Lista de obras - James K Chen - Dominio Público Uruguay

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

artículo científico publicado en 2018

A crucial requirement for Hedgehog signaling in small cell lung cancer

artículo científico publicado en 2011

A novel missense variant in the GLI3 zinc finger domain in a family with digital anomalies

artículo científico publicado en 2017

A small molecule that binds Hedgehog and blocks its signaling in human cells

artículo científico publicado en 2009

A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury

artículo científico publicado en 2011

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

artículo científico publicado en 2004

Affinity electrophoresis in multisectional polyacrylamide slab gels is a useful and convenient technique for measuring binding constants of aryl sulfonamides to bovine carbonic anhydrase B

scientific article published on 01 May 1993

An inducible long noncoding RNA amplifies DNA damage signaling.

artículo científico publicado en 2016

Arhgap36-dependent activation of Gli transcription factors

artículo científico publicado en 2014

Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and Focal Adhesion Kinase

Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage.

artículo científico publicado en 2013

Chemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathways

artículo científico publicado en 2011

Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

artículo científico publicado en 2017

Chemical technologies for probing embryonic development

artículo científico publicado en 2008

Control of inflammation by stromal Hedgehog pathway activation restrains colitis.

artículo científico publicado en 2016

Controlling destiny through chemistry: small-molecule regulators of cell fate

artículo científico publicado en 2010

Converse conformational control of smoothened activity by structurally related small molecules

artículo científico publicado en 2009

Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator

artículo científico publicado en 2018

Crystal structure of P13K SH3 domain at 20 angstroms resolution

artículo científico publicado en 1996

Cyclic caged morpholinos: conformationally gated probes of embryonic gene function

artículo científico publicado en 2012

Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity

artículo científico publicado en 2015

Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II

artículo científico publicado en 2013

Direct kinetochore-spindle pole connections are not required for chromosome segregation

artículo científico publicado en 2014

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

artículo científico publicado en 2000

Emerging technologies in molecular imaging: new windows into biology

artículo científico publicado en 2013

Fish 'n clicks

artículo científico publicado en 2008

Functional inhibition of UQCRB suppresses angiogenesis in zebrafish.

artículo científico publicado en 2013

Gene regulation technologies in zebrafish.

artículo científico publicado en 2008

General method for regulating protein stability with light

artículo científico publicado en 2013

Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent

artículo científico publicado en 2009

Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish

artículo científico publicado en 2011

Hyaluronic acid synthesis is required for zebrafish tail fin regeneration

artículo científico publicado en 2017

I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs

artículo científico publicado en 2016

Illuminating developmental biology through photochemistry

artículo científico publicado en 2017

In vivo imaging of Hedgehog pathway activation with a nuclear fluorescent reporter

artículo científico publicado en 2014

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

artículo científico publicado en 2002

Light-controlled gene silencing in zebrafish embryos

artículo científico publicado en 2007

Lineage labeling of zebrafish cells with laser uncagable fluorescein dextran

artículo científico publicado en 2011

Medulloblastoma growth inhibition by hedgehog pathway blockade

artículo científico publicado en 2002

Neuropilins are positive regulators of Hedgehog signal transduction.

artículo científico publicado en 2011

Nitroreductase-activatable morpholino oligonucleotides for in vivo gene silencing

artículo científico publicado en 2014

Oligonucleotide-based tools for studying zebrafish development

artículo científico publicado en 2010

Optochemical dissection of T-box gene-dependent medial floor plate development

artículo científico publicado en 2015

Post-transcriptional mechanisms contribute to Etv2 repression during vascular development

artículo científico publicado en 2013

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

artículo científico publicado en 2005

Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons

artículo científico publicado en 2011

Sequential gene silencing using wavelength-selective caged morpholino oligonucleotides

artículo científico publicado en 2014

Small molecule modulation of Smoothened activity

artículo científico publicado en 2002

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

artículo científico publicado en 2012

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

scientific article published on 05 August 2009

Small-molecule regulation of zebrafish gene expression

artículo científico publicado en 2007

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2

artículo científico publicado en 2006

Spatiotemporal control of embryonic gene expression using caged morpholinos.

artículo científico publicado en 2011

Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development

artículo científico publicado en 2012

Stromal response to Hedgehog signaling restrains pancreatic cancer progression

artículo científico publicado en 2014

Structure-activity mapping of ARHGAP36 reveals regulatory roles for its GAP homology and C-terminal domains

artículo científico publicado en 2021

Synthetic strategies for studying embryonic development

artículo científico publicado en 2010

Targeted and Conditional Gene Expression Workshop, 8th International Conference on Zebrafish Development and Genetics

artículo científico publicado en 2008

Targeted cell ablation in zebrafish using optogenetic transcriptional control

scientific article published on 15 May 2020

Tbx16 regulates hox gene activation in mesodermal progenitor cells

artículo científico publicado en 2016

The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome

artículo científico publicado en 2012

The Stanford Institute for Chemical Biology

artículo científico publicado en 2013

The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning

artículo científico publicado en 2008

The identification of myriocin-binding proteins

artículo científico publicado en 1999

The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling

artículo científico publicado en 2009

Thinking big with small molecules

artículo científico publicado en 2015

Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions

artículo científico publicado en 1994

Ultrasensitive optical imaging with lanthanide lumiphores

artículo científico publicado en 2017

Versatile synthesis and rational design of caged morpholinos

artículo científico publicado en 2009

Lista de obras de James K Chen

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

A crucial requirement for Hedgehog signaling in small cell lung cancer

A novel missense variant in the GLI3 zinc finger domain in a family with digital anomalies

A small molecule that binds Hedgehog and blocks its signaling in human cells

A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

Affinity electrophoresis in multisectional polyacrylamide slab gels is a useful and convenient technique for measuring binding constants of aryl sulfonamides to bovine carbonic anhydrase B

An inducible long noncoding RNA amplifies DNA damage signaling.

Arhgap36-dependent activation of Gli transcription factors

Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and Focal Adhesion Kinase

Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage.

Chemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathways

Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

Chemical technologies for probing embryonic development

Control of inflammation by stromal Hedgehog pathway activation restrains colitis.

Controlling destiny through chemistry: small-molecule regulators of cell fate

Converse conformational control of smoothened activity by structurally related small molecules

Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator

Crystal structure of P13K SH3 domain at 20 angstroms resolution

Cyclic caged morpholinos: conformationally gated probes of embryonic gene function

Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity

Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II

Direct kinetochore-spindle pole connections are not required for chromosome segregation

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Emerging technologies in molecular imaging: new windows into biology

Fish 'n clicks

Functional inhibition of UQCRB suppresses angiogenesis in zebrafish.

Gene regulation technologies in zebrafish.

General method for regulating protein stability with light

Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent

Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish

Hyaluronic acid synthesis is required for zebrafish tail fin regeneration

I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs

Illuminating developmental biology through photochemistry

In vivo imaging of Hedgehog pathway activation with a nuclear fluorescent reporter

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Light-controlled gene silencing in zebrafish embryos

Lineage labeling of zebrafish cells with laser uncagable fluorescein dextran

Medulloblastoma growth inhibition by hedgehog pathway blockade

Neuropilins are positive regulators of Hedgehog signal transduction.

Nitroreductase-activatable morpholino oligonucleotides for in vivo gene silencing

Oligonucleotide-based tools for studying zebrafish development

Optochemical dissection of T-box gene-dependent medial floor plate development

Post-transcriptional mechanisms contribute to Etv2 repression during vascular development

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons

Sequential gene silencing using wavelength-selective caged morpholino oligonucleotides

Small molecule modulation of Smoothened activity

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

Small-molecule regulation of zebrafish gene expression

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2

Spatiotemporal control of embryonic gene expression using caged morpholinos.

Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development

Stromal response to Hedgehog signaling restrains pancreatic cancer progression

Structure-activity mapping of ARHGAP36 reveals regulatory roles for its GAP homology and C-terminal domains

Synthetic strategies for studying embryonic development

Targeted and Conditional Gene Expression Workshop, 8th International Conference on Zebrafish Development and Genetics

Targeted cell ablation in zebrafish using optogenetic transcriptional control

Tbx16 regulates hox gene activation in mesodermal progenitor cells

The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome

The Stanford Institute for Chemical Biology

The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning

The identification of myriocin-binding proteins

The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling

Thinking big with small molecules

Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions

Ultrasensitive optical imaging with lanthanide lumiphores

Versatile synthesis and rational design of caged morpholinos