Lista de obras - Alejandro Romero Martínez

5-Methyl--(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5-indolo[2,3-]quinolin-11-amine: a highly potent human cholinesterase inhibitor

artículo científico publicado en 2017

A History of the Pharmacological Treatment of Bipolar Disorder

artículo científico publicado en 2018

A review of metal-catalyzed molecular damage: protection by melatonin

artículo científico

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy.

artículo científico publicado en 2016

Analysis of gene expression profiles of CR80, a neuroprotective 1,8-Naphthyridine

artículo científico publicado en 2018

Both creatine and its product phosphocreatine reduce oxidative stress and afford neuroprotection in an in vitro Parkinson's model

artículo científico publicado en 2014

Cadmium exposure differentially modifies the circadian patterns of norepinephrine at the median eminence and plasma LH, FSH and testosterone levels

artículo científico publicado en 2004

Calcium signalling mediated through α7 and non-α7 nAChR stimulation is differentially regulated in bovine chromaffin cells to induce catecholamine release

artículo científico publicado en 2011

Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles

artículo científico publicado en 2010

Coronavirus Disease 2019 (COVID-19) and Its Neuroinvasive Capacity: Is It Time for Melatonin?

artículo científico publicado en 2020

Corrigendum: Melatonin and Nitrones As Potential Therapeutic Agents for Stroke.

artículo científico publicado en 2017

Cytotoxicity induced by deltamethrin and its metabolites in SH-SY5Y cells can be differentially prevented by selected antioxidants.

artículo científico publicado en 2012

Development of HuperTacrines as Non-Toxic, Cholinesterase Inhibitors for the Potential Treatment of Alzheimer’s Disease

article

Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases

artículo científico publicado en 2014

Differential induction of cytochrome P450 isoforms and peroxisomal proliferation by cyfluthrin in male Wistar rats.

artículo científico publicado en 2013

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

artículo científico publicado en 2014

Effect of cadmium on 24-h variations in hypothalamic dopamine and serotonin metabolism in adult male rats

artículo científico publicado en 2003

Effect of cadmium on lymphocyte subsets distribution in thymus and spleen

artículo científico publicado en 2003

Effect of natamycin on cytochrome P450 enzymes in rats

artículo científico publicado en 2013

Effect of nitric oxide on prolactin secretion and hypothalamic biogenic amine contents.

artículo científico publicado en 2004

Effects of in utero and lactational exposure to endosulfan in prefrontal cortex of male rats

artículo científico publicado en 2007

Enantioselective neuroprotective effects of Tacripyrine ITH122 against oxygen and glucose deprivation in rat hippocampal slices

artículo científico publicado en 2013

Evidence for dose-additive effects of a type II pyrethroid mixture. In vitro assessment

artículo científico publicado en 2015

Fipronil sulfone induced higher cytotoxicity than fipronil in SH-SY5Y cells: Protection by antioxidants

artículo científico publicado en 2016

Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia/reoxygenation.

artículo científico publicado en 2011

Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K/Akt/GSK-3β pathway.

artículo científico publicado en 2012

Highlights of ASS234: a novel and promising therapeutic agent for Alzheimer's disease therapy

artículo científico publicado en 2020

ITH12410/SC058: a new neuroprotective compound with potential in the treatment of Alzheimer's disease

artículo científico

In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases

artículo científico publicado en 2020

In silico assessment of the metabolism and its safety significance of multitarget propargylamine ASS234

artículo científico publicado en 2018

Ischemic brain injury: New insights on the protective role of melatonin

artículo científico publicado en 2017

Isoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer's disease

artículo científico publicado en 2014

Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux

scientific article published on 18 December 2020

Melatonin and Nitrones As Potential Therapeutic Agents for Stroke.

artículo científico publicado en 2016

Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration

artículo científico

Melatonin as potential candidate to prevent the toxicity induced by chemical warfare agents

artículo científico publicado en 2013

Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices

artículo científico publicado en 2016

Melatonin's efficacy in stroke patients; a matter of dose? A systematic review

scientific article published on 26 February 2020

Melatonin: A hypothesis for Kawasaki disease treatment

scientific article published on 17 July 2018

Methoxychlor modifies the ultradian secretory pattern of prolactin and affects its TRH response.

artículo científico publicado en 2003

Modulation of Heat Shock Response Proteins by ASS234, Targeted for Neurodegenerative Diseases Therapy

artículo científico publicado en 2018

Modulation of serine/threonine phosphatases by melatonin: therapeutic approaches in neurodegenerative diseases

artículo científico publicado en 2018

Modulatory Effects of Melatonin on Cadmium-Induced Changes in Biogenic Amines in Rat Hypothalamus

artículo científico publicado en 2011

Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chlo

artículo científico publicado en 2010

Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases.

artículo científico publicado en 2017

Mycotoxins modify the barrier function of Caco-2 cells through differential gene expression of specific claudin isoforms: Protective effect of illite mineral clay

artículo científico publicado en 2016

N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease

artículo científico publicado en 2011

Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease

artículo científico publicado en 2018

Neuroinflammation Signaling Modulated by ASS234, a Multitarget Small Molecule for Alzheimer’s Disease Therapy

artículo científico publicado en 2018

Neuroprotective effect of dimebon against ischemic neuronal damage

artículo científico publicado en 2014

Neuroprotective effect of guanosine against glutamate-induced cell death in rat hippocampal slices is mediated by the phosphatidylinositol-3 kinase/Akt/ glycogen synthase kinase 3β pathway activation and inducible nitric oxide synthase inhibition.

artículo científico publicado en 2011

Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression

artículo científico publicado en 2014

Neuroprotective effects of E-PodoFavalin-15999 (Atremorine®).

artículo científico publicado en 2017

Neurotoxicity induced by dexamethasone in the human neuroblastoma SH-SY5Y cell line can be prevented by folic acid.

artículo científico publicado en 2011

Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation

artículo científico publicado en 2011

New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties

artículo científico publicado en 2016

New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

artículo científico publicado en 2019

New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease

artículo científico publicado en 2014

Nontoxic and neuroprotective β-naphthotacrines for Alzheimer's disease

artículo científico publicado en 2013

Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia

artículo científico publicado en 2012

Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids

artículo científico publicado en 2014

Oxidative stress and gene expression profiling of cell death pathways in alpha-cypermethrin-treated SH-SY5Y cells

artículo científico publicado en 2016

PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice

scientific article published on 13 June 2013

Permethrin-induced oxidative stress and toxicity and metabolism. A review

artículo científico publicado en 2016

Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via α7 nicotinic receptors linked to a Jak2/Akt/HO-1 signaling pathway

artículo científico publicado en 2010

Protective effect of creatine against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells: Involvement of intracellular signaling pathways.

artículo científico publicado en 2013

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy

scientific article published on 17 April 2019

Recent Developments on Multi-Target-Directed Tacrines for Alzheimer's Disease. I. The Pyranotacrines.

artículo científico publicado en 2018

Relationship between blood concentrations of heavy metals and cytogenetic and endocrine parameters among subjects involved in cleaning coastal areas affected by the 'Prestige' tanker oil spill

artículo científico publicado en 2008

Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells

artículo científico publicado en 2010

Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives

artículo científico publicado en 2011

Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.

artículo científico publicado en 2012

Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives

artículo científico publicado en 2010

The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

artículo científico publicado en 2016

The emergence of melatonin in oncology: Focus on colorectal cancer

artículo científico publicado en 2019

The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease.

artículo científico publicado en 2016

Toxic effects of cadmium on GABA and taurine content in different brain areas of adult male rats

artículo científico publicado en 2005

Toxic effects of cadmium on the regulatory mechanism of dopamine and serotonin on prolactin secretion in adult male rats.

artículo científico publicado en 2005

Toxicity induced by chemical warfare agents: insights on the protective role of melatonin

artículo científico

Toxicological and pharmacological evaluation, antioxidant, ADMET and molecular modeling of selected racemic chromenotacrines {11-amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ols} for the potential prevention and treatment of Alzhe

artículo científico publicado en 2014

Toxins as Weapons: A Historical Review.

artículo científico

Understanding the oncostatic actions displayed by melatonin in colorectal cancer therapy

artículo científico publicado en 2020

Upregulation of Antioxidant Enzymes by ASS234, a Multitarget Directed Propargylamine for Alzheimer's Disease Therapy.

artículo científico publicado en 2016

Wnt signaling pathway, a potential target for Alzheimer's disease treatment, is activated by a novel multitarget compound ASS234.

artículo científico publicado en 2014

Lista de obras de Alejandro Romero Martínez

5-Methyl--(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5-indolo[2,3-]quinolin-11-amine: a highly potent human cholinesterase inhibitor

A History of the Pharmacological Treatment of Bipolar Disorder

A review of metal-catalyzed molecular damage: protection by melatonin

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy.

Analysis of gene expression profiles of CR80, a neuroprotective 1,8-Naphthyridine

Both creatine and its product phosphocreatine reduce oxidative stress and afford neuroprotection in an in vitro Parkinson's model

Cadmium exposure differentially modifies the circadian patterns of norepinephrine at the median eminence and plasma LH, FSH and testosterone levels

Calcium signalling mediated through α7 and non-α7 nAChR stimulation is differentially regulated in bovine chromaffin cells to induce catecholamine release

Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles

Coronavirus Disease 2019 (COVID-19) and Its Neuroinvasive Capacity: Is It Time for Melatonin?

Corrigendum: Melatonin and Nitrones As Potential Therapeutic Agents for Stroke.

Cytotoxicity induced by deltamethrin and its metabolites in SH-SY5Y cells can be differentially prevented by selected antioxidants.

Development of HuperTacrines as Non-Toxic, Cholinesterase Inhibitors for the Potential Treatment of Alzheimer’s Disease

Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases

Differential induction of cytochrome P450 isoforms and peroxisomal proliferation by cyfluthrin in male Wistar rats.

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

Effect of cadmium on 24-h variations in hypothalamic dopamine and serotonin metabolism in adult male rats

Effect of cadmium on lymphocyte subsets distribution in thymus and spleen

Effect of natamycin on cytochrome P450 enzymes in rats

Effect of nitric oxide on prolactin secretion and hypothalamic biogenic amine contents.

Effects of in utero and lactational exposure to endosulfan in prefrontal cortex of male rats

Enantioselective neuroprotective effects of Tacripyrine ITH122 against oxygen and glucose deprivation in rat hippocampal slices

Evidence for dose-additive effects of a type II pyrethroid mixture. In vitro assessment

Fipronil sulfone induced higher cytotoxicity than fipronil in SH-SY5Y cells: Protection by antioxidants

Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia/reoxygenation.

Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K/Akt/GSK-3β pathway.

Highlights of ASS234: a novel and promising therapeutic agent for Alzheimer's disease therapy

ITH12410/SC058: a new neuroprotective compound with potential in the treatment of Alzheimer's disease

In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases

In silico assessment of the metabolism and its safety significance of multitarget propargylamine ASS234

Ischemic brain injury: New insights on the protective role of melatonin

Isoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer's disease

Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux

Melatonin and Nitrones As Potential Therapeutic Agents for Stroke.

Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration

Melatonin as potential candidate to prevent the toxicity induced by chemical warfare agents

Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices

Melatonin's efficacy in stroke patients; a matter of dose? A systematic review

Melatonin: A hypothesis for Kawasaki disease treatment

Methoxychlor modifies the ultradian secretory pattern of prolactin and affects its TRH response.

Modulation of Heat Shock Response Proteins by ASS234, Targeted for Neurodegenerative Diseases Therapy

Modulation of serine/threonine phosphatases by melatonin: therapeutic approaches in neurodegenerative diseases

Modulatory Effects of Melatonin on Cadmium-Induced Changes in Biogenic Amines in Rat Hypothalamus

Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chlo

Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases.

Mycotoxins modify the barrier function of Caco-2 cells through differential gene expression of specific claudin isoforms: Protective effect of illite mineral clay

N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease

Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease

Neuroinflammation Signaling Modulated by ASS234, a Multitarget Small Molecule for Alzheimer’s Disease Therapy

Neuroprotective effect of dimebon against ischemic neuronal damage

Neuroprotective effect of guanosine against glutamate-induced cell death in rat hippocampal slices is mediated by the phosphatidylinositol-3 kinase/Akt/ glycogen synthase kinase 3β pathway activation and inducible nitric oxide synthase inhibition.

Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression

Neuroprotective effects of E-PodoFavalin-15999 (Atremorine®).

Neurotoxicity induced by dexamethasone in the human neuroblastoma SH-SY5Y cell line can be prevented by folic acid.

Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation

New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties

New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease

Nontoxic and neuroprotective β-naphthotacrines for Alzheimer's disease

Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia

Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids

Oxidative stress and gene expression profiling of cell death pathways in alpha-cypermethrin-treated SH-SY5Y cells

PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice

Permethrin-induced oxidative stress and toxicity and metabolism. A review

Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via α7 nicotinic receptors linked to a Jak2/Akt/HO-1 signaling pathway

Protective effect of creatine against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells: Involvement of intracellular signaling pathways.

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy

Recent Developments on Multi-Target-Directed Tacrines for Alzheimer's Disease. I. The Pyranotacrines.

Relationship between blood concentrations of heavy metals and cytogenetic and endocrine parameters among subjects involved in cleaning coastal areas affected by the 'Prestige' tanker oil spill

Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells

Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives

Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.

Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives

The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

The emergence of melatonin in oncology: Focus on colorectal cancer

The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease.

Toxic effects of cadmium on GABA and taurine content in different brain areas of adult male rats

Toxic effects of cadmium on the regulatory mechanism of dopamine and serotonin on prolactin secretion in adult male rats.

Toxicity induced by chemical warfare agents: insights on the protective role of melatonin