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Lista de obras de Jesper Wengel

"Clickable" LNA/DNA probes for fluorescence sensing of nucleic acids and autoimmune antibodies.

artículo científico publicado en 2013

2'-Spiro ribo- and arabinonucleosides: synthesis, molecular modelling and incorporation into oligodeoxynucleotides.

artículo científico publicado en 2003

2′-N-(Pyren-1-yl)acetyl-2′-Amino-α-L-LNA: Synthesis and Detection of Single Nucleotide Mismatches in DNA and RNA Targets

artículo científico publicado en 2007

3'-C-Branched LNA-type nucleosides locked in an N-type furanose ring conformation: synthesis, incorporation into oligodeoxynucleotides, and hybridization studies

artículo científico publicado en 2004

3'-Pyrene-modified unlocked nucleic acids: synthesis, fluorescence properties and a surprising stabilization effect on duplexes and triplexes

artículo científico publicado en 2017

3′,4′-trans-Linked bicyclic nucleosides locked in S-type conformations

artículo científico publicado en 2002

A Novel Class of Oligonucleotide Analogues Containing 2‘-O,3‘-C-Linked [3.2.0]Bicycloarabinonucleoside Monomers: Synthesis, Thermal Affinity Studies, and Molecular Modeling

artículo científico publicado en 1998

A chemical perspective on transcriptional fidelity: dominant contributions of sugar integrity revealed by unlocked nucleic acids

artículo científico publicado en 2013

A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis

artículo científico publicado en 2017

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

artículo científico publicado en 2009

A locked nucleic acid-based nanocrawler: designed and reversible movement detected by multicolor fluorescence.

artículo científico publicado en 2013

A quencher-free molecular beacon design based on pyrene excimer fluorescence using pyrene-labeled UNA (unlocked nucleic acid).

artículo científico publicado en 2013

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

artículo científico publicado en 2010

A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine

artículo científico publicado en 2019

A structure-activity study of the inhibition of HIV-1 Tat-dependent trans-activation by mixmer 2'-O-methyl oligoribonucleotides containing locked nucleic acid (LNA), alpha-L-LNA, or 2'-thio-LNA residues.

artículo científico

ADAMTS-targeting gapmers as a gene modulation strategy in osteoarthritis

artículo científico publicado en 2020

Adsorption and surface dynamics of short DNA and LNA oligonucleotides on single-crystal Au(111) electrode surfaces

Albumin-Binding Fatty Acid-Modified Gapmer Antisense Oligonucleotides for Modulation of Pharmacokinetics

scientific article published on 01 January 2020

Alpha-L-RNA (alpha-L-ribo configured RNA): synthesis and RNA-selective hybridization of alpha-L-RNA/alpha-L-LNA chimera.

artículo científico publicado en 2002

Alpha-l-Locked Nucleic Acid-Modified Antisense Oligonucleotides Induce Efficient Splice Modulation In Vitro

scientific article published on 31 March 2020

Amino acids attached to 2'-amino-LNA: synthesis and excellent duplex stability.

artículo científico publicado en 2010

Amplification and re-generation of LNA-modified libraries

artículo científico publicado en 2012

An Albumin-Oligonucleotide Assembly for Potential Combinatorial Drug Delivery and Half-Life Extension Applications

artículo científico publicado en 2017

An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing

artículo científico publicado en 2016

Anti-invasive activity of alkaloids and polyphenolics in vitro

artículo científico publicado en 1997

Application of locked nucleic acid-based probes in fluorescence in situ hybridization

artículo científico publicado en 2016

Aryl-β-C-LNA Monomers as Universal Hybridization Probes[1] [2]

artículo científico publicado en 2003

Biocatalytic Separation ofN-7/N-9 Guanine Nucleosides

Biological activity and biotechnological aspects of locked nucleic acids.

artículo científico

Bis-Pyrene-Modified Unlocked Nucleic Acids: Synthesis, Hybridization Studies, and Fluorescent Properties

artículo científico publicado en 2014

Boronic acid-based autoligation of nucleic acids: influence of the nature of the 3′-end ribonucleotidic strand

article

Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene–perylene 2′-α-l-amino-LNA FRET pairs

artículo científico publicado en 2013

Branched oligonucleotides containing bicyclic nucleotides as branching points and DNA or LNA as triplex forming branch

artículo científico publicado en 2000

Brightness through local constraint--LNA-enhanced FIT hybridization probes for in vivo ribonucleotide particle tracking

artículo científico publicado en 2014

By-product formation in repetitive PCR amplification of DNA libraries during SELEX.

artículo científico publicado en 2014

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression.

artículo científico publicado en 2017

Can Vitamin B12 Assist the Internalization of Antisense LNA Oligonucleotides into Bacteria?

artículo científico publicado en 2021

Carbazole modified oligonucleotides: synthesis, hybridization studies and fluorescence properties

scientific article published on 02 September 2020

Chemical fidelity of an RNA polymerase ribozyme

article by James Attwater et al published 2013 in Chemical Science

Cleavage and protection of locked nucleic acid–modified DNA by restriction endonucleases

artículo científico publicado en 2012

Conformationally controlled high-affinity targeting of RNA or DNA by novel 2′-amino-DNA/LNA mixmers and pyrenyl-functionalized 2′-amino-DNA

article

Convenient Syntheses of 7-Hydroxy-1-(hydroxymethyl)- 3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptanes: α-l-Ribo- and α-l-Xylo-Configured LNA Nucleosides

artículo científico publicado en 2000

Corrigendum: Interfacing Click Chemistry with Automated Oligonucleotide Synthesis for the Preparation of Fluorescent DNA Probes Containing Internal Xanthene and Cyanine Dyes

scholarly article published in Chemistry—A European Journal

DNA and LNA oligonucleotides containing N2′-functionalised derivatives of 2′-amino-2′-deoxyuridine

artículo científico publicado en 2006

DNA self-assembling systems: branched oligonucleotides as building blocks and monitoring by pyrene excimer band formation

artículo científico publicado en 2005

David versus Goliath

artículo científico publicado en 2010

Deacylation studies on furanose triesters using an immobilized lipase: Synthesis of a key precursor for bicyclonucleosides

scientific article published on 27 March 2007

Delivery, Effect on Cell Viability, and Plasticity of Modified Aptamer Constructs.

artículo científico publicado en 2016

Design of LNA-modified siRNAs against the highly structured 5' UTR of coxsackievirus B3.

artículo científico publicado en 2008

Detection and discrimination of biofilm populations using locked nucleic acid/2′-O-methyl-RNA fluorescence in situ hybridization (LNA/2′OMe-FISH)

scholarly article by Andreia S M Azevedo et al published December 2015 in Biochemical Engineering Journal

Development of an Efficient G-Quadruplex-Stabilised Thrombin-Binding Aptamer Containing a Three-Carbon Spacer Molecule.

artículo científico publicado en 2017

Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA.

artículo científico publicado en 2013

Direct imaging of hexaamine-ruthenium(III) in domain boundaries in monolayers of single-stranded DNA.

artículo científico

Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues.

artículo científico publicado en 2014

Dual-Probe System Using Pyrenylmethyl-Modified Amino-Lna for Mismatch Detection

artículo científico publicado en 2007

Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori

artículo científico publicado en 2015

Effective Modulation of DNA Duplex Stability by Reversible Transition Metal Complex Formation in the Minor Groove

artículo científico publicado en 2007

Efficient enzymatic synthesis of LNA-modified DNA duplexes using KOD DNA polymerase

artículo científico publicado en 2009

Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites

artículo científico publicado en 2007

Efficient reverse transcription using locked nucleic acid nucleotides towards the evolution of nuclease resistant RNA aptamers ⬇️

artículo científico publicado el 25 de abril de 2012

Electrochemical intercalator binding to single- and double-strand DNA- and LNA-based molecules on Au(111)-electrode surfaces

artículo científico publicado en 2020

Electrochemistry and in situ scanning tunnelling microscopy of pure and redox-marked DNA- and UNA-based oligonucleotides on Au(111)-electrode surfaces

artículo científico publicado en 2013

Electrochemistry of single metalloprotein and DNA-based molecules at Au(111) electrode surfaces.

artículo científico

Electron injection from the side of an M-DNA duplex

artículo científico publicado en 2005

Enhanced Inhibition of Transcription Start by Targeting with 2′-OMe Pentaribonucleotides Comprising Locked Nucleic Acids and Intercalating Nucleic Acids

artículo científico publicado en 2005

Enzymatic incorporation of LNA nucleotides into DNA strands.

artículo científico publicado en 2007

Enzymatic polymerisation involving 2′-amino-LNA nucleotides

artículo científico publicado en 2012

Enzymatic synthesis of DNA strands containing α-L-LNA (α-L-configured locked nucleic acid) thymine nucleotides

artículo científico publicado en 2012

Erratum to: mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids.

artículo científico publicado en 2015

Evaluation of Oligonucleotides with Novel Modifications

Exploring cellular activity of locked nucleic acid-modified triplex-forming oligonucleotides and defining its molecular basis

artículo científico publicado en 2005

Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation.

artículo científico publicado en 2017

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

scientific article published on 18 December 2018

Fibrin/hyaluronic acid hydrogel for combined delivery of gapmers and chondrocytes as a gene therapy approach for osteoarthritis

artículo científico publicado en 2018

Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4'-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer

artículo científico publicado en 2009

Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model

artículo científico publicado en 2016

Fluorescent oligonucleotides containing a novel perylene 2′-amino-α-L-LNA monomer: Synthesis and analytical potential

Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex

artículo científico publicado en 2017

Functionalization of 2'-amino-LNA with additional nucleobases.

artículo científico publicado en 2009

Functionalization of 2″-C-(Piperazinomethyl)-2′,3′-BcNA (Bicyclic Nucleic Acids) with Pyren-1-ylcarbonyl Units

Functionalized 2'-amino-alpha-L-LNA: directed positioning of intercalators for DNA targeting.

artículo científico publicado en 2009

G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold

artículo científico publicado en 2013

Gapmer Antisense Oligonucleotides Containing 2',3'-Dideoxy-2'-fluoro-3'-C-hydroxymethyl-β-d-lyxofuranosyl Nucleotides Display Site-Specific RNase H Cleavage and Induce Gene Silencing

scientific article published on 20 January 2020

Highly fluorescent conjugated pyrenes in nucleic acid probes: (phenylethynyl)pyrenecarbonyl-functionalized locked nucleic acids.

artículo científico publicado en 2008

Hybridization-based detection of Helicobacter pylori at human body temperature using advanced locked nucleic acid (LNA) probes

artículo científico publicado en 2013

Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury.

artículo científico publicado en 2018

Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA.

artículo científico publicado en 2013

Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach

artículo científico publicado en 2008

Improved Cancer Targeting by Multimerizing Aptamers on Nanoscaffolds

scientific article published on 15 October 2020

Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects

artículo científico publicado en 2019

Improved Synthesis of 2′-Amino-LNA

artículo científico publicado en 2003

Improved silencing properties using small internally segmented interfering RNAs

artículo científico publicado en 2007

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer

artículo científico publicado en 2010

Improvement of a streptavidin-binding aptamer by LNA- and α-l-LNA-substitutions.

artículo científico

In Vitro Incorporation of LNA Nucleotides

scientific article published on 01 January 2007

In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3' and 5' thiophosphate linkages

artículo científico publicado en 2020

In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts

artículo científico publicado en 2010

In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important

artículo científico publicado en 2012

Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides.

artículo científico publicado en 2001

Inside Back Cover: Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex (Chem. Eur. J. 39/2017)

Intercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: improving DNA binding properties and reaching cellular activities.

artículo científico publicado en 2005

Interfacing click chemistry with automated oligonucleotide synthesis for the preparation of fluorescent DNA probes containing internal xanthene and cyanine dyes.

artículo científico publicado en 2012

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

LNA (locked nucleic acid) and analogs as triplex-forming oligonucleotides

artículo científico publicado en 2007

LNA (locked nucleic acid) and the diastereoisomeric alpha-L-LNA: conformational tuning and high-affinity recognition of DNA/RNA targets.

artículo científico

LNA 5'-phosphoramidites for 5'→3'-oligonucleotide synthesis

artículo científico publicado en 2010

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

artículo científico publicado en 2017

LNA for optimization of fluorescent oligonucleotide probes: improved spectral properties and target binding.

artículo científico publicado en 2011

LNA nucleotides improve cleavage efficiency of singular and binary hammerhead ribozymes

artículo científico publicado en 2007

LNA-modified oligonucleotides effectively drive intramolecular-stable hairpin to intermolecular-duplex state.

artículo científico publicado en 2006

LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage.

artículo científico publicado en 2002

Large Scale Synthesis of 2′-Amino-LNA Thymine and 5-Methylcytosine Nucleosides

artículo científico publicado en 2012

Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids

artículo científico publicado en 2002

Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics

artículo científico publicado en 2005

Locked nucleic acid and aptamers

artículo científico publicado en 2012

Locked nucleic acid nucleoside triphosphates and polymerases: on the way towards evolution of LNA aptamers.

artículo científico publicado en 2009

Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology.

artículo científico publicado en 2004

Locked nucleic acids and intercalating nucleic acids in the design of easily denaturing nucleic acids: thermal stability studies

artículo científico publicado en 2004

Locked nucleic acids: promising nucleic acid analogs for therapeutic applications.

artículo científico publicado en 2010

Locked nucleoside analogues expand the potential of DNAzymes to cleave structured RNA targets

artículo científico publicado en 2006

Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals ⬇️

artículo científico publicado el 10 de mayo de 2011

Mechanism of Biochemical Action of Substituted 4-Methylbenzopyran-2-ones. Part 4: Hyperbolic Activation of Rat Liver Microsomal NADPH-Cytochrome C Reductase by the Novel Acetylator 7,8-Diacetoxy-4-methylcoumarin

artículo científico publicado en 1999

Mechanism of Biochemical Action of Substituted 4-Methylbenzopyran-2-ones. Part I: Dioxygenated 4-Methyl Coumarins as Superb Antioxidant and Radical Scavenging Agents

artículo científico publicado en 1998

Mechanism of biochemical action of substituted 4-Methylbenzopyran-2-ones. Part 3: A novel mechanism for the inhibition of biological membrane lipid peroxidation by dioxygenated 4-Methylcoumarins mediated by the formation of a stable ADP-Fe-Inhibitor

artículo científico publicado en 1998

Mechanism of biochemical action of substituted 4-Methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7,8-diacetoxy-4-methylcoumarin

artículo científico publicado en 1999

Mechanism of biochemical action of substituted 4-Methylbenzopyran-2-ones. Part 6: hydrolysis of 7,8-diacetoxy-4-methylcoumarin by a novel deacetylase in rat liver microsomes — a simple method for assay and characterisation

artículo científico publicado en 2000

Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 7: assay and characterization of 7,8-diacetoxy-4-methylcoumarin:protein transacetylase from rat liver microsomes based on the irreversible inhibition of cytosolic glutathi

artículo científico publicado en 2000

Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part II: Mechanism-based inhibition of rat liver microsome-mediated aflatoxin B 1 –DNA binding by the candidate antimutagen 7,8-diacetoxy-4-methylcoumarin

scientific article published on 01 October 1998

Mechanism of biochemical action of substituted benzopyran-2-ones. Part 8: Acetoxycoumarin: protein transacetylase specificity for aromatic nuclear acetoxy groups in proximity to the oxygen heteroatom.

artículo científico publicado en 2001

Methylphosphonate LNA: a locked nucleic acid with a methylphosphonate linkage.

artículo científico publicado en 2003

MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells

scholarly article by Annalisa Ferino published in October 2018

Minimal substrate features for Erm methyltransferases defined by using a combinatorial oligonucleotide library.

artículo científico publicado en 2011

Mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids.

artículo científico

Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions

scientific article published on 01 July 2018

Modular Assembly of Cell-targeting Devices Based on an Uncommon G-quadruplex Aptamer

artículo científico publicado en 2015

Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization

artículo científico publicado en 2012

Modulation of i-motif thermodynamic stability by the introduction of UNA (unlocked nucleic acid) monomers

artículo científico publicado en 2010

Molecular determinants for agonist recognition and discrimination in P2X2 receptors

artículo científico publicado en 2019

Multifunctional nucleic acids for tumor cell treatment.

artículo científico

Multilabeled pyrene-functionalized 2'-amino-LNA probes for nucleic acid detection in homogeneous fluorescence assays

artículo científico publicado en 2005

N-methylpiperazinocarbonyl-2',3'-BcNA and 4'-C-(N-methylpiperazino)methyl-DNA: introduction of basic functionalities facing the major groove and the minor groove of a DNA:DNA duplex

artículo científico publicado en 2003

N2'-functionalized 2'-amino-alpha-L-LNA adenine derivatives--efficient targeting of single stranded DNA.

artículo científico publicado en 2007

NMR Studies of Fully Modified Locked Nucleic Acid (LNA) Hybrids: Solution Structure of an LNA:RNA Hybrid and Characterization of an LNA:DNA Hybrid

scientific article published on 01 May 2004

NMR solution structure of dsDNA containing a bicyclic D-arabino-configured nucleotide fixed in an O4'-endo sugar conformation

artículo científico publicado en 2003

Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration

artículo científico publicado en 2009

Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

artículo científico publicado en 2016

NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery into dendritic cells and during skin inflammation

artículo científico publicado en 2020

Novel (phenylethynyl)pyrene-LNA constructs for fluorescence SNP sensing in polymorphic nucleic acid targets.

artículo científico publicado en 2012

Novel assemblies based on oligonucleotides containing intercalating nucleic acid monomers

artículo científico publicado en 2019

Novel bicyclic nucleoside analogue (1S,5S,6S)-6- hydroxy-5-hydroxymethyl-1-(uracil-1-yl)-3,8-dioxabicyclo[3.2.1]octane: synthesis and incorporation into oligodeoxynucleotides

artículo científico publicado en 2001

Novel chemoselective de-esterification of esters of polyacetoxy aromatic acids by lipases

Novel conformationally constrained 2'-C-methylribonucleosides: synthesis and incorporation into oligonucleotides

artículo científico publicado en 2018

Novel insights into the use of Glowing LNA as nucleic acid detection probes--influence of labeling density and nucleobases

artículo científico publicado en 2010

Novel interstrand communication systems within DNA duplexes based on 1-, 2- and 4-(phenylethynyl)pyrenes attached to 2′-amino-LNA: high-affinity hybridization and fluorescence sensing

scientific article published on 04 October 2010

Novel selective biocatalytic deacylation studies on key precursors for bicyclonucleosides

artículo científico publicado en 2007

Nucleic acid nanotechnology-towards Angstrom-scale engineering.

artículo científico publicado en 2003

Nucleic acid structural engineering using pyrene-functionalized 2'-amino-alpha-L-LNA monomers and abasic sites

artículo científico publicado en 2008

Nucleosides with 1,4-dioxane as sugar moiety

artículo científico publicado en 2008

Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers

artículo científico publicado en 2017

Oligodeoxynucleotides containing alpha-L-ribo configured LNA-type C-aryl nucleotides

artículo científico publicado en 2003

Oligonucleotide Binding to Non-B-DNA in

artículo científico publicado en 2019

Oligonucleotides Containing Aminated 2'-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA.

artículo científico publicado en 2017

Oligonucleotides Targeting DNA Repeats Downregulate <i>Huntingtin</i> Gene Expression in Huntington's Patient-Derived Neural Model System

scientific article published on 13 September 2021

Oligonucleotides containing 4'-C-aminomethyl-2'-modified thymidines show increased binding affinity towards DNA and RNA.

artículo científico publicado en 1999

Oligonucleotides containing a piperazino-modified 2′-amino-LNA monomer exhibit very high duplex stability and remarkable nuclease resistance

scientific article published on 01 March 2015

Oligonucleotides with 1,4-Dioxane-Based Nucleotide Monomers ⬇️

artículo científico publicado el 2 de abril de 2012

On the influence of conformational locking of sugar moieties on the absorption and circular dichroism of nucleosides from synchrotron radiation experiments

article by Anne I.S. Holm et al published April 2007 in Journal of Photochemistry and Photobiology A

Optimized DNA targeting using N,N-bis(2-pyridylmethyl)-beta-alanyl 2'-amino-LNA.

artículo científico publicado en 2005

Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA.

artículo científico publicado en 2010

Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity

article

Parallel RNA-strand recognition by 2'-amino-beta-L-LNA.

artículo científico publicado en 2009

Peptide-LNA oligonucleotide conjugates.

artículo científico

Peptide-oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic.

artículo científico publicado en 2016

Perylene attached to 2'-amino-LNA: synthesis, incorporation into oligonucleotides, and remarkable fluorescence properties in vitro and in cell culture.

artículo científico publicado en 2008

Photoinduced reductive electron transfer in LNA:DNA hybrids: a compromise between conformation and base stacking

artículo científico publicado en 2012

Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2′-amino-LNA monomers

scientific article published on 20 October 2011

Polyamine-functionalized 2'-amino-LNA in oligonucleotides: Facile synthesis of novel monomers and high affinity binding towards ssDNA and dsDNA

artículo científico publicado en 2020

Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates

artículo científico publicado en 2008

Polymerase-directed synthesis of C5-ethynyl locked nucleic acids.

artículo científico publicado en 2010

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

artículo científico publicado en 2000

Prediction of melting temperatures in fluorescence in situ hybridization (FISH) procedures using thermodynamic models.

artículo científico publicado en 2015

Pyrene-Modified Unlocked Nucleic Acids: Synthesis, Thermodynamic Studies, and Fluorescent Properties

scientific article published on 07 February 2012

Pyrene-functionalized 2'-amino-alpha-L-LNA as potential diagnostic probes

artículo científico publicado en 2007

Pyrene-perylene as a FRET pair coupled to the N2'-functionality of 2'-amino-LNA.

artículo científico publicado en 2007

Reprint of "Electrochemical intercalator binding to single- and double-strand DNA- and LNA-based molecules on Au(111)-electrode surfaces"

artículo científico publicado en 2020

Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies.

artículo científico publicado en 2017

SYNTHESIS OF A 2′-AMINO-α-L-LNA-T PHOSPHORAMIDITE

artículo científico publicado en 2005

Scaffolding along nucleic acid duplexes using 2'-amino-locked nucleic acids.

artículo científico

Selection of LNA-containing DNA aptamers against recombinant human CD73.

artículo científico publicado en 2015

Selective Biocatalytic Acylation Studies on 5′-O-(4,4′-Dimethoxytrityl)-2′,3′-Secouridine: An Efficient Synthesis of UNA Monomer

scientific article published on 01 January 2012

Selective biocatalytic deacylation studies on furanose triesters: a novel and efficient approach towards bicyclonucleosides

artículo científico publicado en 2007

Self-assembly of DNA-peptide supermolecules: Coiled-coil peptide structures templated by D-DNA and L-DNA triplexes exhibit chirality-independent but orientation-dependent stabilizing cooperativity

artículo científico publicado en 2020

Sequence and pH effects of LNA-containing triple helix-forming oligonucleotides: physical chemistry, biochemistry, and modeling studies

artículo científico publicado en 2004

Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding.

artículo científico publicado en 2017

Solution Structure of an LNA Hybridized to DNA: NMR Study of the d(CTLGCTLTLCTLGC):d(GCAGAAGCAG) Duplex Containing Four Locked Nucleotides

artículo científico publicado en 2000

Some recent isolation studies from potential insecticidal Piper species

article

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model

artículo científico publicado en 2014

Splice-switching efficiency and specificity for oligonucleotides with locked nucleic acid monomers

artículo científico publicado en 2008

Stepping towards highly flexible aptamers: enzymatic recognition studies of unlocked nucleic acid nucleotides.

artículo científico publicado en 2012

Stereocontrolled synthesis of LNA dinucleoside phosphorothioate by the oxathiaphospholane approach

artículo científico publicado en 2001

Stereoselective synthesis of C-branched nucleoside analogues

Stereoselective synthesis, chemistry and antiviral evaluation of 1-(2,3-dideoxy-3-C-hydroxymethyl-beta-D-threo-pentofuranosyl)thymine derivatives

artículo científico publicado en 1995

Structural Characterization of LNA and α-L-LNA Hybridized to RNA

artículo científico publicado en 2003

Structural basis of cleavage by RNase H of hybrids of arabinonucleic acids and RNA

artículo científico publicado en 2000

Synergy of Two Highly Specific Biomolecular Recognition Events: Aligning an AT-Hook Peptide in DNA Minor Grooves via Covalent Conjugation to 2'-Amino-LNA.

artículo científico publicado en 2018

Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA, and 2'-Amino-LNA Monomers

artículo científico publicado en 2016

Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2'-Amino-LNA Functionalized with Galactose Units.

artículo científico publicado en 2017

Synthesis and Hybridization Studies of 2‘-Amino-α-L-LNA and Tetracyclic “Locked LNA”†

scientific article published on 01 May 2006

Synthesis and anti-inflammatory activity evaluation of novel chroman derivatives

artículo científico publicado en 2020

Synthesis and biological evaluation of branched and conformationally restricted analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd).

artículo científico publicado en 2005

Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd).

artículo científico publicado en 2005

Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd).

artículo científico publicado en 2005

Synthesis and biophysical properties of oligodeoxynucleotides containing 2'-deoxy-5-(4-nitro-1H-imidazol-1-yl)-beta-D-uridine and 2'-deoxy-5-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-beta-D-uridine monomers

artículo científico publicado en 2010

Synthesis and biophysical studies of N2'-functionalized 2'-amino-alpha-L-LNA.

artículo científico publicado en 2007

Synthesis and biophysical studies of coronene functionalized 2'-amino-LNA: a novel class of fluorescent nucleic acids

artículo científico publicado en 2010

Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-amino-α-L-LNA adenine monomers: high-affinity targeting of single-stranded DNA

artículo científico publicado en 2013

Synthesis and evaluation of oligodeoxynucleotides containing acyclic nucleosides: Introduction of three novel analogues and a summary

artículo científico publicado en 1995

Synthesis and hybridization properties of oligodeoxynucleotides containing 3'-deoxy-3'-C-methyleneuridine.

artículo científico

Synthesis and properties of α- and β-oligodeoxynucleotides containing α- and β-1-(2-O-methyl-d-arabinofuranosyl)thymine

artículo científico publicado en 1996

Synthesis and structural characterization of 2'-fluoro-α-L-RNA-modified oligonucleotides.

artículo científico publicado en 2011

Synthesis and structural characterization of piperazino-modified DNA that favours hybridization towards DNA over RNA.

artículo científico publicado en 2010

Synthesis of 1-(3-(1,2,4-triazol-1-yl)-2,3,6-trideoxy-L-arabino-hexofuranosyl)uracils via an ?,?-unsaturated aldehydrohexose

Synthesis of 2'-amino-LNA: a new strategy.

artículo científico publicado en 2003

Synthesis of 2′-Spiro Ribo- and Arabinonucleosides

artículo científico publicado en 2003

Synthesis of Abasic Locked Nucleic Acid and Twoseco-LNA Derivatives and Evaluation of Their Hybridization Properties Compared with Their More Flexible DNA Counterparts

scientific article published on 01 August 2000

Synthesis of a base-protected alpha-L-LNA guanine nucleoside

artículo científico publicado en 2003

Synthesis of a base-protected xylo-LNA adenine nucleoside

artículo científico publicado en 2003

Synthesis of a novel bicyclic nucleoside restricted to an S-type conformation and initial evaluation of its hybridization properties when incorporated into oligodeoxynucleotides.

artículo científico publicado en 2001

Synthesis of an asymmetrically substituted AZA crown ether as metal and amino acid binding site in DNA conjugates.

artículo científico

Synthesis of an unlocked nucleic acid terpyridine monomer and binding of divalent metal ion in nucleic acid duplexes.

artículo científico publicado en 2009

Synthesis, nucleic acid hybridization properties and molecular modelling studies of conformationally restricted 3′- O ,4′- C -methylene-linked α- l -ribonucleotides

artículo científico publicado en 2006

Synthetic genetic polymers capable of heredity and evolution

artículo científico publicado en 2012

Synthetic, Structural, and Anticancer Activity Evaluation Studies on Novel Pyrazolylnucleosides

scientific article published on 30 October 2019

Systemic Evaluation of Chimeric LNA/2'-O-Methyl Steric Blockers for Myotonic Dystrophy Type 1 Therapy

scientific article published on 23 December 2019

Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition.

artículo científico

Targeting miR-9 in gastric cancer cells using locked nucleic acid oligonucleotides.

artículo científico publicado en 2018

Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2'-amino-alpha-l-LNA.

artículo científico publicado en 2005

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

artículo científico publicado en 2019

The adenine derivative of alpha-L-LNA (alpha-L-ribo configured locked nucleic acid): synthesis and high-affinity hybridization towards DNA, RNA, LNA and alpha-L-LNA complementary sequences

artículo científico publicado en 2001

The advantages of being locked. Assessing the cleavage of short and long RNAs by locked nucleic acid-containing 8-17 deoxyribozymes.

artículo científico publicado en 2007

The conformations of locked nucleic acids (LNA)

artículo científico publicado en 2000

The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice.

artículo científico publicado en 2009

The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNA

scientific article published on 01 August 1998

The sugar conformation governs (6-4) photoproduct formation at the dinucleotide level

artículo científico publicado en 2007

Thermodynamic and biological evaluation of a thrombin binding aptamer modified with several unlocked nucleic acid (UNA) monomers and a 2'-C-piperazino-UNA monomer

artículo científico publicado en 2011

Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative.

artículo científico publicado en 2017

Thermodynamic, counterion, and hydration effects for the incorporation of locked nucleic acid nucleotides into DNA duplexes.

artículo científico publicado en 2006

Thermodynamics of DNA-RNA heteroduplex formation: effects of locked nucleic acid nucleotides incorporated into the DNA strand.

artículo científico

Towards Fluorescence In Vivo Hybridization (FIVH) Detection of H. pylori in Gastric Mucosa Using Advanced LNA Probes

artículo científico publicado en 2015

Transcription factor decoy oligonucleotides modified with locked nucleic acids: an in vitro study to reconcile biostability with binding affinity.

artículo científico publicado en 2004

Triplex-forming ability of modified oligonucleotides

artículo científico publicado en 2007

UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability.

artículo científico publicado en 2009

Universal hybridization using LNA (locked nucleic acid) containing a novel pyrene LNA nucleotide monomer.

artículo científico publicado en 2001

Unlocked Nucleic Acids with a Pyrene-Modified Uracil: Synthesis, Hybridization Studies, Fluorescent Properties and i-Motif Stability

artículo científico publicado en 2014

Unlocked nucleic acid modified primer-based enzymatic polymerization assay: towards allele-specific genotype detection of human platelet antigens

scholarly article in RSC Advances, vol. 8 no. 57, 2018

Unlocked nucleic acid--an RNA modification with broad potential.

scientific article published on 23 March 2011

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

artículo científico publicado en 2010

Watson-Crick hydrogen bonding of unlocked nucleic acids.

artículo científico publicado en 2015

X-ray crystal structure of a locked nucleic acid (LNA) duplex composed of a palindromic 10-mer DNA strand containing one LNA thymine monomer

Xylo-Configured oligonucleotides (XNA, xylo nucleic acid): synthesis of conformationally restricted derivatives and hybridization towards DNA and RNA complements.

artículo científico publicado en 2003

alpha-L-ribo-configured locked nucleic acid (alpha-L-LNA): synthesis and properties

artículo científico publicado en 2002

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

artículo científico publicado en 2019

xylo-configured oligonucleotides (XNA, xylo nucleic acids): synthesis and hybridization studies

artículo científico publicado en 2003

α-l-LNA (α-i-riboConfigured Locked Nucleic Acid) Recognition of RNA. A Study by NMR Spectroscopy and Molecular Dynamics Simulations

article

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