Lista de obras - Kevin A Reynolds - Dominio Público Uruguay

1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)

artículo científico publicado en 2004

A novel alternate anaplerotic pathway to the glyoxylate cycle in streptomycetes ⬇️

artículo científico publicado el 1 de agosto de 1997

A novel delta(3),delta(2)-enoyl-CoA isomerase involved in the biosynthesis of the cyclohexanecarboxylic acid-derived moiety of the polyketide ansatrienin A.

artículo científico publicado en 2000

A pH-stability study of phoslactomycin B and analysis of the acid and base degradation products

artículo científico publicado en 2005

Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS.

artículo científico publicado en 2011

Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes

artículo científico publicado en 2007

Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH).

artículo científico publicado en 2005

An O-phosphotransferase catalyzes phosphorylation of hygromycin A in the antibiotic-producing organism Streptomyces hygroscopicus

artículo científico publicado en 2008

An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis

artículo científico publicado en 2002

Antibacterial targets in fatty acid biosynthesis

artículo científico publicado en 2007

Antimalarial activity of natural and synthetic prodiginines

artículo científico publicado en 2011

Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin

artículo científico publicado en 2002

Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892. ⬇️

artículo científico publicado en 1999

Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity.

scientific article published on August 2009

Biosynthesis of the Shikimate-derived Starter Unit of the Immunosuppressant Ascomycin: Stereochemistry of the 1,4-Conjugate Elimination ⬇️

artículo científico publicado el 1 de agosto de 1997

Biosynthesis of the aminocyclitol subunit of hygromycin A in Streptomyces hygroscopicus NRRL 2388.

artículo científico publicado en 2009

Biosynthetic origin of hygromycin A.

artículo científico publicado en 2003

Biosynthetic origins of the natural product, thiolactomycin: a unique and selective inhibitor of type II dissociated fatty acid synthases

artículo científico publicado en 2003

Branched-chain fatty acid biosynthesis in Escherichia coli

artículo científico publicado en 2001

Characterization of FabG and FabI of the Streptomyces coelicolor dissociated fatty acid synthase

artículo científico publicado en 2015

Cloning, expression, and characterization of a type II 3-dehydroquinate dehydratase gene from Streptomyces hygroscopicus.

artículo científico publicado en 1998

Combinatorial biosynthesis: lesson learned from nature

artículo científico publicado en 1998

Crotonyl-coenzyme A reductase provides methylmalonyl-CoA precursors for monensin biosynthesis by Streptomyces cinnamonensis in an oil-based extended fermentation

artículo científico publicado en 2004

Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A

scientific journal article

Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A

artículo científico publicado en 2015

Elucidation of final steps of the marineosins biosynthetic pathway through identification and characterization of the corresponding gene cluster ⬇️

scientific article published on 12 March 2014

Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis

artículo científico publicado en 2008

Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster

artículo científico publicado en 2003

Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering ⬇️

artículo científico publicado el 23 de junio de 1998

Fatty-acid biosynthesis in a branched-chain alpha-keto acid dehydrogenase mutant of Streptomyces avermitilis

artículo científico publicado en 2000

Functional characterization of an NADPH dependent 2-alkyl-3-ketoalkanoic acid reductase involved in olefin biosynthesis in Stenotrophomonas maltophilia

artículo científico publicado en 2011

Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules by using a matched pair of heterologous docking domains

artículo científico publicado en 2009

Functional modular dissection of DEBS1-TE changes triketide lactone ratios and provides insight into Acyl group loading, hydrolysis, and ACP transfer.

artículo científico publicado en 2012

Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae

artículo científico publicado en 2002

Generation of novel pikromycin antibiotic products through mutasynthesis

artículo científico publicado en 2008

Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production.

artículo científico publicado en 1999

Genetic manipulation of the biosynthetic process leading to phoslactomycins, potent protein phosphatase 2A inhibitors.

artículo científico publicado en 2006

High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain.

artículo científico publicado en 2009

Identification and Characterization of FabA from the Type II Fatty Acid Synthase of Streptomyces coelicolor

artículo científico publicado en 2016

Identification and disruptional analysis of the Streptomyces cinnamonensis msdA gene, encoding methylmalonic acid semialdehyde dehydrogenase ⬇️

artículo científico publicado en 2005

In vivo analysis of straight-chain and branched-chain fatty acid biosynthesis in three actinomycetes.

artículo científico publicado en 1995

Isotopically sensitive regioselectivity in the oxidative deamination of a homologous series of diamines catalyzed by diamine oxidase

artículo científico publicado en 1992

Iterative chain elongation by a pikromycin monomodular polyketide synthase

artículo científico publicado en 2003

MarH, a Bifunctional Enzyme Involved in the Condensation and Hydroxylation Steps of the Marineosin Biosynthetic Pathway

artículo científico publicado en 2017

MeaA, a putative coenzyme B12-dependent mutase, provides methylmalonyl coenzyme A for monensin biosynthesis in Streptomyces cinnamonensis. ⬇️

artículo científico publicado en 2001

Mechanisms of molecular recognition in the pikromycin polyketide synthase

artículo científico publicado en 2000

Mechanistic studies of two amino acid racemases of broad substrate specificity from Pseudomonas striata and Aeromonas caviae

scientific article published on 01 January 1991

Multiple pathways for acetate assimilation in Streptomyces cinnamonensis ⬇️

artículo científico publicado en 2005

Polyketide synthase acyl carrier protein (ACP) as a substrate and a catalyst for malonyl ACP biosynthesis

artículo científico publicado en 1999

Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates

artículo científico publicado en 2008

Production of Hygromycin A Analogs in Streptomyces hygroscopicus NRRL 2388 through Identification and Manipulation of the Biosynthetic Gene Cluster

artículo científico publicado en 2006

Production of branched-chain alkylprodiginines in S. coelicolor by replacement of the 3-ketoacyl ACP synthase III initiation enzyme, RedP.

artículo científico publicado en 2005

Purification and characterization of a novel enoyl coenzyme A reductase from Streptomyces collinus

artículo científico publicado en 1992

Purification of crotonyl-CoA reductase from Streptomyces collinus and cloning, sequencing and expression of the corresponding gene in Escherichia coli.

artículo científico publicado en 1995

Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH

artículo científico publicado en 2008

Stenotrophomonas maltophilia OleC-Catalyzed ATP-Dependent Formation of Long-Chain Z-Olefins from 2-Alkyl-3-hydroxyalkanoic Acids

artículo científico publicado en 2016

Stereospecific synthesis of 23-hydroxyundecylprodiginines and analogues and conversion to antimalarial premarineosins via a Rieske oxygenase catalyzed bicyclization

artículo científico publicado en 2014

Streptomyces coelicolor RedP and FabH enzymes, initiating undecylprodiginine and fatty acid biosynthesis, exhibit distinct acyl-CoA and malonyl-acyl carrier protein substrate specificities

artículo científico publicado en 2012

Structural Basis for Binding Specificity between Subclasses of Modular Polyketide Synthase Docking Domains

artículo científico publicado en 2009

Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene

artículo científico publicado en 2013

Structure and Function of the RedJ Protein, a Thioesterase from the Prodiginine Biosynthetic Pathway in Streptomyces coelicolor

artículo científico publicado en 2011

Substrate recognition and channeling of monomodules from the pikromycin polyketide synthase

artículo científico publicado en 2003

Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials

artículo científico publicado en 2015

Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors

artículo científico publicado en 2008

Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH).

artículo científico publicado en 2006

The final step of hygromycin A biosynthesis, oxidation of C-5''-dihydrohygromycin A, is linked to a putative proton gradient-dependent efflux

artículo científico publicado en 2009

The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase

artículo científico publicado en 2002

The plmS2-encoded cytochrome P450 monooxygenase mediates hydroxylation of phoslactomycin B in Streptomyces sp. strain HK803.

artículo científico publicado en 2005

Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis

artículo científico publicado en 2008

Lista de obras de Kevin A Reynolds

1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)

A novel alternate anaplerotic pathway to the glyoxylate cycle in streptomycetes ⬇️

A novel delta(3),delta(2)-enoyl-CoA isomerase involved in the biosynthesis of the cyclohexanecarboxylic acid-derived moiety of the polyketide ansatrienin A.

A pH-stability study of phoslactomycin B and analysis of the acid and base degradation products

Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS.

Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes

Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH).

An O-phosphotransferase catalyzes phosphorylation of hygromycin A in the antibiotic-producing organism Streptomyces hygroscopicus

An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis

Antibacterial targets in fatty acid biosynthesis

Antimalarial activity of natural and synthetic prodiginines

Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin

Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892. ⬇️

Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity.

Biosynthesis of the Shikimate-derived Starter Unit of the Immunosuppressant Ascomycin: Stereochemistry of the 1,4-Conjugate Elimination ⬇️

Biosynthesis of the aminocyclitol subunit of hygromycin A in Streptomyces hygroscopicus NRRL 2388.

Biosynthetic origin of hygromycin A.

Biosynthetic origins of the natural product, thiolactomycin: a unique and selective inhibitor of type II dissociated fatty acid synthases

Branched-chain fatty acid biosynthesis in Escherichia coli

Characterization of FabG and FabI of the Streptomyces coelicolor dissociated fatty acid synthase

Cloning, expression, and characterization of a type II 3-dehydroquinate dehydratase gene from Streptomyces hygroscopicus.

Combinatorial biosynthesis: lesson learned from nature

Crotonyl-coenzyme A reductase provides methylmalonyl-CoA precursors for monensin biosynthesis by Streptomyces cinnamonensis in an oil-based extended fermentation

Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A

Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A

Elucidation of final steps of the marineosins biosynthetic pathway through identification and characterization of the corresponding gene cluster ⬇️

Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis

Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster

Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering ⬇️

Fatty-acid biosynthesis in a branched-chain alpha-keto acid dehydrogenase mutant of Streptomyces avermitilis

Functional characterization of an NADPH dependent 2-alkyl-3-ketoalkanoic acid reductase involved in olefin biosynthesis in Stenotrophomonas maltophilia

Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules by using a matched pair of heterologous docking domains

Functional modular dissection of DEBS1-TE changes triketide lactone ratios and provides insight into Acyl group loading, hydrolysis, and ACP transfer.

Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae

Generation of novel pikromycin antibiotic products through mutasynthesis

Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production.

Genetic manipulation of the biosynthetic process leading to phoslactomycins, potent protein phosphatase 2A inhibitors.

High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain.

Identification and Characterization of FabA from the Type II Fatty Acid Synthase of Streptomyces coelicolor

Identification and disruptional analysis of the Streptomyces cinnamonensis msdA gene, encoding methylmalonic acid semialdehyde dehydrogenase ⬇️

In vivo analysis of straight-chain and branched-chain fatty acid biosynthesis in three actinomycetes.

Isotopically sensitive regioselectivity in the oxidative deamination of a homologous series of diamines catalyzed by diamine oxidase

Iterative chain elongation by a pikromycin monomodular polyketide synthase

MarH, a Bifunctional Enzyme Involved in the Condensation and Hydroxylation Steps of the Marineosin Biosynthetic Pathway

MeaA, a putative coenzyme B12-dependent mutase, provides methylmalonyl coenzyme A for monensin biosynthesis in Streptomyces cinnamonensis. ⬇️

Mechanisms of molecular recognition in the pikromycin polyketide synthase

Mechanistic studies of two amino acid racemases of broad substrate specificity from Pseudomonas striata and Aeromonas caviae

Multiple pathways for acetate assimilation in Streptomyces cinnamonensis ⬇️

Polyketide synthase acyl carrier protein (ACP) as a substrate and a catalyst for malonyl ACP biosynthesis

Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates

Production of Hygromycin A Analogs in Streptomyces hygroscopicus NRRL 2388 through Identification and Manipulation of the Biosynthetic Gene Cluster

Production of branched-chain alkylprodiginines in S. coelicolor by replacement of the 3-ketoacyl ACP synthase III initiation enzyme, RedP.

Purification and characterization of a novel enoyl coenzyme A reductase from Streptomyces collinus

Purification of crotonyl-CoA reductase from Streptomyces collinus and cloning, sequencing and expression of the corresponding gene in Escherichia coli.

Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH

Stenotrophomonas maltophilia OleC-Catalyzed ATP-Dependent Formation of Long-Chain Z-Olefins from 2-Alkyl-3-hydroxyalkanoic Acids

Stereospecific synthesis of 23-hydroxyundecylprodiginines and analogues and conversion to antimalarial premarineosins via a Rieske oxygenase catalyzed bicyclization

Streptomyces coelicolor RedP and FabH enzymes, initiating undecylprodiginine and fatty acid biosynthesis, exhibit distinct acyl-CoA and malonyl-acyl carrier protein substrate specificities

Structural Basis for Binding Specificity between Subclasses of Modular Polyketide Synthase Docking Domains

Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene

Structure and Function of the RedJ Protein, a Thioesterase from the Prodiginine Biosynthetic Pathway in Streptomyces coelicolor

Substrate recognition and channeling of monomodules from the pikromycin polyketide synthase

Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials

Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors

Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH).

The final step of hygromycin A biosynthesis, oxidation of C-5''-dihydrohygromycin A, is linked to a putative proton gradient-dependent efflux

The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase

The plmS2-encoded cytochrome P450 monooxygenase mediates hydroxylation of phoslactomycin B in Streptomyces sp. strain HK803.

Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis