Lista de obras - Pablo Sarobe - Dominio Público Uruguay

A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C.

artículo científico publicado en 2013

A fusion protein between streptavidin and the endogenous TLR4 ligand EDA targets biotinylated antigens to dendritic cells and induces T cell responses in vivo.

scientific article published on 05 September 2013

A peptide inhibitor of FOXP3 impairs regulatory T cell activity and improves vaccine efficacy in mice.

artículo científico publicado en 2010

A recombinant adenovirus encoding hepatitis C virus core and E1 proteins protects mice against cytokine-induced liver damage

artículo científico publicado en 2003

A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats

artículo científico publicado en 2008

Abnormal priming of CD4(+) T cells by dendritic cells expressing hepatitis C virus core and E1 proteins.

artículo científico publicado en 2002

Adjuvant Combination and Antigen Targeting as a Strategy to Induce Polyfunctional and High-Avidity T-Cell Responses against Poorly Immunogenic Tumors

article

B cell epitopes of HIV type 1 p24 capsid protein: a reassessment

artículo científico publicado en 1996

Bivalent therapeutic vaccine against HPV16/18 genotypes consisting of a fusion protein between the extra domain A from human fibronectin and HPV16/18 E7 viral antigens

scientific article published on 01 June 2020

CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination.

artículo científico publicado en 2003

CD4-modified synthetic peptides containing phenylalanine inhibit HIV-1 infection in vitro.

artículo científico publicado en 1994

Carcinoembryonic antigen as a target to induce anti-tumor immune responses.

artículo científico publicado en 2004

Cells as vehicles for therapeutic genes to treat liver diseases.

artículo científico publicado en 2008

Characterization of T-cell responses against immunodominant epitopes from hepatitis C virus E2 and NS4a proteins.

artículo científico publicado en 2006

Characterization of an immunologically conserved epitope from hepatitis C virus E2 glycoprotein recognized by HLA-A2 restricted cytotoxic T lymphocytes

artículo científico publicado en 2001

Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection

artículo científico publicado en 2013

Clinical testing of a dendritic cell targeted therapeutic vaccine in patients with chronic hepatitis C virus infection.

artículo científico publicado en 2015

Combination of a TLR4 ligand and anaphylatoxin C5a for the induction of antigen-specific cytotoxic T cell responses

artículo científico publicado en 2012

Combined immunization with adjuvant molecules poly(I:C) and anti-CD40 plus a tumor antigen has potent prophylactic and therapeutic antitumor effects

artículo científico publicado en 2007

Dendritic cells: Nearly 40 years later…

Depletion of dendritic cells delays ovarian cancer progression by boosting antitumor immunity.

artículo científico publicado en 2008

Dysregulation of interferon regulatory factors impairs the expression of immunostimulatory molecules in hepatitis C virus genotype 1-infected hepatocytes.

artículo científico publicado en 2013

Engineered promiscuous T helper peptides for the induction of immune responses

artículo científico publicado en 2006

Engineering Th determinants for efficient priming of humoral and cytotoxic T cell responses

artículo científico publicado en 2003

Enhanced T cell responses against hepatitis C virus by ex vivo targeting of adenoviral particles to dendritic cells

artículo científico publicado en 2011

Enhanced anti-tumor efficacy of checkpoint inhibitors in combination with the histone deacetylase inhibitor Belinostat in a murine hepatocellular carcinoma model

artículo científico publicado en 2018

Enhanced in vitro potency and in vivo immunogenicity of a CTL epitope from hepatitis C virus core protein following amino acid replacement at secondary HLA-A2.1 binding positions

artículo científico publicado en 1998

Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus

artículo científico publicado en 2005

Enhancement of peptide immunogenicity by insertion of a cathepsin B cleavage site between determinants recognized by B and T cells

artículo científico publicado en 1993

Enhancing immunogenicity of a CTL epitope from carcinoembryonic antigen by selective amino acid replacements.

artículo científico publicado en 2002

Epitope enhancement of a CD4 HIV epitope toward the development of the next generation HIV vaccine

artículo científico publicado en 2006

Eradication of large tumors expressing human papillomavirus E7 protein by therapeutic vaccination with E7 fused to the extra domain a from fibronectin

artículo científico publicado en 2011

Expansion of Tumor-Infiltrating CD8+ T cells Expressing PD-1 Improves the Efficacy of Adoptive T-cell Therapy.

artículo científico publicado en 2017

Fine analysis of immunoreactivity of V3 peptides: antibodies specific for V3 domain of laboratory HIV type 1 strains recognize multiple V3 sequences synthesized from field HIV type 1 isolates

artículo científico publicado en 1996

Further insights on the inhibition of HIV type 1 infection in vitro by CD4-modified synthetic peptides containing phenylalanine

artículo científico publicado en 1996

Gene expression analysis during acute hepatitis C virus infection associates dendritic cell activation with viral clearance.

artículo científico publicado en 2015

Helper cell-independent antitumor activity of potent CD8(+) T cell epitope peptide vaccines is dependent upon CD40L.

artículo científico publicado en 2013

Hepatitis C Virus Structural Proteins Impair Dendritic Cell Maturation and Inhibit In Vivo Induction of Cellular Immune Responses

artículo científico publicado en 2003

Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection.

artículo científico publicado en 2010

IL-10 expression defines an immunosuppressive dendritic cell population induced by antitumor therapeutic vaccination.

artículo científico publicado en 2017

Identification and characterization of a T-helper peptide from carcinoembryonic antigen.

artículo científico publicado en 2004

Identification of CD4+ and CD8+ T cell epitopes of woodchuck hepatitis virus core and surface antigens in BALB/c mice.

artículo científico publicado en 2010

Identification of HLA-B27-restricted cytotoxic T lymphocyte epitope from carcinoembryonic antigen

artículo científico publicado en 2002

Identification of an antigenic epitope for helper T lymphocytes from carcinoembryonic antigen

artículo científico publicado en 2002

Identification of peptide inhibitors of transforming growth factor beta 1 using a phage-displayed peptide library

artículo científico publicado en 2007

Immune monitoring of immunosuppression withdrawal of liver transplant recipients

artículo científico publicado en 2015

Immunization against hepatitis C virus with a fusion protein containing the extra domain A from fibronectin and the hepatitis C virus NS3 protein

artículo científico publicado en 2009

Immunization with a tumor-associated CTL epitope plus a tumor-related or unrelated Th1 helper peptide elicits protective CTL immunity

artículo científico publicado en 2001

Immunomodulatory Properties of Carvone Inhalation and Its Effects on Contextual Fear Memory in Mice.

artículo científico publicado en 2018

In vitro and in vivo down-regulation of regulatory T cell activity with a peptide inhibitor of TGF-beta1.

artículo científico publicado en 2008

In vivo cytotoxic T-lymphocyte induction may take place via CD8 T helper lymphocytes

artículo científico publicado en 1995

Induction of Monocyte Chemoattractant Protein-1 and Interleukin-10 by TGF 1 in Melanoma Enhances Tumor Infiltration and Immunosuppression

scientific article published on 15 December 2010

Induction of antibodies against a peptide hapten does not require covalent linkage between the hapten and a class II presentable T helper peptide

scientific article published on 01 June 1991

Induction of cytotoxic T lymphocytes in mice against the principal neutralizing domain of HIV-1 by immunization with an engineered T-cytotoxic-T-helper synthetic peptide construct

scientific article published on 01 April 1992

Induction of multiepitopic and long-lasting immune responses against tumour antigens by immunization with peptides, DNA and recombinant adenoviruses expressing minigenes

artículo científico publicado en 2008

Induction of neutralizing antibodies against human immunodeficiency virus type 1 using synthetic peptide constructs containing an immunodominant T-helper cell determinant from vpr.

artículo científico publicado en 1994

Induction of potent and long-lasting CD4 and CD8 T-cell responses against hepatitis C virus by immunization with viral antigens plus poly(I:C) and anti-CD40.

artículo científico publicado en 2007

Inhibition of FOXP3/NFAT Interaction Enhances T Cell Function after TCR Stimulation.

artículo científico publicado en 2015

Insights on the amino acid side-chain interactions of a synthetic T-cell determinant

artículo científico publicado en 1991

International symposium on CTL and immunostimulation, Pamplona (Spain), October 26th and 27th 2010.

artículo científico publicado en 2011

Is plasma cardiotrophin-1 a marker of hypertensive heart disease?

artículo científico publicado en 2005

Low molecular weight hyaluronan preconditioning of tumor-pulsed dendritic cells increases their migratory ability and induces immunity against murine colorectal carcinoma

artículo científico publicado en 2011

MAGE antigens: therapeutic targets in hepatocellular carcinoma?

scientific article published on 01 January 2004

Monocyte-derived dendritic cells from HCV-infected patients transduced with an adenovirus expressing NS3 are functional when stimulated with the TLR3 ligand poly(I:C).

artículo científico publicado en 2008

Neoantigens as potential vaccines in hepatocellular carcinoma

artículo científico publicado en 2022

New therapies for hepatitis C

artículo científico publicado en 2006

Oncostatin M Enhances the Antiviral Effects of Type I Interferon and Activates Immunostimulatory Functions in Liver Epithelial Cells

artículo científico publicado en 2009

Overcoming class II-linked non-responsiveness to hepatitis B vaccine

artículo científico publicado en 1994

PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity.

artículo científico publicado en 2017

Peptide inhibitors of transforming growth factor-beta enhance the efficacy of antitumor immunotherapy.

artículo científico publicado en 2009

Polarity of immunogens: implications for vaccine design

artículo científico publicado en 1990

Production of interleukin-2 in response to synthetic peptides from hepatitis C virus E1 protein in patients with chronic hepatitis C: relationship with the response to interferon treatment

artículo científico publicado en 1996

Radioembolization of hepatocellular carcinoma activates liver regeneration, induces inflammation and endothelial stress and activates coagulation

artículo científico publicado en 2014

Simple strategy to induce antibodies of distinct specificity: Application to the mapping of gp120 and inhibition of HIV-1 infectivity

article

Specific and general HLA-DR binding motifs: comparison of algorithms

artículo científico publicado en 2000

Synthesis and anti-HIV-1 activities of new pyrimido[5,4-b]indoles

artículo científico publicado en 1999

Synthesis and evaluation of new Reissert analogs as HIV-1 RT inhibitors. 2. Benzo[f]quinoline and pyridine derivatives.

artículo científico publicado en 1997

Synthesis and evaluation of new Reissert analogs as HIV-1 reverse transcriptase inhibitors. 1. Quinoline and quinoxaline derivatives

artículo científico publicado en 1997

T(h)1 but not T(h)0 cell help is efficient to induce cytotoxic T lymphocytes by immunization with short synthetic peptides

artículo científico publicado en 1999

T-helper cell response to woodchuck hepatitis virus antigens after therapeutic vaccination of chronically-infected animals treated with lamivudine

artículo científico publicado en 2001

The Toll like receptor 4 ligand cold-inducible RNA-binding protein as vaccination platform against cancer

artículo científico publicado en 2017

The combined actions of NK and T lymphocytes are necessary to reject an EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFN gamma.

artículo científico publicado en 2007

The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression.

artículo científico publicado en 2009

The extra domain A from fibronectin targets antigens to TLR4-expressing cells and induces cytotoxic T cell responses in vivo

artículo científico publicado en 2007

Therapeutic effect of a peptide inhibitor of TGF-β on pulmonary fibrosis ⬇️

artículo científico publicado el 23 de diciembre de 2010

Therapeutic vaccination of woodchucks against chronic woodchuck hepatitis virus infection.

artículo científico publicado en 1997

Tim-3 expression in tumour-associated macrophages: a new player in HCC progression

artículo científico publicado en 2015

Trial of complete weaning from immunosuppression for liver transplant recipients: factors predictive of tolerance

artículo científico publicado en 2013

Tumor therapy in mice by using a tumor antigen linked to modulin peptides from Staphylococcus epidermidis

artículo científico publicado en 2010

Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection

artículo científico publicado en 2007

Vaccination against hepatitis C virus with dendritic cells transduced with an adenovirus encoding NS3 protein.

artículo científico publicado en 2007

Vaccination with an adenoviral vector encoding hepatitis C virus (HCV) NS3 protein protects against infection with HCV-recombinant vaccinia virus

artículo científico publicado en 2002

Vaccine-induced but not tumor-derived Interleukin-10 dictates the efficacy of Interleukin-10 blockade in therapeutic vaccination.

artículo científico publicado en 2015

Lista de obras de Pablo Sarobe

A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C.

A fusion protein between streptavidin and the endogenous TLR4 ligand EDA targets biotinylated antigens to dendritic cells and induces T cell responses in vivo.

A peptide inhibitor of FOXP3 impairs regulatory T cell activity and improves vaccine efficacy in mice.

A recombinant adenovirus encoding hepatitis C virus core and E1 proteins protects mice against cytokine-induced liver damage

A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats

Abnormal priming of CD4(+) T cells by dendritic cells expressing hepatitis C virus core and E1 proteins.

Adjuvant Combination and Antigen Targeting as a Strategy to Induce Polyfunctional and High-Avidity T-Cell Responses against Poorly Immunogenic Tumors

B cell epitopes of HIV type 1 p24 capsid protein: a reassessment

Bivalent therapeutic vaccine against HPV16/18 genotypes consisting of a fusion protein between the extra domain A from human fibronectin and HPV16/18 E7 viral antigens

CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination.

CD4-modified synthetic peptides containing phenylalanine inhibit HIV-1 infection in vitro.

Carcinoembryonic antigen as a target to induce anti-tumor immune responses.

Cells as vehicles for therapeutic genes to treat liver diseases.

Characterization of T-cell responses against immunodominant epitopes from hepatitis C virus E2 and NS4a proteins.

Characterization of an immunologically conserved epitope from hepatitis C virus E2 glycoprotein recognized by HLA-A2 restricted cytotoxic T lymphocytes

Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection

Clinical testing of a dendritic cell targeted therapeutic vaccine in patients with chronic hepatitis C virus infection.

Combination of a TLR4 ligand and anaphylatoxin C5a for the induction of antigen-specific cytotoxic T cell responses

Combined immunization with adjuvant molecules poly(I:C) and anti-CD40 plus a tumor antigen has potent prophylactic and therapeutic antitumor effects

Dendritic cells: Nearly 40 years later…

Depletion of dendritic cells delays ovarian cancer progression by boosting antitumor immunity.

Dysregulation of interferon regulatory factors impairs the expression of immunostimulatory molecules in hepatitis C virus genotype 1-infected hepatocytes.

Engineered promiscuous T helper peptides for the induction of immune responses

Engineering Th determinants for efficient priming of humoral and cytotoxic T cell responses

Enhanced T cell responses against hepatitis C virus by ex vivo targeting of adenoviral particles to dendritic cells

Enhanced anti-tumor efficacy of checkpoint inhibitors in combination with the histone deacetylase inhibitor Belinostat in a murine hepatocellular carcinoma model

Enhanced in vitro potency and in vivo immunogenicity of a CTL epitope from hepatitis C virus core protein following amino acid replacement at secondary HLA-A2.1 binding positions

Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus

Enhancement of peptide immunogenicity by insertion of a cathepsin B cleavage site between determinants recognized by B and T cells

Enhancing immunogenicity of a CTL epitope from carcinoembryonic antigen by selective amino acid replacements.

Epitope enhancement of a CD4 HIV epitope toward the development of the next generation HIV vaccine

Eradication of large tumors expressing human papillomavirus E7 protein by therapeutic vaccination with E7 fused to the extra domain a from fibronectin

Expansion of Tumor-Infiltrating CD8+ T cells Expressing PD-1 Improves the Efficacy of Adoptive T-cell Therapy.

Fine analysis of immunoreactivity of V3 peptides: antibodies specific for V3 domain of laboratory HIV type 1 strains recognize multiple V3 sequences synthesized from field HIV type 1 isolates

Further insights on the inhibition of HIV type 1 infection in vitro by CD4-modified synthetic peptides containing phenylalanine

Gene expression analysis during acute hepatitis C virus infection associates dendritic cell activation with viral clearance.

Helper cell-independent antitumor activity of potent CD8(+) T cell epitope peptide vaccines is dependent upon CD40L.

Hepatitis C Virus Structural Proteins Impair Dendritic Cell Maturation and Inhibit In Vivo Induction of Cellular Immune Responses

Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection.

IL-10 expression defines an immunosuppressive dendritic cell population induced by antitumor therapeutic vaccination.

Identification and characterization of a T-helper peptide from carcinoembryonic antigen.

Identification of CD4+ and CD8+ T cell epitopes of woodchuck hepatitis virus core and surface antigens in BALB/c mice.

Identification of HLA-B27-restricted cytotoxic T lymphocyte epitope from carcinoembryonic antigen

Identification of an antigenic epitope for helper T lymphocytes from carcinoembryonic antigen

Identification of peptide inhibitors of transforming growth factor beta 1 using a phage-displayed peptide library

Immune monitoring of immunosuppression withdrawal of liver transplant recipients

Immunization against hepatitis C virus with a fusion protein containing the extra domain A from fibronectin and the hepatitis C virus NS3 protein

Immunization with a tumor-associated CTL epitope plus a tumor-related or unrelated Th1 helper peptide elicits protective CTL immunity

Immunomodulatory Properties of Carvone Inhalation and Its Effects on Contextual Fear Memory in Mice.

In vitro and in vivo down-regulation of regulatory T cell activity with a peptide inhibitor of TGF-beta1.

In vivo cytotoxic T-lymphocyte induction may take place via CD8 T helper lymphocytes

Induction of Monocyte Chemoattractant Protein-1 and Interleukin-10 by TGF 1 in Melanoma Enhances Tumor Infiltration and Immunosuppression

Induction of antibodies against a peptide hapten does not require covalent linkage between the hapten and a class II presentable T helper peptide

Induction of cytotoxic T lymphocytes in mice against the principal neutralizing domain of HIV-1 by immunization with an engineered T-cytotoxic-T-helper synthetic peptide construct

Induction of multiepitopic and long-lasting immune responses against tumour antigens by immunization with peptides, DNA and recombinant adenoviruses expressing minigenes

Induction of neutralizing antibodies against human immunodeficiency virus type 1 using synthetic peptide constructs containing an immunodominant T-helper cell determinant from vpr.

Induction of potent and long-lasting CD4 and CD8 T-cell responses against hepatitis C virus by immunization with viral antigens plus poly(I:C) and anti-CD40.

Inhibition of FOXP3/NFAT Interaction Enhances T Cell Function after TCR Stimulation.

Insights on the amino acid side-chain interactions of a synthetic T-cell determinant

International symposium on CTL and immunostimulation, Pamplona (Spain), October 26th and 27th 2010.

Is plasma cardiotrophin-1 a marker of hypertensive heart disease?

Low molecular weight hyaluronan preconditioning of tumor-pulsed dendritic cells increases their migratory ability and induces immunity against murine colorectal carcinoma

MAGE antigens: therapeutic targets in hepatocellular carcinoma?

Monocyte-derived dendritic cells from HCV-infected patients transduced with an adenovirus expressing NS3 are functional when stimulated with the TLR3 ligand poly(I:C).

Neoantigens as potential vaccines in hepatocellular carcinoma

New therapies for hepatitis C

Oncostatin M Enhances the Antiviral Effects of Type I Interferon and Activates Immunostimulatory Functions in Liver Epithelial Cells

Overcoming class II-linked non-responsiveness to hepatitis B vaccine

PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity.

Peptide inhibitors of transforming growth factor-beta enhance the efficacy of antitumor immunotherapy.

Polarity of immunogens: implications for vaccine design

Production of interleukin-2 in response to synthetic peptides from hepatitis C virus E1 protein in patients with chronic hepatitis C: relationship with the response to interferon treatment

Radioembolization of hepatocellular carcinoma activates liver regeneration, induces inflammation and endothelial stress and activates coagulation

Simple strategy to induce antibodies of distinct specificity: Application to the mapping of gp120 and inhibition of HIV-1 infectivity

Specific and general HLA-DR binding motifs: comparison of algorithms

Synthesis and anti-HIV-1 activities of new pyrimido[5,4-b]indoles

Synthesis and evaluation of new Reissert analogs as HIV-1 RT inhibitors. 2. Benzo[f]quinoline and pyridine derivatives.

Synthesis and evaluation of new Reissert analogs as HIV-1 reverse transcriptase inhibitors. 1. Quinoline and quinoxaline derivatives

T(h)1 but not T(h)0 cell help is efficient to induce cytotoxic T lymphocytes by immunization with short synthetic peptides