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Lista de obras de Tetsuya Terasaki

1α,25-Dihydroxyvitamin D3 enhances cerebral clearance of human amyloid-β peptide(1-40) from mouse brain across the blood-brain barrier.

artículo científico publicado en 2011

24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression

artículo científico publicado en 2006

A carrier-mediated transport system for benzylpenicillin in isolated hepatocytes

artículo científico publicado en 1985

A functional in vitro model of rat blood-brain barrier for molecular analysis of efflux transporters

artículo científico publicado en 2007

A new in vitro model for blood-cerebrospinal fluid barrier transport studies: an immortalized choroid plexus epithelial cell line derived from the tsA58 SV40 large T-antigen gene transgenic rat.

artículo científico publicado en 2004

A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FV

artículo científico publicado en 2013

ATA2 is predominantly expressed as system A at the blood-brain barrier and acts as brain-to-blood efflux transport for L-proline

artículo científico publicado en 2002

ATP-binding cassette transporter A subfamily 8 is a sinusoidal efflux transporter for cholesterol and taurocholate in mouse and human liver

artículo científico publicado en 2018

ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-beta peptide (1-40) at the blood-brain barrier.

artículo científico publicado en 2007

ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells

artículo científico publicado en 2006

Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta

artículo científico publicado en 2009

Abnormal N-Glycosylation of a Novel Missense Creatine Transporter Mutant, G561R, Associated with Cerebral Creatine Deficiency Syndromes Alters Transporter Activity and Localization

artículo científico publicado en 2017

Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes

artículo científico publicado en 2011

Absorptive-mediated endocytosis of an adrenocorticotropic hormone (ACTH) analogue, ebiratide, into the blood-brain barrier: studies with monolayers of primary cultured bovine brain capillary endothelial cells

artículo científico publicado en 1992

Acidic amino acid transport characteristics of a newly developed conditionally immortalized rat type 2 astrocyte cell line (TR-AST).

artículo científico publicado en 2001

Acidic drug transport in vivo through the blood-brain barrier. A role of the transport carrier for monocarboxylic acids

artículo científico publicado en 1990

Actin filament-associated protein 1 (AFAP-1) is a key mediator in inflammatory signaling-induced rapid attenuation of intrinsic P-gp function in human brain capillary endothelial cells

artículo científico publicado en 2017

Activation of carrier-mediated transport of L-cystine at the blood-brain and blood-retinal barriers in vivo

artículo científico publicado en 2001

Age-related change in tissue-to-plasma partition coefficient of cefazolin for noneliminating organs in the rat.

artículo científico publicado en 1989

Age-related change of cefazolin binding to rat serum proteins and its relation to the molar ratio of free fatty acid to serum albumin

scientific article published on 01 January 1986

All-trans retinoic acid enhances gemcitabine cytotoxicity in human pancreatic cancer cell line AsPC-1 by up-regulating protein expression of deoxycytidine kinase.

artículo científico publicado en 2017

Altered expression of basement membrane-related molecules in rat brain pericyte, endothelial, and astrocyte cell lines after transforming growth factor-beta1 treatment

artículo científico publicado en 2007

Amyloid beta25-35 impairs docosahexaenoic acid efflux by down-regulating fatty acid transport protein 1 (FATP1/SLC27A1) protein expression in human brain capillary endothelial cells

scientific article published on 25 June 2019

Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier

artículo científico publicado en 2011

An application of microdialysis to drug tissue distribution study: in vivo evidence for free-ligand hypothesis and tissue binding of beta-lactam antibiotics in interstitial fluids.

artículo científico publicado en 1992

Application of Quantitative Targeted Absolute Proteomics to Profile Protein Expression Changes of Hepatic Transporters and Metabolizing Enzymes During Cholic Acid-Promoted Liver Regeneration

artículo científico publicado en 2017

Atrial natriuretic peptide is eliminated from the brain by natriuretic peptide receptor-C-mediated brain-to-blood efflux transport at the blood-brain barrier

artículo científico publicado en 2010

Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: targeted proteomic and metabolomic analyses in PK9 cells.

artículo científico publicado en 2012

Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole

artículo científico publicado en 2011

Augmented expression of the tight junction protein occludin in brain endothelial cell line TR-BBB by rat angiopoietin-1 expressed in baculovirus-infected Sf plus insect cells

artículo científico publicado en 2002

BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier

artículo científico publicado en 2008

Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency

artículo científico publicado en 2009

Beta-lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane

scientific article published on 01 February 1987

Blood-brain barrier (BBB) pharmacoproteomics: reconstruction of in vivo brain distribution of 11 P-glycoprotein substrates based on the BBB transporter protein concentration, in vitro intrinsic transport activity, and unbound fraction in plasma and

artículo científico publicado en 2011

Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2.

artículo científico publicado en 2000

Blood-brain barrier permeability of novel [D-arg2]dermorphin (1-4) analogs: transport property is related to the slow onset of antinociceptive activity in the central nervous system

artículo científico publicado en 2004

Blood-brain barrier pharmacoproteomics-based reconstruction of the in vivo brain distribution of P-glycoprotein substrates in cynomolgus monkeys

artículo científico publicado en 2014

Blood-brain barrier transport of a novel micro 1-specific opioid peptide, H-Tyr-D-Arg-Phe-beta-Ala-OH (TAPA).

artículo científico publicado en 2003

Blood-brain barrier transport of ebiratide and its uptake by cerebral neuronal cells.

artículo científico publicado en 1993

Blood-to-brain influx transport of nicotine at the rat blood-brain barrier: involvement of a pyrilamine-sensitive organic cation transport process.

artículo científico publicado en 2012

Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-retinal barrier

artículo científico publicado en 2004

Brain and heart specific alteration of methamphetamine (MAP) distribution in MAP-sensitized rat.

artículo científico publicado en 2003

Brain insulin impairs amyloid-beta(1-40) clearance from the brain.

artículo científico publicado en 2004

Brain-to-blood active transport of beta-alanine across the blood-brain barrier

artículo científico publicado en 1997

Brain-to-blood efflux transport of estrone-3-sulfate at the blood-brain barrier in rats

artículo científico publicado en 2000

Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier

artículo científico publicado en 2007

Brain-to-blood transporters for endogenous substrates and xenobiotics at the blood-brain barrier: an overview of biology and methodology

artículo científico publicado en 2005

CS-25MOLECULAR SUBCLASSIFICATION OF GLIOBLASTOMA BASED ON THE ABSOLUTE QUANTITATIVE PROTEOMICS

Carbenicillin prodrugs: kinetics of intestinal absorption competing degradation of the alpha-esters of carbenicillin and prediction of prodrug absorbability from quantitative structure-absorption rate relationship

artículo científico publicado en 1982

Carbenicillin prodrugs: stability kinetics of alpha-phenyl and alpha-indanyl esters in aqueous solution

artículo científico publicado en 1979

Carrier-mediated transport of H1-antagonist at the blood-brain barrier: a common transport system of H1-antagonists and lipophilic basic drugs

artículo científico publicado en 1994

Carrier-mediated transport of H1-antagonist at the blood-brain barrier: mepyramine uptake into bovine brain capillary endothelial cells in primary monolayer cultures

artículo científico publicado en 1994

Carrier-mediated uptake of nicotinic acid by rat intestinal brush-border membrane vesicles and relation to monocarboxylic acid transport

artículo científico publicado en 1990

Cell density-dependent mitogenic effect and -independent cellular handling of epidermal growth factor in primary cultured rat hepatocytes

scientific article published on 01 February 1997

Cell-Type-Specific Spatiotemporal Expression of Creatine Biosynthetic Enzyme S-adenosylmethionine:guanidinoacetate N-methyltransferase in Developing Mouse Brain

artículo científico publicado en 2017

Cerebral clearance of human amyloid-beta peptide (1-40) across the blood-brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes

artículo científico publicado en 2007

Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier

artículo científico publicado en 2010

Characterization of the amino acid transport of new immortalized choroid plexus epithelial cell lines: a novel in vitro system for investigating transport functions at the blood-cerebrospinal fluid barrier

artículo científico publicado en 2001

Characterization of the mechanism of zidovudine uptake by rat conditionally immortalized syncytiotrophoblast cell line TR-TBT.

artículo científico publicado en 2008

Characterization of the transport properties of a quinolone antibiotic, fleroxacin, in rat choroid plexus

artículo científico publicado en 1996

Cluster of Differentiation 46 Is the Major Receptor in Human Blood-Brain Barrier Endothelial Cells for Uptake of Exosomes Derived from Brain-Metastatic Melanoma Cells (SK-Mel-28)

artículo científico publicado en 2018

Conditionally immortalized cell lines as a new in vitro model for the study of barrier functions.

artículo científico publicado en 2001

Conditionally immortalized retinal capillary endothelial cell lines (TR-iBRB) expressing differentiated endothelial cell functions derived from a transgenic rat.

artículo científico publicado en 2001

Contribution of pannexin 1 and connexin 43 hemichannels to extracellular calcium-dependent transport dynamics in human blood-brain barrier endothelial cells.

artículo científico publicado en 2015

Contribution of parenchymal and non-parenchymal liver cells to the clearance of hepatocyte growth factor from the circulation in rats

artículo científico publicado en 1995

Contributions of degradation and brain-to-blood elimination across the blood-brain barrier to cerebral clearance of human amyloid-β peptide(1-40) in mouse brain

artículo científico publicado en 2013

Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation

scientific journal article

Correlation of Organic Cation/Carnitine Transporter 1 and Multidrug Resistance-Associated Protein 1 Transport Activities With Protein Expression Levels in Primary Cultured Human Tracheal, Bronchial, and Alveolar Epithelial Cells

artículo científico publicado en 2015

Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor.

artículo científico publicado en 2007

Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy

artículo científico publicado en 2013

Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs.

artículo científico publicado en 2017

Degradation kinetics of (+/-)-4'-ethyl-2-methyl-3-(1-pyrrolidinyl)propiophenone hydrochloride (HY-770) and structure-stability relationship among its analogues in aqueous solution

artículo científico publicado en 1989

Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease

artículo científico publicado en 2009

Differential binding of testosterone and estradiol to isoforms of sex hormone-binding globulin: selective alteration of estradiol binding in cirrhosis

artículo científico publicado en 1988

Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats

artículo científico publicado en 2005

Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo

artículo científico publicado en 2011

Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis

artículo científico publicado en 2004

Distinct roles of ezrin, radixin and moesin in maintaining the plasma membrane localizations and functions of human blood-brain barrier transporters

artículo científico publicado en 2019

Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain

artículo científico publicado en 2005

Dominant expression of androgen receptors and their functional regulation of organic anion transporter 3 in rat brain capillary endothelial cells; comparison of gene expression between the blood-brain and -retinal barriers

artículo científico publicado en 2005

Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics.

artículo científico publicado en 2017

Drug Clearance from Cerebrospinal Fluid Mediated by Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8) at Arachnoid Membrane of Rats.

artículo científico publicado en 2018

Drug Transporter Protein Quantification of Immortalized Human Lung Cell Lines Derived from Tracheobronchial Epithelial Cells (Calu-3 and BEAS2-B), Bronchiolar-Alveolar Cells (NCI-H292 and NCI-H441), and Alveolar Type II-like Cells (A549) by Liquid C

artículo científico publicado en 2015

Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier transport and antinociceptive effect

artículo científico publicado en 2010

Dysfunction of choline transport system through blood-brain barrier in stroke-prone spontaneously hypertensive rats

artículo científico publicado en 1990

Effect of extracellular water volume on the distribution kinetics of beta-lactam antibiotics as a function of age.

artículo científico publicado en 1985

Effect of receptor up-regulation on insulin pharmacokinetics in streptozotocin-treated diabetic rats

scientific article published on 01 May 1991

Effects of arginine-vasopressin fragment 4-9 on rodent cholinergic systems

artículo científico publicado en 1999

Efficient delivery of circulating poliovirus to the central nervous system independently of poliovirus receptor.

artículo científico publicado en 1997

Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier

artículo científico publicado en 2004

Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier

artículo científico publicado en 2001

Endothelial cells constituting blood-nerve barrier have highly specialized characteristics as barrier-forming cells

artículo científico publicado en 2007

Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment

artículo científico publicado en 2002

Enhancement of zidovudine uptake by dehydroepiandrosterone sulfate in rat syncytiotrophoblast cell line TR-TBT 18d-1.

artículo científico publicado en 2008

Epidermal growth factor targeting of bacteriophage to the choroid plexus for gene delivery to the central nervous system via cerebrospinal fluid

artículo científico publicado en 2010

Establishing a method to isolate rat brain capillary endothelial cells by magnetic cell sorting and dominant mRNA expression of multidrug resistance-associated protein 1 and 4 in highly purified rat brain capillary endothelial cells

artículo científico publicado en 2007

Establishment and characterization of conditionally immortalized endothelial cell lines from the thoracic duct and inferior vena cava of tsA58/EGFP double-transgenic rats

artículo científico publicado en 2006

Establishment and characterization of human peripheral nerve microvascular endothelial cell lines: a new in vitro blood-nerve barrier (BNB) model.

artículo científico publicado en 2012

Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood-brain barrier function

artículo científico publicado en 2010

Establishment of bone marrow-derived endothelial cell lines from ts-SV40 T-antigen gene transgenic rats

artículo científico publicado en 2001

Establishment of conditionally immortalized rat retinal pericyte cell lines (TR-rPCT) and their application in a co-culture system using retinal capillary endothelial cell line (TR-iBRB2).

artículo científico publicado en 2003

Evidence for creatine biosynthesis in Müller glia

artículo científico publicado en 2005

Exogenous expression of claudin-5 induces barrier properties in cultured rat brain capillary endothelial cells

artículo científico publicado en 2007

Experimental evidence of characteristic tissue distribution of adriamycin. Tissue DNA concentration as a determinant

artículo científico publicado en 1982

Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant

artículo científico publicado en 2008

Expression and regulation of L-cystine transporter, system xc-, in the newly developed rat retinal Müller cell line (TR-MUL).

artículo científico publicado en 2003

Expression of ABC-type transport proteins in human platelets

artículo científico publicado en 2010

Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood-brain barrier

artículo científico publicado en 2007

Expression of the Na+ dependent uridine transport system of rabbit small intestine: studies with mRNA-injected Xenopus laevis oocytes.

artículo científico publicado en 1993

Fgf2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus epithelial cell behaviour

artículo científico publicado en 2008

Fluids and Barriers of the CNS: a new journal encompassing Cerebrospinal Fluid Research ⬇️

artículo científico publicado el 18 de enero de 2011

From somatostatin to sandostatin: pharmacodynamics and pharmacokinetics

artículo científico publicado el 1 de septiembre de 1992

Function and regulation of taurine transport at the inner blood-retinal barrier

artículo científico publicado en 2006

Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers

scientific journal article

Functional characterization of the brain-to-blood efflux clearance of human amyloid-beta peptide (1-40) across the rat blood-brain barrier

artículo científico publicado en 2006

Functional expression of intestinal dipeptide/beta-lactam antibiotic transporter in Xenopus laevis oocytes

artículo científico publicado en 1994

Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s)

scientific journal article

GSK-3β/CREB axis mediates IGF-1-induced ECM/adhesion molecule expression, cell cycle progression and monolayer permeability in retinal capillary endothelial cells: Implications for diabetic retinopathy

artículo científico publicado en 2011

Gene expression of A6-like subgroup of ATP-binding cassette transporters in mouse brain parenchyma and microvessels.

artículo científico publicado en 2018

Gene therapy for Glut1-deficient mouse using an adeno-associated virus vector with the human intrinsic GLUT1 promoter

artículo científico publicado en 2018

Gene therapy for a mouse model of glucose transporter-1 deficiency syndrome.

artículo científico publicado en 2017

Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type, Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases

artículo científico publicado en 2014

Global and Targeted Proteomics of Prostate Cancer Cell Secretome: Combination of 2-Dimensional Image-Converted Analysis of Liquid Chromatography and Mass Spectrometry and In Silico Selection Selected Reaction Monitoring Analysis

artículo científico publicado en 2016

Hepatic uptake of octreotide, a long-acting somatostatin analogue, via a bile acid transport system

scientific article published on 01 January 1995

High Expression of UGT1A1/1A6 in Monkey Small Intestine: Comparison of Protein Expression Levels of Cytochromes P450, UDP-Glucuronosyltransferases, and Transporters in Small Intestine of Cynomolgus Monkey and Human

artículo científico publicado en 2017

Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin

artículo científico publicado en 2009

Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro

artículo científico publicado en 2006

Identification of Blood-Brain Barrier-Permeable Proteins Derived from a Peripheral Organ: In Vivo and in Vitro Evidence of Blood-to-Brain Transport of Creatine Kinase

scientific article published on 12 December 2018

Identification of IGFBP2 and IGFBP3 As Compensatory Biomarkers for CA19-9 in Early-Stage Pancreatic Cancer Using a Combination of Antibody-Based and LC-MS/MS-Based Proteomics

artículo científico publicado en 2016

Identification of blood biomarkers in glioblastoma by SWATH mass spectrometry and quantitative targeted absolute proteomics.

artículo científico publicado en 2018

Identification of transporters associated with Etoposide sensitivity of stomach cancer cell lines and methotrexate sensitivity of breast cancer cell lines by quantitative targeted absolute proteomics.

artículo científico publicado en 2012

In vitro models for the blood-brain barrier.

artículo científico publicado en 2005

In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors

artículo científico publicado en 1994

In vivo and in vitro evidence for a common carrier mediated transport of choline and basic drugs through the blood-brain barrier

artículo científico publicado en 1990

In vivo delivery of small interfering RNA targeting brain capillary endothelial cells

artículo científico publicado en 2005

In vivo evidence for brain-to-blood efflux transport of valproic acid across the blood-brain barrier

artículo científico publicado en 2002

In vivo transport of a dynorphin-like analgesic peptide, E-2078, through the blood-brain barrier: an application of brain microdialysis

artículo científico publicado el 1 de julio de 1991

In-vitro evidence for carrier-mediated uptake of acidic drugs by isolated bovine brain capillaries

artículo científico publicado en 1991

In-vivo and in-vitro evidence of a carrier-mediated efflux transport system for oestrone-3-sulphate across the blood-cerebrospinal fluid barrier

artículo científico publicado en 2000

In-vivo blood-brain barrier transport of a novel adrenocorticotropic hormone analogue, ebiratide, demonstrated by brain microdialysis and capillary depletion methods

artículo científico publicado el 1 de julio de 1992

Increased JNK phosphorylation and oxidative stress in response to increased glucose flux through increased GLUT1 expression in rat retinal endothelial cells

artículo científico publicado en 2005

Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy

artículo científico publicado en 2007

Induction of endoplasmic reticulum stress in retinal pericytes by glucose deprivation

artículo científico publicado en 2006

Inhibition of TXNIP expression in vivo blocks early pathologies of diabetic retinopathy ⬇️

artículo científico publicado el 19 de agosto de 2010

Inner Blood-Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig.

artículo científico publicado en 2017

Inner blood-retinal barrier mediates l-isomer-predominant transport of serine

artículo científico publicado en 2011

Insulin facilitates the hepatic clearance of plasma amyloid beta-peptide (1 40) by intracellular translocation of low-density lipoprotein receptor-related protein 1 (LRP-1) to the plasma membrane in hepatocytes

artículo científico publicado en 2007

Interaction of doxorubicin with nuclei isolated from rat liver and kidney

scientific article published on 01 April 1984

Internalization of basic fibroblast growth factor at the mouse blood-brain barrier involves perlecan, a heparan sulfate proteoglycan

artículo científico publicado en 2002

Intestinal brush-border transport of the oral cephalosporin antibiotic, cefdinir, mediated by dipeptide and monocarboxylic acid transport systems in rabbits

scientific article published on 01 November 1993

Investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) on pharmacokinetics and central nervous system penetration of abacavir and zidovudine in the mouse.

artículo científico publicado en 2008

Involvement of Claudin-11 in Disruption of Blood-Brain, -Spinal Cord, and -Arachnoid Barriers in Multiple Sclerosis

scientific article published on 08 July 2018

Involvement of insulin-degrading enzyme in insulin- and atrial natriuretic peptide-sensitive internalization of amyloid-β peptide in mouse brain capillary endothelial cells

artículo científico publicado en 2014

Involvement of multidrug resistance-associated protein 4 in efflux transport of prostaglandin E(2) across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins

artículo científico publicado en 2010

Involvement of organic anion transporters in the efflux of uremic toxins across the blood-brain barrier

artículo científico publicado en 2006

Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone

artículo científico publicado en 2008

Is P-glycoprotein involved in amyloid-β elimination across the blood-brain barrier in Alzheimer's disease?

artículo científico publicado en 2010

Kinetic evidence for a common transport route of benzylpenicillin and probenecid by freshly prepared hepatocytes in rats. Influence of sodium ion, organic anions, amino acids and peptides on benzylpenicillin uptake

artículo científico publicado en 1986

Kinetics of quinolone antibiotics in rats: efflux from cerebrospinal fluid to the circulation

artículo científico publicado en 1996

L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier

artículo científico publicado en 2005

LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line

artículo científico publicado en 2017

Lack of brain-to-blood efflux transport activity of low-density lipoprotein receptor-related protein-1 (LRP-1) for amyloid-beta peptide(1-40) in mouse: involvement of an LRP-1-independent pathway

artículo científico publicado en 2010

Large-scale multiplex absolute protein quantification of drug-metabolizing enzymes and transporters in human intestine, liver, and kidney microsomes by SWATH-MS: Comparison with MRM/SRM and HR-MRM/PRM.

artículo científico publicado en 2016

Liver Zonation Index of Drug Transporter and Metabolizing Enzyme Protein Expressions in Mouse Liver Acinus

artículo científico publicado en 2018

Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells

artículo científico publicado en 2002

Localization of organic anion transporting polypeptide 3 (oatp3) in mouse brain parenchymal and capillary endothelial cells.

artículo científico publicado en 2004

MCT1-mediated transport of L-lactic acid at the inner blood-retinal barrier: a possible route for delivery of monocarboxylic acid drugs to the retina

artículo científico publicado en 2001

MK2461, a Multitargeted Kinase Inhibitor, Suppresses the Progression of Pancreatic Cancer by Disrupting the Interaction Between Pancreatic Cancer Cells and Stellate Cells

artículo científico publicado en 2017

Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells.

artículo científico publicado en 2015

Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver

artículo científico publicado en 2006

Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney

artículo científico publicado en 2002

Mechanisms of intestinal absorption of the antibiotic, fosfomycin, in brush-border membrane vesicles in rabbits and humans.

artículo científico publicado en 1992

Modulation and compensation of the mRNA expression of energy related transporters in the brain of glucose transporter 1-deficient mice

artículo científico publicado en 2006

Molecular mechanisms of drug influx and efflux transport at the blood-brain barrier

artículo científico publicado en 2003

Molecular-weight-dependent, anionic-substrate-preferential transport of β-lactam antibiotics via multidrug resistance-associated protein 4.

artículo científico publicado en 2011

Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier

artículo científico publicado en 2004

Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter

artículo científico publicado en 2007

Muscle microdialysis as a model study to relate the drug concentration in tissue interstitial fluid and dialysate.

artículo científico publicado en 1991

Na(+)- and Cl(-)-dependent transport of taurine at the blood-brain barrier

scientific article published on 01 November 1995

New approaches to in vitro models of blood-brain barrier drug transport.

artículo científico publicado en 2003

Newly developed rat brain pericyte cell line, TR-PCT1, responds to transforming growth factor-beta1 and beta-glycerophosphate.

artículo científico publicado en 2002

Nuclear binding as a determinant of tissue distribution of adriamycin, daunomycin, adriamycinol, daunorubicinol and actinomycin D

scientific article published on 01 May 1984

Oral Morphine Pharmacokinetic in Obesity: The Role of P-Glycoprotein, MRP2, MRP3, UGT2B7, and CYP3A4 Jejunal Contents and Obesity-Associated Biomarkers.

artículo científico publicado en 2016

Organic Anion-Transporting Polypeptide 1a4 (Oatp1a4/Slco1a4) at the Blood-Arachnoid Barrier is the Major Pathway of Sulforhodamine-101 Clearance from Cerebrospinal Fluid of Rats

artículo científico publicado en 2019

Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs

artículo científico publicado en 2004

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

artículo científico publicado el 1 de enero de 1992

PKC/MAPK signaling suppression by retinal pericyte conditioned medium prevents retinal endothelial cell proliferation

artículo científico publicado en 2005

Participation of monocarboxylic anion and bicarbonate exchange system for the transport of acetic acid and monocarboxylic acid drugs in the small intestinal brush-border membrane vesicles

scientific article published on 01 September 1991

Peripheral nerve pericytes modify the blood-nerve barrier function and tight junctional molecules through the secretion of various soluble factors

artículo científico publicado en 2011

Peripheral nerve pericytes originating from the blood-nerve barrier expresses tight junctional molecules and transporters as barrier-forming cells

artículo científico publicado en 2008

Perspectives on a pharmacokinetics legend: C versus T (contributions over time).

artículo científico publicado en 2013

Pharmacokinetic study on the mechanism of tissue distribution of doxorubicin: interorgan and interspecies variation of tissue-to-plasma partition coefficients in rats, rabbits, and guinea pigs

artículo científico publicado en 1984

Pharmacological significance of prostaglandin E2 and D2 transport at the brain barriers.

artículo científico publicado en 2014

Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models

artículo científico publicado en 2014

Physiologically based pharmacokinetic model for beta-lactam antibiotics I: Tissue distribution and elimination in rats

artículo científico publicado en 1983

Platelet-derived growth factor-BB (PDGF-BB) induces differentiation of bone marrow endothelial progenitor cell-derived cell line TR-BME2 into mural cells, and changes the phenotype

artículo científico publicado en 2005

Polarized glucose transporters and mRNA expression properties in newly developed rat syncytiotrophoblast cell lines, TR-TBTs

artículo científico publicado en 2002

Polyol formation in cell lines of rat retinal capillary pericytes and endothelial cells (TR-rPCT and TR-iBRB)

artículo científico publicado en 2009

Professor Akira Tsuji: scientist, educator, and leader

artículo científico publicado en 2011

Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist.

artículo científico publicado en 2017

Quantification of Transporter and Receptor Proteins in Dog Brain Capillaries and Choroid Plexus: Relevance for the Distribution in Brain and CSF of Selected BCRP and P-gp Substrates.

artículo científico publicado en 2017

Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects.

artículo científico publicado en 2016

Quantitative Determination of Luminal and Abluminal Membrane Distributions of Transporters in Porcine Brain Capillaries by Plasma Membrane Fractionation and Quantitative Targeted Proteomics

artículo científico publicado en 2015

Quantitative Proteomics of Transporter Expression in Brain Capillary Endothelial Cells Isolated from P-Glycoprotein (P-gp), Breast Cancer Resistance Protein (Bcrp), and P-gp/Bcrp Knockout Mice ⬇️

artículo científico publicado el 8 de marzo de 2012

Quantitative Targeted Absolute Proteomics (QTAP)-based Pharmacoproteomics: The Importance of International Collaboration.

artículo científico publicado en 2017

Quantitative Targeted Absolute Proteomics for 28 Transporters in Brush-Border and Basolateral Membrane Fractions of Rat Kidney

scientific journal article

Quantitative Targeted Absolute Proteomics of Transporters and Pharmacoproteomics-Based Reconstruction of P-Glycoprotein Function in Mouse Small Intestine

artículo científico publicado en 2016

Quantitative Targeted Proteomics of Pancreatic Cancer: Deoxycytidine Kinase Protein Level Correlates to Progression-Free Survival of Patients Receiving Gemcitabine Treatment

artículo científico publicado en 2015

Quantitative atlas of blood-brain barrier transporters, receptors, and tight junction proteins in rats and common marmoset

artículo científico publicado en 2013

Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria

scientific article published on 01 June 2008

Quantitative expression of human drug transporter proteins in lung tissues: analysis of regional, gender, and interindividual differences by liquid chromatography-tandem mass spectrometry.

artículo científico publicado en 2013

Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys

artículo científico publicado en 2011

Quantitative targeted absolute proteomics for 28 human transporters in plasma membrane of Caco-2 cell monolayer cultured for 2, 3, and 4 weeks

artículo científico publicado en 2014

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

artículo científico publicado en 2011

Quantitative targeted absolute proteomics of rat blood-cerebrospinal fluid barrier transporters: comparison with a human specimen

artículo científico publicado en 2015

Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: methodology, advantages, strategy, and prospects.

artículo científico publicado en 2011

Quantitative targeted absolute proteomics-based large-scale quantification of proline-hydroxylated α-fibrinogen in plasma for pancreatic cancer diagnosis

artículo científico publicado en 2013

Quantitative targeted proteomics for understanding the blood-brain barrier: towards pharmacoproteomics.

artículo científico

Rat brain pericyte cell lines expressing beta2-adrenergic receptor, angiotensin II receptor type 1A, klotho, and CXCR4 mRNAs despite having endothelial cell markers

artículo científico publicado en 2003

Receptor-mediated endocytosis of A14-125I-insulin by the nonfiltering perfused rat kidney

artículo científico publicado en 1991

Receptor-recycling model of clearance and distribution of insulin in the perfused mouse liver

artículo científico publicado en 1991

Recombinant arginine deiminase as a differential modulator of inducible (iNOS) and endothelial (eNOS) nitric oxide synthetase activity in cultured endothelial cells

artículo científico publicado en 2003

Recurrent anaplastic meningioma treated by sunitinib based on results from quantitative proteomics

artículo científico publicado en 2012

Reduction of L-type amino acid transporter 1 mRNA expression in brain capillaries in a mouse model of Parkinson's disease

artículo científico publicado en 2010

Regulation of extracellular-superoxide dismutase in rat retina pericytes

artículo científico publicado en 2010

Regulation of taurine transport at the blood-brain barrier by tumor necrosis factor-alpha, taurine and hypertonicity

artículo científico publicado en 2002

Relationship between lipophilicity and binding affinity with human serum albumin for penicillin and cephem antibiotics.

artículo científico publicado en 1992

Reliability and robustness of simultaneous absolute quantification of drug transporters, cytochrome P450 enzymes, and Udp-glucuronosyltransferases in human liver tissue by multiplexed MRM/selected reaction monitoring mode tandem mass spectrometry wi

artículo científico publicado en 2011

Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein

artículo científico publicado en 1993

Retinal-specific ATP-binding cassette transporter (ABCR/ABCA4) is expressed at the choroid plexus in rat brain.

artículo científico publicado en 2005

Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain

artículo científico publicado en 2002

Roles of inner blood-retinal barrier organic anion transporter 3 in the vitreous/retina-to-blood efflux transport of p-aminohippuric acid, benzylpenicillin, and 6-mercaptopurine

artículo científico publicado en 2008

Saturable uptake of cefixime, a new oral cephalosporin without an alpha-amino group, by the rat intestine

artículo científico publicado en 1987

Scrambled Internal Standard Method for High-Throughput Protein Quantification by Matrix-Assisted Laser Desorption Ionization Tandem Mass Spectrometry

artículo científico publicado en 2017

Selective analysis of mutual displacement effects at the primary binding sites of phenoxymethylpenicillin and cephalothin bindings to human serum albumin.

artículo científico publicado en 1992

Selective gene silencing of rat ATP-binding cassette G2 transporter in an in vitro blood-brain barrier model by short interfering RNA.

artículo científico publicado en 2005

Serum protein binding of lomefloxacin, a new antimicrobial agent, and its related quinolones

scientific article published on 01 June 1989

Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities

artículo científico publicado en 2011

Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection

artículo científico publicado en 2010

Sodium and pH dependent carrier-mediated transport of antibiotic, fosfomycin, in the rat intestinal brush-border membrane

artículo científico publicado en 1990

Specific binding of beta-endorphin to the isolated renal basolateral membranes in vitro.

artículo científico publicado en 1990

Spleen lymphocyte kinetics in mice under normal and inflammatory conditions: an application of the transgenic mouse expressing beta-galactosidase (ROSA 26)

artículo científico publicado en 2002

Stereospecificity of triiodothyronine transport into brain, liver, and salivary gland: role of carrier- and plasma protein-mediated transport

artículo científico publicado en 1987

Studies on the Mechanism of Drug Distribution in Tissues ⬇️

artículo científico publicado el 1 de diciembre de 1992

Targeted drug delivery to the brain; (blood-brain barrier, efflux, endothelium, biological transport).

artículo científico publicado en 2000

Targeting choroid plexus epithelia and ventricular ependyma for drug delivery to the central nervous system

artículo científico publicado en 2011

The blood-brain barrier efflux transporters as a detoxifying system for the brain

scientific article published on 01 April 1999

The blood-brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport

artículo científico publicado en 2016

The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats: involvement of creatine and taurine transporters

artículo científico publicado en 2009

The blood-cerebrospinal fluid barrier is a major pathway of cerebral creatinine clearance: involvement of transporter-mediated process

artículo científico publicado en 2008

The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier

artículo científico publicado en 2003

The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells

artículo científico publicado en 2008

Theoretical consideration of drug distribution kinetics in a noneliminating organ: comparison between a "homogeneous (well-stirred)" model and "nonhomogeneous (tube)" model

article published in 1985

Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions.

artículo científico publicado en 2009

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.

artículo científico publicado en 2012

Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels

artículo científico publicado en 2011

Transport of the new quinolone antibacterial agents of lomefloxacin and ofloxacin by rat erythrocytes, and its relation to the nicotinic acid transport system

scientific article published on 01 August 1991

Uptake of benzylpenicillin, cefpiramide and cefazolin by freshly prepared rat hepatocytes. Evidence for a carrier-mediated transport system

artículo científico publicado en 1986

Uptake of drugs and expression of P-glycoprotein in the rat 9L glioma

artículo científico publicado en 1993

Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport

artículo científico publicado en 2015

Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS.

artículo científico publicado en 2014

Vascular endothelium-selective gene induction by Tie2 promoter/enhancer in the brain and retina of a transgenic rat.

artículo científico publicado en 2005

Vitamin C transport in oxidized form across the rat blood-retinal barrier

artículo científico publicado en 2004

[Multi-disciplinary research approaches on the brain barrier transport system, a dynamic interface]

artículo científico publicado en 2013

mRNA expression and amino acid transport characteristics of cultured human brain microvascular endothelial cells (hBME).

artículo científico publicado en 2002

mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting

artículo científico publicado en 2007

mRNA expression of the ATP-binding cassette transporter subfamily A (ABCA) in rat and human brain capillary endothelial cells

artículo científico publicado en 2004

pH-dependent intestinal transport of monocarboxylic acids: carrier-mediated and H(+)-cotransport mechanism versus pH-partition hypothesis

artículo científico publicado en 1990

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