Lista de obras - Sonsoles Martín-Santamaría

Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepacia

artículo científico publicado en 2015

Adrenomedullin: a new and promising target for drug discovery

artículo científico publicado en 2006

Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities

artículo científico publicado en 2005

Amphiphilic Guanidinocalixarenes Inhibit Lipopolysaccharide (LPS)- and Lectin-Stimulated Toll-like Receptor 4 (TLR4) Signaling

artículo científico publicado en 2017

Antagonistic Pleiotropy in the Bifunctional Surface Protein FadL (OmpP1) during Adaptation of Haemophilus influenzae to Chronic Lung Infection Associated with Chronic Obstructive Pulmonary Disease

scientific article published on 25 September 2018

Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance

artículo científico publicado en 2017

Chemistry of lipid A: at the heart of innate immunity.

artículo científico publicado en 2014

Computational Approaches to Toll-Like Receptor 4 Modulation

artículo científico publicado en 2016

Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings.

artículo científico publicado en 2015

Conformational selection in glycomimetics: human galectin-1 only recognizes syn-Ψ-type conformations of β-1,3-linked lactose and its C-glycosyl derivative.

artículo científico

Development of a new family of conformationally restricted peptides as potent nucleators of beta-turns. Design, synthesis, structure, and biological evaluation of a beta-lactam peptide analogue of melanostatin

artículo científico publicado en 2003

Diastereoselective reactions in glycine templates containing an ent-ardeemin fragment

artículo científico publicado en 2002

ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor

artículo científico publicado en 2004

Editorial :Chemistry Bordering Biology: highlights from the XXXIV Biennial Meeting of the RSEQ.

artículo científico publicado en 2014

Engineering O-Glycosylation Points in Non-extended Peptides: Implications for the Molecular Recognition of Short Tumor-Associated Glycopeptides

artículo científico publicado en 2011

Enhancing Potency and Selectivity of a DC-SIGN Glycomimetic Ligand by Fragment-Based Design: Structural Basis

artículo científico publicado en 2019

Glycolipid-based TLR4 Modulators and Fluorescent Probes: Rational Design, Synthesis, and Biological Properties.

artículo científico publicado en 2016

Glycomimetics Targeting Glycosyltransferases: Synthetic, Computational and Structural Studies of Less-Polar Conjugates

artículo científico publicado en 2016

Guanidinium receptors as enantioselective amino acid membrane carriers

artículo científico publicado en 2003

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

artículo científico publicado en 2019

Insights into the key determinants of membrane protein topology enable the identification of new monotopic folds

artículo científico publicado en 2018

Interactions of bacterial cell division protein FtsZ with C8-substituted guanine nucleotide inhibitors. A combined NMR, biochemical and molecular modeling perspective.

artículo científico publicado en 2013

Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex

artículo científico publicado en 2018

MMP-2 selectivity in hydroxamate-type inhibitors.

artículo científico publicado en 2012

Mimicking chitin: chemical synthesis, conformational analysis, and molecular recognition of the beta(1-->3) N-acetylchitopentaose analogue

artículo científico publicado en 2010

Minimizing the Entropy Penalty for Ligand Binding: Lessons from the Molecular Recognition of the Histo Blood-Group Antigens by Human Galectin-3

artículo científico publicado en 2019

Modulation of Binding Strength in Several Classes of Active Site Inhibitors of Acetylcholinesterase Studied by Comparative Binding Energy Analysis

article

Modulation of CD14 and TLR4·MD-2 activities by a synthetic lipid A mimetic.

artículo científico publicado en 2013

Modulation of toll-like receptor 4. Insights from x-ray crystallography and molecular modeling.

artículo científico publicado en 2014

Multisite-directed inhibitors of protein kinase CK2: new challenges.

artículo científico publicado en 2011

New Therapeutic Strategies for Osteoarthritis by Targeting Sialic Acid Receptors

scientific article published on 21 April 2020

New clicked full agonists of the estrogen receptor β

scholarly article in RSC Advances, vol. 3 no. 11, 2013

New scaffolds for the design of selective estrogen receptor modulators

artículo científico publicado en 2008

Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties

scientific article published in Scientific Reports

Potent “Clicked” MMP2 Inhibitors: Synthesis, Molecular Modeling and Biological Exploration

scientific article published on 06 May 2011

Potential anti-inflammatory, anti-adhesive, anti/estrogenic, and angiotensin-converting enzyme inhibitory activities of anthocyanins and their gut metabolites ⬇️

artículo científico publicado el 5 de enero de 2012

Rational design of a Tn antigen mimic

artículo científico publicado en 2011

Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations.

artículo científico publicado en 2004

Selective human adenosine A3 antagonists based on pyrido[2,1-f]purine-2,4-diones: novel features of hA3 antagonist binding.

artículo científico publicado en 2008

Serine versus threonine glycosylation with α-O-GalNAc: unexpected selectivity in their molecular recognition with lectins.

artículo científico publicado en 2014

Small-molecule negative modulators of adrenomedullin: design, synthesis, and 3D-QSAR study

artículo científico publicado en 2008

Structural aspects of binding of α-linked digalactosides to human galectin-1

artículo científico publicado en 2011

Structural basis for the binding of didemnins to human elongation factor eEF1A and rationale for the potent antitumor activity of these marine natural products

artículo científico publicado en 2004

Structure of micelle-bound adrenomedullin: a first step toward the analysis of its interactions with receptors and small molecules

artículo científico publicado en 2012

Structure-Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists.

artículo científico publicado en 2018

Symmetric dithiodigalactoside: strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins.

artículo científico publicado en 2011

Synthesis, biological evaluation, and three-dimensional quantitative structure-activity relationship study of small-molecule positive modulators of adrenomedullin

artículo científico publicado en 2005

Towards β-selectivity in functional estrogen receptor antagonists

artículo científico publicado en 2012

Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators

artículo científico publicado en 2016

gem-Difluorocarbadisaccharides: Restoring theexo-Anomeric Effect

artículo científico publicado en 2014

Lista de obras de Sonsoles Martín-Santamaría

Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepacia

Adrenomedullin: a new and promising target for drug discovery

Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities

Amphiphilic Guanidinocalixarenes Inhibit Lipopolysaccharide (LPS)- and Lectin-Stimulated Toll-like Receptor 4 (TLR4) Signaling

Antagonistic Pleiotropy in the Bifunctional Surface Protein FadL (OmpP1) during Adaptation of Haemophilus influenzae to Chronic Lung Infection Associated with Chronic Obstructive Pulmonary Disease

Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance

Chemistry of lipid A: at the heart of innate immunity.

Computational Approaches to Toll-Like Receptor 4 Modulation

Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings.

Conformational selection in glycomimetics: human galectin-1 only recognizes syn-Ψ-type conformations of β-1,3-linked lactose and its C-glycosyl derivative.

Development of a new family of conformationally restricted peptides as potent nucleators of beta-turns. Design, synthesis, structure, and biological evaluation of a beta-lactam peptide analogue of melanostatin

Diastereoselective reactions in glycine templates containing an ent-ardeemin fragment

ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor

Editorial :Chemistry Bordering Biology: highlights from the XXXIV Biennial Meeting of the RSEQ.

Engineering O-Glycosylation Points in Non-extended Peptides: Implications for the Molecular Recognition of Short Tumor-Associated Glycopeptides

Enhancing Potency and Selectivity of a DC-SIGN Glycomimetic Ligand by Fragment-Based Design: Structural Basis

Glycolipid-based TLR4 Modulators and Fluorescent Probes: Rational Design, Synthesis, and Biological Properties.

Glycomimetics Targeting Glycosyltransferases: Synthetic, Computational and Structural Studies of Less-Polar Conjugates

Guanidinium receptors as enantioselective amino acid membrane carriers

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

Insights into the key determinants of membrane protein topology enable the identification of new monotopic folds

Interactions of bacterial cell division protein FtsZ with C8-substituted guanine nucleotide inhibitors. A combined NMR, biochemical and molecular modeling perspective.

Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex

MMP-2 selectivity in hydroxamate-type inhibitors.

Mimicking chitin: chemical synthesis, conformational analysis, and molecular recognition of the beta(1-->3) N-acetylchitopentaose analogue

Minimizing the Entropy Penalty for Ligand Binding: Lessons from the Molecular Recognition of the Histo Blood-Group Antigens by Human Galectin-3

Modulation of Binding Strength in Several Classes of Active Site Inhibitors of Acetylcholinesterase Studied by Comparative Binding Energy Analysis

Modulation of CD14 and TLR4·MD-2 activities by a synthetic lipid A mimetic.

Modulation of toll-like receptor 4. Insights from x-ray crystallography and molecular modeling.

Multisite-directed inhibitors of protein kinase CK2: new challenges.

New Therapeutic Strategies for Osteoarthritis by Targeting Sialic Acid Receptors

New clicked full agonists of the estrogen receptor β

New scaffolds for the design of selective estrogen receptor modulators

Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties

Potent “Clicked” MMP2 Inhibitors: Synthesis, Molecular Modeling and Biological Exploration

Potential anti-inflammatory, anti-adhesive, anti/estrogenic, and angiotensin-converting enzyme inhibitory activities of anthocyanins and their gut metabolites ⬇️

Rational design of a Tn antigen mimic

Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations.

Selective human adenosine A3 antagonists based on pyrido[2,1-f]purine-2,4-diones: novel features of hA3 antagonist binding.

Serine versus threonine glycosylation with α-O-GalNAc: unexpected selectivity in their molecular recognition with lectins.

Small-molecule negative modulators of adrenomedullin: design, synthesis, and 3D-QSAR study

Structural aspects of binding of α-linked digalactosides to human galectin-1

Structural basis for the binding of didemnins to human elongation factor eEF1A and rationale for the potent antitumor activity of these marine natural products

Structure of micelle-bound adrenomedullin: a first step toward the analysis of its interactions with receptors and small molecules

Structure-Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists.

Symmetric dithiodigalactoside: strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins.

Synthesis, biological evaluation, and three-dimensional quantitative structure-activity relationship study of small-molecule positive modulators of adrenomedullin

Towards β-selectivity in functional estrogen receptor antagonists

Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators

gem-Difluorocarbadisaccharides: Restoring theexo-Anomeric Effect