Lista de obras - Cyril Goudet - Dominio Público Uruguay

A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design

artículo científico publicado en 2010

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential ⬇️

artículo científico publicado el 5 de enero de 2012

A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists

artículo científico publicado en 2010

Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations

artículo científico publicado en 2021

Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor.

artículo científico publicado en 2013

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer.

artículo científico publicado en 2017

Allosteric functioning of dimeric class C G-protein-coupled receptors.

artículo científico publicado en 2005

Allosteric modulation of metabotropic glutamate receptors by chloride ions

artículo científico publicado en 2015

An allosteric modulator to control endogenous G protein-coupled receptors with light.

artículo científico publicado en 2014

Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators.

artículo científico publicado en 2005

Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3

artículo científico publicado en 2018

Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type 4 Metabotropic Glutamate Receptors ⬇️

artículo científico publicado el 6 de febrero de 2012

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

artículo científico publicado en 2018

D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation

artículo científico publicado en 2006

Determination of the absolute configuration of phosphinic analogues of glutamate

artículo científico publicado en 2014

Development and validation of a mass spectrometry binding assay for mGlu5 receptor

scientific article published on 20 June 2020

Dimers and beyond: The functional puzzles of class C GPCRs.

artículo científico publicado en 2011

Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4.

artículo científico publicado en 2016

Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism.

artículo científico publicado en 2009

Electrophysiological characterization of BmK M1, an alpha-like toxin from Buthus martensi Karsch venom

artículo científico publicado en 2001

Electrophysiological properties of the hypokalaemic periodic paralysis mutation (R528H) of the skeletal muscle alpha 1s subunit as expressed in mouse L cells.

artículo científico publicado en 1996

Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors

artículo científico publicado en 2018

Exploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptor

scientific article published on 05 September 2014

Group III and subtype 4 metabotropic glutamate receptor agonists: Discovery and pathophysiological applications in Parkinson's disease ⬇️

artículo científico publicado el 1 de junio de 2012

Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain.

artículo científico publicado en 2007

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals

artículo científico publicado en 2016

Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1: the hydrophobic surface region revisited.

artículo científico publicado en 2003

Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.

artículo científico publicado en 2018

Integrated synthetic, pharmacological, and computational investigation of cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid enantiomers as positive allosteric modulators of metabotropic glutamate receptor subtype 4.

artículo científico publicado en 2011

Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.

artículo científico publicado en 2007

L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.

artículo científico publicado en 2007

Locking the dimeric GABA(B) G-protein-coupled receptor in its active state.

artículo científico publicado en 2004

Magnesium ions promote assembly of channel-like structures from beticolin 0, a non-peptide fungal toxin purified from Cercospora beticola.

artículo científico publicado en 1998

Metabotropic receptors for glutamate and GABA in pain.

artículo científico publicado en 2008

Molecular mechanisms of GABA(B) receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator.

artículo científico publicado en 2004

New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.

artículo científico publicado en 2016

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

artículo científico publicado en 2017

OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity.

artículo científico publicado en 2016

Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors

scientific article published on 23 October 2014

Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu5 negative allosteric modulation.

artículo científico publicado en 2017

Roles of disulfide bridges in scorpion toxin BmK M1 analyzed by mutagenesis

artículo científico publicado en 2002

Shedding light on metabotropic glutamate receptors using optogenetics and photopharmacology

artículo científico publicado en 2018

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective

artículo científico publicado en 2015

Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists

artículo científico publicado en 2007

Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.

artículo científico publicado en 2015

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors ⬇️

artículo científico publicado en 2021

Therapeutic potential of group III metabotropic glutamate receptor ligands in pain.

artículo científico publicado en 2014

α-Amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: Synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4

article

Lista de obras de Cyril Goudet

A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential ⬇️

A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists

Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations

Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor.

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer.

Allosteric functioning of dimeric class C G-protein-coupled receptors.

Allosteric modulation of metabotropic glutamate receptors by chloride ions

An allosteric modulator to control endogenous G protein-coupled receptors with light.

Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators.

Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3

Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type 4 Metabotropic Glutamate Receptors ⬇️

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation

Determination of the absolute configuration of phosphinic analogues of glutamate

Development and validation of a mass spectrometry binding assay for mGlu5 receptor

Dimers and beyond: The functional puzzles of class C GPCRs.

Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4.

Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism.

Electrophysiological characterization of BmK M1, an alpha-like toxin from Buthus martensi Karsch venom

Electrophysiological properties of the hypokalaemic periodic paralysis mutation (R528H) of the skeletal muscle alpha 1s subunit as expressed in mouse L cells.

Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors

Exploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptor

Group III and subtype 4 metabotropic glutamate receptor agonists: Discovery and pathophysiological applications in Parkinson's disease ⬇️

Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain.

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals

Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1: the hydrophobic surface region revisited.

Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.

Integrated synthetic, pharmacological, and computational investigation of cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid enantiomers as positive allosteric modulators of metabotropic glutamate receptor subtype 4.

Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.

L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.

Locking the dimeric GABA(B) G-protein-coupled receptor in its active state.

Magnesium ions promote assembly of channel-like structures from beticolin 0, a non-peptide fungal toxin purified from Cercospora beticola.

Metabotropic receptors for glutamate and GABA in pain.

Molecular mechanisms of GABA(B) receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator.

New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity.

Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors

Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu5 negative allosteric modulation.

Roles of disulfide bridges in scorpion toxin BmK M1 analyzed by mutagenesis

Shedding light on metabotropic glutamate receptors using optogenetics and photopharmacology

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective

Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists

Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors ⬇️

Therapeutic potential of group III metabotropic glutamate receptor ligands in pain.

α-Amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: Synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4