Lista de obras - Amadeu Llebaria - Dominio Público Uruguay

2-aminohydroxamic acid derivatives as inhibitors of Bacillus cereus phosphatidylcholine preferred phospholipase C PC-PLC(Bc).

artículo científico publicado en 2010

3,4-Dihydroxymethamphetamine (HHMA). A major in vivo 3,4-methylenedioxymethamphetamine (MDMA) metabolite in humans

artículo científico publicado en 2001

A Prospect for Pyrrolidine Iminosugars as Antidiabetic α-Glucosidase Inhibitors ⬇️

artículo científico publicado el 28 de noviembre de 2012

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer.

artículo científico publicado en 2017

Aminocyclitol-Substituted Phytoceramides and their Effects on iNKT Cell Stimulation

artículo científico publicado en 2009

Aminocyclitols as pharmacological chaperones for glucocerebrosidase, a defective enzyme in Gaucher disease

artículo científico publicado en 2007

An allosteric modulator to control endogenous G protein-coupled receptors with light.

artículo científico publicado en 2014

An unexpected chelation-controlled Yb(OTf)(3)-catalyzed aminolysis and azidolysis of cyclitol epoxides

scientific article published on 01 October 2002

Analogs of the dihydroceramide desaturase inhibitor GT11 modified at the amide function: synthesis and biological activities

artículo científico publicado en 2005

Aziridine ring opening for the synthesis of sphingolipid analogues: inhibitors of sphingolipid-metabolizing enzymes.

artículo científico publicado en 2014

Barbier-type diastereoselective allylation of alpha-amino aldehydes with an enantiopure 2-sulfinylallyl building block

artículo científico publicado en 2002

Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase ⬇️

artículo científico publicado el 30 de marzo de 2011

Blockade of arachidonic acid incorporation into phospholipids induces apoptosis in U937 promonocytic cells.

artículo científico publicado en 2005

C75 activates malonyl-CoA sensitive and insensitive components of the CPT system.

artículo científico publicado en 2004

Chemical tools to investigate sphingolipid metabolism and functions.

artículo científico publicado en 2007

Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease

artículo científico publicado en 2010

Combinatorial approach to N-substituted aminocyclitol libraries by solution-phase parallel synthesis and preliminary evaluation as glucocerebrosidase inhibitors

artículo científico publicado en 2007

Computational analysis of negative and positive allosteric modulator binding and function in metabotropic glutamate receptor 5 (in)activation

artículo científico publicado en 2014

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

artículo científico publicado en 2018

Cytotoxicity and acid ceramidase inhibitory activity of 2-substituted aminoethanol amides.

artículo científico publicado en 2008

Development and validation of a mass spectrometry binding assay for mGlu5 receptor

scientific article published on 20 June 2020

Diastereoselective allylation of aldehydes with an enantiopure 2-sulfinylallyl halide under environmentally friendly Barbier-type conditions

scientific article published on 01 February 2000

Direct coupling of detergent purified human mGlu5 receptor to the heterotrimeric G proteins Gq and Gs.

artículo científico publicado en 2018

Disclosing new inhibitors by finding similarities in three-dimensional active-site architectures of polynuclear zinc phospholipases and aminopeptidases

artículo científico publicado en 2004

Exploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptor

scientific article published on 05 September 2014

Fungal growth inhibitory properties of new phytosphingolipid analogues.

artículo científico publicado en 2007

Galacto configured N-aminoaziridines: a new type of irreversible inhibitor of β-galactosidases

Galacto-configured aminocyclitol phytoceramides are potent in vivo invariant natural killer T cell stimulators

artículo científico publicado en 2011

Glucocerebrosidase inhibitors for the treatment of Gaucher disease.

artículo científico publicado en 2013

Glucocerebrosidase inhibitors: future drugs for the treatment of Gaucher disease?

artículo científico publicado en 2014

High-performance liquid chromatography with electrochemical detection applied to the analysis of 3,4-dihydroxymethamphetamine in human plasma and urine.

artículo científico publicado en 2002

Inhibitors of sphingolipid metabolism enzymes.

artículo científico publicado en 2006

Integrated synthetic, pharmacological, and computational investigation of cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid enantiomers as positive allosteric modulators of metabotropic glutamate receptor subtype 4.

artículo científico publicado en 2011

Iodocyclization of O-(3-Cyclohexenyl)thiocarbamidates. An unexpected approach to vicinal cis-aminocyclohexenols

scientific article published on 01 August 2000

Molecular basis for beta-glucosidase inhibition by ring-modified calystegine analogues

artículo científico publicado en 2008

NKT TCR Recognition of CD1d- -C-Galactosylceramide

artículo científico publicado en 2011

New aminocyclitols as modulators of glucosylceramide metabolism

artículo científico publicado en 2005

New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening

artículo científico publicado en 2011

Nucleophile-dependent stereodivergence in the Pd-catalyzed intramolecular cyclization of 2-(p-tolylsulfinyl)allylacetates

On the regio- and stereoselective synthesis of aminocyclitols from cyclitol epoxides: the effect of Li as a chelating agent.

artículo científico publicado en 2005

Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches

artículo científico publicado en 2016

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

artículo científico publicado en 2017

OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity.

artículo científico publicado en 2016

Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors

scientific article published on 23 October 2014

PG12, a phospholipid analog with potent antimalarial activity, inhibits Plasmodium falciparum CTP:phosphocholine cytidylyltransferase activity

artículo científico publicado en 2011

Parallel synthesis and yeast growth inhibition screening of succinamic acid libraries

artículo científico publicado en 2007

Polyhydroxylated bicyclic isoureas and guanidines are potent glucocerebrosidase inhibitors and nanomolar enzyme activity enhancers in Gaucher cells.

artículo científico publicado en 2011

Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu5 negative allosteric modulation.

artículo científico publicado en 2017

Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease

artículo científico publicado en 2012

Practical synthesis of (-)-1-amino-1-deoxy-myo-inositol from achiral precursors

artículo científico publicado en 2007

Regio- and stereoselective synthesis of aminoinositols and 1,2-diaminoinositols from conduritol B epoxide

artículo científico publicado en 2005

Reversible silencing of endogenous receptors in intact brain tissue using two-photon pharmacology

scholarly article published 9 January 2019

Shedding light on metabotropic glutamate receptors using optogenetics and photopharmacology

artículo científico publicado en 2018

Solid-phase synthesis of a combinatorial library of dihydroceramide analogues and its activity in human alveolar epithelial cells

artículo científico publicado en 2006

Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones

scientific article published on 05 March 2008

Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11) in primary cultured cerebellar neurons.

artículo científico publicado en 2004

Stereochemical analysis of 3,4-methylenedioxymethamphetamine and its main metabolites by gas chromatography/mass spectrometry.

artículo científico publicado en 2003

Structural and Functional Characterization of a Novel Nonglycosidic Type I NKT Agonist with Immunomodulatory Properties

artículo científico publicado en 2012

Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase

artículo científico publicado en 2008

Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines.

artículo científico publicado en 2008

Synthesis and capillary electrophoretic analysis of enantiomerically enriched reference standards of MDMA and its main metabolites.

artículo científico publicado en 2002

Synthesis and evaluation of diverse analogs of amygdalin as potential peptidomimetics of peptide T.

artículo científico publicado en 2005

Synthesis and evaluation of hydroxymethylaminocyclitols as glycosidase inhibitors

artículo científico publicado en 2015

Synthesis and phospholipase C inhibitory activity of D609 diastereomers

artículo científico publicado en 2002

Synthesis and preliminary antifungal evaluation of a library of phytosphingolipid analogues

artículo científico publicado en 2007

Synthesis of a Cyclopropene Analogue of Ceramide, a Potent Inhibitor of Dihydroceramide Desaturase

artículo científico publicado en 2001

Synthesis of cyclopropene analogues of ceramide and their effect on dihydroceramide desaturase

artículo científico publicado en 2003

The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease.

artículo científico publicado en 2011

Lista de obras de Amadeu Llebaria

2-aminohydroxamic acid derivatives as inhibitors of Bacillus cereus phosphatidylcholine preferred phospholipase C PC-PLC(Bc).

3,4-Dihydroxymethamphetamine (HHMA). A major in vivo 3,4-methylenedioxymethamphetamine (MDMA) metabolite in humans

A Prospect for Pyrrolidine Iminosugars as Antidiabetic α-Glucosidase Inhibitors ⬇️

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer.

Aminocyclitol-Substituted Phytoceramides and their Effects on iNKT Cell Stimulation

Aminocyclitols as pharmacological chaperones for glucocerebrosidase, a defective enzyme in Gaucher disease

An allosteric modulator to control endogenous G protein-coupled receptors with light.

An unexpected chelation-controlled Yb(OTf)(3)-catalyzed aminolysis and azidolysis of cyclitol epoxides

Analogs of the dihydroceramide desaturase inhibitor GT11 modified at the amide function: synthesis and biological activities

Aziridine ring opening for the synthesis of sphingolipid analogues: inhibitors of sphingolipid-metabolizing enzymes.

Barbier-type diastereoselective allylation of alpha-amino aldehydes with an enantiopure 2-sulfinylallyl building block

Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase ⬇️

Blockade of arachidonic acid incorporation into phospholipids induces apoptosis in U937 promonocytic cells.

C75 activates malonyl-CoA sensitive and insensitive components of the CPT system.

Chemical tools to investigate sphingolipid metabolism and functions.

Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease

Combinatorial approach to N-substituted aminocyclitol libraries by solution-phase parallel synthesis and preliminary evaluation as glucocerebrosidase inhibitors

Computational analysis of negative and positive allosteric modulator binding and function in metabotropic glutamate receptor 5 (in)activation

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

Cytotoxicity and acid ceramidase inhibitory activity of 2-substituted aminoethanol amides.

Development and validation of a mass spectrometry binding assay for mGlu5 receptor

Diastereoselective allylation of aldehydes with an enantiopure 2-sulfinylallyl halide under environmentally friendly Barbier-type conditions

Direct coupling of detergent purified human mGlu5 receptor to the heterotrimeric G proteins Gq and Gs.

Disclosing new inhibitors by finding similarities in three-dimensional active-site architectures of polynuclear zinc phospholipases and aminopeptidases

Exploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptor

Fungal growth inhibitory properties of new phytosphingolipid analogues.

Galacto configured N-aminoaziridines: a new type of irreversible inhibitor of β-galactosidases

Galacto-configured aminocyclitol phytoceramides are potent in vivo invariant natural killer T cell stimulators

Glucocerebrosidase inhibitors for the treatment of Gaucher disease.

Glucocerebrosidase inhibitors: future drugs for the treatment of Gaucher disease?

High-performance liquid chromatography with electrochemical detection applied to the analysis of 3,4-dihydroxymethamphetamine in human plasma and urine.

Inhibitors of sphingolipid metabolism enzymes.

Integrated synthetic, pharmacological, and computational investigation of cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid enantiomers as positive allosteric modulators of metabotropic glutamate receptor subtype 4.

Iodocyclization of O-(3-Cyclohexenyl)thiocarbamidates. An unexpected approach to vicinal cis-aminocyclohexenols

Molecular basis for beta-glucosidase inhibition by ring-modified calystegine analogues

NKT TCR Recognition of CD1d- -C-Galactosylceramide

New aminocyclitols as modulators of glucosylceramide metabolism

New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening

Nucleophile-dependent stereodivergence in the Pd-catalyzed intramolecular cyclization of 2-(p-tolylsulfinyl)allylacetates

On the regio- and stereoselective synthesis of aminocyclitols from cyclitol epoxides: the effect of Li as a chelating agent.

Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity.

Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors

PG12, a phospholipid analog with potent antimalarial activity, inhibits Plasmodium falciparum CTP:phosphocholine cytidylyltransferase activity

Parallel synthesis and yeast growth inhibition screening of succinamic acid libraries

Polyhydroxylated bicyclic isoureas and guanidines are potent glucocerebrosidase inhibitors and nanomolar enzyme activity enhancers in Gaucher cells.

Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu5 negative allosteric modulation.

Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease

Practical synthesis of (-)-1-amino-1-deoxy-myo-inositol from achiral precursors

Regio- and stereoselective synthesis of aminoinositols and 1,2-diaminoinositols from conduritol B epoxide

Reversible silencing of endogenous receptors in intact brain tissue using two-photon pharmacology

Shedding light on metabotropic glutamate receptors using optogenetics and photopharmacology

Solid-phase synthesis of a combinatorial library of dihydroceramide analogues and its activity in human alveolar epithelial cells

Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones

Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11) in primary cultured cerebellar neurons.

Stereochemical analysis of 3,4-methylenedioxymethamphetamine and its main metabolites by gas chromatography/mass spectrometry.

Structural and Functional Characterization of a Novel Nonglycosidic Type I NKT Agonist with Immunomodulatory Properties

Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase

Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines.

Synthesis and capillary electrophoretic analysis of enantiomerically enriched reference standards of MDMA and its main metabolites.

Synthesis and evaluation of diverse analogs of amygdalin as potential peptidomimetics of peptide T.

Synthesis and evaluation of hydroxymethylaminocyclitols as glycosidase inhibitors

Synthesis and phospholipase C inhibitory activity of D609 diastereomers

Synthesis and preliminary antifungal evaluation of a library of phytosphingolipid analogues

Synthesis of a Cyclopropene Analogue of Ceramide, a Potent Inhibitor of Dihydroceramide Desaturase

Synthesis of cyclopropene analogues of ceramide and their effect on dihydroceramide desaturase

The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease.