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Lista de obras de Manfred Jung

4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines

artículo científico publicado en 2020

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading

artículo científico publicado en 2013

4-Biphenylalanine- and 3-Phenyltyrosine-Derived Hydroxamic Acids as Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.

artículo científico publicado en 2016

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

artículo científico publicado en 2019

A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation

artículo científico publicado en 2016

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.

artículo científico publicado en 2018

A bioluminogenic HDAC activity assay: validation and screening.

artículo científico publicado en 2011

A homogeneous nonisotopic histone deacetylase activity assay

artículo científico publicado en 2003

A non-isotopic assay for histone deacetylase activity

artículo científico publicado en 1999

A novel arginine methyltransferase inhibitor with cellular activity

artículo científico publicado en 2007

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.

artículo científico publicado en 2012

A quinone mediator drives oxidations catalysed by alcohol dehydrogenase-containing cell lysates

artículo científico publicado en 2016

Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.

artículo científico publicado en 2011

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition

artículo científico publicado en 2006

Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines

artículo científico publicado en 2017

Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation

artículo científico publicado en 1999

Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study

artículo científico publicado en 2016

Arginine methylation of the B cell antigen receptor promotes differentiation.

artículo científico publicado en 2010

Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation

artículo científico publicado en 2016

Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: towards the design of photoswitchable sirtuin inhibitors

artículo científico publicado en 2019

BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways ⬇️

artículo científico publicado el 6 de mayo de 2013

Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells

artículo científico publicado en 2012

Binding free energy calculations and biological testing of novel thiobarbiturates as inhibitors of the human NAD+dependent histone deacetylase Sirt2

Bioorganometallic chemistry--synthesis and antitumor activity of cobalt carbonyl complexes

artículo científico publicado en 1997

Cancer treatment of the future: inhibitors of histone methyltransferases

artículo científico publicado en 2008

Carbamate prodrug concept for hydroxamate HDAC inhibitors

artículo científico publicado en 2011

Carbamates as Potential Prodrugs and a New Warhead for HDAC Inhibition

artículo científico publicado en 2018

Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants

article

Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals).

artículo científico publicado en 2017

Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins

Cofactor Analogues as Active Site Probes in Lysine Acetyltransferases

scientific article published on 06 March 2019

Computer- and structure-based lead design for epigenetic targets

artículo científico publicado en 2011

Current trends in epigenetic drug discovery

artículo científico

Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups

artículo científico publicado en 2017

Design, Synthesis, and Biological Evaluation of 2-Aminobenzanilide Derivatives as Potent and Selective HDAC Inhibitors

scientific article published on 24 May 2012

Destabilization of ERBB2 transcripts by targeting 3' untranslated region messenger RNA associated HuR and histone deacetylase-6

artículo científico publicado en 2008

Determination of drug-serum protein interactions via fluorescence polarization measurements

artículo científico publicado en 2007

Determination of the antifungal agent posaconazole in human serum by HPLC with parallel column-switching technique.

artículo científico publicado en 2009

Development of albumin-binding camptothecin prodrugs using a Peptide positional scanning library

artículo científico publicado en 2007

Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood

artículo científico publicado en 2010

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)

scientific article published on 24 July 2019

Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation

artículo científico publicado en 2014

Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives

artículo científico

Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines

artículo científico publicado en 2005

Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis

artículo científico publicado en 2014

Epigenetic drug discovery special issue

artículo científico publicado en 2011

Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6

scientific article published on 19 December 2019

Farnesyl anthranilate suppresses the growth, in vitro and in vivo, of murine B16 melanomas

artículo científico publicado en 2000

Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells

artículo científico publicado en 2003

Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni.

artículo científico publicado en 2014

From cosubstrate similarity to inhibitor diversity--inhibitors of ADP-ribosyltransferases from kinase inhibitor screening

artículo científico publicado en 2010

HDAC6 as a target for antileukemic drugs in acute myeloid leukemia ⬇️

artículo científico publicado el 29 de marzo de 2012

HDAC8: a multifaceted target for therapeutic interventions

artículo científico

Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate

artículo científico publicado en 2014

High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding

artículo científico publicado en 2012

Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo

artículo científico publicado en 2015

Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy.

artículo científico publicado en 2010

Histone deacetylase inhibitor, trichostatin A, affects gene expression patterns during morphogenesis of chicken limb buds in vivo

artículo científico publicado en 2009

Histone deacetylase inhibitors that target tubulin

artículo científico publicado en 2009

Hydroxamates of para-aminobenzoic acid as selective inhibitors of HDAC8.

artículo científico publicado en 2014

Hydroxamide derivatives of short-chain fatty acid have erythropoietic activity and induce gamma gene expression in vivo

artículo científico publicado en 2005

Hydroxamide derivatives of short-chain fatty acids are potent inducers of human fetal globin gene expression

artículo científico publicado en 2003

Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and In Vitro Testing

artículo científico publicado en 2018

Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and in Vitro Testing

Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing

artículo científico publicado en 2016

Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.

artículo científico publicado en 2016

Identification of tri- and tetracyclic pyrimidinediones as sirtuin inhibitors

artículo científico publicado en 2010

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor

artículo científico publicado en 2012

In vitro assays for the determination of histone deacetylase activity

artículo científico publicado en 2005

In vivo application of histone deacetylase inhibitor trichostatin-a impairs murine male meiosis

artículo científico publicado en 2007

Induction of human gamma globin gene expression by histone deacetylase inhibitors

artículo científico publicado en 2003

Inhibition of bromodomain-mediated protein–protein interactions as a novel therapeutic strategy

article published in 2012

Inhibition of p300 suppresses growth of breast cancer. Role of p300 subcellular localization

artículo científico publicado en 2014

Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood

artículo científico publicado en 2007

Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5

artículo científico publicado en 2012

Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins).

artículo científico publicado en 2010

Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity

artículo científico publicado en 2018

KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases

artículo científico publicado en 2015

KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells

scientific article published on 06 May 2019

Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells

artículo científico publicado en 2012

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy

artículo científico publicado en 2019

Limited efficacy of specific HDAC6 inhibition in urothelial cancer cells.

artículo científico publicado en 2014

Metabolite Patterns in Human Myeloid Hematopoiesis Result from Lineage-Dependent Active Metabolic Pathways

artículo científico publicado en 2020

Mind the methyl: methyllysine binding proteins in epigenetic regulation

artículo científico

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni

artículo científico publicado en 2014

NAD(+) -dependent histone deacetylases (sirtuins) as novel therapeutic targets

artículo científico publicado en 2010

NIK is required for NF-κB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathways

artículo científico publicado en 2015

New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2.

artículo científico publicado en 2018

New lysine methyltransferase drug targets in cancer

artículo científico publicado en 2012

No taste for methyl: methylation sensitive proteolysis in drug screening

scientific article published on 01 July 2010

Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity

artículo científico publicado en 2013

Nonradioactive In Vitro Assays for Histone Deacetylases ⬇️

artículo científico publicado el 1 de enero de 2013

Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).

artículo científico publicado en 2010

Opening the Selectivity Pocket in the Human Lysine Deacetylase Sirtuin2 - New Opportunities, New Questions

artículo científico publicado en 2018

Oxidized cytosine metabolites offer a fresh perspective for active DNA demethylation

artículo científico publicado en 2011

Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)

artículo científico publicado en 2008

Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies

artículo científico publicado en 2016

Photochromic Indolyl Fulgimides as Chromo-pharmacophores Targeting Sirtuins

artículo científico publicado en 2018

Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides.

artículo científico publicado en 2017

Posaconazole Therapeutic Drug Monitoring in the Real‐life Setting: A Single‐Center Experience and Review of the Literature ⬇️

artículo científico publicado el 17 de julio de 2013

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes.

artículo científico publicado en 2016

Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs)

Pyridylalanine-containing hydroxamic acids as selective HDAC6 inhibitors

artículo científico publicado en 2009

R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies

artículo científico publicado en 2007

Rhodanine carboxylic acids as novel inhibitors of histone acetyltransferases

SIRT1 regulates HIV transcription via Tat deacetylation

artículo científico publicado en 2005

Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets

artículo científico publicado en 2013

Schistosome sirtuins as drug targets

artículo científico

Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents

scientific article published on 12 November 2019

Screening assays for epigenetic targets using native histones as substrates

scientific article published on 30 September 2011

Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking

artículo científico publicado en 2015

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

artículo científico publicado en 2015

Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates

artículo científico publicado en 2011

Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula ⬇️

artículo científico publicado en 2009

Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni

artículo científico publicado en 2013

Structure-Activity Relationship of Propargylamine-Based HDAC Inhibitors.

artículo científico publicado en 2017

Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity

artículo científico publicado en 2017

Structure-Based Design and Computational Studies of Sirtuin Inhibitors

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

artículo científico publicado en 2016

Structure-Based Development of an Affinity Probe for Sirtuin 2

artículo científico publicado en 2016

Structure-Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases

artículo científico publicado en 2019

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2)

scientific article published on 20 September 2019

Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode

artículo científico publicado en 2008

Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins)

scholarly article by Johannes Trapp et al published 8 October 2007 in ChemMedChem

Suberoylanilide hydroxamic acid: a potential epigenetic therapeutic agent for lung fibrosis?

artículo científico publicado en 2009

Substituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylases

artículo científico publicado en 2016

Subtype selective substrates for histone deacetylases

artículo científico publicado en 2004

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors

artículo científico publicado en 2015

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors

scientific article published on 01 February 2019

Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins)

artículo científico publicado en 2011

Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)

Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors

artículo científico publicado en 2011

Target-based approach to inhibitors of histone arginine methyltransferases

artículo científico publicado en 2007

Targeting epigenetic mechanisms: potential of natural products in cancer chemoprevention.

artículo científico publicado en 2008

Targeting epigenetic modifiers: Inhibitors of histone methyltransferases

article published in 2010

Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases

artículo científico publicado en 2016

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

artículo científico publicado en 2016

Tetrazolylhydrazides as Selective Fragment-Like Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.

artículo científico publicado en 2015

The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases

scientific article published on 19 July 2019

The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors.

artículo científico publicado en 2012

The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors

artículo científico publicado en 2009

The ergot alkaloid gene cluster: functional analyses and evolutionary aspects

artículo científico publicado en 2009

The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells

artículo científico publicado en 2013

The nephronophthisis gene product NPHP2/Inversin interacts with Aurora A and interferes with HDAC6-mediated cilia disassembly

article

The role of histone demethylases in cancer therapy

artículo científico publicado en 2012

Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method

artículo científico publicado en 2010

Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing

artículo científico publicado en 2008

Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).

artículo científico publicado en 2016

Total synthesis of (18S)- and (18R)-homolargazole by rhodium-catalyzed hydrocarboxylation

artículo científico publicado en 2014

Two-Step Synthesis of Novel, Bioactive Derivatives of the Ubiquitous Cofactor Nicotinamide Adenine Dinucleotide (NAD)

artículo científico publicado en 2011

Use of systemic antifungals in daily clinical practice in the haematology and oncology setting: results of a prospective observational analysis

artículo científico publicado en 2012

Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology

artículo científico publicado en 2019

Valproic acid as a histone deacetylase inhibitor. New application for a well-known drug

artículo científico publicado en 2010

Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors

artículo científico publicado en 2009

Virtual screening of PRK1 inhibitors: ensemble docking, rescoring using binding free energy calculation and QSAR model development

artículo científico publicado en 2014

[Bookmarks in the book of life. Epigenetics]

scientific article published on 01 May 2010

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