGEMENTS ARE RECURRENT TARGETABLE EVENTS IN GLIOBLASTOMA

artículo científico publicado en 2018

PHASE I INDIVIDUAL DOSE TITRATION TRIAL OF THE HUMAN CORTICOTROPIN-RELEASING FACTOR (HCRF), CORTICORELIN ACETATE INJECTION (XERECEPT) IN PEDIATRIC PATIENTS WITH PERITUMORAL EDEMA OF THE BRAIN.

artículo científico publicado en 2014

PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition.

artículo científico publicado en 2008

PPARalpha deficiency in inflammatory cells suppresses tumor growth

artículo científico publicado en 2007

PPARgamma as a therapeutic target for tumor angiogenesis and metastasis

artículo científico publicado en 2005

PPARs: A Double-Edged Sword in Cancer Therapy?

artículo científico publicado en 2008

PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

artículo científico publicado en 2022

Paediatric Strategy Forum for medicinal product development for acute myeloid leukaemia in children and adolescents: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration

artículo científico publicado en 2020

Paediatric Strategy Forum for medicinal product development of epigenetic modifiers for children: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration

scientific article published on 25 September 2020

Parent-perceived child cognitive function: results from a sample drawn from the US general population

artículo científico publicado en 2010

Paucicellular Fibrointimal Proliferation Characterizes Pediatric Pulmonary Vein Stenosis: Clinicopathologic Analysis of 213 Samples From 97 Patients

artículo científico publicado en 2017

Pediatric Low-Grade Gliomas: Next Biologically Driven Steps

artículo científico publicado en 2017

Pediatric brainstem gliomas: new understanding leads to potential new treatments for two very different tumors.

artículo científico publicado en 2015

Pediatric cancer research: Surviving COVID-19

artículo científico publicado en 2020

Pediatric high-grade glioma: biologically and clinically in need of new thinking

artículo científico publicado en 2016

Pediatric low-grade gliomas: how modern biology reshapes the clinical field

artículo científico publicado en 2014

Pediatric low-grade gliomas: implications of the biologic era.

artículo científico publicado en 2016

Pediatric neuro-oncology: current status and future directions.

artículo científico

Perfusion MRI of U87 brain tumors in a mouse model

artículo científico publicado en 2004

Phase 2 randomized, flexible crossover, double-blinded, placebo-controlled trial of the farnesyltransferase inhibitor tipifarnib in children and young adults with neurofibromatosis type 1 and progressive plexiform neurofibromas.

artículo científico publicado en 2014

Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central nervous system tumors using a modified continuous reassessment method: a Pediatric Brain Tumo

artículo científico publicado en 2007

Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012.

artículo científico publicado en 2008

Phase I clinical trial of mafosfamide in infants and children aged 3 years or younger with newly diagnosed embryonal tumors: a pediatric brain tumor consortium study (PBTC-001).

artículo científico publicado en 2005

Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors

artículo científico publicado en 2009

Phase I study of gene-mediated cytotoxic immunotherapy with AdV-tk as adjuvant to surgery and radiation for pediatric malignant glioma and recurrent ependymoma

scientific article published on 01 March 2019

Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma.

artículo científico publicado en 2017

Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium report

artículo científico publicado en 2007

Phase II study of cilengitide in the treatment of refractory or relapsed high-grade gliomas in children: a report from the Children's Oncology Group

scientific article published on 05 September 2013

Phase II study of metronomic chemotherapy for recurrent malignant gliomas in adults.

artículo científico publicado en 2007

Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults

artículo científico publicado en 2008

Phase II study of thalidomide and radiation in children with newly diagnosed brain stem gliomas and glioblastoma multiforme

artículo científico publicado en 2006

Phase II trial of pegylated interferon alfa-2b in young patients with neurofibromatosis type 1 and unresectable plexiform neurofibromas

artículo científico publicado en 2017

Phase II trial of pirfenidone in children and young adults with neurofibromatosis type 1 and progressive plexiform neurofibromas.

artículo científico publicado en 2014

Phase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcoma

artículo científico publicado en 2011

Pilot study of systemic and intrathecal mafosfamide followed by conformal radiation for infants with intracranial central nervous system tumors: a pediatric brain tumor consortium study (PBTC-001)

artículo científico publicado en 2012

Platelets actively sequester angiogenesis regulators

artículo científico publicado en 2008

Portohepatic shunt in a Down syndrome patient with an interchange trisomy 47,XY,-2,+der(2),+der(21)t(2;21)(p13;q22.1)mat

artículo científico publicado en 1992

Predictors of neoplastic disease in children with isolated pituitary stalk thickening.

artículo científico publicado en 2013

Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases

scientific article published on 17 June 2019

Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back.

artículo científico publicado en 2010

Profiling critical cancer gene mutations in clinical tumor samples

artículo científico publicado en 2009

Prognostic value of tumor microinvasion and metalloproteinases expression in intracranial pediatric ependymomas

artículo científico publicado en 2008

Prospective Feasibility and Safety Assessment of Surgical Biopsy for Patients with Newly Diagnosed Diffuse Intrinsic Pontine Glioma.

artículo científico publicado en 2018

Proteomic profiling of cerebrospinal fluid identifies prostaglandin D2 synthase as a putative biomarker for pediatric medulloblastoma: A pediatric brain tumor consortium study

artículo científico publicado en 2011

Psychosocial and behavioral functioning among pediatric brain tumor survivors

artículo científico publicado en 2003

Pubertal Progression in Adolescent Females with Progeria.

artículo científico publicado en 2017

Pulmonary vein stenosis: expression of receptor tyrosine kinases by lesional cells

artículo científico publicado en 2006

QOL-28. CUTANEOUS REACTIONS TO TARGETED THERAPIES IN CHILDREN WITH CNS TUMORS: A CROSS-SECTIONAL STUDY

Quantification of water diffusion and relaxation times of human U87 tumors in a mouse model.

artículo científico publicado en 2004

RTHP-08. RE-EVALUATING THE SEQUENCING OF RADIOTHERAPY AND CHEMOTHERAPY IN PEDIATRIC MEDULLOBLASTOMA

Recurrence after gross-total resection of low-grade pediatric brain tumors: the frequency and timing of postoperative imaging.

artículo científico publicado en 2014

Recurrent ascites in a patient with low-grade astrocytoma and ventriculo-peritoneal shunt treated with the multikinase inhibitor sorafenib.

artículo científico publicado en 2014

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

artículo científico publicado en 2013

Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

artículo científico publicado en 2014

Remission of infantile generalized myofibromatosis after interferon alpha therapy

artículo científico publicado en 2008

Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'

artículo científico publicado en 2019

Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression

scientific article published on 14 August 2020

Resolvins suppress tumor growth and enhance cancer therapy.

artículo científico publicado en 2017

Response Assessment in Medulloblastoma and Leptomeningeal Seeding Tumors: Recommendations from the Response Assessment in Pediatric Neuro-Oncology Committee

artículo científico publicado en 2017

Response to Harreld re: "Response assessment in medulloblastoma and leptomeningeal seeding tumors: recommendations from the Response Assessment in Pediatric Neuro-Oncology Committee".

artículo científico publicado en 2018

Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival.

artículo científico publicado en 2017

Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression

artículo científico publicado en 2013

Single-agent erlotinib versus oral etoposide in patients with recurrent or refractory pediatric ependymoma: a randomized open-label study.

artículo científico publicado en 2016

Sixty years single institutional experience with pediatric craniopharyngioma: between the past and the future

artículo científico publicado en 2019

Sleep dysfunction in long term survivors of craniopharyngioma

artículo científico

Small molecule inhibitors in children with malignant gliomas

artículo científico publicado en 2009

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas

artículo científico publicado en 2014

Specific uptake of 99mTc-NC100692, an αvβ3-targeted imaging probe, in subcutaneous and orthotopic tumors.

artículo científico publicado en 2013

Stereotactic radiotherapy for localized low-grade gliomas in children: final results of a prospective trial

artículo científico publicado en 2005

Stereotactic radiotherapy for pediatric intracranial germ cell tumors

artículo científico publicado en 2001

Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor

artículo científico publicado en 2019

Survey of plasma proteins in children with progeria pre-therapy and on-therapy with lonafarnib

artículo científico publicado en 2018

TB-03IMMUNOPHENOTYPING OF PEDIATRIC BRAIN TUMORS: CORRELATING IMMUNE INFILTRATE WITH HISTOLOGY, MUTATIONAL LOAD, AND SURVIVAL.

artículo científico publicado en 2016

TBIO-18. LIQUID BIOPSY DETECTION OF GENOMIC ALTERATIONS IN PEDIATRIC BRAIN TUMORS FROM CELL FREE DNA IN PERIPHERAL BLOOD, CSF, AND URINE

TMOD-14. A PATIENT-DERIVED CANCER CELL LINE ATLAS OF PRIMARY AND METASTATIC CENTRAL NERVOUS SYSTEM TUMORS

TR-14A FEASIBILITY AND RANDOMIZED PHASE II STUDY OF VORINOSTAT, BEVACIZUMAB, OR TEMOZOLOMIDE DURING RADIATION FOLLOWED BY MAINTENANCE CHEMOTHERAPY IN NEWLY-DIAGNOSED PEDIATRIC HIGH-GRADE GLIOMA: CHILDREN'S ONCOLOGY GROUP STUDY ACNS0822.

artículo científico publicado en 2015

TRTH-23. FEASIBILITY AND SAFETY OF SURGICAL BIOPSY FOR PATIENTS WITH DIPG: PRELIMINARY RESULTS FROM DIPG-BATS.

artículo científico publicado en 2017

TUMOUR BIOLOGY

Targeted treatment for sonic hedgehog-dependent medulloblastoma.

artículo científico publicado en 2014

The Critical Role of Academic Clinical Trials in Pediatric Cancer Drug Approvals: Design, Conduct, and Fit for Purpose Data for Positive Regulatory Decisions

scientific article published in 2022

The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product

artículo científico publicado en 1990

The Integration of Biology Into the Treatment of Diffuse Intrinsic Pontine Glioma: A Review of the North American Clinical Trial Perspective.

artículo científico publicado en 2018

The VEGF pathway in cancer and disease: responses, resistance, and the path forward.

artículo científico publicado en 2012

The decision-making process and criteria in selecting candidate drugs for progeria clinical trials

artículo científico publicado en 2016

The growing role of eicosanoids in tissue regeneration, repair, and wound healing

artículo científico publicado en 2013

The rationale for nonsteroidal anti-inflammatory drug therapy for inflammatory myofibroblastic tumors: a Children's Oncology Group study

artículo científico publicado en 2005

Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas

artículo científico

Therapeutic potential of thiazolidinediones as anticancer agents

artículo científico publicado en 2003

Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression

artículo científico publicado en 2004

Time to rethink the unthinkable: upfront biopsy of children with newly diagnosed diffuse intrinsic pontine glioma (DIPG).

artículo científico publicado en 2014

Transverse myelitis after therapy for primitive neuroectodermal tumors

artículo científico publicado en 2006

Treatment of low-grade gliomas in children: an update.

artículo científico publicado en 2004

Tumor dissemination through surgical tracts in diffuse intrinsic pontine glioma

artículo científico publicado en 2018

Type IV collagen α6 chain-derived noncollagenous domain 1 (α6(IV)NC1) inhibits angiogenesis and tumor growth

scientific article published on 01 April 2008

Visual outcomes following everolimus targeted therapy for neurofibromatosis type 1-associated optic pathway gliomas in children

artículo científico publicado en 2020

Wilms tumor screening is unnecessary in Klippel-Trenaunay syndrome

scientific article published on 01 April 2004

ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors

artículo científico publicado en 2005

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