Lista de obras - John Sondek - Dominio Público Uruguay

A Cdc42 mutant specifically activated by intersectin

artículo científico publicado en 2005

A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis

artículo científico publicado en 2011

A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs

artículo científico publicado en 2005

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation

artículo científico publicado en 2014

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

artículo científico publicado en 2002

A fluorogenic, small molecule reporter for mammalian phospholipase C isozymes

artículo científico publicado en 2011

A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q

artículo científico publicado en 2002

Accommodation of single amino acid insertions by the native state of staphylococcal nuclease

artículo científico publicado en 1990

Activation of human phospholipase C-eta2 by Gbetagamma

artículo científico publicado en 2008

An effector site that stimulates G-protein GTPase in photoreceptors.

artículo científico publicado en 1995

Assays of complex formation between RGS protein G gamma subunit-like domains and G beta subunits

artículo científico publicado en 2002

Auto-inhibition of the Dbl Family Protein Tim by an N-terminal Helical Motif

scientific article published in Journal of Biological Chemistry

Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-γ Isozymes

artículo científico publicado en 2013

AvrRpm1 missense mutations weakly activate RPS2-mediated immune response in Arabidopsis thaliana

artículo científico publicado en 2012

Calcium-dependent properties of CIB binding to the integrin alphaIIb cytoplasmic domain and translocation to the platelet cytoskeleton

artículo científico publicado en 1999

Crystal Structure of the DH/PH Fragment of Dbs without Bound GTPase

article

Crystal structure of Rac1 bound to its effector phospholipase C-β2

article

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

artículo científico publicado en 2000

Crystal structure of the multifunctional Gβ5–RGS9 complex

artículo científico publicado en 2008

Crystal structures of the type III effector protein AvrPphF and its chaperone reveal residues required for plant pathogenesis

artículo científico publicado en 2004

Direct activation of human phospholipase C by its well known inhibitor u73122.

artículo científico publicado en 2011

Direct activation of phospholipase C-epsilon by Rho.

artículo científico publicado en 2003

Direct activation of purified phospholipase C epsilon by RhoA studied in reconstituted phospholipid vesicles.

artículo científico publicado en 2006

Dual activation of phospholipase C-epsilon by Rho and Ras GTPases

artículo científico publicado en 2008

Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11

artículo científico publicado en 1999

Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C.

artículo científico publicado en 2012

Functional analysis of cdc42 residues required for Guanine nucleotide exchange

artículo científico publicado en 2002

Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA

artículo científico publicado en 2001

Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain

artículo científico publicado en 2007

General and Versatile Autoinhibition of PLC Isozymes

artículo científico publicado en 2008

Ggamma-like (GGL) domains: new frontiers in G-protein signaling and beta-propeller scaffolding.

artículo científico publicado en 2001

High-throughput fluorescence polarization assay for the enzymatic activity of GTPase-activating protein of ADP-ribosylation factor (ARFGAP).

artículo científico publicado en 2011

High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay

artículo científico publicado en 2009

Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras

artículo científico publicado en 2004

Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

artículo científico publicado en 2010

Larger than Dbl: new structural insights into RhoA activation

artículo científico publicado en 2005

Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA

artículo científico publicado en 2001

Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting

scientific journal article

Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes

artículo científico publicado en 2011

Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes

artículo científico publicado en 2010

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors

artículo científico publicado en 2001

Molecular cloning and characterization of PLC-eta2.

artículo científico publicado en 2005

Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation

scientific journal article

Multiplexed GTPase and GEF biosensor imaging enables network connectivity analysis

scientific article published on 18 May 2020

PH domain of ELMO functions in trans to regulate Rac activation via Dock180

artículo científico publicado en 2004

Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO

artículo científico publicado en 2004

Phospholipase C isozymes as effectors of Ras superfamily GTPases

artículo científico publicado en 2008

Prediction of protein-protein interfaces on G-protein beta subunits reveals a novel phospholipase C beta2 binding domain

artículo científico publicado en 2009

Quantification of isozyme-specific activation of phospholipase C-beta2 by Rac GTPases and phospholipase C-epsilon by Rho GTPases in an intact cell assay system

artículo científico publicado en 2006

Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

artículo científico publicado en 2001

Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

artículo científico publicado en 2004

Regulation of PLCbeta isoforms by Rac.

artículo científico publicado en 2006

Regulation of phospholipase C isozymes by ras superfamily GTPases

artículo científico publicado en 2006

Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression

artículo científico publicado en 2007

Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation

artículo científico publicado en 2004

RhoA activates purified phospholipase C-epsilon by a guanine nucleotide-dependent mechanism

artículo científico publicado en 2004

RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity

artículo científico publicado en 2002

Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins

artículo científico publicado en 2008

Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling

artículo científico publicado en 2003

Small molecule inhibitors of phospholipase C from a novel high-throughput screen.

artículo científico publicado en 2013

SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC.

artículo científico publicado en 2011

Structural Features of RhoGEFs

Structural Insights into Fibronectin Type III Domain-mediated Signaling

artículo científico publicado en 2007

Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins

artículo científico publicado en 2004

Structural and energetic differences between insertions and substitutions in staphylococcal nuclease.

artículo científico publicado en 1992

Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations

artículo científico publicado en 2019

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

artículo científico publicado en 2002

Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits

artículo científico publicado en 2002

Structure and Function of Vps15 in the Endosomal G Protein Signaling Pathway ,

artículo científico publicado en 2009

Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange

artículo científico publicado en 2005

The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation

artículo científico publicado en 2007

The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity

artículo científico publicado en 2006

The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation

artículo científico publicado en 2005

The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae.

artículo científico publicado en 2012

The pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac.

artículo científico publicado en 2003

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

artículo científico publicado en 2002

Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction

artículo científico publicado en 2007

Lista de obras de John Sondek

A Cdc42 mutant specifically activated by intersectin

A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis

A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

A fluorogenic, small molecule reporter for mammalian phospholipase C isozymes

A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q

Accommodation of single amino acid insertions by the native state of staphylococcal nuclease

Activation of human phospholipase C-eta2 by Gbetagamma

An effector site that stimulates G-protein GTPase in photoreceptors.

Assays of complex formation between RGS protein G gamma subunit-like domains and G beta subunits

Auto-inhibition of the Dbl Family Protein Tim by an N-terminal Helical Motif

Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-γ Isozymes

AvrRpm1 missense mutations weakly activate RPS2-mediated immune response in Arabidopsis thaliana

Calcium-dependent properties of CIB binding to the integrin alphaIIb cytoplasmic domain and translocation to the platelet cytoskeleton

Crystal Structure of the DH/PH Fragment of Dbs without Bound GTPase

Crystal structure of Rac1 bound to its effector phospholipase C-β2

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

Crystal structure of the multifunctional Gβ5–RGS9 complex

Crystal structures of the type III effector protein AvrPphF and its chaperone reveal residues required for plant pathogenesis

Direct activation of human phospholipase C by its well known inhibitor u73122.

Direct activation of phospholipase C-epsilon by Rho.

Direct activation of purified phospholipase C epsilon by RhoA studied in reconstituted phospholipid vesicles.

Dual activation of phospholipase C-epsilon by Rho and Ras GTPases

Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11

Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C.

Functional analysis of cdc42 residues required for Guanine nucleotide exchange

Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA

Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain

General and Versatile Autoinhibition of PLC Isozymes

Ggamma-like (GGL) domains: new frontiers in G-protein signaling and beta-propeller scaffolding.

High-throughput fluorescence polarization assay for the enzymatic activity of GTPase-activating protein of ADP-ribosylation factor (ARFGAP).

High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay

Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras

Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

Larger than Dbl: new structural insights into RhoA activation

Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA

Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting

Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes

Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors

Molecular cloning and characterization of PLC-eta2.

Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation

Multiplexed GTPase and GEF biosensor imaging enables network connectivity analysis

PH domain of ELMO functions in trans to regulate Rac activation via Dock180

Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO

Phospholipase C isozymes as effectors of Ras superfamily GTPases

Prediction of protein-protein interfaces on G-protein beta subunits reveals a novel phospholipase C beta2 binding domain

Quantification of isozyme-specific activation of phospholipase C-beta2 by Rac GTPases and phospholipase C-epsilon by Rho GTPases in an intact cell assay system

Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

Regulation of PLCbeta isoforms by Rac.

Regulation of phospholipase C isozymes by ras superfamily GTPases

Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression

Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation

RhoA activates purified phospholipase C-epsilon by a guanine nucleotide-dependent mechanism

RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity

Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins

Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling

Small molecule inhibitors of phospholipase C from a novel high-throughput screen.

SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC.

Structural Features of RhoGEFs

Structural Insights into Fibronectin Type III Domain-mediated Signaling

Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins

Structural and energetic differences between insertions and substitutions in staphylococcal nuclease.

Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits

Structure and Function of Vps15 in the Endosomal G Protein Signaling Pathway ,

Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange

The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation

The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity

The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation

The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae.

The pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac.

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction