Lista de obras - Frank Dekker - Dominio Público Uruguay

A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices

artículo científico publicado en 2017

A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices ⬇️

scientific article published on 27 February 2019

A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1

artículo científico publicado en 2019

A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [¹⁸F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging.

artículo científico publicado en 2014

A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

artículo científico publicado en 2009

Activity-Based Probes for 15-Lipoxygenase-1.

artículo científico publicado en 2016

Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the Syk SH2 domains with equally high affinity as the natural ligand

artículo científico publicado en 2003

Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases

artículo científico publicado en 2012

Antibody-Free Detection of Protein Tyrosine Nitration in Tissue Sections

scientific article published on 11 July 2011

Aqueous oxidative Heck reaction as a protein-labeling strategy

artículo científico publicado en 2013

Basic nuclear processes affected by histone acetyltransferases and histone deacetylase inhibitors.

artículo científico publicado en 2013

Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study.

artículo científico publicado en 2005

Catalytic asymmetric total synthesis of (S)-(-)-zearalenone, a novel lipoxygenase inhibitor

artículo científico publicado en 2013

Characterization of a thermostable methylaspartate ammonia lyase from Carboxydothermus hydrogenoformans

artículo científico publicado en 2011

Cyclic phosphopeptides for interference with Grb2 SH2 domain signal transduction prepared by ring-closing metathesis and phosphorylation

scientific article published on 01 October 2003

Delivery of epidrugs

artículo científico

Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties

artículo científico publicado en 2016

Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC).

artículo científico publicado en 2005

Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups

artículo científico publicado en 2017

Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design

artículo científico publicado en 2011

Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection.

artículo científico publicado en 2013

Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids

artículo científico publicado en 2012

Enhancement of the enantioselectivity of carboxylesterase A by structure-based mutagenesis

scientific article published on 12 January 2012

Enrichment and Detection of Tyrosine-Nitrated Proteins

artículo científico publicado en 2012

Enzyme kinetics and inhibition of histone acetyltransferase KAT8.

artículo científico publicado en 2015

HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity.

artículo científico publicado en 2016

Histone acetyl transferases as emerging drug targets.

artículo científico publicado en 2009

Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation.

artículo científico publicado en 2011

Histone acetyltransferases: challenges in targeting bi-substrate enzymes

artículo científico publicado en 2016

Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation

artículo científico publicado en 2016

Identification of 6-benzyloxysalicylates as a novel class of inhibitors of 15-lipoxygenase-1.

artículo científico publicado en 2015

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

artículo científico publicado en 2011

Identification of potential antivirulence agents by substitution-oriented screening for inhibitors of Streptococcus pyogenes sortase A

artículo científico publicado en 2018

Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative

artículo científico publicado en 2010

Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage

artículo científico publicado en 2012

Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked

artículo científico publicado en 2014

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras

artículo científico publicado en 2011

Inhibition of PCAF by anacardic acid derivative leads to apoptosis and breaks resistance to DNA damage in BCR-ABL-expressing cells

artículo científico publicado en 2013

Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones.

artículo científico publicado en 2008

Inhibitory selectivity among class I HDACs has a major impact on inflammatory gene expression in macrophages

artículo científico publicado en 2019

Isothiazolones; thiol-reactive inhibitors of cysteine protease cathepsin B and histone acetyltransferase PCAF

scientific article published on 25 January 2011

Light-Controlled Histone Deacetylase (HDAC) Inhibitors: Towards Photopharmacological Chemotherapy

artículo científico publicado en 2015

Metabolic alkene labeling and in vitro detection of histone acylation via the aqueous oxidative Heck reaction

artículo científico publicado en 2015

Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity

artículo científico publicado en 2019

Photoactivation provides a mechanistic explanation for pan-assay interference behaviour of 2-aminopyrroles in lipoxygenase inhibition

artículo científico publicado en 2017

Protein flexibility and ligand rigidity: a thermodynamic and kinetic study of ITAM-based ligand binding to Syk tandem SH2.

artículo científico publicado en 2005

Raft protein clustering alters N-Ras membrane interactions and activation pattern.

artículo científico publicado en 2011

Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties

artículo científico publicado en 2015

Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase

artículo científico publicado en 2009

Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry

artículo científico publicado en 2019

Replacement of the intervening amino acid sequence of a Syk-binding diphosphopeptide by a nonpeptide spacer with preservation of high affinity

artículo científico publicado en 2002

Role of solution conformation and flexibility of short peptide ligands that bind to the p56(lck) SH2 domain.

artículo científico publicado en 2003

SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells

artículo científico publicado en 2019

SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans

artículo científico publicado en 2020

Site-specific quantification of lysine acetylation in the N-terminal tail of histone H4 using a double-labelling, targeted UHPLC MS/MS approach

artículo científico publicado en 2016

Small Multitarget Molecules Incorporating the Enone Moiety

artículo científico publicado en 2019

Small molecule inhibition of protein depalmitoylation as a new approach towards downregulation of oncogenic Ras signalling

artículo científico publicado en 2010

Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases.

artículo científico publicado en 2013

Small-molecule inhibition of APT1 affects Ras localization and signaling

artículo científico publicado en 2010

Stability of energy metabolites-An often overlooked issue in metabolomics studies: A review.

artículo científico

Structure-activity relationships for binding of 4-substituted triazole-phenols to macrophage migration inhibitory factor (MIF)

artículo científico publicado en 2019

Surface plasmon resonance thermodynamic and kinetic analysis as a strategic tool in drug design. Distinct ways for phosphopeptides to plug into Src- and Grb2 SH2 domains.

artículo científico publicado en 2005

Synthesis of Peptoid-Based Class I-Selective Histone Deacetylase Inhibitors with Chemosensitizing Properties

scientific article published on 17 December 2019

The Process and Strategy for Developing Selective Histone Deacetylase 3 Inhibitors.

artículo científico publicado en 2018

The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases.

artículo científico publicado en 2015

Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity

artículo científico publicado en 2016

Lista de obras de Frank Dekker

A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices

A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices ⬇️

A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1

A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [¹⁸F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging.

A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

Activity-Based Probes for 15-Lipoxygenase-1.

Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the Syk SH2 domains with equally high affinity as the natural ligand

Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases

Antibody-Free Detection of Protein Tyrosine Nitration in Tissue Sections

Aqueous oxidative Heck reaction as a protein-labeling strategy

Basic nuclear processes affected by histone acetyltransferases and histone deacetylase inhibitors.

Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study.

Catalytic asymmetric total synthesis of (S)-(-)-zearalenone, a novel lipoxygenase inhibitor

Characterization of a thermostable methylaspartate ammonia lyase from Carboxydothermus hydrogenoformans

Cyclic phosphopeptides for interference with Grb2 SH2 domain signal transduction prepared by ring-closing metathesis and phosphorylation

Delivery of epidrugs

Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties

Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC).

Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups

Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design

Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection.

Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids

Enhancement of the enantioselectivity of carboxylesterase A by structure-based mutagenesis

Enrichment and Detection of Tyrosine-Nitrated Proteins

Enzyme kinetics and inhibition of histone acetyltransferase KAT8.

HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity.

Histone acetyl transferases as emerging drug targets.

Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation.

Histone acetyltransferases: challenges in targeting bi-substrate enzymes

Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation

Identification of 6-benzyloxysalicylates as a novel class of inhibitors of 15-lipoxygenase-1.

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

Identification of potential antivirulence agents by substitution-oriented screening for inhibitors of Streptococcus pyogenes sortase A

Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative

Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage

Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras

Inhibition of PCAF by anacardic acid derivative leads to apoptosis and breaks resistance to DNA damage in BCR-ABL-expressing cells

Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones.

Inhibitory selectivity among class I HDACs has a major impact on inflammatory gene expression in macrophages

Isothiazolones; thiol-reactive inhibitors of cysteine protease cathepsin B and histone acetyltransferase PCAF

Light-Controlled Histone Deacetylase (HDAC) Inhibitors: Towards Photopharmacological Chemotherapy

Metabolic alkene labeling and in vitro detection of histone acylation via the aqueous oxidative Heck reaction

Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity

Photoactivation provides a mechanistic explanation for pan-assay interference behaviour of 2-aminopyrroles in lipoxygenase inhibition

Protein flexibility and ligand rigidity: a thermodynamic and kinetic study of ITAM-based ligand binding to Syk tandem SH2.

Raft protein clustering alters N-Ras membrane interactions and activation pattern.

Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties

Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase

Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry

Replacement of the intervening amino acid sequence of a Syk-binding diphosphopeptide by a nonpeptide spacer with preservation of high affinity

Role of solution conformation and flexibility of short peptide ligands that bind to the p56(lck) SH2 domain.

SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells

SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans

Site-specific quantification of lysine acetylation in the N-terminal tail of histone H4 using a double-labelling, targeted UHPLC MS/MS approach

Small Multitarget Molecules Incorporating the Enone Moiety

Small molecule inhibition of protein depalmitoylation as a new approach towards downregulation of oncogenic Ras signalling

Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases.

Small-molecule inhibition of APT1 affects Ras localization and signaling

Stability of energy metabolites-An often overlooked issue in metabolomics studies: A review.

Structure-activity relationships for binding of 4-substituted triazole-phenols to macrophage migration inhibitory factor (MIF)

Surface plasmon resonance thermodynamic and kinetic analysis as a strategic tool in drug design. Distinct ways for phosphopeptides to plug into Src- and Grb2 SH2 domains.

Synthesis of Peptoid-Based Class I-Selective Histone Deacetylase Inhibitors with Chemosensitizing Properties

The Process and Strategy for Developing Selective Histone Deacetylase 3 Inhibitors.

The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases.

Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity