Lista de obras - Thomas Mercher - Dominio Público Uruguay

A Novel Developmental Gene Expressed in Late Gestation Lung Identified Using Representational Difference Analysis

A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation

scientific article published on 24 April 2019

A functional role for the histone demethylase UTX in normal and malignant hematopoietic cells

artículo científico publicado en 2012

A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia

artículo científico publicado en 2007

AIF loss deregulates hematopoiesis and reveals different adaptive metabolic responses in bone marrow cells and thymocytes.

artículo científico publicado en 2018

Acquired initiating mutations in early hematopoietic cells of CLL patients

artículo científico publicado en 2014

Activating alleles of JAK3 in acute megakaryoblastic leukemia

artículo científico publicado en 2006

Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia

artículo científico publicado en 2009

Acute megakaryoblastic leukemia (excluding Down syndrome) remains an acute myeloid subgroup with inferior outcome in the French ELAM02 trial

artículo científico publicado en 2018

B-cell tumor development in -deficient mice

article

Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis

artículo científico publicado en 2010

Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models

artículo científico publicado en 2012

Chromosomal Translocation Formation Is Sufficient to Produce Fusion Circular RNAs Specific to Patient Tumor Cells

scientific article published on 19 June 2018

Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models

artículo científico publicado en 2009

Constitutive activation of RAS/MAPK pathway cooperates with trisomy 21 and is therapeutically exploitable in Down syndrome B-cell leukemia

scientific article published on 27 March 2020

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification ⬇️

artículo científico publicado en 2011

DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

artículo científico publicado en 2016

Developmental changes in human megakaryopoiesis.

artículo científico publicado en 2013

ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

artículo científico publicado en 2017

Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model

artículo científico publicado en 2006

Fondements moléculaires de la translocation t(1;22)(p13;q13) des leucémies aiguës à mégacaryoblastes

artículo científico publicado en 2003

FoxO: stress or eternal life

artículo científico publicado en 2007

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

artículo científico publicado en 2012

Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling

artículo científico publicado en 2013

Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export

artículo científico publicado en 2005

Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia

artículo científico publicado en 2001

JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model

artículo científico publicado en 2006

JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.

artículo científico publicado en 2013

JAK3: a two-faced player in hematological disorders

artículo científico publicado en 2009

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

artículo científico publicado en 2006

Molecular pathways driven by ETO2-GLIS2 in aggressive pediatric leukemia.

artículo científico publicado en 2017

Notch signaling specifies megakaryocyte development from hematopoietic stem cells.

artículo científico publicado en 2008

OTT-MAL is a deregulated activator of serum response factor-dependent gene expression

artículo científico publicado en 2008

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia

scientific article published on 29 October 2019

Ott1(Rbm15) has pleiotropic roles in hematopoietic development

artículo científico publicado en 2007

Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models

scientific article published on 01 July 2018

Pediatric Acute Megakaryoblastic Leukemia: Multitasking Fusion Proteins and Oncogenic Cooperations.

artículo científico publicado en 2017

Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells

artículo científico publicado en 2010

RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization

artículo científico publicado en 2012

Recurrence of OTT-MAL fusion in t(1;22) of infant AML-M7.

artículo científico

Recurrent TET2 mutations in adult T cell leukemia.

artículo científico publicado en 2014

STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model.

artículo científico publicado en 2013

STAT5 is crucial to maintain leukemic stem cells in acute myelogenous leukemias induced by MOZ-TIF2.

artículo científico publicado en 2012

Screening of ETO2-GLIS2-induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia

artículo científico publicado en 2022

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

artículo científico publicado en 2013

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells.

artículo científico publicado en 2014

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

scientific journal article

TET2, a tumor suppressor in hematological disorders.

artículo científico

The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model

artículo científico publicado en 2009

[Novel ETO2-GLIS2 fusion and therapeutic strategy in acute megakaryoblastic leukemia]

artículo científico publicado en 2012

Lista de obras de Thomas Mercher

A Novel Developmental Gene Expressed in Late Gestation Lung Identified Using Representational Difference Analysis

A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation

A functional role for the histone demethylase UTX in normal and malignant hematopoietic cells

A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia

AIF loss deregulates hematopoiesis and reveals different adaptive metabolic responses in bone marrow cells and thymocytes.

Acquired initiating mutations in early hematopoietic cells of CLL patients

Activating alleles of JAK3 in acute megakaryoblastic leukemia

Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia

Acute megakaryoblastic leukemia (excluding Down syndrome) remains an acute myeloid subgroup with inferior outcome in the French ELAM02 trial

B-cell tumor development in -deficient mice

Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis

Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models

Chromosomal Translocation Formation Is Sufficient to Produce Fusion Circular RNAs Specific to Patient Tumor Cells

Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models

Constitutive activation of RAS/MAPK pathway cooperates with trisomy 21 and is therapeutically exploitable in Down syndrome B-cell leukemia

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification ⬇️

DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

Developmental changes in human megakaryopoiesis.

ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model

Fondements moléculaires de la translocation t(1;22)(p13;q13) des leucémies aiguës à mégacaryoblastes

FoxO: stress or eternal life

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling

Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export

Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia

JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model

JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.

JAK3: a two-faced player in hematological disorders

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

Molecular pathways driven by ETO2-GLIS2 in aggressive pediatric leukemia.

Notch signaling specifies megakaryocyte development from hematopoietic stem cells.

OTT-MAL is a deregulated activator of serum response factor-dependent gene expression

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia

Ott1(Rbm15) has pleiotropic roles in hematopoietic development

Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models

Pediatric Acute Megakaryoblastic Leukemia: Multitasking Fusion Proteins and Oncogenic Cooperations.

Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells

RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization

Recurrence of OTT-MAL fusion in t(1;22) of infant AML-M7.

Recurrent TET2 mutations in adult T cell leukemia.

STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model.

STAT5 is crucial to maintain leukemic stem cells in acute myelogenous leukemias induced by MOZ-TIF2.

Screening of ETO2-GLIS2-induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells.

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

TET2, a tumor suppressor in hematological disorders.

The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model

[Novel ETO2-GLIS2 fusion and therapeutic strategy in acute megakaryoblastic leukemia]