Lista de obras - Chiara Gabbiani - Dominio Público Uruguay

2D-DIGE analysis of ovarian cancer cell responses to cytotoxic gold compounds

artículo científico publicado en 2011

Activity of Rat Cytosolic Thioredoxin Reductase Is Strongly Decreased bytrans-[Bis(2-amino-5- methylthiazole)tetrachlororuthenate(III)]: First Report of Relevant Thioredoxin Reductase Inhibition for a Ruthenium Compound

artículo científico publicado en 2007

Aluminum, copper, iron and zinc differentially alter amyloid-Aβ(1-42) aggregation and toxicity

artículo científico publicado en 2011

Auranofin, Et3PAuCl, and Et3PAuI Are Highly Cytotoxic on Colorectal Cancer Cells: A Chemical and Biological Study.

artículo científico publicado en 2017

Biophysical characterisation of adducts formed between anticancer metallodrugs and selected proteins: new insights from X-ray diffraction and mass spectrometry studies

artículo científico publicado en 2008

Butyltin(IV) benzoates: inhibition of thioredoxin reductase, tumor cell growth inhibition, and interactions with proteins

artículo científico publicado en 2012

Cell and Cell-Free Mechanistic Studies on Two Gold(III) Complexes with Proven Antitumor Properties

Chemistry and biology of three representative gold(III) compounds as prospective anticancer agents

Chemistry and biology of two novel gold(I) carbene complexes as prospective anticancer agents

artículo científico publicado en 2014

Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(III) compounds for cancer treatment: a systematic study

artículo científico publicado en 2009

Cisplatin and its dibromido analogue: a comparison of chemical and biological profiles

artículo científico publicado en 2016

Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease

artículo científico publicado en 2009

Correction to Promising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Complex

scholarly article published in ACS Medicinal Chemistry Letters

Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel "Rule-Breaker" Iodidoplatinum(II) Complex

artículo científico publicado en 2010

DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery studied by circular dichroism and other biophysical techniques

article

ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

artículo científico publicado en 2007

ESI–MS Characterisation of Protein Adducts of Anticancer Ruthenium(II)-Arene PTA (RAPTA) Complexes

artículo científico publicado en 2007

Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds

artículo científico publicado en 2008

Exploiting soft and hard X-ray absorption spectroscopy to characterize metallodrug/protein interactions: the binding of [trans-RuCl4(Im)(dimethylsulfoxide)][ImH] (Im = imidazole) to bovine serum albumin

artículo científico publicado en 2008

Exploring Metallodrug–Protein Interactions by ESI Mass Spectrometry: The Reaction of Anticancer Platinum Drugs with Horse Heart Cytochrome c

scholarly article by Angela Casini et al published 10 April 2006 in ChemMedChem

Exploring metallodrug-protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound

artículo científico publicado en 2009

Exploring the Reactions of β-Amyloid (Aβ) Peptide 1–28 with AlIIIand FeIIIIons

artículo científico publicado en 2011

Exploring the biochemical mechanisms of cytotoxic gold compounds: a proteomic study

artículo científico publicado en 2010

First Crystal Structure for a Gold Carbene-Protein Adduct

artículo científico publicado en 2016

Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies

artículo científico publicado en 2010

Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents

artículo científico publicado en 2017

Gold(III) complexes with 2-substituted pyridines as experimental anticancer agents: solution behavior, reactions with model proteins, antiproliferative properties

artículo científico publicado en 2011

Gold(III) compounds as anticancer agents: relevance of gold-protein interactions for their mechanism of action

artículo científico publicado en 2007

Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones

artículo científico publicado en 2010

Insights into the molecular mechanisms of protein platination from a case study: the reaction of anticancer platinum(II) iminoethers with horse heart cytochrome c.

artículo científico publicado en 2007

Insights on the mechanism of thioredoxin reductase inhibition by gold N-heterocyclic carbene compounds using the synthetic linear selenocysteine containing C-terminal peptide hTrxR(488-499): an ESI-MS investigation

artículo científico publicado en 2014

Interaction of a gold(i) dicarbene anticancer drug with human telomeric DNA G-quadruplex: solution and computationally aided X-ray diffraction analysis

Interactions of the organogold(III) compound Aubipyc with the copper chaperone Atox1: a joint mass spectrometry and circular dichroism investigation

artículo científico publicado en 2015

Mass spectrometry and metallomics: A general protocol to assess stability of metallodrug-protein adducts in bottom-up MS experiments.

artículo científico publicado en 2017

Mechanisms of cytotoxicity of selected organogold(III) compounds

artículo científico publicado en 2005

Mechanistic studies on two dinuclear organogold(III) compounds showing appreciable antiproliferative properties and a high redox stability

artículo científico publicado en 2011

Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications

scientific article published on 01 December 2012

Metal compounds as inhibitors of β-amyloid aggregation. Perspectives for an innovative metallotherapeutics on Alzheimer's disease

scholarly article by Daniela Valensin et al published October 2012 in Coordination Chemistry Reviews

Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes

artículo científico publicado en 2013

Metal-based drugs for malaria, trypanosomiasis and leishmaniasis: recent achievements and perspectives

artículo científico publicado en 2010

Nanoparticles of Mg(OH)2: synthesis and application to paper conservation

artículo científico publicado en 2005

New Copper(II)/Cyclic Tetrapeptide System That Easily Oxidizes to Copper(III) under Atmospheric Oxygen

artículo científico publicado en 2007

New platinum-oxicam complexes as anti-cancer drugs. Synthesis, characterization, release studies from smart hydrogels, evaluation of reactivity with selected proteins and cytotoxic activity in vitro

artículo científico publicado en 2010

New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implications

artículo científico publicado en 2008

Nitrate as a probe of cytochrome c surface: crystallographic identification of crucial "hot spots" for protein-protein recognition

artículo científico publicado en 2014

Novel platinum(II) compounds with O,S bidentate ligands: synthesis, characterization, antiproliferative properties and biomolecular interactions

artículo científico publicado en 2014

Organogold(III) compounds as experimental anticancer agents: chemical and biological profiles

artículo científico publicado en 2016

Outstanding plasmodicidal properties within a small panel of metallic compounds: Hints for the development of new metal-based antimalarials

artículo científico publicado en 2008

Peculiar features in the crystal structure of the adduct formed between cis-PtI2(NH3)2 and hen egg white lysozyme

artículo científico publicado en 2013

Peculiar mechanistic and structural features of the carboplatin-cytochrome c system revealed by ESI-MS analysis

artículo científico publicado en 2008

Photocytotoxic Pt(iv) complexes as prospective anticancer agents

scientific article published on 05 June 2019

Potent in vitro antiproliferative properties for a triplatinum cluster toward triple negative breast cancer cells

artículo científico publicado en 2016

Proanthocyanidin glycosides from the leaves of Quercus ilex L. (Fagaceae)

Promising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Complex

artículo científico publicado en 2013

Protein metalation by metal-based drugs: reactions of cytotoxic gold compounds with cytochrome c and lysozyme

scientific article published on 07 November 2012

Proteomic analysis of A2780/S ovarian cancer cell response to the cytotoxic organogold(III) compound Aubipy(c).

artículo científico publicado en 2014

Proteomic analysis of ovarian cancer cell responses to cytotoxic gold compounds

artículo científico publicado en 2012

Proteomic analysis of the cytotoxic effects induced by the organogold(III) complex Aubipyc in cisplatin-resistant A2780 ovarian cancer cells: further evidence for the glycolytic pathway implication

artículo científico publicado en 2015

PtI2(DACH), the iodido analogue of oxaliplatin as a candidate for colorectal cancer treatment: chemical and biological features.

artículo científico publicado en 2017

Reactions of medicinally relevant gold compounds with the C-terminal motif of thioredoxin reductase elucidated by MS analysis

article

Reactions of metallodrugs with proteins: selective binding of phosphane-based platinum(ii) dichlorides to horse heart cytochrome c probed by ESI MS coupled to enzymatic cleavage

artículo científico publicado en 2011

Reactivity and biological properties of a series of cytotoxic PtI2(amine)2 complexes, either cis or trans configured

artículo científico publicado en 2012

Reactivity of an antimetastatic organometallic ruthenium compound with metallothionein-2: relevance to the mechanism of action

artículo científico publicado en 2009

Recent progress in the application of analytical techniques to anticancer metallodrug proteomics

Ruthenium anticancer drugs and proteins: a study of the interactions of the ruthenium(III) complex imidazolium trans-[tetrachloro(dimethyl sulfoxide)(imidazole)ruthenate(III)] with hen egg white lysozyme and horse heart cytochrome c

scholarly article by Angela Casini et al published 7 August 2007 in Journal of Biological Inorganic Chemistry

Ruthenium arene complexes with triphenylphosphane ligands: cytotoxicity towards pancreatic cancer cells, interaction with model proteins, and effect of ethacrynic acid substitution

article

Selected cytotoxic gold compounds cause significant inhibition of 20S proteasome catalytic activities

artículo científico publicado en 2014

Selected gold compounds cause pronounced inhibition of Falcipain 2 and effectively block P. falciparum growth in vitro

artículo científico publicado en 2011

Solution behaviour and biomolecular interactions of two cytotoxic trans-platinum(II) complexes bearing aliphatic amine ligands

artículo científico publicado en 2009

Solution chemistry and cytotoxic properties of novel organogold(III) compounds

artículo científico publicado en 2004

Structural and solution chemistry, antiproliferative effects, and DNA and protein binding properties of a series of dinuclear gold(III) compounds with bipyridyl ligands

artículo científico publicado en 2006

Structural and solution chemistry, protein binding and antiproliferative profiles of gold(I)/(III) complexes bearing the saccharinato ligand

artículo científico publicado en 2010

Structural characterization, solution studies, and DFT calculations on a series of binuclear gold(III) oxo complexes: relationships to biological properties

artículo científico publicado en 2008

Structure, solution chemistry, antiproliferative actions and protein binding properties of non-conventional platinum(II) compounds with sulfur and phosphorus donors

artículo científico publicado en 2011

Structure-function relationships within Keppler-type antitumor ruthenium(III) complexes: the case of 2-aminothiazolium[trans-tetrachlorobis(2-aminothiazole)ruthenate(III)].

artículo científico publicado en 2005

Synthesis, structural characterization, solution behavior, and in vitro antiproliferative properties of a series of gold complexes with 2-(2'-pyridyl)benzimidazole as ligand: comparisons of gold(III) versus gold(I) and mononuclear versus binuclear d

artículo científico publicado en 2012

The C2 variant of human serum transferrin retains the iron binding properties of the native protein.

artículo científico publicado en 2005

The copper(II) binding properties of the cyclic peptide c(HGHK).

artículo científico publicado en 2004

The copper(II) coordination abilities of three novel cyclic tetrapeptides with -His-Xaa-His- motif

artículo científico publicado en 2006

The influence of auranofin, a clinically established antiarthritic gold drug, on bone metabolism: analysis of its effects on human multipotent adipose-derived stem cells, taken as a model

artículo científico publicado en 2008

The mode of action of anticancer gold-based drugs: a structural perspective

artículo científico publicado en 2013

The molecular mechanisms of antimetastatic ruthenium compounds explored through DIGE proteomics

artículo científico publicado en 2012

The reaction of artemisinins with hemoglobin: a unified picture

artículo científico publicado en 2006

The x-ray structure of the adduct between NAMI-A and carbonic anhydrase provides insights into the reactivity of this metallodrug with proteins

artículo científico publicado en 2010

Thioredoxin reductase, an emerging target for anticancer metallodrugs. Enzyme inhibition by cytotoxic gold(iii) compounds studied with combined mass spectrometry and biochemical assays

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

Trace copper(II) or zinc(II) ions drastically modify the aggregation behavior of amyloid-beta1-42: an AFM study

artículo científico publicado en 2010

Trans-cis-cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B.

artículo científico publicado en 2009

Unravelling the chemical nature of copper cuprizone

artículo científico publicado en 2007

X-ray absorption spectroscopy studies of the adducts formed between cytotoxic gold compounds and two major serum proteins

artículo científico publicado en 2010

[Au2(phen(2Me))2(μ-O)2](PF6)2, a Novel Dinuclear Gold(III) Complex Showing Excellent Antiproliferative Properties

artículo científico publicado en 2010

cis-Pt I2(NH3)2: a reappraisal

artículo científico publicado en 2015

fac-{Ru(CO)(3)}(2+) selectively targets the histidine residues of the beta-amyloid peptide 1-28. Implications for new Alzheimer's disease treatments based on ruthenium complexes

artículo científico publicado en 2010

Lista de obras de Chiara Gabbiani

2D-DIGE analysis of ovarian cancer cell responses to cytotoxic gold compounds

Activity of Rat Cytosolic Thioredoxin Reductase Is Strongly Decreased bytrans-[Bis(2-amino-5- methylthiazole)tetrachlororuthenate(III)]: First Report of Relevant Thioredoxin Reductase Inhibition for a Ruthenium Compound

Aluminum, copper, iron and zinc differentially alter amyloid-Aβ(1-42) aggregation and toxicity

Auranofin, Et3PAuCl, and Et3PAuI Are Highly Cytotoxic on Colorectal Cancer Cells: A Chemical and Biological Study.

Biophysical characterisation of adducts formed between anticancer metallodrugs and selected proteins: new insights from X-ray diffraction and mass spectrometry studies

Butyltin(IV) benzoates: inhibition of thioredoxin reductase, tumor cell growth inhibition, and interactions with proteins

Cell and Cell-Free Mechanistic Studies on Two Gold(III) Complexes with Proven Antitumor Properties

Chemistry and biology of three representative gold(III) compounds as prospective anticancer agents

Chemistry and biology of two novel gold(I) carbene complexes as prospective anticancer agents

Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(III) compounds for cancer treatment: a systematic study

Cisplatin and its dibromido analogue: a comparison of chemical and biological profiles

Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease

Correction to Promising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Complex

Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel "Rule-Breaker" Iodidoplatinum(II) Complex

DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery studied by circular dichroism and other biophysical techniques

ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

ESI–MS Characterisation of Protein Adducts of Anticancer Ruthenium(II)-Arene PTA (RAPTA) Complexes

Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds

Exploiting soft and hard X-ray absorption spectroscopy to characterize metallodrug/protein interactions: the binding of [trans-RuCl4(Im)(dimethylsulfoxide)][ImH] (Im = imidazole) to bovine serum albumin

Exploring Metallodrug–Protein Interactions by ESI Mass Spectrometry: The Reaction of Anticancer Platinum Drugs with Horse Heart Cytochrome c

Exploring metallodrug-protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound

Exploring the Reactions of β-Amyloid (Aβ) Peptide 1–28 with AlIIIand FeIIIIons

Exploring the biochemical mechanisms of cytotoxic gold compounds: a proteomic study

First Crystal Structure for a Gold Carbene-Protein Adduct

Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies

Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents

Gold(III) complexes with 2-substituted pyridines as experimental anticancer agents: solution behavior, reactions with model proteins, antiproliferative properties

Gold(III) compounds as anticancer agents: relevance of gold-protein interactions for their mechanism of action

Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones

Insights into the molecular mechanisms of protein platination from a case study: the reaction of anticancer platinum(II) iminoethers with horse heart cytochrome c.

Insights on the mechanism of thioredoxin reductase inhibition by gold N-heterocyclic carbene compounds using the synthetic linear selenocysteine containing C-terminal peptide hTrxR(488-499): an ESI-MS investigation

Interaction of a gold(i) dicarbene anticancer drug with human telomeric DNA G-quadruplex: solution and computationally aided X-ray diffraction analysis

Interactions of the organogold(III) compound Aubipyc with the copper chaperone Atox1: a joint mass spectrometry and circular dichroism investigation

Mass spectrometry and metallomics: A general protocol to assess stability of metallodrug-protein adducts in bottom-up MS experiments.

Mechanisms of cytotoxicity of selected organogold(III) compounds

Mechanistic studies on two dinuclear organogold(III) compounds showing appreciable antiproliferative properties and a high redox stability

Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications

Metal compounds as inhibitors of β-amyloid aggregation. Perspectives for an innovative metallotherapeutics on Alzheimer's disease

Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes

Metal-based drugs for malaria, trypanosomiasis and leishmaniasis: recent achievements and perspectives

Nanoparticles of Mg(OH)2: synthesis and application to paper conservation

New Copper(II)/Cyclic Tetrapeptide System That Easily Oxidizes to Copper(III) under Atmospheric Oxygen

New platinum-oxicam complexes as anti-cancer drugs. Synthesis, characterization, release studies from smart hydrogels, evaluation of reactivity with selected proteins and cytotoxic activity in vitro

New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implications

Nitrate as a probe of cytochrome c surface: crystallographic identification of crucial "hot spots" for protein-protein recognition

Novel platinum(II) compounds with O,S bidentate ligands: synthesis, characterization, antiproliferative properties and biomolecular interactions

Organogold(III) compounds as experimental anticancer agents: chemical and biological profiles

Outstanding plasmodicidal properties within a small panel of metallic compounds: Hints for the development of new metal-based antimalarials

Peculiar features in the crystal structure of the adduct formed between cis-PtI2(NH3)2 and hen egg white lysozyme

Peculiar mechanistic and structural features of the carboplatin-cytochrome c system revealed by ESI-MS analysis

Photocytotoxic Pt(iv) complexes as prospective anticancer agents

Potent in vitro antiproliferative properties for a triplatinum cluster toward triple negative breast cancer cells

Proanthocyanidin glycosides from the leaves of Quercus ilex L. (Fagaceae)

Promising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Complex

Protein metalation by metal-based drugs: reactions of cytotoxic gold compounds with cytochrome c and lysozyme

Proteomic analysis of A2780/S ovarian cancer cell response to the cytotoxic organogold(III) compound Aubipy(c).

Proteomic analysis of ovarian cancer cell responses to cytotoxic gold compounds

Proteomic analysis of the cytotoxic effects induced by the organogold(III) complex Aubipyc in cisplatin-resistant A2780 ovarian cancer cells: further evidence for the glycolytic pathway implication

PtI2(DACH), the iodido analogue of oxaliplatin as a candidate for colorectal cancer treatment: chemical and biological features.

Reactions of medicinally relevant gold compounds with the C-terminal motif of thioredoxin reductase elucidated by MS analysis

Reactions of metallodrugs with proteins: selective binding of phosphane-based platinum(ii) dichlorides to horse heart cytochrome c probed by ESI MS coupled to enzymatic cleavage

Reactivity and biological properties of a series of cytotoxic PtI2(amine)2 complexes, either cis or trans configured

Reactivity of an antimetastatic organometallic ruthenium compound with metallothionein-2: relevance to the mechanism of action

Recent progress in the application of analytical techniques to anticancer metallodrug proteomics

Ruthenium anticancer drugs and proteins: a study of the interactions of the ruthenium(III) complex imidazolium trans-[tetrachloro(dimethyl sulfoxide)(imidazole)ruthenate(III)] with hen egg white lysozyme and horse heart cytochrome c

Ruthenium arene complexes with triphenylphosphane ligands: cytotoxicity towards pancreatic cancer cells, interaction with model proteins, and effect of ethacrynic acid substitution

Selected cytotoxic gold compounds cause significant inhibition of 20S proteasome catalytic activities

Selected gold compounds cause pronounced inhibition of Falcipain 2 and effectively block P. falciparum growth in vitro

Solution behaviour and biomolecular interactions of two cytotoxic trans-platinum(II) complexes bearing aliphatic amine ligands

Solution chemistry and cytotoxic properties of novel organogold(III) compounds

Structural and solution chemistry, antiproliferative effects, and DNA and protein binding properties of a series of dinuclear gold(III) compounds with bipyridyl ligands

Structural and solution chemistry, protein binding and antiproliferative profiles of gold(I)/(III) complexes bearing the saccharinato ligand

Structural characterization, solution studies, and DFT calculations on a series of binuclear gold(III) oxo complexes: relationships to biological properties

Structure, solution chemistry, antiproliferative actions and protein binding properties of non-conventional platinum(II) compounds with sulfur and phosphorus donors

Structure-function relationships within Keppler-type antitumor ruthenium(III) complexes: the case of 2-aminothiazolium[trans-tetrachlorobis(2-aminothiazole)ruthenate(III)].

Synthesis, structural characterization, solution behavior, and in vitro antiproliferative properties of a series of gold complexes with 2-(2'-pyridyl)benzimidazole as ligand: comparisons of gold(III) versus gold(I) and mononuclear versus binuclear d

The C2 variant of human serum transferrin retains the iron binding properties of the native protein.

The copper(II) binding properties of the cyclic peptide c(HGHK).

The copper(II) coordination abilities of three novel cyclic tetrapeptides with -His-Xaa-His- motif