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Lista de obras de Andrew Owen

A multi-system approach assessing the interaction of anticonvulsants with P-gp

artículo científico publicado en 2013

A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication

artículo científico publicado en 2014

A physiologically based pharmacokinetic model to predict the superparamagnetic iron oxide nanoparticles (SPIONs) accumulation in vivo

A simplified approach to determining P-glycoprotein expression in peripheral blood mononuclear cell subsets

artículo científico publicado en 2003

ABCB1 single nucleotide polymorphisms (1236C>T, 2677G>T, and 3435C>T) do not affect transport activity of human P-glycoprotein

artículo científico publicado en 2013

Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies.

artículo científico publicado en 2016

Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex

artículo científico publicado en 2008

Adipogenic gene variants in patients with HIV-associated lipodystrophy

article

Antiretroviral solid drug nanoparticles with enhanced oral bioavailability: production, characterization, and in vitro-in vivo correlation

artículo científico publicado en 2013

Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS

artículo científico publicado en 2012

Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C-->T) with reduced concentrations of unboosted atazanavir

artículo científico publicado en 2008

Augmented Inhibition of CYP3A4 in Human Primary Hepatocytes by Ritonavir Solid Drug Nanoparticles

artículo científico publicado en 2015

Breast milk pharmacokinetics of efavirenz and breastfed infants' exposure in genetically defined subgroups of mother-infant pairs: an observational study.

artículo científico publicado en 2015

CYP2B6 516G>T (rs3745274) and smoking status are associated with efavirenz plasma concentration in a Serbian cohort of HIV patients.

artículo científico publicado en 2014

CYP3A4*22 (c.522-191 C>T; rs35599367) is associated with lopinavir pharmacokinetics in HIV-positive adults.

artículo científico publicado en 2014

Carbamazepine is not a substrate for P-glycoprotein

artículo científico publicado en 2001

Cerebrospinal fluid exposure of efavirenz and its major metabolites when dosed at 400 mg and 600 mg once daily: a randomized controlled trial

artículo científico publicado en 2014

Chapter 12. The Challenge of Regulating Nanomedicine: Key Issues

artículo científico

Chasing COVID-19 chemotherapeutics without putting the cart before the horse

artículo científico publicado en 2020

Class-specific relative genetic contribution for key antiretroviral drugs

artículo científico publicado en 2015

Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells

artículo científico publicado en 2007

Comprehensive Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Evaluation of Once-Daily Efavirenz 400 and 600 mg in Treatment-Naïve HIV-Infected Patients at 96 Weeks: Results of the ENCORE1 Study

artículo científico publicado en 2015

Considerations for clinically-relevant nanomedicine therapies for chronic diseases

scholarly article by Andrew Owen & Steven P. Rannard published October 2015 in Nanomedicine

Correlates of efavirenz exposure in Chilean patients affected with human immunodeficiency virus reveals a novel association with a polymorphism in the constitutive androstane receptor

artículo científico publicado en 2013

Cultured CD4T cells and primary human lymphocytes express hOATPs: intracellular accumulation of saquinavir and lopinavir

artículo científico publicado en 2008

Current Progress in the Pharmacogenetics of Infectious Disease Therapy

scholarly article published 2011

Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens

artículo científico publicado en 2011

Cytochrome P450 2B6 516G-->T is associated with plasma concentrations of nevirapine at both 200 mg twice daily and 400 mg once daily in an ethnically diverse population

artículo científico publicado en 2009

Cytotoxic chemotherapy and the evolution of cellular and viral resistance to antiretroviral therapy in HIV- infected individuals with lymphoma

artículo científico publicado en 2016

Detection and biochemical characterisation of a novel polymorphism in the human GSTP1 gene.

artículo científico publicado en 2007

Detection and quantification of minority HIV isolates harbouring the D30N mutation by real-time PCR amplification

article

Detection of ABCC2, CYP2B6 and CYP3A4 in human peripheral blood mononuclear cells using flow cytometry

artículo científico publicado en 2008

Detection of low-frequency K103N mutants after unstructured discontinuation of efavirenz in the presence of the CYP2B6 516 TT polymorphism

artículo científico publicado en 2011

Detection of low-frequency K103N mutants after unstructured discontinuation of efavirenz in the presence of the CYP2B6 516 TT polymorphism

artículo científico publicado en 2008

Determining the relationship between nanoparticle characteristics and immunotoxicity: key challenges and approaches.

artículo científico publicado en 2016

Development and validation of an LC-MS/MS assay for the quantification of efavirenz in different biological matrices

artículo científico publicado en 2016

Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes.

artículo científico publicado en 2005

Development, validation and clinical application of a novel method for the quantification of efavirenz in dried breast milk spots using LC-MS/MS.

artículo científico publicado en 2014

Differential drug susceptibility of intracellular and extracellular tuberculosis, and the impact of P-glycoprotein

artículo científico publicado en 2007

Differential expression of human immunodeficiency virus coreceptors, by CEM, CEMVBL, and CEM E1000 cells

artículo científico publicado en 2003

Dissecting the relative contribution of OATP1B1-mediated uptake of xenobiotics into human hepatocytes using siRNA

article published in 2013

Divalent metals and pH alter raltegravir disposition in vitro

artículo científico publicado en 2012

Dolutegravir and elvitegravir plasma concentrations following cessation of drug intake

artículo científico publicado en 2015

Dose Prediction for Repurposing Nitazoxanide in SARS-CoV-2 Treatment or Chemoprophylaxis

artículo científico publicado en 2020

Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis

artículo científico publicado en 2020

Down regulation of multidrug resistance protein-1 expression in patients with early rheumatoid arthritis exposed to methotrexate as a first disease-modifying antirheumatic drug.

artículo científico publicado en 2006

Drug delivery strategies and systems for HIV/AIDS pre-exposure prophylaxis and treatment

artículo científico publicado en 2015

Drug-regulated expression of Plasmodium falciparum P-glycoprotein homologue 1: a putative role for nuclear receptors.

artículo científico publicado en 2008

Efavirenz Is Predicted To Accumulate in Brain Tissue: an In Silico, In Vitro, and In Vivo Investigation

artículo científico publicado en 2016

Effect of SLCO1B1 Polymorphisms on Rifabutin Pharmacokinetics in African HIV-Infected Patients with Tuberculosis.

artículo científico publicado en 2015

Effect of diurnal variation, CYP2B6 genotype and age on the pharmacokinetics of nevirapine in African children

artículo científico publicado en 2016

Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells

artículo científico publicado en 2010

Emerging nanomedicine applications and manufacturing: progress and challenges

artículo científico publicado en 2016

Erratum for Siccardi et al., Validation of Computational Approaches for Antiretroviral Dose Optimization

artículo científico publicado en 2016

Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults

artículo científico publicado en 2012

Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance

artículo científico publicado en 2006

Expression of P-glycoprotein, multidrug-resistance proteins 1 and 2 in CEM, CEM(VBL), CEM(E1000), MDCKII(MRP1) and MDCKII(MRP2) cell lines

artículo científico publicado en 2003

Facile synthesis of complex multi-component organic and organic–magnetic inorganic nanocomposite particles

article

Factors impacting the expression of membrane-bound proteins in lymphocytes from HIV-positive subjects

article

Flow cytometric analysis of the physical and protein-binding characteristics of solid drug nanoparticle suspensions

Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4.

artículo científico publicado en 2004

Genetic Determinants of the Pharmacokinetic Variability of Rifampin in Malawian Adults with Pulmonary Tuberculosis

artículo científico publicado en 2017

Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction

artículo científico publicado en 2011

HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms

artículo científico publicado en 2010

Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort

artículo científico publicado en 2010

High-throughput nanoprecipitation of the organic antimicrobial triclosan and enhancement of activity against Escherichia coli

article

Hyperbranched polydendrons: a new controlled macromolecular architecture with self-assembly in water and organic solvents

article

Hyperbranched polydendrons: a new nanomaterials platform with tuneable permeation through model gut epithelium

artículo científico publicado en 2014

IFN-γ 874A>T Genotype Is Associated With Higher CCR5 Expression in Peripheral Blood Mononuclear Cells From HIV+ Patients

article

Impact of CYP2B6 983T>C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients

artículo científico publicado en 2008

Impact of efavirenz pharmacokinetics and pharmacogenomics on neuropsychological performance in older HIV-infected patients

artículo científico publicado en 2016

In Silico Dose Prediction for Long-Acting Rilpivirine and Cabotegravir Administration to Children and Adolescents

artículo científico publicado en 2017

In Vitro Determination of the Immunogenic Impact of Nanomaterials on Primary Peripheral Blood Mononuclear Cells

artículo científico publicado en 2020

In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine

artículo científico publicado en 2005

Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements

artículo científico publicado en 2006

Induction of influx and efflux transporters and cytochrome P450 3A4 in primary human hepatocytes by rifampin, rifabutin, and rifapentine

artículo científico publicado en 2013

Influence of SLCO1B1 polymorphisms on lopinavir Ctrough in Serbian HIV/AIDS patients

artículo científico publicado en 2020

Inhibition of P-glycoprotein and multidrug resistance-associated proteins modulates the intracellular concentration of lopinavir in cultured CD4 T cells and primary human lymphocytes

artículo científico publicado en 2007

Integrated pharmacokinetic modelling for accelerated nanomedicine translation

scholarly article by Marco Siccardi et al published 1 January 2017 in European journal of nanomedicine

Integration of population pharmacokinetics and pharmacogenetics: an aid to optimal nevirapine dose selection in HIV-infected individuals

artículo científico publicado en 2011

Interaction of Rifampin and Darunavir-Ritonavir or Darunavir-Cobicistat In Vitro

artículo científico publicado en 2017

Interactions between tenofovir and nevirapine in CD4+ T cells and monocyte-derived macrophages restrict their intracellular accumulation.

artículo científico publicado en 2013

Interactions of antiretroviral drugs with the SLC22A1 (OCT1) drug transporter

artículo científico publicado en 2015

Intracellular 'boosting' of darunavir using known transport inhibitors in primary PBMC.

artículo científico publicado en 2009

Intracellular accumulation of efavirenz and nevirapine is independent of P-glycoprotein activity in cultured CD4 T cells and primary human lymphocytes

artículo científico publicado en 2009

Intrapatient and Interpatient Pharmacokinetic Variability of Raltegravir in the Clinical Setting

Is methanol really a bad solvent for poly(n-butyl methacrylate)? Low dispersity and high molecular weight polymers of n-butyl methacrylate synthesised via ATRP in anhydrous methanol

LC determination of carbamazepine in murine brain

artículo científico publicado en 2001

Lamotrigine is a substrate for OCT1 in brain endothelial cells

artículo científico publicado en 2011

Long-Acting Injectable Statins-Is It Time for a Paradigm Shift?

scientific article published on 24 July 2019

Long-acting injectable atovaquone nanomedicines for malaria prophylaxis.

artículo científico publicado en 2018

Lopinavir/ritonavir single agent therapy as a universal combination antiretroviral therapy stopping strategy: results from the STOP 1 and STOP 2 studies

article published in 2011

Maraviroc is a substrate for OATP1B1 in vitro and maraviroc plasma concentrations are influenced by SLCO1B1 521 T>C polymorphism

artículo científico publicado en 2010

Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients

artículo científico publicado en 2013

Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry

artículo científico publicado en 2015

Mitochondria are sensors for HIV drugs

artículo científico publicado en 2005

Multicomponent Organic Nanoparticles for Fluorescence Studies in Biological Systems

article

Multiple and Co-Nanoprecipitation Studies of Branched Hydrophobic Copolymers and A–B Amphiphilic Block Copolymers, Allowing Rapid Formation of Sterically Stabilized Nanoparticles in Aqueous Media

Nanoformulation strategies for the enhanced oral bioavailability of antiretroviral therapeutics

artículo científico

Nanomedicine: Not a case of “One size fits all”

scholarly article by Steven P. Rannard & Andrew Owen published October 2009 in Nano Today

Nanomedicines for HIV therapy

artículo científico publicado en 2013

Neuroinvasion and Neurotropism by SARS-CoV-2 Variants in the K18-hACE2 Mouse

artículo científico publicado en 2022

New approaches to antiretroviral drug delivery: challenges and opportunities associated with the use of long-acting injectable agents

artículo científico

No relationship between drug transporter genetic variants and tenofovir plasma concentrations or changes in glomerular filtration rate in HIV-infected adults

artículo científico publicado en 2015

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

artículo científico publicado en 2011

Once daily maraviroc 300 mg or 150 mg in combination with ritonavir-boosted darunavir 800/100 mg.

artículo científico

Partial mitigation of gold nanoparticle interactions with human lymphocytes by surface functionalization with a ‘mixed matrix’

article by Neill J Liptrott et al published November 2014 in Nanomedicine

Pharmacogenetic associations with plasma efavirenz concentrations and clinical correlates in a retrospective cohort of Ghanaian HIV-infected patients

artículo científico publicado en 2013

Pharmacogenetics of HIV therapy

artículo científico publicado en 2006

Pharmacogenetics of antiretroviral agents

artículo científico publicado en 2008

Pharmacogenetics of nevirapine excretion into breast milk and infants' exposure through breast milk versus postexposure prophylaxis.

artículo científico publicado en 2016

Pharmacogenetics of pregnancy-induced changes in efavirenz pharmacokinetics

artículo científico publicado en 2015

Pharmacokinetic and Pharmacodynamic Comparison of Once-Daily Efavirenz (400 mg vs. 600 mg) in Treatment-Naïve HIV-Infected Patients: Results of the ENCORE1 Study

artículo científico publicado en 2015

Pharmacokinetic and pharmacodynamic analysis of efavirenz dose reduction using an in vitro-in vivo extrapolation model

artículo científico publicado en 2012

Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV.

artículo científico publicado en 2015

Physiologically based pharmacokinetic models for the optimization of antiretroviral therapy: recent progress and future perspective

Plasma HIV-1 RNA detection below 50 copies/ml and risk of virologic rebound in patients receiving highly active antiretroviral therapy

artículo científico publicado en 2012

Plasmodium falciparum and dihydrofolate reductase I164L mutations in Africa

artículo científico publicado en 2009

Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure

artículo científico publicado en 2008

Population pharmacokinetic analysis and pharmacogenetics of raltegravir in HIV-positive and healthy individuals

artículo científico publicado en 2012

Population pharmacokinetic modeling of the association between 63396C->T pregnane X receptor polymorphism and unboosted atazanavir clearance

artículo científico publicado en 2010

Population pharmacokinetics of efavirenz in an unselected cohort of HIV-1-infected individuals

artículo científico publicado en 2006

Potential effect of pharmacogenetics on maternal, fetal and infant antiretroviral drug exposure during pregnancy and breastfeeding.

artículo científico

Predicting intestinal absorption of raltegravir using a population-based ADME simulation

artículo científico publicado en 2013

Prediction of drug-drug interactions between various antidepressants and efavirenz or boosted protease inhibitors using a physiologically based pharmacokinetic modelling approach

artículo científico publicado en 2013

Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study

artículo científico publicado en 2009

Pregnancy affects nevirapine pharmacokinetics: evidence from a CYP2B6 genotype-guided observational study.

artículo científico publicado en 2016

Prevalence of potential drug-drug interactions involving antiretroviral drugs in a large Kenyan cohort

artículo científico publicado en 2011

Prioritisation of potential anti-SARS-CoV-2 drug repurposing opportunities based on ability to achieve adequate target site concentrations derived from their established human pharmacokinetics

artículo científico publicado en 2020

RXRγ gene variants are associated with HIV lipodystrophy

artículo científico publicado en 2013

Raltegravir is a substrate for SLC22A6: a putative mechanism for the interaction between raltegravir and tenofovir

artículo científico publicado en 2010

Reactions of hydrophobic organic nanoparticle mixtures in water: nanoparticle-on-nanoparticle oxidative dye bleaching

article

Regulation of CYP3A4 and CYP3A5 expression and modulation of "intracrine" metabolism of androgens in prostate cells by liganded vitamin D receptor

artículo científico publicado en 2012

Relationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver

artículo científico publicado en 2005

Research capacity. Enabling the genomic revolution in Africa

artículo científico publicado en 2014

Rilpivirine inhibits drug transporters ABCB1, SLC22A1, and SLC22A2 in vitro

artículo científico publicado en 2013

Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies

article

Sensitive assessment of the virologic outcomes of stopping and restarting non-nucleoside reverse transcriptase inhibitor-based antiretroviral therapy

artículo científico publicado en 2013

Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum

artículo científico publicado en 2011

Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate.

artículo científico publicado en 2017

Simultaneous pharmacogenetics-based population pharmacokinetic analysis of darunavir and ritonavir in HIV-infected patients

artículo científico publicado en 2013

Simultaneous population pharmacokinetic modelling of atazanavir and ritonavir in HIV-infected adults and assessment of different dose reduction strategies

artículo científico publicado en 2013

Sound understanding of environmental, health and safety, clinical, and market aspects is imperative to clinical translation of nanomedicines

artículo científico publicado en 2017

Special issue of BJP on nanomedicine

artículo científico publicado en 2014

Special populations and pharmacogenetic issues in tuberculosis drug development and clinical research

artículo científico publicado en 2015

Stable, polymer-directed and SPION-nucleated magnetic amphiphilic block copolymer nanoprecipitates with readily reversible assembly in magnetic fields

artículo científico publicado en 2016

Strengths, weaknesses, opportunities and challenges for long acting injectable therapies: Insights for applications in HIV therapy

artículo científico publicado en 2016

Synthesis, nanoprecipitation and pH sensitivity of amphiphilic linear–dendritic hybrid polymers and hyperbranched-polydendrons containing tertiary amine functional dendrons

artículo científico publicado en 2015

Tacrine-induced liver damage: an analysis of 19 candidate genes

artículo científico publicado en 2007

The Application of Nanotechnology to Drug Delivery in Medicine

The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein.

artículo científico publicado en 2011

The Effect of Gene Variants on Levonorgestrel Pharmacokinetics When Combined With Antiretroviral Therapy Containing Efavirenz or Nevirapine.

artículo científico publicado en 2017

The SLCO1B1 rs4149032 polymorphism is highly prevalent in South Africans and is associated with reduced rifampin concentrations: dosing implications.

artículo científico publicado en 2011

The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes

artículo científico publicado en 2009

The application of nanotechnology in medicine: treatment and diagnostics

The effects of protease inhibitors and nonnucleoside reverse transcriptase inhibitors on p-glycoprotein expression in peripheral blood mononuclear cells in vitro

artículo científico publicado en 2003

The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC.

artículo científico publicado en 2009

The impact of genetic polymorphisms on the pharmacokinetics of efavirenz in African children

artículo científico publicado en 2016

The impact of host pharmacogenetics on antiretroviral drug disposition

artículo científico publicado en 2006

The impact of pharmacogenetics on HIV therapy

artículo científico publicado en 2009

The implications of P-glycoprotein in HIV: friend or foe?

artículo científico publicado en 2005

The mechanisms that control intracellular penetration of the HIV protease inhibitors

artículo científico publicado en 2003

The relationships of ABCB1 3435C>T and CYP2B6 516G>T with high-density lipoprotein cholesterol in HIV-infected patients receiving Efavirenz.

artículo científico publicado en 2009

The role of cytokines in the regulation of drug disposition: extended functional pleiotropism? ⬇️

artículo científico publicado el 8 de febrero de 2011

The role of drug transporters in the kidney: lessons from tenofovir

artículo científico publicado en 2014

Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation

artículo científico publicado en 2015

Toxicity and inflammatory response in Swiss albino mice after intraperitoneal and oral administration of polyurethane nanoparticles.

artículo científico publicado en 2016

Transport of gabapentin by LAT1 (SLC7A5).

artículo científico publicado en 2013

Use of in vitro to in vivo extrapolation to predict the optimal strategy for patients switching from efavirenz to maraviroc or nevirapine.

artículo científico publicado en 2015

Validation and clinical application of a method to quantify efavirenz in cervicovaginal secretions from flocked swabs using liquid chromatography tandem mass spectrometry

artículo científico publicado en 2022

Validation and clinical application of a method to quantify efavirenz in cervicovaginal secretions from flocked swabs using liquid chromatography tandem mass spectrometry

artículo científico publicado en 2021

Validation and clinical application of a method to quantify nevirapine in dried blood spots and dried breast-milk spots.

artículo científico publicado en 2015

Validation of Computational Approaches for Antiretroviral Dose Optimization

artículo científico publicado en 2016

Whole-blood cultures from renal-transplant patients stimulated ex vivo show that the effects of cyclosporine on lymphocyte proliferation are related to P-glycoprotein expression

artículo científico publicado en 2004

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