Lista de obras - Francesco Simone Ruggeri

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

artículo científico publicado en 2016

AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species.

scientific article published on 18 May 2016

Amyloid single-cell cytotoxicity assays by nanomotion detection

artículo científico publicado en 2017

Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis

artículo científico publicado en 2019

Atomic force microscopy for single molecule characterisation of protein aggregation

artículo científico publicado en 2019

Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition

artículo científico publicado en 2020

Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy

scientific article published on 12 September 2019

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

artículo científico publicado en 2018

Concentration-dependent and surface-assisted self-assembly properties of a bioactive estrogen receptor α-derived peptide

artículo científico publicado en 2014

Controlled self-assembly of plant proteins into high-performance multifunctional nanostructured films

artículo científico publicado en 2021

Detecting nanoscale vibrations as signature of life

artículo científico publicado en 2014

Determination of Polypeptide Conformation with Nanoscale Resolution in Water

artículo científico publicado en 2018

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

article

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

artículo científico publicado en 2018

Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules

scientific article published on 06 March 2019

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils

article published in the Proceedings of the National Academy of Sciences of the United States of America

Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy

scientific article published on 30 August 2018

Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization

artículo científico publicado en 2015

Infrared nanospectroscopic mapping of a single metaphase chromosome

artículo científico publicado en 2019

Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation

artículo científico publicado en 2015

Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method

artículo científico publicado en 2012

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity

artículo científico publicado en 2018

Molecular determinants of the interaction of EGCG with ordered and disordered proteins

scientific article published on 30 March 2018

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.

artículo científico publicado en 2017

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.

artículo científico publicado en 2018

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

artículo científico publicado en 2017

Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection

scientific article published on 25 August 2017

Nanoscale spatially resolved infrared spectra from single microdroplets ⬇️

artículo científico publicado en 2014

Nanoscale studies link amyloid maturity with polyglutamine diseases onset.

scientific article published on 08 August 2016

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

artículo científico publicado en 2020

Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers

artículo científico publicado en 2020

Silk micrococoons for protein stabilisation and molecular encapsulation

artículo científico publicado en 2017

Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy

artículo científico publicado en 2020

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

artículo científico publicado en 2020

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression

artículo científico publicado en 2019

Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes

scholarly article by Zhaoying Li published in September 2018

Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions

artículo científico publicado en 2018

The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity

artículo científico publicado en 2014

The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils

scientific article published on 17 March 2020

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

artículo científico publicado en 2020

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

scientific article published on 13 August 2020

Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes

scientific article published in Nature Communications

Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion

artículo científico publicado en 2018

Lista de obras de Francesco Simone Ruggeri

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species.

Amyloid single-cell cytotoxicity assays by nanomotion detection

Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis

Atomic force microscopy for single molecule characterisation of protein aggregation

Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition

Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

Concentration-dependent and surface-assisted self-assembly properties of a bioactive estrogen receptor α-derived peptide

Controlled self-assembly of plant proteins into high-performance multifunctional nanostructured films

Detecting nanoscale vibrations as signature of life

Determination of Polypeptide Conformation with Nanoscale Resolution in Water

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils

Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy

Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization

Infrared nanospectroscopic mapping of a single metaphase chromosome

Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation

Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity

Molecular determinants of the interaction of EGCG with ordered and disordered proteins

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection

Nanoscale spatially resolved infrared spectra from single microdroplets ⬇️

Nanoscale studies link amyloid maturity with polyglutamine diseases onset.

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers

Silk micrococoons for protein stabilisation and molecular encapsulation

Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression

Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes

Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions

The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity

The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes

Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion