Lista de obras - Simona Rapposelli - Dominio Público Uruguay

(E)-[2-(4-Methylsulphonylphenyl)-1-cyclopentenyl-1-methyliden](arylmethyloxy)amines. Methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: synthesis and biological properties

artículo científico publicado en 2002

2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties

artículo científico publicado en 2008

A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions.

artículo científico publicado en 2017

A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs

artículo científico publicado en 2005

A patent update on PDK1 inhibitors (2015-present)

artículo científico publicado en 2019

A review on the hybrids of hydroxycinnamic acid as multi-target-directed ligands against Alzheimer's disease

artículo científico publicado en 2017

Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel

artículo científico publicado en 2009

Antiarrhythmic activity of a new spiro-cyclic benzopyran activator of the cardiac mitochondrial ATP dependent potassium channels

artículo científico publicado en 2016

Areca catechu-From farm to food and biomedical applications

scientific article published on 11 March 2020

Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties

artículo científico publicado en 2002

Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition

artículo científico publicado en 2006

Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo

artículo científico publicado en 2013

Cardiac ATP-sensitive potassium channels: a potential target for an anti-ischaemic pharmacological strategy.

artículo científico publicado en 2007

Ceramide analogues in apoptosis: a new strategy for anticancer drug development.

artículo científico publicado en 2003

Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

artículo científico publicado en 2021

Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics

scientific article published on 31 January 2020

Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells

artículo científico publicado en 2015

Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity.

artículo científico publicado en 2003

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

artículo científico publicado en 2015

Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer's disease?

scientific article published on 27 September 2019

Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists

artículo científico publicado en 2015

Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis

scientific article published on 23 December 2019

Design, synthesis and pharmacological evaluation of novel tacrine–caffeic acid hybrids as multi-targeted compounds against Alzheimer’s disease ⬇️

artículo científico publicado el 16 de agosto de 2012

Development of classification models for identifying "true" P-glycoprotein (P-gp) inhibitors through inhibition, ATPase activation and monolayer efflux assays

artículo científico publicado en 2012

Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands

artículo científico publicado en 2004

Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease

artículo científico publicado en 2016

Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells.

artículo científico publicado en 2016

Dual PDK1/Aurora Kinase A Inhibitors Reduce Pancreatic Cancer Cell Proliferation and Colony Formation

scientific article published on 31 October 2019

Editorial [Hot topic: Effect of Stereochemistry in Medicinal Chemistry and Drug Discovery (Guest Editor: Simona Rapposelli)]

artículo científico publicado en 2011

Editorial: Multi-Target-Directed Ligands (MTDL) as Challenging Research Tools in Drug Discovery: From Design to Pharmacological Evaluation

scientific article published on 18 February 2019

Enantiopure 3-(arylmethylidene)aminoxy-2-methylpropionic acids: synthesis and antiinflammatory properties

artículo científico publicado en 2001

Enantioselectivity in Cardioprotection induced by (S)- (−)-2,2-Dimethyl-N-(4′-acetamido-benzyl)-4-spiromorpholone-chromane

artículo científico publicado en 2009

Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents Through the Modulation of SIRT6

artículo científico publicado en 2020

Epibatidine: A Promising Natural Alkaloid in Health

article

Evaluation of the NO-releasing properties of NO-donor linkers

artículo científico publicado en 2008

Hit-to-Lead Optimization of Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists with a Diphenylmethane-Scaffold: Design, Synthesis, and Biological Study.

artículo científico publicado en 2016

Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs.

artículo científico publicado en 2017

Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects.

artículo científico publicado en 2017

Investigating Curcumin/Intestinal Epithelium Interaction in a Millifluidic Bioreactor

artículo científico publicado en 2020

Lipolytic Effects of 3-Iodothyronamine (T1AM) and a Novel Thyronamine-Like Analog SG-2 through the AMPK Pathway

artículo científico publicado en 2019

Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma

artículo científico publicado en 2016

Memantine prodrug as a new agent for Alzheimer's Disease

artículo científico publicado en 2019

Mitochondrial potassium channels as pharmacological target for cardioprotective drugs.

artículo científico publicado en 2014

Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor beta

artículo científico publicado en 2008

Multi-targeted ChEI-copper chelating molecules as neuroprotective agents

scientific article published on 23 April 2019

NO-Releasing Hybrids of Cardiovascular Drugs

NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs.

artículo científico publicado en 2009

NO-releasing hybrids of cardiovascular drugs

artículo científico publicado en 2006

NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs

artículo científico publicado en 2004

Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease

artículo científico publicado en 2017

New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties

artículo científico publicado en 2006

New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection

artículo científico publicado en 2017

New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective

artículo científico publicado en 2018

New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2).

artículo científico publicado en 2004

New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design, Synthesis, and Biopharmacological Properties

artículo científico publicado en 2006

New emerging prospects in the pharmacotherapy of hypertension.

artículo científico publicado en 2008

Novel adenosine 5′-triphosphate-sensitive potassium channel ligands: a patent overview (2005 – 2010) ⬇️

artículo científico publicado el 27 de enero de 2011

Novel estrogen receptor ligands based on an anthranylaldoxime structure: role of the phenol-type pseudocycle in the binding process

artículo científico publicado en 2003

Oxidative Stress, Mitochondrial Abnormalities and Proteins Deposition: Multitarget Approaches in Alzheimer's Disease

artículo científico publicado en 2017

P-gp transporter and its role in neurodegenerative diseases

scientific article published on January 2009

Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits

scientific article published in 2021

Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors

artículo científico publicado en 2004

Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors

Potential role of two novel agonists of thyroid hormone receptor-β on liver regeneration

artículo científico publicado en 2020

Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer

artículo científico publicado en 2019

Predictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers

artículo científico publicado en 2009

Proposal of a New Binding Orientation for Non-Peptide AT1 Antagonists: Homology Modeling, Docking and Three-Dimensional Quantitative Structure−Activity Relationship Analysis

article

SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity

artículo científico publicado en 2014

SodiumN-(Methylsulfonyl)-N-(4-nitro-2-phenoxyphenyl)sulfamate: A Water-Soluble Nimesulide Prodrug for Parenteral Use

artículo científico publicado en 2010

Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel

artículo científico publicado en 2008

Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity.

artículo científico publicado en 2003

Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase

artículo científico publicado en 2004

Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta

artículo científico publicado en 2009

Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors

artículo científico publicado en 2017

Synthesis and 5-HT2A, 5-HT1A and alpha1-binding affinities of 2-[2-Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-hydroxy-3-(2-pyridin-2-yl-ethyl)amino]- and 2-[2-hydroxy-3-(4-N-methyl-piperazin-1-yl)-amino]propoxybenzaldehyde-O-(substituted) benzyl o

artículo científico publicado en 2007

Synthesis and Affinity Evaluation for AT1 Receptor of Phenylsalicylaldoxime-Derivatives Structurally Related to Sartans

Synthesis and Biological Evaluation of 2′-Oxo-2,3-dihydro-3′H- spiro[chromene-4,5′-[1,3]oxazolidin]-3′yl]acetic Acid Derivatives as Aldose Reductase Inhibitors

artículo científico publicado en 2011

Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs

artículo científico publicado en 2004

Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold

artículo científico publicado en 2017

Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein.

artículo científico publicado en 2016

Synthesis and antimicrobial activity of new 7 beta-(benzo[a]dihydrocarbazolyloxyacetyl)-substituted cephalosporins

artículo científico publicado en 2004

Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase ⬇️

artículo científico publicado el 25 de noviembre de 2011

Synthesis and biological evaluation of (hetero)arylmethyloxy- and arylmethylamine-phenyl derivatives as potent P-glycoprotein modulating agents

artículo científico publicado en 2008

Synthesis and biological evaluation of 5-membered spiro heterocycle-benzopyran derivatives against myocardial ischemia

artículo científico publicado en 2011

Synthesis and evaluation of multi-functional NO-donor/insulin-secretagogue derivatives for the treatment of type II diabetes and its cardiovascular complications

artículo científico publicado en 2014

Synthesis and inhibitory activity towards human leukocyte elastase of new 7alpha-methoxy and 7alpha-chloro (2-acyloxymethyl) cephem derivatives.

artículo científico publicado en 2001

Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.

artículo científico publicado en 2015

Synthesis and prostaglandin synthase inhibitory activity of new aromatic O-alkyloxime ethers substituted with methylsulfonamido or methylsulfonyl groups on their aliphatic portion

artículo científico publicado en 2003

Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes

scientific article published on 01 August 2006

Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer

artículo científico publicado en 2013

Synthesis of Stable Analogues of Geranylgeranyl Diphosphate Possessing a (Z,E,E)-Geranylgeranyl Side Chain, Docking Analysis, and Biological Assays for Prenyl Protein Transferase Inhibition

artículo científico publicado en 2006

Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells

artículo científico publicado en 2005

Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity

artículo científico publicado en 2003

Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring

artículo científico publicado en 2003

Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole

artículo científico publicado en 2002

Synthesis, binding affinity, and transcriptional activity of hydroxy- and methoxy-substituted 3,4-diarylsalicylaldoximes on estrogen receptors alpha and beta

artículo científico publicado en 2003

Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells

artículo científico publicado en 2012

Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents.

artículo científico publicado en 2005

alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors

artículo científico publicado en 2008

Lista de obras de Simona Rapposelli

(E)-[2-(4-Methylsulphonylphenyl)-1-cyclopentenyl-1-methyliden](arylmethyloxy)amines. Methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: synthesis and biological properties

2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties

A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions.

A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs

A patent update on PDK1 inhibitors (2015-present)

A review on the hybrids of hydroxycinnamic acid as multi-target-directed ligands against Alzheimer's disease

Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel

Antiarrhythmic activity of a new spiro-cyclic benzopyran activator of the cardiac mitochondrial ATP dependent potassium channels

Areca catechu-From farm to food and biomedical applications

Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties

Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition

Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo

Cardiac ATP-sensitive potassium channels: a potential target for an anti-ischaemic pharmacological strategy.

Ceramide analogues in apoptosis: a new strategy for anticancer drug development.

Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics

Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells

Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity.

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer's disease?

Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists

Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis

Design, synthesis and pharmacological evaluation of novel tacrine–caffeic acid hybrids as multi-targeted compounds against Alzheimer’s disease ⬇️

Development of classification models for identifying "true" P-glycoprotein (P-gp) inhibitors through inhibition, ATPase activation and monolayer efflux assays

Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands

Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease

Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells.

Dual PDK1/Aurora Kinase A Inhibitors Reduce Pancreatic Cancer Cell Proliferation and Colony Formation

Editorial [Hot topic: Effect of Stereochemistry in Medicinal Chemistry and Drug Discovery (Guest Editor: Simona Rapposelli)]

Editorial: Multi-Target-Directed Ligands (MTDL) as Challenging Research Tools in Drug Discovery: From Design to Pharmacological Evaluation

Enantiopure 3-(arylmethylidene)aminoxy-2-methylpropionic acids: synthesis and antiinflammatory properties

Enantioselectivity in Cardioprotection induced by (S)- (−)-2,2-Dimethyl-N-(4′-acetamido-benzyl)-4-spiromorpholone-chromane

Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents Through the Modulation of SIRT6

Epibatidine: A Promising Natural Alkaloid in Health

Evaluation of the NO-releasing properties of NO-donor linkers

Hit-to-Lead Optimization of Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists with a Diphenylmethane-Scaffold: Design, Synthesis, and Biological Study.

Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs.

Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects.

Investigating Curcumin/Intestinal Epithelium Interaction in a Millifluidic Bioreactor

Lipolytic Effects of 3-Iodothyronamine (T1AM) and a Novel Thyronamine-Like Analog SG-2 through the AMPK Pathway

Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma

Memantine prodrug as a new agent for Alzheimer's Disease

Mitochondrial potassium channels as pharmacological target for cardioprotective drugs.

Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor beta

Multi-targeted ChEI-copper chelating molecules as neuroprotective agents

NO-Releasing Hybrids of Cardiovascular Drugs

NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs.

NO-releasing hybrids of cardiovascular drugs

NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs

Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease

New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties

New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection

New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective

New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2).

New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design, Synthesis, and Biopharmacological Properties

New emerging prospects in the pharmacotherapy of hypertension.

Novel adenosine 5′-triphosphate-sensitive potassium channel ligands: a patent overview (2005 – 2010) ⬇️

Novel estrogen receptor ligands based on an anthranylaldoxime structure: role of the phenol-type pseudocycle in the binding process

Oxidative Stress, Mitochondrial Abnormalities and Proteins Deposition: Multitarget Approaches in Alzheimer's Disease

P-gp transporter and its role in neurodegenerative diseases

Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits

Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors

Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors

Potential role of two novel agonists of thyroid hormone receptor-β on liver regeneration

Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer

Predictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers

Proposal of a New Binding Orientation for Non-Peptide AT1 Antagonists: Homology Modeling, Docking and Three-Dimensional Quantitative Structure−Activity Relationship Analysis

SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity

SodiumN-(Methylsulfonyl)-N-(4-nitro-2-phenoxyphenyl)sulfamate: A Water-Soluble Nimesulide Prodrug for Parenteral Use

Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel

Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity.

Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase

Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta

Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors

Synthesis and 5-HT2A, 5-HT1A and alpha1-binding affinities of 2-[2-Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-hydroxy-3-(2-pyridin-2-yl-ethyl)amino]- and 2-[2-hydroxy-3-(4-N-methyl-piperazin-1-yl)-amino]propoxybenzaldehyde-O-(substituted) benzyl o

Synthesis and Affinity Evaluation for AT1 Receptor of Phenylsalicylaldoxime-Derivatives Structurally Related to Sartans

Synthesis and Biological Evaluation of 2′-Oxo-2,3-dihydro-3′H- spiro[chromene-4,5′-[1,3]oxazolidin]-3′yl]acetic Acid Derivatives as Aldose Reductase Inhibitors

Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs

Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold