Lista de obras - David A Harris - Dominio Público Uruguay

A C-terminal membrane anchor affects the interactions of prion proteins with lipid membranes

artículo científico publicado en 2014

A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: A practical guide

artículo científico publicado en 2010

A Mutant Prion Protein Displays an Aberrant Membrane Association When Expressed in Cultured Cells ⬇️

artículo científico publicado el 13 de octubre de 1995

A Neuronal Culture System to Detect Prion Synaptotoxicity

artículo científico publicado en 2016

A Transmembrane Form of the Prion Protein Is Localized in the Golgi Apparatus of Neurons

artículo científico publicado en 2005

A deleted prion protein that is neurotoxic in vivo is localized normally in cultured cells

artículo científico publicado en 2008

A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits.

artículo científico publicado en 1994

A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death

artículo científico publicado en 2010

A murine model of a familial prion disease.

artículo científico publicado en 2003

A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity

artículo científico publicado en 2013

A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation.

artículo científico publicado en 2011

A nine amino acid domain is essential for mutant prion protein toxicity

artículo científico publicado en 2011

A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.

artículo científico publicado en 2009

A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells

artículo científico publicado en 1993

A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity ⬇️

artículo científico publicado el 1 de septiembre de 1991

A transmembrane form of the prion protein contains an uncleaved signal peptide and is retained in the endoplasmic Reticulum.

artículo científico publicado en 2001

A wild-type prion protein does not acquire properties of the scrapie isoform when coexpressed with a mutant prion protein in cultured cells ⬇️

artículo científico publicado el 1 de diciembre de 1997

Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo.

artículo científico publicado en 2016

Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent.

artículo científico publicado en 2008

Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities.

artículo científico publicado en 2008

An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo

artículo científico publicado en 2013

An inter-domain regulatory mechanism controls toxic activities of PrPC.

artículo científico publicado en 2017

Analysis of the mechanism of fast axonal transport by intracellular injection of potentially inhibitory macromolecules: evidence for a possible role of actin filaments

artículo científico publicado en 1980

Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease.

artículo científico publicado en 2004

Biosynthesis and cellular processing of the prion protein.

artículo científico publicado en 2001

Blockade of glycosylation promotes acquisition of scrapie-like properties by the prion protein in cultured cells

scientific article published on 01 August 1997

Brain copper content and cuproenzyme activity do not vary with prion protein expression level

scientific article published on 01 March 2000

Brevin, a serum protein that acts on the barbed end of actin filaments

scientific article published on 01 December 1983

Cell surface expression of the prion protein in yeast does not alter copper utilization phenotypes

artículo científico publicado en 2004

Cellular and transgenic models of familial prion diseases.

artículo científico publicado en 2001

Cellular prion protein targets amyloid-β fibril ends via its C-terminal domain to prevent elongation

artículo científico publicado en 2017

Characterization of brevin, a serum protein that shortens actin filaments.

artículo científico publicado en 1981

Cloning of non-polyadenylated RNAs from rat brain.

artículo científico publicado en 1991

Copper and zinc cause delivery of the prion protein from the plasma membrane to a subset of early endosomes and the Golgi

artículo científico publicado en 2003

Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations

artículo científico publicado en 2005

Differential activation of myotube nuclei following exposure to an acetylcholine receptor-inducing factor

scientific article published in Nature

Doppel induces degeneration of cerebellar Purkinje cells independently of Bax

artículo científico publicado en 2007

Fishing for prion protein function

artículo científico publicado en 2009

GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice

artículo científico publicado en 2004

Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans

artículo científico publicado en 2007

Identification of Anti-prion Compounds using a Novel Cellular Assay.

artículo científico publicado en 2016

Identification of anti-prion drugs and targets using toxicity-based assays

scientific article published on 23 January 2019

Identification of intermediate steps in the conversion of a mutant prion protein to a scrapie-like form in cultured cells

scientific article published on 01 April 1997

Immunopurification of pathological prion protein aggregates

artículo científico publicado en 2009

Ion channels induced by the prion protein: mediators of neurotoxicity.

artículo científico publicado en 2012

Localization of the mRNA for a chicken prion protein by in situ hybridization

artículo científico publicado en 1993

Mammalian prion protein suppresses Bax-induced cell death in yeast

scientific journal article

Mechanisms of prion-induced neurodegeneration.

artículo científico publicado en 2016

Molecular distinction between pathogenic and infectious properties of the prion protein

artículo científico publicado en 2003

Multiple biochemical similarities between infectious and non-infectious aggregates of a prion protein carrying an octapeptide insertion

artículo científico publicado en 2007

Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation

artículo científico publicado en 2003

Mutant and infectious prion proteins display common biochemical properties in cultured cells.

artículo científico publicado en 1996

Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway

artículo científico publicado en 2009

Mutational analysis of topological determinants in prion protein (PrP) and measurement of transmembrane and cytosolic PrP during prion infection

artículo científico publicado en 2003

N-terminally deleted forms of the prion protein activate both Bax-dependent and Bax-independent neurotoxic pathways.

artículo científico publicado en 2007

Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.

artículo científico publicado en 2007

Nerve growth factor-induced differentiation does not alter the biochemical properties of a mutant prion protein expressed in PC12 cells

artículo científico publicado en 2000

Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein.

artículo científico publicado en 2005

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

artículo científico publicado en 1998

New insights into prion structure and toxicity.

artículo científico publicado en 2006

Non-infectious aggregates of the prion protein react with several PrPSc-directed antibodies.

artículo científico publicado en 2008

Optimal promoter usage for lentiviral vector-mediated transduction of cultured central nervous system cells.

artículo científico publicado en 2010

Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons

artículo científico publicado en 2003

PrP-dependent cell adhesion in N2a neuroblastoma cells.

artículo científico publicado en 2002

Prion diseases.

artículo científico publicado en 2000

Prion neurotoxicity

scientific article published on 17 January 2019

Prion neurotoxicity: insights from prion protein mutants

artículo científico publicado en 2009

Prion permissive pathways: extracellular matrix genes control susceptibility to prion infection

artículo científico publicado en 2014

Prion protein at the crossroads of physiology and disease.

artículo científico publicado en 2011

Prion protein lacks robust cytoprotective activity in cultured cells

artículo científico publicado en 2008

Prion protein repeat expansion results in increased aggregation and reveals phenotypic variability.

artículo científico publicado en 2007

Prion protein with an insertional mutation accumulates on axonal and dendritic plasmalemma and is associated with distinctive ultrastructural changes.

artículo científico publicado en 2009

Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice

artículo científico publicado en 2007

Prions activate a p38 MAPK synaptotoxic signaling pathway

scholarly article published by Thibaut Imberdis in 2018

Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites.

artículo científico publicado en 1993

Reversion of prion protein conformational changes by synthetic b-sheet breaker peptides

scientific article published in The Lancet

Studies on the mechanism of fast axoplasmic transport using microinjection into single giant neurons

artículo científico publicado en 1982

Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein

artículo científico publicado en 2000

Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells.

artículo científico publicado en 1995

Synthetic Prions Provide Clues for Understanding Prion Diseases.

artículo científico publicado en 2016

Targeting the cellular prion protein to treat neurodegeneration.

artículo científico publicado en 2012

The N-terminal domain of a glycolipid-anchored prion protein is essential for its endocytosis via clathrin-coated pits

artículo científico publicado en 1995

The N-terminal, polybasic region is critical for prion protein neuroprotective activity

artículo científico publicado en 2011

The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc).

artículo científico publicado en 2012

The N-terminus of the prion protein is a toxic effector regulated by the C-terminus.

artículo científico publicado en 2017

The cellular prion protein (PrP(C)): its physiological function and role in disease

artículo científico publicado en 2007

The neuroprotective effect of Klotho is mediated via regulation of members of the redox system

artículo científico publicado en 2014

The neurotoxicity of prion protein (PrP) peptide 106-126 is independent of the expression level of PrP and is not mediated by abnormal PrP species.

artículo científico publicado en 2005

The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells

artículo científico publicado en 2012

Trafficking, turnover and membrane topology of PrP.

artículo científico publicado en 2003

Two mutant prion proteins expressed in cultured cells acquire biochemical properties reminiscent of the scrapie isoform.

artículo científico publicado en 1996

Visualization of prion infection in transgenic mice expressing green fluorescent protein-tagged prion protein.

artículo científico publicado en 2005

Lista de obras de David A Harris

A C-terminal membrane anchor affects the interactions of prion proteins with lipid membranes

A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: A practical guide

A Mutant Prion Protein Displays an Aberrant Membrane Association When Expressed in Cultured Cells ⬇️

A Neuronal Culture System to Detect Prion Synaptotoxicity

A Transmembrane Form of the Prion Protein Is Localized in the Golgi Apparatus of Neurons

A deleted prion protein that is neurotoxic in vivo is localized normally in cultured cells

A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits.

A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death

A murine model of a familial prion disease.

A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity

A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation.

A nine amino acid domain is essential for mutant prion protein toxicity

A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.

A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells

A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity ⬇️

A transmembrane form of the prion protein contains an uncleaved signal peptide and is retained in the endoplasmic Reticulum.

A wild-type prion protein does not acquire properties of the scrapie isoform when coexpressed with a mutant prion protein in cultured cells ⬇️

Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo.

Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent.

Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities.

An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo

An inter-domain regulatory mechanism controls toxic activities of PrPC.

Analysis of the mechanism of fast axonal transport by intracellular injection of potentially inhibitory macromolecules: evidence for a possible role of actin filaments

Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease.

Biosynthesis and cellular processing of the prion protein.

Blockade of glycosylation promotes acquisition of scrapie-like properties by the prion protein in cultured cells

Brain copper content and cuproenzyme activity do not vary with prion protein expression level

Brevin, a serum protein that acts on the barbed end of actin filaments

Cell surface expression of the prion protein in yeast does not alter copper utilization phenotypes

Cellular and transgenic models of familial prion diseases.

Cellular prion protein targets amyloid-β fibril ends via its C-terminal domain to prevent elongation

Characterization of brevin, a serum protein that shortens actin filaments.

Cloning of non-polyadenylated RNAs from rat brain.

Copper and zinc cause delivery of the prion protein from the plasma membrane to a subset of early endosomes and the Golgi

Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations

Differential activation of myotube nuclei following exposure to an acetylcholine receptor-inducing factor

Doppel induces degeneration of cerebellar Purkinje cells independently of Bax

Fishing for prion protein function

GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice

Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans

Identification of Anti-prion Compounds using a Novel Cellular Assay.

Identification of anti-prion drugs and targets using toxicity-based assays

Identification of intermediate steps in the conversion of a mutant prion protein to a scrapie-like form in cultured cells

Immunopurification of pathological prion protein aggregates

Ion channels induced by the prion protein: mediators of neurotoxicity.

Localization of the mRNA for a chicken prion protein by in situ hybridization

Mammalian prion protein suppresses Bax-induced cell death in yeast

Mechanisms of prion-induced neurodegeneration.

Molecular distinction between pathogenic and infectious properties of the prion protein

Multiple biochemical similarities between infectious and non-infectious aggregates of a prion protein carrying an octapeptide insertion

Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation

Mutant and infectious prion proteins display common biochemical properties in cultured cells.

Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway

Mutational analysis of topological determinants in prion protein (PrP) and measurement of transmembrane and cytosolic PrP during prion infection

N-terminally deleted forms of the prion protein activate both Bax-dependent and Bax-independent neurotoxic pathways.

Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.

Nerve growth factor-induced differentiation does not alter the biochemical properties of a mutant prion protein expressed in PC12 cells

Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein.

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

New insights into prion structure and toxicity.

Non-infectious aggregates of the prion protein react with several PrPSc-directed antibodies.

Optimal promoter usage for lentiviral vector-mediated transduction of cultured central nervous system cells.

Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons

PrP-dependent cell adhesion in N2a neuroblastoma cells.

Prion diseases.

Prion neurotoxicity

Prion neurotoxicity: insights from prion protein mutants

Prion permissive pathways: extracellular matrix genes control susceptibility to prion infection

Prion protein at the crossroads of physiology and disease.

Prion protein lacks robust cytoprotective activity in cultured cells

Prion protein repeat expansion results in increased aggregation and reveals phenotypic variability.

Prion protein with an insertional mutation accumulates on axonal and dendritic plasmalemma and is associated with distinctive ultrastructural changes.

Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice

Prions activate a p38 MAPK synaptotoxic signaling pathway

Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites.

Reversion of prion protein conformational changes by synthetic b-sheet breaker peptides

Studies on the mechanism of fast axoplasmic transport using microinjection into single giant neurons

Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein

Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells.