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Lista de obras de Clare L Hawkins

8-Chloroadenosine Alters the Metabolic Profile and Downregulates Antioxidant and DNA Damage Repair Pathways in Macrophages

artículo científico publicado en 2019

8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response

scientific article published on 10 July 2019

A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity

artículo científico publicado en 2016

A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation

artículo científico publicado en 2019

A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid

artículo científico publicado en 2018

A therapeutic role for selenoprotein T in reducing ischaemia/reperfusion injury in the heart?

artículo científico publicado en 2018

Ability of hypochlorous acid and N-chloramines to chlorinate DNA and its constituents

artículo científico publicado en 2010

Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations

artículo científico publicado en 2009

Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome

artículo científico publicado en 2010

Assessing the Efficacy of Dietary Selenomethionine Supplementation in the Setting of Cardiac Ischemia/Reperfusion Injury

artículo científico publicado en 2019

Bilirubin scavenges chloramines and inhibits myeloperoxidase-induced protein/lipid oxidation in physiologically relevant hyperbilirubinemic serum.

artículo científico publicado en 2015

CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis.

artículo científico publicado en 2016

Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes.

artículo científico publicado en 2017

Cellular effects of peptide and protein hydroperoxides

artículo científico publicado en 2010

Cellular effects of photogenerated oxidants and long-lived, reactive, hydroperoxide photoproducts

artículo científico publicado en 2010

Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages

artículo científico publicado en 2016

Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space

artículo científico publicado en 2016

Characterization of the cellular effects of myeloperoxidase-derived oxidants on H9c2 cardiac myoblasts

scientific article published on 11 March 2019

Chasing great paths of Helmut Sies "Oxidative Stress".

artículo científico publicado en 2016

Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells

artículo científico

Comparative reactivity of the myeloperoxidase-derived oxidants HOCl and HOSCN with low-density lipoprotein (LDL): Implications for foam cell formation in atherosclerosis

artículo científico publicado en 2015

Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells

artículo científico publicado en 2013

Cross-linking of lens crystallin proteins induced by tryptophan metabolites and metal ions: implications for cataract development

artículo científico publicado en 2016

Degradation of Hyaluronic Acid, Poly- and Mono-Saccharides, and Model Compounds by Hypochlorite: Evidence for Radical Intermediates and Fragmentation

article

Detection and characterisation of radicals in biological materials using EPR methodology

artículo científico publicado en 2013

Detection, identification, and quantification of oxidative protein modifications

scientific article published on 31 October 2019

Direct detection and identification of radicals generated during the hydroxyl radical-induced degradation of hyaluronic acid and related materials

scientific article published on 01 January 1996

EPR spin trapping of protein radicals

artículo científico publicado en 2004

Generation and propagation of radical reactions on proteins.

artículo científico publicado en 2001

Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction

artículo científico publicado en 2014

High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase

article

Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase

artículo científico publicado en 2019

Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulphates

artículo científico publicado en 2004

Hypochlorite- and hypobromite-mediated radical formation and its role in cell lysis.

artículo científico publicado en 2001

Hypochlorite-Mediated Fragmentation of Hyaluronan, Chondroitin Sulfates, and RelatedN-Acetyl Glycosamines: Evidence for Chloramide Intermediates, Free Radical Transfer Reactions, and Site-Specific Fragmentation ⬇️

artículo científico publicado el 12 de noviembre de 2003

Hypochlorite-induced damage to DNA, RNA, and polynucleotides: formation of chloramines and nitrogen-centered radicals

artículo científico publicado en 2002

Hypochlorite-induced damage to nucleosides: formation of chloramines and nitrogen-centered radicals.

artículo científico publicado en 2001

Hypochlorite-induced oxidation of amino acids, peptides and proteins.

artículo científico publicado en 2003

Hypochlorite-induced oxidation of proteins in plasma: formation of chloramines and nitrogen-centred radicals and their role in protein fragmentation

artículo científico publicado en 1999

Hypochlorite-induced oxidation of thiols: Formation of thiyl radicals and the role of sulfenyl chlorides as intermediates

artículo científico publicado en 2000

Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin

artículo científico publicado en 2008

Hypochlorous acid-mediated oxidation of lipid components and antioxidants present in low-density lipoproteins: absolute rate constants, product analysis, and computational modeling

artículo científico publicado en 2003

Hypochlorous acid-mediated protein oxidation: how important are chloramine transfer reactions and protein tertiary structure?

artículo científico publicado en 2007

Hypochlorous acid-modified extracellular matrix contributes to the behavioral switching of human coronary artery smooth muscle cells

artículo científico publicado en 2019

Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid

artículo científico publicado en 2008

Hypothiocyanous acid: benign or deadly?

artículo científico publicado en 2011

Identification of plasma proteins that are susceptible to thiol oxidation by hypochlorous acid and N-chloramines

artículo científico publicado en 2008

Identification of proteins susceptible to thiol oxidation in endothelial cells exposed to hypochlorous acid and N-chloramines

article

In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages

artículo científico publicado en 2019

Inactivation of protease inhibitors and lysozyme by hypochlorous acid: role of side-chain oxidation and protein unfolding in loss of biological function

artículo científico publicado en 2005

Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates

artículo científico publicado en 2012

Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides

artículo científico publicado en 2014

Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction

artículo científico publicado en 2017

Mammalian heme peroxidases: from molecular mechanisms to health implications

artículo científico publicado en 2008

Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin, and enhances rat gastric tumor cell invasion.

artículo científico publicado en 2015

Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway

scientific article published on 06 December 2019

Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis.

artículo científico publicado en 2017

Myeloperoxidase Modulates Hydrogen Peroxide Mediated Cellular Damage in Murine Macrophages

artículo científico publicado en 2020

Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl).

artículo científico publicado en 2013

Nitric Oxide Storage and Transport in Cells Are Mediated by Glutathione S-Transferase P1-1 and Multidrug Resistance Protein 1 via Dinitrosyl Iron Complexes ⬇️

artículo científico publicado el 14 de noviembre de 2011

Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1.

artículo científico publicado en 2006

Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function

artículo científico publicado en 2019

Oxidative damage to collagen and related substrates by metal ion/hydrogen peroxide systems: random attack or site-specific damage?

artículo científico publicado en 1997

Photo-oxidation of cells generates long-lived intracellular protein peroxides

artículo científico publicado en 2003

Protein carbamylation: a key driver of vascular calcification during chronic kidney disease

artículo científico publicado en 2018

Quantification of protein modification by oxidants

artículo científico publicado en 2009

Reaction of protein chloramines with DNA and nucleosides: evidence for the formation of radicals, protein-DNA cross-links and DNA fragmentation

artículo científico publicado en 2002

Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids

artículo científico

Reactivity of selenium-containing compounds with myeloperoxidase-derived chlorinating oxidants: Second-order rate constants and implications for biological damage

artículo científico publicado en 2015

Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome

artículo científico publicado en 2012

Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function

artículo científico publicado en 2017

Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?

artículo científico publicado en 2016

Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?

artículo científico publicado en 2014

Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation

scientific article published on 04 September 2018

Selenomethionine supplementation reduces lesion burden, improves vessel function and modulates the inflammatory response within the setting of atherosclerosis

artículo científico publicado en 2019

Sensitizer-mediated photooxidation of histidine residues: evidence for the formation of reactive side-chain peroxides

artículo científico publicado en 2005

Separation, detection, and quantification of hydroperoxides formed at side-chain and backbone sites on amino acids, peptides, and proteins

artículo científico publicado en 2008

Singlet oxygen-mediated protein oxidation: evidence for the formation of reactive peroxides

article

Singlet oxygen-mediated protein oxidation: evidence for the formation of reactive side chain peroxides on tyrosine residues

artículo científico publicado en 2002

Singlet-oxygen-mediated amino acid and protein oxidation: formation of tryptophan peroxides and decomposition products

artículo científico publicado en 2009

Special issue on “Peroxidase”

scientific article published on 27 May 2015

The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: an EPR study.

artículo científico publicado en 2010

The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

artículo científico publicado en 2010

The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity.

artículo científico publicado en 2011

The role of aromatic amino acid oxidation, protein unfolding, and aggregation in the hypobromous acid-induced inactivation of trypsin inhibitor and lysozyme.

artículo científico publicado en 2005

The role of hypothiocyanous acid (HOSCN) in biological systems.

artículo científico publicado en 2009

The role of reactive N-bromo species and radical intermediates in hypobromous acid-induced protein oxidation

artículo científico publicado en 2005

Tryptophan oxidation in proteins exposed to thiocyanate-derived oxidants

artículo científico publicado en 2014

Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation

artículo científico publicado en 2008

What are the plasma targets of the oxidant hypochlorous acid? A kinetic modeling approach

artículo científico publicado en 2009

β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia.

artículo científico publicado en 2016

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