Lista de obras - Patrick Emond - Dominio Público Uruguay

(E)-[125I]-5-AOIBV: a SPECT radioligand for the vesicular acetylcholine transporter.

artículo científico publicado en 2007

1H-13C NMR-based urine metabolic profiling in autism spectrum disorders.

artículo científico publicado en 2013

1H-NMR-based metabolomic profiling of CSF in early amyotrophic lateral sclerosis

artículo científico publicado en 2010

3D QSAR study, synthesis, and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the vesicular acetylcholine transporter (VAChT).

artículo científico publicado en 2010

A Multiplatform Metabolomics Approach to Characterize Plasma Levels of Phenylalanine and Tyrosine in Phenylketonuria.

artículo científico publicado en 2016

A multiplatform metabolomic approach to characterize fecal signatures of negative postnatal events in chicks: a pilot study

scientific article published on 09 April 2019

A radiometabolite study of the serotonin transporter PET radioligand [(11)C]MADAM.

artículo científico publicado en 2014

A selective radiobrominated cocaine analogue for imaging of dopamine uptake sites: pharmacological evaluation and PET experiments.

artículo científico publicado en 1999

ADAM is an effective tool for in vivo study of serotonergic function: validation in rat models.

artículo científico publicado en 2004

ATP-activated P2X7 receptor in the pathophysiology of mood disorders and as an emerging target for the development of novel antidepressant therapeutics. ⬇️

artículo científico publicado en 2018

Acetylenic pyridines for use in PET imaging of nicotinic receptors.

artículo científico publicado en 2007

An UPLC-MSMS method to measure plasma homocysteine concentration.

artículo científico publicado en 2017

Analytical methodology for metabolomics study of adherent mammalian cells using NMR, GC-MS and LC-HRMS.

artículo científico publicado en 2015

Assessing the metabolic effects of calcineurin inhibitors in renal transplant recipients by urine metabolic profiling

artículo científico publicado en 2014

Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice

scientific article published on 17 November 2018

Biomarkers in amyotrophic lateral sclerosis: combining metabolomic and clinical parameters to define disease progression.

artículo científico publicado en 2015

Combined 1H-NMR and 1H-13C HSQC-NMR to improve urinary screening in autism spectrum disorders

artículo científico publicado en 2014

Comparative analysis of targeted metabolomics: dominance-based rough set approach versus orthogonal partial least square-discriminant analysis

artículo científico publicado en 2014

Correction: 1H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis.

artículo científico publicado en 2010

Correction: Elucidating time-dependent changes in the urinary metabolome of renal transplant patients by a combined 1H NMR and GC-MS approach.

artículo científico publicado en 2017

Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [F] PET tracer

scholarly article by Jonathan Elie et al published December 2019 in Journal of Enzyme Inhibition and Medicinal Chemistry

Disruption of TCA Cycle and Glutamate Metabolism Identified by Metabolomics in an In Vitro Model of Amyotrophic Lateral Sclerosis

artículo científico publicado en 2015

Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging

artículo científico publicado en 2008

Does lipidomic serum analysis support the assessment of digestive efficiency in chickens?

artículo científico publicado en 2019

Endogenous metabolites that are substrates of organic anion transporter's (OATs) predict methotrexate clearance.

artículo científico publicado en 2016

Erratum to "Validation of amino-acids measurement in dried blood spot by FIA-MS/MS for PKU management" [Clin. Biochem. 49 (2016) 1047-1050]

scientific article published on 02 May 2017

Ex vivo and in vivo evaluation of (2R,3R)-5-[(18)F]-fluoroethoxy- and fluoropropoxy-benzovesamicol, as PET radioligands for the vesicular acetylcholine transporter

artículo científico publicado en 2007

Exploration of the dopamine transporter: in vitro and in vivo characterization of a high-affinity and high-specificity iodinated tropane derivative (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-m ethylph enyl)nortropane (PE2I).

artículo científico publicado en 1998

Extensive exploration of a novel rat model of Parkinson's disease using partial 6-hydroxydopamine lesion of dopaminergic neurons suggests new therapeutic approaches

scientific article published on 12 November 2018

Fragmentation pathway of dopamine transporter ligands: N-substituted-2beta-carbomethoxy-3beta-phenylnortropane derivatives

artículo científico publicado en 2004

GC-MS-based urine metabolic profiling of autism spectrum disorders.

artículo científico publicado en 2013

Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes

artículo científico publicado en 2018

Hyperphenylalaninemia Correlated with Global Decrease of Antioxidant Genes Expression in White Blood Cells of Adult Patients with Phenylketonuria.

artículo científico publicado en 2017

Identification of metabolic pathway disturbances using multimodal metabolomics in autistic disorders in a Middle Eastern population

artículo científico publicado en 2018

Imaging of the striatal and extrastriatal dopamine transporter with (18)F-LBT-999: quantification, biodistribution, and radiation dosimetry in nonhuman primates

artículo científico publicado en 2011

Is NMR metabolic profiling of spent embryo culture media useful to assist in vitro human embryo selection?

artículo científico publicado en 2012

Metabolomics Study of Urine in Autism Spectrum Disorders Using a Multiplatform Analytical Methodology

artículo científico publicado en 2015

Metabolomics in Cerebrospinal Fluid of Patients with Amyotrophic Lateral Sclerosis: An Untargeted Approach via High-Resolution Mass Spectrometry

Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury

scientific article published on 01 October 2020

Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model

artículo científico publicado en 2017

New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET.

artículo científico publicado en 2007

PET examination of [(11)C]5-methyl-6-nitroquipazine, a radioligand for visualization of the serotonin transporter

artículo científico publicado en 2002

PET examination of three potent cocaine derivatives as specific radioligands for the serotonin transporter

artículo científico publicado en 1999

Pharmacokinetics and dosimetry of iodine-123 labelled PE2I in humans, a radioligand for dopamine transporter imaging

artículo científico publicado en 1998

Pharmacological characterisation of (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methylphenyl)nortropane (PE2I) binding to the rat neuronal dopamine transporter expressed in COS cells

artículo científico publicado en 2002

Pharmacological characterization of N,N-dimethyl-2-(2-amino-4-methylphenyl thio)benzylamine as a ligand of the serotonin transporter with high affinity and selectivity.

artículo científico publicado en 2003

Prenatal exposure to methylphenidate affects the dopamine system and the reactivity to natural reward in adulthood in rats

artículo científico publicado en 2014

QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT).

artículo científico publicado en 2012

Relationship between Metabolomics Profile of Perilymph in Cochlear-Implanted Patients and Duration of Hearing Loss

scientific article published on 01 November 2019

Single nucleotide polymorphisms of ABCC2 modulate renal secretion of endogenous organic anions.

artículo científico publicado en 2017

Specific Metabolome Profile of Exhaled Breath Condensate in Patients with Shock and Respiratory Failure: A Pilot Study.

artículo científico publicado en 2016

Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.

artículo científico publicado en 2002

Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1).

artículo científico publicado en 2005

Synthesis and biological evaluation of halogenated naphthyridone carboxamides as potential ligands for in vivo imaging studies of substance P receptors

artículo científico publicado en 2003

Synthesis and evaluation of iodine-123 labelled tricyclic tropanes as radioligands for the serotonin transporter

artículo científico publicado en 2003

Synthesis and in vitro evaluation of N-substituted aza-trozamicol analogs as vesicular acetylcholine transporter ligands.

artículo científico publicado en 2006

Synthesis and in vitro evaluation of fluorinated diphenyloxide derivatives and sulfur analogs as serotonin transporter ligands.

artículo científico publicado en 2009

Synthesis and in vitro evaluation of new benzovesamicol analogues as potential imaging probes for the vesicular acetylcholine transporter

artículo científico publicado en 2005

Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands.

artículo científico publicado en 2005

Synthesis and ligand binding of nortropane derivatives: N-substituted 2beta-carbomethoxy-3beta-(4'-iodophenyl)nortropane and N-(3-iodoprop-(2E)-enyl)-2beta-carbomethoxy-3beta-(3',4'-disubstituted phenyl)nortropane. New high-affinity and selective co

artículo científico publicado en 1997

Synthesis of tropane and nortropane analogues with phenyl substitutions as serotonin transporter ligands.

artículo científico publicado en 2001

Synthesis, radiolabeling and preliminary biological evaluation of radiolabeled 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter

artículo científico publicado en 2002

Synthesis, radiosynthesis and in vivo preliminary evaluation of [11C]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET.

artículo científico publicado en 2005

The Metabolic Disturbances of Motoneurons Exposed to Glutamate.

artículo científico publicado en 2018

The combination of four analytical methods to explore skeletal muscle metabolomics: Better coverage of metabolic pathways or a marketing argument?

artículo científico publicado en 2017

Toxicity, mutagenicity, and behavioral effects of beta-CIT, a ligand for dopamine transporter exploration by SPECT.

artículo científico publicado en 1998

Trough infliximab concentrations predict efficacy and sustained control of disease activity in rheumatoid arthritis

scientific article published on 01 April 2010

Untargeted 1H-NMR metabolomics in CSF: toward a diagnostic biomarker for motor neuron disease

artículo científico publicado en 2014

Validation of a global quantitative analysis methodology of tryptophan metabolites in mice using LC-MS

artículo científico publicado en 2018

Validation of amino-acids measurement in dried blood spot by FIA-MS/MS for PKU management.

artículo científico publicado en 2016

Validation of metabolomics analysis of human perilymph fluid using liquid chromatography-mass spectroscopy

artículo científico publicado en 2018

Visualization of the dopamine transporter in the human brain postmortem with the new selective ligand [125I]PE2I.

artículo científico publicado en 1999

Whole-body distribution and radiation dosimetry of the dopamine transporter radioligand [(11)C]PE2I in healthy volunteers

artículo científico publicado en 2007

Wildtype motoneurons, ALS-Linked SOD1 mutation and glutamate profoundly modify astrocyte metabolism and lactate shuttling.

artículo científico publicado en 2017

Workflow methodology for rat brain metabolome exploration using NMR, LC-MS and GC-MS analytical platforms

artículo científico publicado en 2017

[(11)C]MADAM, a new serotonin transporter radioligand characterized in the monkey brain by PET.

artículo científico publicado en 2005

[(11)C]PE2I: a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain

artículo científico publicado en 2003

[Investigation of hyperhomocysteinemia].

artículo científico publicado en 2013

[Mass spectrometry for steroid assays]

artículo científico publicado en 2015

Lista de obras de Patrick Emond

(E)-[125I]-5-AOIBV: a SPECT radioligand for the vesicular acetylcholine transporter.

1H-13C NMR-based urine metabolic profiling in autism spectrum disorders.

1H-NMR-based metabolomic profiling of CSF in early amyotrophic lateral sclerosis

3D QSAR study, synthesis, and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the vesicular acetylcholine transporter (VAChT).

A Multiplatform Metabolomics Approach to Characterize Plasma Levels of Phenylalanine and Tyrosine in Phenylketonuria.

A multiplatform metabolomic approach to characterize fecal signatures of negative postnatal events in chicks: a pilot study

A radiometabolite study of the serotonin transporter PET radioligand [(11)C]MADAM.

A selective radiobrominated cocaine analogue for imaging of dopamine uptake sites: pharmacological evaluation and PET experiments.

ADAM is an effective tool for in vivo study of serotonergic function: validation in rat models.

ATP-activated P2X7 receptor in the pathophysiology of mood disorders and as an emerging target for the development of novel antidepressant therapeutics. ⬇️

Acetylenic pyridines for use in PET imaging of nicotinic receptors.

An UPLC-MSMS method to measure plasma homocysteine concentration.

Analytical methodology for metabolomics study of adherent mammalian cells using NMR, GC-MS and LC-HRMS.

Assessing the metabolic effects of calcineurin inhibitors in renal transplant recipients by urine metabolic profiling

Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice

Biomarkers in amyotrophic lateral sclerosis: combining metabolomic and clinical parameters to define disease progression.

Combined 1H-NMR and 1H-13C HSQC-NMR to improve urinary screening in autism spectrum disorders

Comparative analysis of targeted metabolomics: dominance-based rough set approach versus orthogonal partial least square-discriminant analysis

Correction: 1H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis.

Correction: Elucidating time-dependent changes in the urinary metabolome of renal transplant patients by a combined 1H NMR and GC-MS approach.

Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [F] PET tracer

Disruption of TCA Cycle and Glutamate Metabolism Identified by Metabolomics in an In Vitro Model of Amyotrophic Lateral Sclerosis

Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging

Does lipidomic serum analysis support the assessment of digestive efficiency in chickens?

Endogenous metabolites that are substrates of organic anion transporter's (OATs) predict methotrexate clearance.

Erratum to "Validation of amino-acids measurement in dried blood spot by FIA-MS/MS for PKU management" [Clin. Biochem. 49 (2016) 1047-1050]

Ex vivo and in vivo evaluation of (2R,3R)-5-[(18)F]-fluoroethoxy- and fluoropropoxy-benzovesamicol, as PET radioligands for the vesicular acetylcholine transporter

Exploration of the dopamine transporter: in vitro and in vivo characterization of a high-affinity and high-specificity iodinated tropane derivative (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-m ethylph enyl)nortropane (PE2I).

Extensive exploration of a novel rat model of Parkinson's disease using partial 6-hydroxydopamine lesion of dopaminergic neurons suggests new therapeutic approaches

Fragmentation pathway of dopamine transporter ligands: N-substituted-2beta-carbomethoxy-3beta-phenylnortropane derivatives

GC-MS-based urine metabolic profiling of autism spectrum disorders.

Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes

Hyperphenylalaninemia Correlated with Global Decrease of Antioxidant Genes Expression in White Blood Cells of Adult Patients with Phenylketonuria.

Identification of metabolic pathway disturbances using multimodal metabolomics in autistic disorders in a Middle Eastern population

Imaging of the striatal and extrastriatal dopamine transporter with (18)F-LBT-999: quantification, biodistribution, and radiation dosimetry in nonhuman primates

Is NMR metabolic profiling of spent embryo culture media useful to assist in vitro human embryo selection?

Metabolomics Study of Urine in Autism Spectrum Disorders Using a Multiplatform Analytical Methodology

Metabolomics in Cerebrospinal Fluid of Patients with Amyotrophic Lateral Sclerosis: An Untargeted Approach via High-Resolution Mass Spectrometry

Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury

Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model

New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET.

PET examination of [(11)C]5-methyl-6-nitroquipazine, a radioligand for visualization of the serotonin transporter

PET examination of three potent cocaine derivatives as specific radioligands for the serotonin transporter

Pharmacokinetics and dosimetry of iodine-123 labelled PE2I in humans, a radioligand for dopamine transporter imaging

Pharmacological characterisation of (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methylphenyl)nortropane (PE2I) binding to the rat neuronal dopamine transporter expressed in COS cells

Pharmacological characterization of N,N-dimethyl-2-(2-amino-4-methylphenyl thio)benzylamine as a ligand of the serotonin transporter with high affinity and selectivity.

Prenatal exposure to methylphenidate affects the dopamine system and the reactivity to natural reward in adulthood in rats

QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT).

Relationship between Metabolomics Profile of Perilymph in Cochlear-Implanted Patients and Duration of Hearing Loss

Single nucleotide polymorphisms of ABCC2 modulate renal secretion of endogenous organic anions.

Specific Metabolome Profile of Exhaled Breath Condensate in Patients with Shock and Respiratory Failure: A Pilot Study.

Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.

Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1).

Synthesis and biological evaluation of halogenated naphthyridone carboxamides as potential ligands for in vivo imaging studies of substance P receptors

Synthesis and evaluation of iodine-123 labelled tricyclic tropanes as radioligands for the serotonin transporter

Synthesis and in vitro evaluation of N-substituted aza-trozamicol analogs as vesicular acetylcholine transporter ligands.

Synthesis and in vitro evaluation of fluorinated diphenyloxide derivatives and sulfur analogs as serotonin transporter ligands.

Synthesis and in vitro evaluation of new benzovesamicol analogues as potential imaging probes for the vesicular acetylcholine transporter

Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands.

Synthesis and ligand binding of nortropane derivatives: N-substituted 2beta-carbomethoxy-3beta-(4'-iodophenyl)nortropane and N-(3-iodoprop-(2E)-enyl)-2beta-carbomethoxy-3beta-(3',4'-disubstituted phenyl)nortropane. New high-affinity and selective co

Synthesis of tropane and nortropane analogues with phenyl substitutions as serotonin transporter ligands.

Synthesis, radiolabeling and preliminary biological evaluation of radiolabeled 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter

Synthesis, radiosynthesis and in vivo preliminary evaluation of [11C]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET.

The Metabolic Disturbances of Motoneurons Exposed to Glutamate.

The combination of four analytical methods to explore skeletal muscle metabolomics: Better coverage of metabolic pathways or a marketing argument?

Toxicity, mutagenicity, and behavioral effects of beta-CIT, a ligand for dopamine transporter exploration by SPECT.

Trough infliximab concentrations predict efficacy and sustained control of disease activity in rheumatoid arthritis

Untargeted 1H-NMR metabolomics in CSF: toward a diagnostic biomarker for motor neuron disease

Validation of a global quantitative analysis methodology of tryptophan metabolites in mice using LC-MS

Validation of amino-acids measurement in dried blood spot by FIA-MS/MS for PKU management.

Validation of metabolomics analysis of human perilymph fluid using liquid chromatography-mass spectroscopy

Visualization of the dopamine transporter in the human brain postmortem with the new selective ligand [125I]PE2I.

Whole-body distribution and radiation dosimetry of the dopamine transporter radioligand [(11)C]PE2I in healthy volunteers

Wildtype motoneurons, ALS-Linked SOD1 mutation and glutamate profoundly modify astrocyte metabolism and lactate shuttling.

Workflow methodology for rat brain metabolome exploration using NMR, LC-MS and GC-MS analytical platforms

[(11)C]MADAM, a new serotonin transporter radioligand characterized in the monkey brain by PET.

[(11)C]PE2I: a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain

[Investigation of hyperhomocysteinemia].

[Mass spectrometry for steroid assays]