Lista de obras - Ingemar Björkhem - Dominio Público Uruguay

-Oxidation of fatty acids. I. Mechanism of microsomal 1- and 2-hydroxylation

scientific article published on 01 December 1971

-Oxidation of fatty acids. II. Enzymatic oxido-reduction of 17-hydroxystearic acid.

artículo científico publicado en 1971

12 alpha-hydroxylase activity in human liver and its relation to cholesterol 7 alpha-hydroxylase activity

artículo científico publicado en 1992

12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one by a reconstituted system from rat liver microsomes

scientific article published on 01 October 1973

14C-triolein breath test as a rapid and convenient screening test for fat malabsorption

artículo científico publicado en 1983

18-Hydroxylation of Deoxycorticosterone by Reconstituted Systems from Rat and Bovine Adrenals ⬇️

artículo científico publicado el 3 de febrero de 1975

24(),25-Epoxycholesterol and () overexpression promote midbrain dopaminergic neurogenesis

artículo científico publicado en 2019

24(S),25-epoxycholesterol--a potential friend.

artículo científico publicado en 2004

24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver

artículo científico publicado en 1993

24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A).

artículo científico publicado en 2000

24S-Hydroxycholesterol Correlates With Tau and Is Increased in Cerebrospinal Fluid in Parkinson's Disease and Corticobasal Syndrome

scholarly article by Ingemar Björkhem et al published 2018 in Frontiers in Neurology

24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

artículo científico publicado en 2002

25-Hydroxylase activity in subcellular fractions from human liver. Evidence for different rates of mitochondrial hydroxylation of vitamin D2 and D3.

artículo científico publicado en 1986

25-Hydroxylation of vitamin D3 by a reconstituted system from rat liver microsomes

artículo científico publicado en 1979

25-Hydroxyvitamin D3-24-hydroxylase in rat kidney mitochondria

artículo científico publicado en 1983

26-Hydroxylation of C27-steroids by soluble liver mitochondrial cytochrome P-450 ⬇️

artículo científico publicado el 25 de julio de 1979

26-hydroxylation of 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol by isolated nonparenchymal cells and hepatocytes from rat liver.

artículo científico publicado en 1982

27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons

artículo científico publicado en 2019

27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation.

artículo científico publicado en 2017

27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice

artículo científico publicado en 2014

3 -Hydroxy- 5 -C 19 -and C 21 -steroid oxidoreductase activity in rat liver

artículo científico publicado en 1972

4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man.

artículo científico publicado en 2009

7 -Hydroxylation of taurodeoxycholic acid by a reconstituted system from rat liver microsomes

artículo científico publicado en 1973

7 Alpha-hydroxylation of cholesterol by reconstituted systems from rat liver microsomes

scientific article published on 01 December 1974

7 alpha hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from cholesterol 7 alpha-hydroxylase

artículo científico publicado en 1994

7 alpha-hydroxylation of 27-hydroxycholesterol in human liver microsomes

scientific article published on 01 September 1992

7α-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier.

artículo científico publicado en 2013

A SLC20A2 gene mutation carrier displaying ataxia and increased levels of cerebrospinal fluid phosphate

artículo científico publicado en 2017

A functional polymorphism in the HMGCR promoter affects transcriptional activity but not the risk for Alzheimer disease in Swedish populations.

artículo científico publicado en 2010

A novel pathway for biosynthesis of cholestanol with 7 alpha-hydroxylated C27-steroids as intermediates, and its importance for the accumulation of cholestanol in cerebrotendinous xanthomatosis

artículo científico publicado en 1985

A novel specific assay of 25-hydroxy vitamin D

scientific article published on 01 May 1976

A novel technique for assay of side-chain cleavage of exogenous and endogenous cholesterol in adrenal mitochondrial and submitochondrial preparations

artículo científico publicado en 1975

A possible model for accuracy control of determination of serum cholesterol with use of reference methods. A NORDKEM project.

artículo científico publicado en 1982

A single high dose of vitamin C counteracts the acute negative effect on microcirculation induced by smoking a cigarette

scientific article published on 01 November 1999

A specific assay of vitamin D-3 in human serum

artículo científico publicado en 1978

ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis.

artículo científico publicado en 2014

Accumulation of 7 alpha-hydroxy-4-cholesten-3-one and cholesta-4,6-dien-3-one in patients with cerebrotendinous xanthomatosis: effect of treatment with chenodeoxycholic acid

artículo científico publicado en 1987

Accuracy of a fully enzymatic method for creatinine, as judged by isotope dilution-mass fragmentography ⬇️

artículo científico publicado el 1 de septiembre de 1979

Accuracy of some routine method used in clinical chemistry as judged by isotope dilution-mass spectrometry

artículo científico publicado en 1981

Activation of rat liver cytosolic phosphatidic acid phosphatase by nucleoside diphosphates

scientific article published on 01 April 1989

Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways

scientific journal article

Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro

artículo científico publicado en 2008

Acyl-coenzyme A:cholesterol O-acyltransferase is not identical to liver microsomal carboxylesterase

artículo científico publicado en 1996

Analysis of ginsenosides by chromatography and mass spectrometry: release of 20 S-protopanaxadiol and 20 S-protopanaxatriol for quantitation

scientific article published on 01 May 1993

Antioxidant treatment inhibits the development of intimal thickening after balloon injury of the aorta in hypercholesterolemic rabbits

artículo científico publicado en 1993

Apparent lack of conversion of sitosterol into C24-bile acids in humans

scientific article published on 01 June 1990

Apparent lack of effect of obesity on the soluble phosphatidic acid phosphatase activity in human adipose tissue

scientific article published on 01 December 1989

Apparent phosphorylation - dephosphorylation of soluble phosphatidic acid phosphatase in rat liver

artículo científico publicado en 1982

Apparent selective bile acid malabsorption as a consequence of ileal exclusion: effects on bile acid, cholesterol, and lipoprotein metabolism

artículo científico publicado en 1994

Are side-chain oxidized oxysterols regulators also in vivo?

scientific article published on 23 October 2008

Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment?

artículo científico publicado en 2006

Assay and properties of 25-hydroxyvitamin D3 23-hydroxylase. Evidence that 23,25-dihydroxyvitamin D3 is a major metabolite in 1,25-dihydroxyvitamin D3-treated or fasted guinea pigs

artículo científico publicado en 1988

Assay and properties of a mitochondrial 25-hydroxylase active on vitamine D3 ⬇️

artículo científico publicado el 10 de febrero de 1978

Assay of 1,25-dihydroxy vitamin D3 by isotope dilution--mass fragmentography ⬇️

artículo científico publicado el 1 de abril de 1979

Assay of 25-hydroxy vitamin D3-1 alpha-hydroxylase in pig kidney mitochondria using isotope dilution-mass spectrometry

artículo científico publicado en 1986

Assay of cortisol with a radioimmunoassay method calibrated by isotope dilution-mass spectrometry. A Nordic collaborative study

artículo científico publicado el 1 de septiembre de 1983

Assay of ethylestrenol in urine by isotope dilution--mass spectrometry

artículo científico publicado en 1982

Assay of intermediates in bile acid biosynthesis using isotope dilution--mass spectrometry: hepatic levels in the normal state and in cerebrotendinous xanthomatosis

artículo científico publicado en 1981

Assay of liver microsomal cholesterol 7 alpha-hydroxylase using deuterated carrier and gas chromatography-mass spectrometry

artículo científico publicado en 1974

Assay of the major bile acids in serum by isotope dilution-mass spectrometry

artículo científico publicado en 1983

Assay of unesterified 7-oxocholesterol in human serum by isotope dilution-mass spectrometry

artículo científico publicado en 1986

Assay of unesterified cholesterol-5,6-epoxide in human serum by isotope dilution mass spectrometry. Levels in the healthy state and in hyperlipoproteinemia

artículo científico publicado en 1988

Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages

artículo científico publicado en 1994

Attempts to define the minimal serum level of vitamin A required for normal visual function in a patient with severe fat malabsorption

scientific article published on 01 June 1988

Beneficial effects of dietary supplementation in a disorder with defective synthesis of cholesterol. A case report of a girl with Smith-Lemli-Opitz syndrome, polyneuropathy and precocious puberty

artículo científico publicado en 1999

Bile acid metabolism in extrahepatic biliary atresia: lithocholic acid in stored dried blood collected at neonatal screening

scientific article published on 01 January 2006

Bile acid synthesis in cultured human hepatocytes: support for an alternative biosynthetic pathway to cholic acid

artículo científico publicado en 2000

Bile acid synthesis in humans: regulation of hepatic microsomal cholesterol 7 alpha-hydroxylase activity

artículo científico publicado en 1989

Bile acid synthesis in man: assay of hepatic microsomal cholesterol 7 alpha-hydroxylase activity by isotope dilution-mass spectrometry

artículo científico publicado en 1986

Bile acid synthesis in primary cultures of rat and human hepatocytes

artículo científico publicado en 1998

Bile acids and bile alcohols in two patients with Zellweger (cerebro-hepato-renal) syndrome.

artículo científico publicado en 1986

Biosynthesis and metabolism of bile acids in man

artículo científico publicado el 1 de enero de 1976

Biosynthesis of bile acids in man. Hydroxylation of the C27-steroid side chain ⬇️

artículo científico publicado el 1 de marzo de 1975

Biosynthesis of cholestanol from bile acid intermediates in the rabbit and the rat

scientific article published on 01 January 1985

Biosynthesis of cholestanol from intestinal 7 alpha-hydroxy-4-cholesten-3-one

artículo científico publicado en 1982

Biosynthesis of cholestanol: conversion of cholesterol into 4-cholesten-3-one by rat liver microsomes.

artículo científico publicado en 1974

Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin

artículo científico publicado en 2005

Brain cholesterol: long secret life behind a barrier.

artículo científico publicado en 2004

Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain

artículo científico publicado en 2003

CREM modulates the circadian expression of CYP51, HMGCR and cholesterogenesis in the liver

artículo científico publicado en 2008

Ca2+ channel blockers verapamil and nifedipine inhibit apoptosis induced by 25-hydroxycholesterol in human aortic smooth muscle cells

scientific article published on 01 October 1997

Can LDL cholesterol be too low? Possible risks of extremely low levels

artículo científico publicado en 2017

Catalytic properties of cytochrome P-450 from human liver

artículo científico publicado en 1976

Cerebrotendinous xanthomatosis in the Israeli Druze: molecular genetics and phenotypic characteristics

artículo científico publicado en 1994

Cerebrotendinous xanthomatosis.

artículo científico

Cerebrotendinous xanthomatosis: a defect in mitochondrial 26-hydroxylation required for normal biosynthesis of cholic acid

artículo científico publicado en 1980

Cerebrotendinous xanthomatosis: an inborn error in bile acid synthesis with defined mutations but still a challenge.

artículo científico publicado en 2010

Cerebrotendinous xanthomatosis: defective liver mitochondrial hydroxylation of chenodeoxycholic acid precursors

scientific article published on 01 May 1981

Cerebrotendinous xanthomatosis: molecular characterization of two Scandinavian sisters

artículo científico publicado en 2002

Cerebrotendinous xanthomatosis: molecular diagnosis enables presymptomatic detection of a treatable disease

artículo científico publicado en 1994

Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis

artículo científico publicado en 2002

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

artículo científico publicado en 2003

Characterization of cholesterol homeostasis in telomerase-immortalized Tangier disease fibroblasts reveals marked phenotype variability.

artículo científico publicado en 2013

Characterization of enzymes involved in formation of ethyl esters of long-chain fatty acids in humans

artículo científico publicado en 2001

Cholestatic liver disease in adults may be due to an inherited defect in bile acid biosynthesis

scientific article published on 01 August 2007

Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain. ⬇️

artículo científico publicado en 2011

Cholestenoic acids regulate motor neuron survival via liver X receptors

artículo científico publicado en 2014

Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells.

artículo científico publicado en 2014

Cholesterol 7 alpha-hydroxylase is up-regulated by the competitive inhibitor 7-oxocholesterol in rat liver.

artículo científico publicado en 1993

Cholesterol binding to cytochrome P450 7A1, a key enzyme in bile acid biosynthesis

artículo científico publicado en 2005

Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.

artículo científico publicado en 2007

Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S-hydroxycholesterol

artículo científico publicado en 2001

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

scientific journal article

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

artículo científico publicado en 1998

Cholesterol in mouse retina originates primarily from in situ de novo biosynthesis

artículo científico publicado en 2015

Cholesterol treatment forever? The first Scandinavian trial of cholesterol supplementation in the cholesterol-synthesis defect Smith-Lemli-Opitz syndrome.

artículo científico publicado en 2002

Cholesterol, oxysterol, triglyceride, and coenzyme Q homeostasis in ALS. Evidence against the hypothesis that elevated 27-hydroxycholesterol is a pathogenic factor

artículo científico publicado en 2014

Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina

artículo científico publicado en 2007

Cholestyramine treatment reduces postprandial but not fasting serum bile acid levels in humans

artículo científico publicado en 1982

Cholic acid as key regulator of cholesterol synthesis, intestinal absorption and hepatic storage in mice.

artículo científico publicado en 2005

Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

artículo científico publicado en 2002

Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

article published in 2002

Choline supplementation prevents diet induced gut mucosa lipid accumulation in post-smolt Atlantic salmon (Salmo salar L.).

artículo científico publicado en 2020

Circulating Fibroblast Growth Factor 19 in Portal and Systemic Blood

artículo científico publicado en 2017

Circulating markers for biosynthesis of cholesterol and bile acids are not depressed in asymptomatic gallstone subjects

artículo científico publicado en 1997

Clinical and molecular characterization of hereditary spastic paraplegias: A next-generation sequencing panel approach

artículo científico publicado en 2017

Clinical value of assessing prednisolone pharmacokinetics before and after renal transplantation

artículo científico publicado en 1984

Clofibrate does not induce peroxisomal 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl coenzyme A oxidation in rat liver. Evidence that this reaction is catalyzed by an enzyme system different from that of peroxisomal acyl-coenzyme A oxidati

artículo científico publicado en 1988

Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme

artículo científico publicado en 1994

Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells.

artículo científico publicado en 2009

Common characteristics of the cytochrome P-450 system involved in 18- and 11 beta-hydroxylation of deoxycorticosterone in rat adrenals ⬇️

artículo científico publicado el 1 de septiembre de 1977

Common polymorphisms in the CYP7A1 gene do not contribute to variation in rates of bile acid synthesis and plasma LDL cholesterol concentration

artículo científico publicado en 2005

Comparison of the proportion of unconjugated to total serum cholic acid and the [14C]-xylose breath test in patients with suspected small intestinal bacterial overgrowth

scientific article (publication date: September 1992)

Comparison of two isotope dilution/mass spectrometric methods for determination of total serum cholesterol

scientific article published on 01 January 1982

Concentration of unsulfated lithocholic acid in portal and systemic venous plasma: evidence that lithocholic acid does not down regulate the hepatic cholesterol 7 alpha-hydroxylase activity in gallstone patients

artículo científico publicado en 1996

Conjugation of cholic acid with taurine and glycine by rat liver peroxisomes

artículo científico publicado en 1986

Coordinate regulation of cholesterol 7 alpha-hydroxylase and HMG-CoA reductase in the liver.

artículo científico publicado en 1997

Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver

artículo científico publicado en 1987

Critical role of cholic acid for development of hypercholesterolemia and gallstones in diabetic mice

artículo científico publicado en 2006

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain.

artículo científico publicado en 2005

Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain.

artículo científico publicado en 2006

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

artículo científico publicado en 2008

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

artículo científico publicado en 2016

Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone

artículo científico publicado en 1997

Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum

artículo científico publicado en 2017

Decreased concentrations of deoxycholic acid in serum of uraemic patients with diarrhoea.

artículo científico publicado en 1990

Defective peroxisomal cleavage of the C27-steroid side chain in the cerebro-hepato-renal syndrome of Zellweger

artículo científico publicado en 1985

Dehydroxylation of a 7 beta-hydroxy-C27 plant sterol in rat liver.

artículo científico publicado en 1989

Demonstration of 26-hydroxylation of C27-steroids in human skin fibroblasts, and a deficiency of this activity in cerebrotendinous xanthomatosis

artículo científico publicado en 1986

Deoxycholic acid in myotonic dystrophy

scientific article published on 01 May 1982

Deoxycholic acid treatment in patients with cholesterol gallstones: failure to detect a suppression of cholesterol 7alpha-hydroxylase activity

artículo científico publicado en 1999

Detecting oxysterols in the human circulation

article

Detection and quantitation of 19-norandrosterone in urine by isotope dilution-mass spectrometry

artículo científico publicado en 1982

Detection and quantitation of 3 alpha-hydroxy-1-methylen-5 alpha-androstan-17-one, the major urinary metabolite of methenolone acetate (Primobolan) by isotope dilution--mass spectrometry

artículo científico publicado en 1983

Detection and quantitation of methandienone (Dianabol) in urine by isotope dilution--mass fragmentography

artículo científico publicado en 1980

Detection and quantitation of stanozolol (Stromba) in urine by isotope dilution-mass fragmentography

artículo científico publicado en 1981

Detection of testosterone administration by increased ratio between serum concentrations of testosterone and 17 alpha-hydroxyprogesterone.

artículo científico publicado en 1992

Determination of 4-methylpyrozol in serum with mass fragmentography

artículo científico publicado en 1975

Determination of aglycones of ginsenosides in ginseng preparations sold in Sweden and in urine samples from Swedish athletes consuming ginseng

scientific article published on 01 April 1996

Determination of cholesteryl sulphate by isotope dilution-mass spectrometry for diagnosis of steroid sulphatase deficiency

artículo científico publicado en 1985

Determination of serum levels of unesterified lanosterol by isotope dilution-mass spectrometry

artículo científico publicado en 1990

Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry

artículo científico publicado en 1989

Determination of serum triglycerides by mass fragmentography

artículo científico publicado en 1976

Determination of serum urea by mass fragmentography

artículo científico publicado en 1976

Diagnosis of Zellweger syndrome by analysis of bile acids and plasmalogens in stored dried blood collected at neonatal screening

artículo científico publicado en 1987

Diagnostic power of 24S-hydroxycholesterol in cerebrospinal fluid: candidate marker of brain health

artículo científico publicado en 2013

Diagnostic use of cerebral and extracerebral oxysterols

artículo científico publicado en 2004

Dietary cholesterol induces transient changes in plasma nitrate levels in rabbits that are correlated to microcirculatory changes

artículo científico publicado en 1996

Dietary cholesterol supplementation to a plant-based diet suppresses the complete pathway of cholesterol synthesis and induces bile acid production in Atlantic salmon (Salmo salar L.).

artículo científico publicado en 2014

Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms

artículo científico publicado en 2012

Differences in the regulation of the classical and the alternative pathway for bile acid synthesis in human liver. No coordinate regulation of CYP7A1 and CYP27A1

artículo científico publicado en 2002

Differential expression and function of ABCG1 and ABCG4 during development and aging

artículo científico publicado en 2010

Differential hepatocellular zonation pattern of cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) in the mouse.

artículo científico publicado en 2007

Differential induction of peroxisomal oxidation of palmitic acid and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid in rat liver

artículo científico publicado en 1990

Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling

artículo científico publicado en 2017

Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.

artículo científico publicado en 1996

Distinct binding of cholesterol and 5beta-cholestane-3alpha,7alpha,12alpha-triol to cytochrome P450 27A1: evidence from modeling and site-directed mutagenesis studies

scientific article published on 01 April 2006

Do oxysterols control cholesterol homeostasis?

artículo científico publicado en 2002

Doping - a medical and ethical problem

artículo científico publicado en 1982

Dose-response relationship between dietary choline and lipid accumulation in pyloric enterocytes of Atlantic salmon (Salmo salar L.) in seawater

artículo científico publicado en 2020

Down-regulation of hepatic HMG-CoA reductase in mice by dietary cholesterol: importance of the delta 5 double bond and evidence that oxidation at C-3, C-5, C-6, or C-7 is not involved

scientific article published on 01 January 1994

Effect of 3-thiadicarboxylic acid on lipid metabolism in experimental nephrosis

artículo científico publicado en 1993

Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers

artículo científico publicado en 2009

Effect of ascorbic acid on microcirculation in patients with Type II diabetes: a randomized placebo-controlled cross-over study.

artículo científico publicado en 2005

Effect of calcium intake on serum levels of 25-hydroxyvitamin D3

artículo científico publicado en 1988

Effect of dibutyryl cyclic AMP on the metabolism of pregnenolone in vivo

artículo científico publicado el 1 de noviembre de 1975

Effect of different dietary triglycerides on 7alpha-hydroxylation of cholesterol and other mixed-function oxidations ⬇️

artículo científico publicado el 1 de marzo de 1978

Effect of ethanol on the ratio between testosterone and epitestosterone in urine

artículo científico publicado en 1988

Effect of lymphatic drainage on 7alpha-hydroxylation of cholesterol in rat liver

artículo científico publicado el 29 de noviembre de 1978

Effect of n-3 fatty acids on the key enzymes involved in cholesterol and triglyceride turnover in rat liver

artículo científico publicado en 1991

Effect of pravastatin on hepatic cholesterol metabolism

artículo científico publicado en 1991

Effect of sitosterol on the rate-limiting enzymes in cholesterol synthesis and degradation

artículo científico publicado en 1989

Effect of ursodeoxycholic acid treatment on intestinal absorption of triglycerides in man.

artículo científico publicado en 1984

Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain.

artículo científico publicado en 2014

Effects of ascorbic acid deficiency on adrenal mitochondrial hydroxylations in guinea pigs ⬇️

artículo científico publicado el 1 de agosto de 1978

Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion.

artículo científico publicado en 2005

Effects of clofibrate on some microsomal hydroxylations involved in the formation and metabolism of bile acids in rat liver

artículo científico publicado en 1976

Effects of combined treatment with pravastatin and ursodeoxycholic acid on hepatic cholesterol metabolism.

artículo científico publicado en 2002

Effects of feeding chenodeoxycholic acid on metabolism of cholesterol and bile acids in germ-free rats

scientific article published on 01 April 1981

Effects of high-dose itraconazole treatment on lipoproteins in men.

artículo científico publicado en 2007

Effects of mevinolin in rat liver: evidence for a lack of coupling between synthesis of hydroxymethylglutaryl-CoA reductase and cholesterol 7 alpha-hydroxylase activity.

artículo científico publicado en 1986

Effects of short-term treatment with pravastatin on the hepatic synthesis of cholesterol and bile acids in gallstone patients.

artículo científico publicado en 1998

Effects of treatment with chenodeoxycholic acid on liver microsomal metabolism of steroids in man.

artículo científico publicado en 1980

Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin.

artículo científico publicado en 1999

Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transport

scientific article published in Journal of Biological Chemistry

Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo

artículo científico publicado en 2011

Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis.

artículo científico publicado en 2015

Evidence against in vitro modulation of rat liver cholesterol 7 alpha-hydroxylase activity by phosphorylation-dephosphorylation: comparison with hydroxymethylglutaryl CoA reductase

scientific article published on 01 July 1986

Evidence for a lack of regulatory importance of the 12 alpha-hydroxylase in formation of bile acids in man: an in vivo study

artículo científico publicado en 1983

Evidence for sex difference in the CSF/plasma albumin ratio in ~20 000 patients and 335 healthy volunteers

artículo científico publicado en 2018

Evidence that 24- and 27-hydroxylation are not involved in the cholesterol-induced down-regulation of hydroxymethylglutaryl-CoA reductase in mouse liver

artículo científico publicado en 1992

Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study

article

Expression and characterization of a C24 bile acid 7 alpha-dehydratase from Eubacterium sp. strain VPI 12708 in Escherichia coli

artículo científico publicado en 1996

Expression of human cytochrome P450 46A1 in Escherichia coli: effects of N- and C-terminal modifications

artículo científico publicado en 2004

Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo

artículo científico publicado en 2001

Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27).

artículo científico publicado en 1997

Fasting levels of monoketonic bile acids in human peripheral and portal circulation.

artículo científico publicado en 1982

Feedback regulation of bile acid synthesis in human liver: importance of HNF-4alpha for regulation of CYP7A1.

artículo científico publicado en 2005

Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor

artículo científico publicado en 2003

First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography-Urgent need for harmonisation of analytical methods

scientific article published on 30 March 2019

Five decades with oxysterols.

artículo científico publicado en 2012

Formation and Metabolism of some Delta4-Cholestenols in the Rat. Bile Acids and Steroids 185 ⬇️

artículo científico

Formation and metabolism of 3-beta-hydroxycholest-5-en-7-one and cholest-5-ene-3-beta, 7-beta-diol. Bile acids and steroids 192.

artículo científico publicado en 1968

Formation and metabolism of 7 alpha-hydroxy-5-alpha-cholestan-3-one and 7 alpha, 12 alpha-dihydroxy-5-alpha-cholestan-3-one in rat liver

scientific article published on 01 March 1970

Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse

artículo científico publicado en 2019

Formation of C21 bile acids from plant sterols in the rat.

artículo científico publicado en 1990

Formation of chenodeoxycholic acid from 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes

scientific article published on 01 June 1986

Formation of cholic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes

artículo científico publicado en 1983

Formation of fatty acid ethyl esters in rat liver microsomes. Evidence for a key role for acyl-CoA: ethanol O-acyltransferase

artículo científico publicado en 1999

Formation of novel C21-bile acids from cholesterol in the rat. Structure identification of the major Di- and trihydroxylated species

artículo científico publicado en 1991

Formation of oxysterols from different pools of cholesterol as studied by stable isotope technique: cerebral origin of most circulating 24S-hydroxycholesterol in rats, but not in mice

artículo científico publicado en 2000

From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans

artículo científico publicado en 2001

From cholesterol to bile acids: a metabolic maze

artículo científico publicado en 1990

Further evidence for a continuous flux of bile acids into the brain: trapping of bile acids in subdural hematomas

artículo científico publicado en 2020

Gas chromatographic-mass spectrometric determination of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol for study on human urinary excretion of ginsenosides after ingestion of ginseng preparations

artículo científico publicado en 1997

Generation of viable cholesterol-free mice

scientific journal article

Genes involved in initial steps of bile acid synthesis

artículo científico publicado en 2001

Genetic analysis of a Japanese cerebrotendinous xanthomatosis family: identification of a novel mutation in the adrenodoxin binding region of the CYP 27 gene

artículo científico publicado en 1996

Genetic connections between neurological disorders and cholesterol metabolism

artículo científico publicado en 2010

Gestational diabetes mellitus modulates cholesterol homeostasis in human fetoplacental endothelium

artículo científico publicado en 2018

Harmonization of methods for analysis of cholesterol oxides in foods--the first portion of a long road toward standardization: interlaboratory study.

artículo científico publicado en 2004

Hepatic 7 alpha-dehydroxylation of bile acid intermediates, and its significance for the pathogenesis of cerebrotendinous xanthomatosis

artículo científico publicado en 1988

Hepatic 7alpha-hydroxylation of cholesterol in ascorbate-deficient and ascorbate-supplemented guinea pigs

artículo científico publicado en 1976

Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice

artículo científico publicado en 2001

Hepatic cholesterol metabolism in cholesterol gallstone disease

artículo científico publicado en 1991

Hepatic cholesterol metabolism in human obesity

artículo científico publicado en 1997

Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones ⬇️

artículo científico publicado el 1 de enero de 1979

Hepatic fatty acid metabolism as a determinant of plasma and liver triacylglycerol levels. Studies on tetradecylthioacetic and tetradecylthiopropionic acids

artículo científico publicado en 1995

Hepatic metabolism of cholesterol in Crohn's disease. Effect of partial resection of ileum

artículo científico publicado en 1991

Hepatic uptake of bile acids in man. Fasting and postprandial concentrations of individual bile acids in portal venous and systemic blood serum

artículo científico publicado en 1982

Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial

artículo científico publicado en 2017

Heterogeneity of hepatic mixed function oxidases

artículo científico publicado en 1973

High circulating levels of 25-hydroxyvitamin D3 in renal stone formers with hyperabsorptive hypercalciuria.

artículo científico publicado en 1986

High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs.

artículo científico publicado en 2004

High levels of 15-oxygenated steroids in circulation of patients with multiple sclerosis: fact or fiction?

artículo científico publicado en 2010

Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis

artículo científico publicado en 2002

Hydroxylations in biosynthesis and metabolism of bile acids

artículo científico publicado en 1974

Hydroxylations of bile acids by reconstituted systems from rat liver microsomes

artículo científico publicado en 1974

Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA.

artículo científico publicado en 1997

Identification of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholest-24-enoic acid as an intermediate in the peroxisomal conversion of 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid to cholic acid

artículo científico publicado en 1989

Identification of intermediates in the peroxisomal beta-oxidation of linoleic acid

artículo científico publicado en 1990

Identification of new mutations in sterol 27-hydroxylase gene in Japanese patients with cerebrotendinous xanthomatosis (CTX)

artículo científico publicado en 1994

Identification of thyroxine in human breast milk by gas chromatography-mass spectrometry

artículo científico publicado en 1983

Identification of unusual 7-oxygenated bile acid sulfates in a patient with Niemann-Pick disease, type C.

artículo científico publicado en 2001

Immunochemical determination of human cholesterol 7 alpha-hydroxylase

scientific article published on 01 February 1995

Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis

artículo científico publicado en 2010

Implications of cerebrovascular ATP-binding cassette transporter G1 (ABCG1) and apolipoprotein M in cholesterol transport at the blood-brain barrier.

artículo científico publicado en 2017

Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro.

artículo científico publicado en 1997

Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans

scientific article published on 01 February 1996

Importance of peroxisomes in the formation of chenodeoxycholic acid in human liver. Metabolism of 3 alpha,7 alpha-dihydroxy-5 beta-cholestanoic acid in Zellweger syndrome

artículo científico publicado en 1991

In vitro formation of bile acids from di- and trihydroxy-5 beta-cholestanoic acid in human liver peroxisomes

artículo científico publicado en 1986

In vitro studies of lipid metabolism in human liver

artículo científico publicado en 1987

In vivo and vitro studies on formation of bile acids in patients with Zellweger syndrome. Evidence that peroxisomes are of importance in the normal biosynthesis of both cholic and chenodeoxycholic acid

artículo científico publicado en 1985

Inborn errors of metabolism with consequences for bile acid biosynthesis. A minireview

artículo científico publicado en 1994

Increased flux of the plant sterols campesterol and sitosterol across a disrupted blood brain barrier

artículo científico publicado en 2015

Increased oxidoreduction of deoxycholic acid in cholecystectomised patients

artículo científico publicado en 1989

Increased serum beta 2 microglobulin during rejection, cyclosporine-induced nephrotoxicity, and cytomegalovirus infection in renal transplant recipients

artículo científico publicado en 1986

Increased urinary testosterone/epitestosterone ratios found in Swedish athletes in connection with a national control program. Evaluation of 28 cases

artículo científico publicado en 1996

Individual bile acids in portal venous and systemic blood serum of fasting man

artículo científico publicado el 1 de diciembre de 1977

Influence of bile acids on the soluble phosphatidic acid phosphates in rat liver

scientific article published on 01 May 1981

Influence of fructose feeding on individual enzymic reactions in the formation and metabolism of bile acids in rat liver homogenates

artículo científico publicado el 1 de septiembre de 1976

Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol

artículo científico publicado en 1990

Inhibition of human sterol Δ7-reductase and other postlanosterol enzymes by LK-980, a novel inhibitor of cholesterol synthesis.

artículo científico publicado en 2010

Interlaboratory evaluation of four RIA kits for determination of plasma cortisol, with special reference to accuracy: influence of matrix in calibration standards

scientific article published on 01 December 1980

International descriptive and interventional survey for oxycholesterol determination by gas- and liquid-chromatographic methods

artículo científico publicado en 2018

Intestinal cholesterol absorption and cardiovascular risk.

artículo científico publicado en 2013

Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain?

artículo científico publicado en 2013

Isolation of 5 alpha-cholestane-3 beta, 7 alpha-diol from bile of patients with cerebrotendinous xanthomatosis. Inefficiency of this steroid as a precursor to cholestanol.

artículo científico publicado en 1983

Isotope dilution--mass spectrometry of thyroxin proposed as a reference method ⬇️

artículo científico publicado el 1 de diciembre de 1983

Lack of 3 beta-hydroxy-delta 5-C27-steroid dehydrogenase/isomerase in fibroblasts from a child with urinary excretion of 3 beta-hydroxy-delta 5-bile acids. A new inborn error of metabolism

artículo científico publicado en 1990

Lack of effects of an increased pool of 25-hydroxyvitamin D3 on urinary excretion of calcium in healthy subjects

artículo científico publicado en 1987

Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats.

artículo científico publicado en 2016

Lessons from hepatocyte-specific Cyp51 knockout mice: impaired cholesterol synthesis leads to oval cell-driven liver injury.

artículo científico publicado en 2015

Levels of 7alpha-hydroxycholesterol and/or 7alpha-hydroxy-4-cholest-3-one are the optimal biochemical markers for the evaluation of treatment of cerebrotendinous xanthomatosis

scientific article published on 28 November 2019

Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders.

artículo científico publicado en 2007

Lipoprotein oxidation and progression of carotid atherosclerosis

artículo científico publicado en 1997

Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques

artículo científico publicado en 1997

Lymphatic transport of bile acids in man.

artículo científico publicado en 1982

Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis

artículo científico publicado en 2009

Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation

artículo científico publicado en 2011

Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells.

artículo científico publicado en 2011

Marked variability in hepatic expression of cytochromes CYP7A1 and CYP27A1 as compared to cerebral CYP46A1. Lessons from a dietary study with omega 3 fatty acids in hamsters

artículo científico publicado en 2010

Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene

artículo científico publicado en 1998

Mass fragmentographic assay of 25-hydroxyvitamin D3

scientific article published on 01 January 1980

Mass fragmentography of creatinine proposed as a reference method ⬇️

artículo científico publicado el 1 de noviembre de 1977

Mechanism and stereochemistry in the sequential enzymatic saturation of the two double bonds in cholesta-4,6-dien-3-one

artículo científico publicado en 1992

Mechanism of Microbial Transformation of Cholesterol into Coprostanol ⬇️

artículo científico publicado el 16 de agosto de 1971

Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1)

artículo científico publicado en 2002

Mechanism of degradation of the steroid side chain in the formation of bile acids ⬇️

artículo científico publicado el 1 de abril de 1992

Mechanism of enzymatic reduction of steroid double bonds

scientific article published on 01 March 1973

Mechanism of intestinal 7 alpha-dehydroxylation of cholic acid: evidence that allo-deoxycholic acid is an inducible side-product

artículo científico publicado en 1991

Mechanism of intestinal formation of deoxycholic acid from cholic acid in humans: evidence for a 3-oxo-delta 4-steroid intermediate

scientific article published on 01 July 1989

Mechanism of peroxisomal 24-hydroxylation of 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid in rat liver

artículo científico publicado en 1984

Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1).

artículo científico publicado en 2004

Metabolism of 3 -hydroxy- 5 - and 3-oxo- 4 -C 19 and C 21 steroids in human liver microsomes.

artículo científico publicado en 1972

Metabolism of 4 beta -hydroxycholesterol in humans.

artículo científico publicado en 2002

Metabolism of Mono-and Dihydroxylated Bile Acids in Preparations of Human Liver ⬇️

artículo científico publicado el 1 de diciembre de 1973

Metabolism of Steroids in Germfree and Conventional Rats Treated with a 3beta-Hydroxy-delta5-Steroid Oxidoreductase Inhibitor ⬇️

artículo científico publicado el 1 de noviembre de 1970

Metabolism of a novel side chain modified Delta8(14)-15-ketosterol, a potential cholesterol lowering drug: 28-hydroxylation by CYP27A1.

artículo científico publicado en 2008

Metabolism of prostaglandin F2 alpha in Zellweger syndrome. Peroxisomal beta-oxidation is a major importance for in vivo degradation of prostaglandins in humans

artículo científico publicado en 1991

Metabolism of the cholestanol precursor cholesta-4,6-dien-3-one in different tissues

artículo científico publicado en 1987

Mice with chimeric livers are an improved model for human lipoprotein metabolism

artículo científico publicado en 2013

Microbial formation of 17-alpha-C21 steroids. Stereochemistry of saturation of the delta-16-double bond

artículo científico publicado en 1971

Microbial transformation of cholesterol into coprostanol. Properties of a 3-oxo- 4-steroid-5 beta-reductase

artículo científico publicado en 1973

Microsomal dehydrogenation of omega1- and omega2-hydroxy fatty acids

artículo científico publicado en 1972

Microsomal long-chain acyl-CoA thioesterase (carboxylesterase ES-4) is regulated by thyroxine

artículo científico publicado en 1999

Mitochondrial omega-hydroxylation of cholesterol side chain

artículo científico publicado en 1974

Modification of membrane phospholipid fatty acyl composition in a leukemic T cell line: effects on receptor mediated intracellular Ca2+ increase.

artículo científico publicado en 1991

Molecular cloning and expression of cDNA encoding 3alpha,7alpha,12alpha-trihydroxy-5beta-chole stanoyl-CoA oxidase from rabbit liver.

artículo científico publicado en 1997

Molecular cloning and expression of rabbit sterol 12alpha-hydroxylase

artículo científico publicado en 1996

Monitoring of serum beta 2 microglobulin and neopterin levels in renal transplant recipients: increased values during impaired renal function and cytomegalovirus infection

artículo científico publicado en 1988

Monitoring of serum neopterin levels in renal transplant recipients: increased values during impaired renal function and cytomegalovirus infection

artículo científico publicado en 1987

Mutation in the sterol 27-hydroxylase gene associated with fatal cholestasis in infancy.

artículo científico publicado en 2005

N-acetylcysteine improves microcirculatory flow during smoking: new effects of an old drug with possible benefits for smokers

artículo científico publicado en 2001

Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk.

artículo científico publicado en 2016

New possibilities for children with Smith-Lemli-Opitz syndrome. A cholesterol synthesis defect discovered

scientific article published on 01 September 1995

Nordic surveys of analytical quality in clinical chemistry laboratories.

artículo científico publicado en 1984

Normal activity of C27-steroid 26-hydroxylase in cultured sitosterolaemia fibroblasts.

artículo científico publicado en 1987

Novel LC-MS/MS method for assay of 7alpha-hydroxy-4-cholesten-3-one in human plasma. Evidence for a significant extrahepatic metabolism

artículo científico publicado en 2007

Novel homozygous and compound heterozygous mutations of sterol 27-hydroxylase gene (CYP27) cause cerebrotendinous xanthomatosis in three Japanese patients from two unrelated families

artículo científico publicado en 1997

Novel pathways for elimination of cholesterol by extrahepatic formation of side-chain oxidized oxysterols.

artículo científico publicado en 1996

Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid.

artículo científico publicado en 2007

Omega- and (omega - 1)-oxidation of fatty acids by rat liver microsomes

artículo científico publicado en 1970

Omega-hydroxylation of steriod side-chain in biosynthesis of bile acids

artículo científico publicado en 1973

On accuracy in clinical chemistry

artículo científico publicado en 1982

On the 25-hydroxylation of vitamin D3 in vitro studied with a mass fragmentographic technique ⬇️

artículo científico publicado el 10 de octubre de 1979

On the Conversion of Cholestanol into Allocholic Acid in Rat Liver ⬇️

artículo científico publicado el 1 de enero de 1971

On the Conversion of Cholesterol to 5beta-Cholestane-3alpha, 7alpha-Diol in Guinea Pig Liver Homogenates ⬇️

artículo científico

On the Formation of Cholic Acid from Cholest-4-ene-3alpha,7-alpha,12alpha-triol and Cholest-4-ene-3beta,7alpha,12alpha-triol. Bile Acids and Steroids 166

artículo científico

On the Metabolism of Cholesterol in Rat Liver Homogenates. Bile Acids and Steroids 193 ⬇️

artículo científico publicado en 1968

On the Synthesis and Metabolism of Cholest-4-en-7alpha-ol-3-one. Bile acids and steroids 156

artículo científico

On the anti-atherogenic effect of the antioxidant BHT in cholesterol-fed rabbits: inverse relation between serum triglycerides and atheromatous lesions

artículo científico publicado en 2001

On the effect of thyroid hormone on 26-hydroxylation of C 27 -steroids in rat liver

artículo científico publicado en 1973

On the fluxes of side-chain oxidized oxysterols across blood-brain and blood-CSF barriers and origin of these steroids in CSF (Review)

scientific article published on 23 December 2018

On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO.

artículo científico publicado en 2014

On the importance of albumin binding for the flux of 7α-hydroxy-3-oxo-4-cholestenoic acid in the brain

artículo científico publicado en 2016

On the mechanism of 11-hydroxylation of lauric acid by rat liver microsomes.

artículo científico publicado en 1973

On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase.

artículo científico publicado en 2010

On the mechanism of biosynthesis of cholestanol from 7 alpha-hydroxycholesterol

artículo científico publicado en 1986

On the mechanism of cerebral accumulation of cholestanol in patients with cerebrotendinous xanthomatosis

artículo científico publicado en 2007

On the mechanism of ethanol-induced accumulation of triglycerides in the liver

artículo científico publicado en 1978

On the mechanism of oxidation of cholesterol at C-7 in a lipoxygenase system

scientific article published on 01 June 1992

On the mechanism of regulation of omega oxidation of fatty acids ⬇️

artículo científico publicado el 10 de septiembre de 1976

On the mechanism of stimulation of cholesterol 7 alpha-hydroxylase by dietary cholesterol.

artículo científico publicado en 1991

On the mechanism of the hypolipidemic effect of sulfur-substituted hexadecanedioic acid (3-thiadicarboxylic acid) in normolipidemic rats

scientific article published on 01 July 1993

On the origin of the cholestenoic acids in human circulation

artículo científico publicado en 2003

On the possible use of the serum level of 7 alpha-hydroxycholesterol as a marker for increased activity of the cholesterol 7 alpha-hydroxylase in humans

artículo científico publicado en 1987

On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function.

artículo científico publicado en 2002

On the rate-limiting step in W-hydroxylation of lauric acid.

artículo científico publicado en 1972

On the rate-limiting step in microsomal hydroxylation of steroids.

artículo científico publicado en 1972

On the regulatory importance of 1,25-dihydroxyvitamin D3 and dietary calcium on serum levels of 25-hydroxyvitamin D3 in rats.

artículo científico publicado en 1987

On the regulatory importance of 27-hydroxycholesterol in mouse liver.

artículo científico publicado en 2016

On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice

artículo científico publicado en 2013

On the saturation of the cholesterol 7 alpha-hydroxylase in human liver microsomes

artículo científico publicado en 1989

On the structural specificity in the regulation of the hydroxymethylglutaryl-CoA reductase and the cholesterol-7 alpha-hydroxylase in rats. Effects of cholestanol feeding

artículo científico publicado en 1985

On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation.

artículo científico publicado en 2003

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

artículo científico publicado en 2001

Oxidation of branched-chain fatty acids in rat liver homogenates

scientific article published on 01 July 1970

Oxidation of omega-hydroxylated fatty acids and steroids by alcohol dehydrogenase

scientific article published on 01 May 1973

Oxidoreduction of different hydroxyl groups in bile acids during their enterohepatic circulation in man

scientific article published on 01 February 1986

Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A).

artículo científico publicado en 2000

Oxysterols and Alzheimer's disease.

artículo científico publicado en 2006

Oxysterols and Parkinson's disease: evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease.

artículo científico publicado en 2013

Oxysterols and neurodegenerative diseases.

artículo científico publicado en 2009

Oxysterols in human circulation: which role do they have?

artículo científico publicado en 2002

Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol.

artículo científico publicado en 2001

Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophages

artículo científico publicado en 1996

Oxysterols: friends, foes, or just fellow passengers?

artículo científico publicado en 2002

Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid

artículo científico publicado en 2005

Peroxisomal bile acid-CoA:amino-acid N-acyltransferase in rat liver

artículo científico publicado en 1989

Peroxisomal dysfunction in a boy with neurologic symptoms and amaurosis (Leber disease): clinical and biochemical findings similar to those observed in Zellweger syndrome

artículo científico publicado en 1986

Phosphatidate phosphatase--a key enzyme in glycerolipid biosynthesis. Studies on the yeast enzyme

artículo científico publicado en 1998

Phospholipids modify substrate binding and enzyme activity of human cytochrome P450 27A1.

artículo científico publicado en 2004

Phytosterolaemia in a Norwegian family: diagnosis and characterization of the first Scandinavian case

scientific article published on 01 May 1996

Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients

artículo científico publicado en 2000

Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease.

artículo científico publicado en 2008

Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease.

artículo científico publicado en 2000

Plasma cerebrosterol and magnetic resonance imaging measures in multiple sclerosis.

artículo científico publicado en 2005

Plasma cortisol determination by mass fragmentography

artículo científico publicado en 1974

Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases.

artículo científico publicado en 2000

Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease.

artículo científico publicado en 2009

Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface

article

Platelet alpha- and beta- secretase activities are not significantly affected by dementia or mild cognitive impairment in Swedish patients.

artículo científico publicado en 2010

Polymorphism in the coding part of the sterol 12alpha-hydroxylase gene does not explain the marked differences in the ratio of cholic acid and chenodeoxycholic acid in human bile.

artículo científico publicado en 2005

Portal venous bile acids in cholesterol gallstone disease: effect of treatment with chenodeoxycholic and cholic acids

artículo científico publicado en 1985

Possibility of prenatal diagnosis of Zellweger syndrome

artículo científico publicado en 1984

Post-occlusive reactive hyperemia in single nutritive capillaries of the nail fold: methodological considerations.

artículo científico publicado en 2002

Postprandial serum bile acids in healthy man. Evidence for differences in absorptive pattern between individual bile acids ⬇️

artículo científico publicado el 1 de agosto de 1977

Prednisolone excretion in human milk

artículo científico publicado en 1985

Preferential utilization of newly synthesized cholesterol as substrate for bile acid biosynthesis. An in vivo study using 18O2-inhalation technique ⬇️

artículo científico publicado el 25 de junio de 1979

Premature termination codon at the sterol 27-hydroxylase gene causes cerebrotendinous xanthomatosis in an Afrikaner family

artículo científico publicado en 1994

Presence of cholesterol 7 alpha-hydroxylase enzyme protein in COS-cells leads to increased HMG CoA reductase activity.

artículo científico publicado en 1994

Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels

artículo científico publicado en 2009

Progressive brain calcifications and signs in a family with the L9R mutation in the PDGFB gene.

artículo científico publicado en 2016

Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease.

artículo científico publicado en 2007

Properties of a reconstituted vitamin D3 25-hydroxylase from rat liver mitochondria ⬇️

artículo científico publicado el 10 de junio de 1980

Properties of guinea-pig kidney 25-hydroxyvitamin D3 1 alpha-hydroxylase assayed by isotope dilution-mass spectrometry

artículo científico publicado en 1988

Putative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1

artículo científico publicado en 2001

Quantitative importance of the 25-hydroxylation pathway for bile acid biosynthesis in the rat

artículo científico publicado en 1988

Rabbit liver contains one major sterol 12alpha-hydroxylase with broad substrate specificity

scientific article published on 01 January 1998

Reconstitution of C27-steroid 26-hydroxylase activity from bovine brain mitochondria

artículo científico publicado en 1989

Reconstitution of vitamin D3 25-hydroxylase activity with a cytochrome P-450 preparation from rat liver mitochondria

artículo científico publicado en 1979

Rediscovery of cerebrosterol.

artículo científico publicado en 2007

Reduced C27-steroid 26-hydroxylase activity in heterozygotes for cerebrotendinous xanthomatosis

scientific article published on 01 September 1988

Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis.

artículo científico publicado en 2015

Reduction of 3-oxosteroids in human liver microsomes ⬇️

artículo científico publicado el 1 de marzo de 1976

Reduction of C19-, C21-, C24-, and C27-3-oxosteroids by rat-liver microsomes

artículo científico publicado en 1973

Refsum's disease, adrenoleucodystrophy, and the Zellweger syndrome

scientific article published on 01 September 1984

Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway

artículo científico publicado en 2007

Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

artículo científico publicado en 2005

Regulation of hepatic cholesterol metabolism in humans: stimulatory effects of cholestyramine on HMG-CoA reductase activity and low density lipoprotein receptor expression in gallstone patients

artículo científico publicado en 1990

Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and cholesterol 7alpha-hydroxylase mRNAs in human liver.

artículo científico publicado en 2002

Regulation of sterol 12alpha-hydroxylase and cholic acid biosynthesis in the rat.

artículo científico publicado en 2000

Regulatory effects of simvastatin and apoJ on APP processing and amyloid-β clearance in blood-brain barrier endothelial cells

artículo científico publicado en 2017

Relation Between Hypercalciuria and Vitamin D3-Status in Patients with Urolithiasis ⬇️

artículo científico publicado el 1 de enero de 1982

Removal of cholesterol from extrahepatic sources by oxidative mechanisms

artículo científico publicado en 1999

Renal 25-hydroxyvitamin D-3 1 alpha-hydroxylase in guinea-pig: activity variations during development and pregnancy

artículo científico publicado en 1990

Role of peroxisomes in the biosynthesis of bile acids

scientific article published on 01 January 1985

Role of the 26-hydroxylase in the biosynthesis of bile acids in the normal state and in cerebrotendinous xanthomatosis. An in vivo study

artículo científico publicado en 1983

Selective Ion Monitoring in Clinical Chemistry ⬇️

artículo científico publicado el 1 de agosto de 1979

Selective inhibition of mitochondrial 27-hydroxylation of bile acid intermediates and 25-hydroxylation of vitamin D3 by cyclosporin A.

artículo científico publicado en 1993

Sensitive kinetic bioluminescent assay of glycerol release from human fat cells ⬇️

artículo científico publicado el 1 de septiembre de 1981

Serum and urinary markers of exogenous testosterone administration

scientific article published on 01 October 1995

Serum cholesterol determination by mass fragmentography

scientific article published on 01 July 1974

Serum concentrations of unconjugated and conjugated cholic acid in portal venous and systemic venous blood of fasting man.

artículo científico publicado en 1989

Serum concentrations of ursodeoxycholic acid in portal venous and systemic venous blood of fasting humans as determined by isotope dilution-mass spectrometry

artículo científico publicado en 1985

Serum testosterone determination by mass fragmentography

artículo científico publicado en 1975

Sex differences in the hepatic cholesterol sensing mechanisms in mice.

artículo científico publicado en 2013

Short-term starvation increases calcidiol-24-hydroxylase activity and mRNA level in rat kidney

artículo científico publicado en 1994

Side chain hydroxylation of C27-steroids and vitamin D3 by a cytochrome P-450 enzyme system isolated from human liver mitochondria ⬇️

artículo científico publicado el 1 de noviembre de 1981

Side chain hydroxylations in biosynthesis of cholic acid. 25- and 26-Hydroxylation of 5beta-cholestane-3alpha, 7alpha, 12alpha-triol by reconstituted systems from rat liver microsomes ⬇️

artículo científico publicado el 10 de junio de 1976

Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers.

artículo científico publicado en 2003

Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism

artículo científico publicado en 2011

Simple diagnosis of the Zellweger syndrome by gas-liquid chromatography of dimethylacetals

scientific article published on 01 July 1986

Simultaneous determination of prednisolone and cortisol in serum by HPLC and by isotope dilution--mass spectrometry.

artículo científico publicado en 1982

Simultaneous quantification of several cholesterol autoxidation and monohydroxylation products by isotope-dilution mass spectrometry

artículo científico publicado en 1990

Simvastatin treatment in the SLO syndrome: a safe approach?

artículo científico publicado en 2002

Single nucleotide polymorphism in the cholesterol-24S-hydroxylase (CYP46A1) gene and its association with CFH and LOC387715 gene polymorphisms in age-related macular degeneration

artículo científico publicado en 2012

Specificity of the Widal test for typhoid fever

artículo científico publicado el 1 de mayo de 1978

Stanozolol and experimental atherosclerosis: atherosclerotic development and blood lipids during anabolic steroid therapy of New Zealand white rabbits

scientific article published on 01 October 1990

Stereochemistry of hydrogen transfer from pyridine nucleotides catalyzed by delta-4-3-oxosteroid 5-beta-reductase and 3-alpha-hydroxysteroid dehydrogenase from rat liver

artículo científico publicado en 1970

Steroid hormone metabolism in developing rats

scientific article published on 01 May 1972

Sterol 27-hydroxylase deficiency: a rare cause of xanthomas in normocholesterolemic humans.

artículo científico publicado en 2000

Sterol 27-hydroxylase in bile acid biosynthesis. Mechanism of oxidation of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,27-tetrol into 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid

artículo científico publicado en 1993

Sterol 27-hydroxylase- and apoAI/phospholipid-mediated efflux of cholesterol from cholesterol-laden macrophages: evidence for an inverse relation between the two mechanisms

article

Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: effect of sitostanol treatment

artículo científico publicado en 1995

Sterol binding by OSBP-related protein 1L regulates late endosome motility and function

artículo científico publicado en 2010

Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients

artículo científico publicado en 2016

Still another activity by the highly promiscuous enzyme CYP3A4: 25-hydroxylation of cholesterol.

artículo científico publicado en 2011

Stimulation of HMG-CoA reductase as a consequence of phenobarbital-induced primary stimulation of cholesterol 7 alpha-hydroxylase in rat liver

scientific article published on 01 February 1994

Stimulatory effect of mevinolin on rat liver phosphatidic acid phosphatase

scientific article published on 01 July 1987

Stimulatory effect of testosterone on renal 25-hydroxyvitamin D-3 1 alpha-hydroxylase in guinea pig

scientific article published on 01 March 1989

Structural characterization of the gene encoding rat 25-hydroxyvitamin D3 24-hydroxylase

artículo científico publicado en 1993

Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns

artículo científico publicado en 1999

Studies in hypertriglyceridaemia. VI: Serum lathosterol concentration is raised in hypertriglyceridaemic non-diabetic males with hyperinsulinaemia.

artículo científico publicado en 1999

Studies of distant members of the P450 superfamily (P450scc and P450c27) by random chimeragenesis.

artículo científico publicado en 1996

Studies of the mechanism of the increased biosynthesis of cholestanol in cerebrotendinous xanthomatosis. The activity of delta 5-3 beta-hydroxysteroid dehydrogenase

artículo científico publicado en 1985

Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice

artículo científico publicado en 2005

Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol

scientific journal article

Studies on the degradation of [U-3H]-phytanic acid and [U-3H]-pristanic acid in cultured fibroblasts from children with peroxisomal disorders

artículo científico publicado en 1996

Studies on the link between HMG-CoA reductase and cholesterol 7 alpha-hydroxylase in lymph-fistula rats: evidence for both transcriptional and post-transcriptional mechanisms for down-regulation of the two enzymes by bile acids

scientific article published on 01 September 1993

Studies on the link between HMG-CoA reductase and cholesterol 7 alpha-hydroxylase in rat liver

artículo científico publicado en 1988

Studies on the mechanism of accumulation of cholesterol in the gallbladder mucosa. Evidence that sterol 27-hydroxylase is not a pathogenetic factor.

artículo científico publicado en 2004

Studies on the regulation of cholesterol 7 alpha-hydroxylase and HMG-CoA reductase in rat liver: effects of lymphatic drainage and ligation of the lymph duct

artículo científico publicado en 1990

Studies on the relationship between vitamin D3 status and urinary excretion of calcium in healthy subjects: effects of increased levels of 25-hydroxyvitamin D3.

artículo científico publicado en 1986

Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes

scientific journal article

Subcellular localization of 3 alpha, 7 alpha-dihydroxy- and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl-coenzyme A ligase(s) in rat liver

artículo científico publicado en 1988

Substrate stereospecificity in oxidation of (25S)-3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoyl-CoA by peroxisomal trihydroxy-5 beta-cholestanoyl-CoA oxidase

artículo científico publicado en 1996

Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice

artículo científico publicado en 2013

Suppression of growth in a leukemic T cell line by n-3 and n-6 polyunsaturated fatty acids

artículo científico publicado en 1989

The 1988 Olympic Games--a turning-point in the doping problem?

artículo científico publicado en 1989

The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

artículo científico publicado en 2009

The antioxidant butylated hydroxytoluene prevents early cholesterol-induced microcirculatory changes in rabbits

artículo científico publicado en 1994

The antioxidant butylated hydroxytoluene protects against atherosclerosis

artículo científico publicado en 1991

The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis

artículo científico publicado en 2000

The bile acid-inducible baiF gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A hydrolase

artículo científico publicado en 1999

The catecholamine concentration in central veins of hypertensive patients--an aid not without problems in locating phaeochromocytoma

scientific article published on 01 January 1986

The desmosterolosis phenotype: spasticity, microcephaly and micrognathia with agenesis of corpus callosum and loss of white matter

artículo científico publicado en 2011

The diagnostic value of fasting individual serum bile acids in anicteric alcoholic liver disease: relation to liver morphology

artículo científico publicado en 1985

The effect of Acipimox on triacylglycerol metabolism in rat

artículo científico publicado en 1990

The metabolism of steroids in the fatty liver induced by orotic acid feeding

artículo científico publicado en 1976

The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells.

artículo científico publicado en 1999

The plasma level of 7 alpha-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7 alpha-hydroxylase in man

artículo científico publicado en 1991

The pool of free cholesterol is not of major importance for regulation of the cholesterol 7 alpha-hydroxylase activity in rat liver microsomes

artículo científico publicado en 1987

The presence of 5 alpha-sitostanol in the serum of a patient with phytosterolemia, and its biosynthesis from plant steroids in rats with bile fistula

artículo científico publicado en 1985

The use of mass fragmentography in the evaluation of routine methods for glucose determination

artículo científico publicado en 1976

Three commercial kits and one liquid-chromatographic method evaluated for determining 25-hydroxyvitamin D3 in serum.

artículo científico publicado en 1987

Thyroid hormone suppresses hepatic sterol 12alpha-hydroxylase (CYP8B1) activity and messenger ribonucleic acid in rat liver: failure to define known thyroid hormone response elements in the gene.

artículo científico publicado en 1999

Tidig diagnos och behandling med gallsyra avgörande vid cerebrotendinös xantomatos

artículo científico publicado en 2018

Total cortisol and L/S-ratio in amniotic fluid in late pregnancies complicated by diabetes mellitus

artículo científico publicado el 1 de noviembre de 1979

Toward absolute methods in clinical chemistry: application of mass fragmentography to high-accuracy analyses ⬇️

artículo científico publicado el 1 de noviembre de 1976

Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1).

artículo científico publicado en 2017

Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors.

artículo científico publicado en 2008

Transformation of subcutaneous nitric oxide into nitrate in the rat.

artículo científico publicado en 1997

Treatment of IgA nephropathy with omega-3-polyunsaturated fatty acids: a prospective, double-blind, randomized study

artículo científico publicado en 1994

Triglyceride metabolism in human liver: studies on hepatic phosphatidic-acid phosphatase in obese and non-obese subjects

scientific article published on 01 June 1984

Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively

artículo científico publicado en 2001

Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit

artículo científico publicado en 2006

Unique case of cerebrotendinous xanthomatosis revisited: All the mutations responsible for this disease are present in the CYP27A1 gene

artículo científico publicado en 2017

Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase.

artículo científico publicado en 2007

Unsuccessful attempts to induce peroxisomes in two cases of Zellweger disease by treatment with clofibrate

artículo científico publicado en 1985

Upregulation of brain renin angiotensin system by 27-hydroxycholesterol in Alzheimer's disease

artículo científico publicado en 2011

Urinary excretion of dicarboxylic acids from patients with the Zellweger syndrome. Importance of peroxisomes in beta-oxidation of dicarboxylic acids

artículo científico publicado en 1984

Use of an 18O2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat. Evidence for in vivo formation of 7-oxo-, 7 beta-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol

artículo científico publicado en 1995

Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1

artículo científico publicado en 2008

Use of isotope dilution--mass spectrometry for accuracy control of different routine methods used in clinical chemistry

scientific article published on 01 October 1980

Use of mass fragmentography for development of reference methods in clinical chemistry

artículo científico publicado el 18 de febrero de 1976

Validation of methods for determination of urinary estriol during pregnancy using mass fragmentography

artículo científico publicado en 1975

Validation of radioimmunoassay for estradiol-17 beta by isotope dilution-mass spectrometry and by a test of radiochemical purity

scientific article published on 01 December 1983

Validation of routine methods for serum progesterone determination using mass fragmentography

artículo científico publicado en 1975

Verapamil increases serum alkaline phosphatase in hypertensive patients

artículo científico publicado en 1990

Verapamil increases serum ionized calcium and serum phosphate in patients with post-surgical hypoparathyroidism

scientific article published on 01 June 1992

Vitamin C reduces cholesterol-induced microcirculatory changes in rabbits

artículo científico publicado en 1997

What do commercial ginseng preparations contain?

artículo científico publicado en 1994

[Decreased quality of clinical chemistry education for physicians]

artículo científico publicado en 1999

[Determination of methyl malonate--a new way for indication of cobalamin deficiency]

scientific article published on 01 October 1992

[New pharmaceuticals for patients with atherosclerosis are under development. Antioxidants inhibit LDL modification]

scientific article published on 01 September 1989

[Patients with increased liver enzyme levels--when and how are they to be examined?]

scientific article published on 01 March 1988

[Peroxisomal defects in Zellweger's disease--a description of 2 Swedish cases]

artículo científico publicado en 1985

[Phytosterolemia is an uknown but serious disease. Xanthomatosis in childhood is a warning signal]

scientific article published on 01 November 1996

[Simple and painless for the patient with stomach ulcer. Blow and reveal the bacteria!]

scientific article published on 01 November 1995

[Use of stored phenylketonuria blood tests suitable in the diagnosis of peroxisomal disease]

artículo científico publicado en 1987

mRNA as a Novel Treatment Strategy for Hereditary Spastic Paraplegia Type 5

scientific article published on 31 October 2019

Lista de obras de Ingemar Björkhem

-Oxidation of fatty acids. I. Mechanism of microsomal 1- and 2-hydroxylation

-Oxidation of fatty acids. II. Enzymatic oxido-reduction of 17-hydroxystearic acid.

12 alpha-hydroxylase activity in human liver and its relation to cholesterol 7 alpha-hydroxylase activity

12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one by a reconstituted system from rat liver microsomes

14C-triolein breath test as a rapid and convenient screening test for fat malabsorption

18-Hydroxylation of Deoxycorticosterone by Reconstituted Systems from Rat and Bovine Adrenals ⬇️

24(),25-Epoxycholesterol and () overexpression promote midbrain dopaminergic neurogenesis

24(S),25-epoxycholesterol--a potential friend.

24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver

24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A).

24S-Hydroxycholesterol Correlates With Tau and Is Increased in Cerebrospinal Fluid in Parkinson's Disease and Corticobasal Syndrome

24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

25-Hydroxylase activity in subcellular fractions from human liver. Evidence for different rates of mitochondrial hydroxylation of vitamin D2 and D3.

25-Hydroxylation of vitamin D3 by a reconstituted system from rat liver microsomes

25-Hydroxyvitamin D3-24-hydroxylase in rat kidney mitochondria

26-Hydroxylation of C27-steroids by soluble liver mitochondrial cytochrome P-450 ⬇️

26-hydroxylation of 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol by isolated nonparenchymal cells and hepatocytes from rat liver.

27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons

27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation.

27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice

3 -Hydroxy- 5 -C 19 -and C 21 -steroid oxidoreductase activity in rat liver

4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man.

7 -Hydroxylation of taurodeoxycholic acid by a reconstituted system from rat liver microsomes

7 Alpha-hydroxylation of cholesterol by reconstituted systems from rat liver microsomes

7 alpha hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from cholesterol 7 alpha-hydroxylase

7 alpha-hydroxylation of 27-hydroxycholesterol in human liver microsomes

7α-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier.

A SLC20A2 gene mutation carrier displaying ataxia and increased levels of cerebrospinal fluid phosphate

A functional polymorphism in the HMGCR promoter affects transcriptional activity but not the risk for Alzheimer disease in Swedish populations.

A novel pathway for biosynthesis of cholestanol with 7 alpha-hydroxylated C27-steroids as intermediates, and its importance for the accumulation of cholestanol in cerebrotendinous xanthomatosis

A novel specific assay of 25-hydroxy vitamin D

A novel technique for assay of side-chain cleavage of exogenous and endogenous cholesterol in adrenal mitochondrial and submitochondrial preparations

A possible model for accuracy control of determination of serum cholesterol with use of reference methods. A NORDKEM project.

A single high dose of vitamin C counteracts the acute negative effect on microcirculation induced by smoking a cigarette

A specific assay of vitamin D-3 in human serum

ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis.

Accumulation of 7 alpha-hydroxy-4-cholesten-3-one and cholesta-4,6-dien-3-one in patients with cerebrotendinous xanthomatosis: effect of treatment with chenodeoxycholic acid

Accuracy of a fully enzymatic method for creatinine, as judged by isotope dilution-mass fragmentography ⬇️

Accuracy of some routine method used in clinical chemistry as judged by isotope dilution-mass spectrometry

Activation of rat liver cytosolic phosphatidic acid phosphatase by nucleoside diphosphates

Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways

Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro

Acyl-coenzyme A:cholesterol O-acyltransferase is not identical to liver microsomal carboxylesterase

Analysis of ginsenosides by chromatography and mass spectrometry: release of 20 S-protopanaxadiol and 20 S-protopanaxatriol for quantitation

Antioxidant treatment inhibits the development of intimal thickening after balloon injury of the aorta in hypercholesterolemic rabbits

Apparent lack of conversion of sitosterol into C24-bile acids in humans

Apparent lack of effect of obesity on the soluble phosphatidic acid phosphatase activity in human adipose tissue

Apparent phosphorylation - dephosphorylation of soluble phosphatidic acid phosphatase in rat liver

Apparent selective bile acid malabsorption as a consequence of ileal exclusion: effects on bile acid, cholesterol, and lipoprotein metabolism

Are side-chain oxidized oxysterols regulators also in vivo?

Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment?

Assay and properties of 25-hydroxyvitamin D3 23-hydroxylase. Evidence that 23,25-dihydroxyvitamin D3 is a major metabolite in 1,25-dihydroxyvitamin D3-treated or fasted guinea pigs

Assay and properties of a mitochondrial 25-hydroxylase active on vitamine D3 ⬇️

Assay of 1,25-dihydroxy vitamin D3 by isotope dilution--mass fragmentography ⬇️

Assay of 25-hydroxy vitamin D3-1 alpha-hydroxylase in pig kidney mitochondria using isotope dilution-mass spectrometry

Assay of cortisol with a radioimmunoassay method calibrated by isotope dilution-mass spectrometry. A Nordic collaborative study

Assay of ethylestrenol in urine by isotope dilution--mass spectrometry

Assay of intermediates in bile acid biosynthesis using isotope dilution--mass spectrometry: hepatic levels in the normal state and in cerebrotendinous xanthomatosis

Assay of liver microsomal cholesterol 7 alpha-hydroxylase using deuterated carrier and gas chromatography-mass spectrometry

Assay of the major bile acids in serum by isotope dilution-mass spectrometry

Assay of unesterified 7-oxocholesterol in human serum by isotope dilution-mass spectrometry

Assay of unesterified cholesterol-5,6-epoxide in human serum by isotope dilution mass spectrometry. Levels in the healthy state and in hyperlipoproteinemia

Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages

Attempts to define the minimal serum level of vitamin A required for normal visual function in a patient with severe fat malabsorption

Beneficial effects of dietary supplementation in a disorder with defective synthesis of cholesterol. A case report of a girl with Smith-Lemli-Opitz syndrome, polyneuropathy and precocious puberty

Bile acid metabolism in extrahepatic biliary atresia: lithocholic acid in stored dried blood collected at neonatal screening

Bile acid synthesis in cultured human hepatocytes: support for an alternative biosynthetic pathway to cholic acid

Bile acid synthesis in humans: regulation of hepatic microsomal cholesterol 7 alpha-hydroxylase activity

Bile acid synthesis in man: assay of hepatic microsomal cholesterol 7 alpha-hydroxylase activity by isotope dilution-mass spectrometry

Bile acid synthesis in primary cultures of rat and human hepatocytes

Bile acids and bile alcohols in two patients with Zellweger (cerebro-hepato-renal) syndrome.

Biosynthesis and metabolism of bile acids in man

Biosynthesis of bile acids in man. Hydroxylation of the C27-steroid side chain ⬇️

Biosynthesis of cholestanol from bile acid intermediates in the rabbit and the rat

Biosynthesis of cholestanol from intestinal 7 alpha-hydroxy-4-cholesten-3-one

Biosynthesis of cholestanol: conversion of cholesterol into 4-cholesten-3-one by rat liver microsomes.

Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin

Brain cholesterol: long secret life behind a barrier.

Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain