Lista de obras - Jeroen Bakkers - Dominio Público Uruguay

A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality

artículo científico publicado en 2013

A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function

scientific journal article

A de novo variant in the human HIST1H4J gene causes a syndrome analogous to the HIST1H4C-associated neurodevelopmental disorder

scientific article published on 05 December 2019

ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9

scientific article published on 01 October 2019

ALK2 mutation in a patient with Down's syndrome and a congenital heart defect

artículo científico publicado en 2011

Actomyosin dynamics, Bmp and Notch signaling pathways drive apical extrusion of proepicardial cells

artículo científico publicado en 2018

An important developmental role for oligosaccharides during early embryogenesis of cyprinid fish

artículo científico publicado en 1997

Animal and in silico models for the study of sarcomeric cardiomyopathies

artículo científico publicado en 2015

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

artículo científico publicado en 2022

Assessment of the Most Optimal Control Tissue for Intracranial Aneurysm Gene Expression Studies

scientific article published on 20 August 2019

Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish

artículo científico publicado en 2011

Bmp signaling exerts opposite effects on cardiac differentiation

artículo científico publicado en 2012

CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function

scientific journal article

Chitin Oligosaccharide Synthesis by Rhizobia and Zebrafish Embryos Starts by Glycosyl Transfer to O4 of the Reducing-Terminal Residue†

artículo científico publicado en 1999

Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm-Associated Regions to Potential Candidate Genes

article

Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries

scientific article published on 10 December 2021

Conserved NPPB+ Border Zone Switches From MEF2- to AP-1-Driven Gene Program

scientific article published on 01 July 2019

Destabilization of DeltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo

artículo científico publicado en 2005

Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies

artículo científico publicado en 2015

Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation.

artículo científico publicado en 2008

Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart

artículo científico publicado en 2009

Dominant-negative ALK2 allele associates with congenital heart defects

artículo científico publicado en 2009

Early endocardial morphogenesis requires Scl/Tal1

artículo científico publicado en 2007

Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders

artículo científico publicado en 2018

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions

artículo científico publicado en 2004

Expression of Rhizobium Chitin Oligosaccharide Fucosyltransferase in Zebrafish Embryos Disrupts Normal Developmenta,

artículo científico publicado en 1998

Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition.

artículo científico publicado en 2004

GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay

scientific article published on 01 January 2019

GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish

artículo científico publicado en 2014

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability

artículo científico publicado en 2016

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.

artículo científico publicado en 2016

Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

artículo científico publicado en 2006

Genes in congenital heart disease: atrioventricular valve formation

artículo científico publicado en 2008

Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I K,ACh)

scientific article published on 09 July 2019

Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer

artículo científico publicado en 2012

Genetics of Congenital Heart Defects: A Candidate Gene Approach ⬇️

artículo científico publicado el 1 de mayo de 2010

Genome-wide RNA Tomography in the zebrafish embryo

artículo científico publicado en 2014

Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control

artículo científico publicado en 2017

Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling.

artículo científico publicado en 2015

Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation

artículo científico

Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity.

artículo científico publicado en 2016

Hyaluronan: a critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation

artículo científico publicado en 2013

Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation

scientific article published on 01 September 2019

Identification and functional characterization of cardiac pacemaker cells in zebrafish

artículo científico publicado en 2012

Identification and regulation of a molecular module for bleb-based cell motility

artículo científico publicado en 2012

Identification of human D lactate dehydrogenase deficiency

scientific article published on 01 April 2019

Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects

artículo científico publicado en 2022

Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis

artículo científico publicado en 2018

Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells

artículo científico publicado en 2007

Loss of the Polycomb group protein Rnf2 results in derepression of tbx-transcription factors and defects in embryonic and cardiac development

artículo científico publicado en 2019

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

artículo científico publicado en 2017

Macrophage development from HSCs requires PU.1-coordinated microRNA expression.

artículo científico publicado en 2011

Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model

artículo científico publicado en 2009

MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production

artículo científico publicado en 2011

Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TGF-β Signaling and Epigenomics

artículo científico publicado en 2018

Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations

artículo científico

Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm

artículo científico publicado en 2014

Nodal signaling range is regulated by proprotein convertase-mediated maturation.

artículo científico publicado en 2015

Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish

artículo científico publicado en 2014

Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2.

artículo científico publicado en 2016

Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium

artículo científico publicado en 2020

On the Evolution of the Cardiac Pacemaker

artículo científico publicado en 2017

On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling

artículo científico publicado en 2013

Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis

scientific article published on 09 September 2018

Rare novel variants in the ZIC3 gene cause X-linked heterotaxy

artículo científico publicado en 2016

Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes

artículo científico publicado en 2015

Revealing details: whole mount microRNA in situ hybridization protocol for zebrafish embryos and adult tissues

artículo científico publicado en 2012

Rhizobium Nod Factors Reactivate the Cell Cycle during Infection and Nodule Primordium Formation, but the Cycle Is Only Completed in Primordium Formation

artículo científico publicado en 1994

Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells

artículo científico publicado en 2008

Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis

artículo científico publicado en 2009

Shaping up with morphogen gradients

scientific article published on 01 September 2018

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

artículo científico publicado en 2019

Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43.

artículo científico publicado en 2011

Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration

artículo científico publicado en 2015

Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate.

artículo científico publicado en 2018

T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system

artículo científico publicado en 2020

The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion

artículo científico publicado en 2007

The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

artículo científico publicado en 2002

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover

artículo científico publicado en 2017

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.

artículo científico publicado en 2017

Tomo-seq: A method to obtain genome-wide expression data with spatial resolution

artículo científico publicado en 2016

Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development

artículo científico publicado en 2011

Twists and turns

artículo científico publicado en 2017

Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish

artículo científico

UDP-glucose dehydrogenase polymorphisms from patients with congenital heart valve defects disrupt enzyme stability and quaternary assembly

artículo científico publicado en 2012

Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis

artículo científico publicado en 2013

Variants in members of the cadherin-catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome.

artículo científico publicado en 2018

Versatile open software to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo

Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2.

artículo científico publicado en 2011

Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points

artículo científico publicado en 2007

Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm

artículo científico publicado en 2002

Zebrafish as a model to study cardiac development and human cardiac disease

artículo científico publicado en 2011

Zebrafish cypher is important for somite formation and heart development

artículo científico publicado en 2006

Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex

artículo científico publicado en 2008

Zebrafish prrx1a mutants have normal hearts

scientific article published on 23 September 2020

αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish

artículo científico publicado en 2016

Lista de obras de Jeroen Bakkers

A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality

A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function

A de novo variant in the human HIST1H4J gene causes a syndrome analogous to the HIST1H4C-associated neurodevelopmental disorder

ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9

ALK2 mutation in a patient with Down's syndrome and a congenital heart defect

Actomyosin dynamics, Bmp and Notch signaling pathways drive apical extrusion of proepicardial cells

An important developmental role for oligosaccharides during early embryogenesis of cyprinid fish

Animal and in silico models for the study of sarcomeric cardiomyopathies

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

Assessment of the Most Optimal Control Tissue for Intracranial Aneurysm Gene Expression Studies

Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish

Bmp signaling exerts opposite effects on cardiac differentiation

CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function

Chitin Oligosaccharide Synthesis by Rhizobia and Zebrafish Embryos Starts by Glycosyl Transfer to O4 of the Reducing-Terminal Residue†

Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm-Associated Regions to Potential Candidate Genes

Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries

Conserved NPPB+ Border Zone Switches From MEF2- to AP-1-Driven Gene Program

Destabilization of DeltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo

Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies

Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation.

Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart

Dominant-negative ALK2 allele associates with congenital heart defects

Early endocardial morphogenesis requires Scl/Tal1

Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions

Expression of Rhizobium Chitin Oligosaccharide Fucosyltransferase in Zebrafish Embryos Disrupts Normal Developmenta,

Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition.

GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay

GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.

Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

Genes in congenital heart disease: atrioventricular valve formation

Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I K,ACh)

Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer

Genetics of Congenital Heart Defects: A Candidate Gene Approach ⬇️

Genome-wide RNA Tomography in the zebrafish embryo

Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control

Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling.

Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation

Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity.

Hyaluronan: a critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation

Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation

Identification and functional characterization of cardiac pacemaker cells in zebrafish

Identification and regulation of a molecular module for bleb-based cell motility

Identification of human D lactate dehydrogenase deficiency

Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects

Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis

Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells

Loss of the Polycomb group protein Rnf2 results in derepression of tbx-transcription factors and defects in embryonic and cardiac development

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

Macrophage development from HSCs requires PU.1-coordinated microRNA expression.

Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model

MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production

Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TGF-β Signaling and Epigenomics

Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations

Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm

Nodal signaling range is regulated by proprotein convertase-mediated maturation.

Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish

Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2.

Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium

On the Evolution of the Cardiac Pacemaker

On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling

Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis

Rare novel variants in the ZIC3 gene cause X-linked heterotaxy

Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes

Revealing details: whole mount microRNA in situ hybridization protocol for zebrafish embryos and adult tissues

Rhizobium Nod Factors Reactivate the Cell Cycle during Infection and Nodule Primordium Formation, but the Cycle Is Only Completed in Primordium Formation

Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells

Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis

Shaping up with morphogen gradients

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43.

Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration

Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate.

T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system

The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion

The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover