Lista de obras - Sergey N. Kochetkov - Dominio Público Uruguay

1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus.

artículo científico publicado en 2016

5-Arylaminouracil Derivatives: New Inhibitors of Mycobacterium tuberculosis

artículo científico publicado en 2015

A new antiviral: chimeric 3TC-AZT phosphonate efficiently inhibits HIV-1 in human tissues ex vivo.

artículo científico publicado en 2014

Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication.

artículo científico publicado en 2010

Benzohydroxamic acids as potent and selective anti-HCV agents.

artículo científico publicado en 2013

Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus.

artículo científico publicado en 2012

Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells.

artículo científico publicado en 2012

DNA-encoding enzymatically active HIV-1 reverse transcriptase, but not the inactive mutant, confers resistance to experimental HIV-1 challenge.

artículo científico publicado en 2000

Determination of binding parameters of cyclic AMP and its analogs to cyclic AMP-dependent protein kinase by the fluorescent probe method ⬇️

artículo científico publicado el 15 de agosto de 1979

Determination of the melting site of the DNA duplex in the active center of bacterial RNA-polymerase by fluorescence quenching technique.

artículo científico publicado en 2007

Dual-targeted anti-TB/anti-HIV heterodimers

artículo científico publicado en 2017

Effect of Hepatitis C virus proteins on the production of proinflammatory and profibrotic cytokines in Huh7.5 human hepatoma cells

artículo científico publicado en 2016

Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.

artículo científico publicado en 2015

Enantioselective Synthesis of (R)- and (S)-3-Methylspermidines

artículo científico publicado en 2015

Enzymatic activity of thymidine kinase of herpes simlex virus strain resistant to H-phosphonates of Acv

artículo científico publicado en 2011

Evaluation of the antiprotozoan properties of 5'-norcarbocyclic pyrimidine nucleosides.

artículo científico publicado en 2017

Gene immunization may induce secondary antibodies reacting with DNA.

artículo científico publicado en 2004

HCV and oxidative stress in the liver.

artículo científico

HCV core protein uses multiple mechanisms to induce oxidative stress in human hepatoma Huh7 cells.

artículo científico publicado en 2015

HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist

artículo científico publicado en 2019

Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1

artículo científico publicado en 2016

Hepatitis C Virus RNA-Dependent RNA Polymerase Is Regulated by Cysteine S-Glutathionylation

artículo científico publicado en 2019

Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system.

artículo científico publicado en 2008

Hepatitis C virus RNA-dependent RNA polymerase: study on the inhibition mechanism by pyrogallol derivatives.

artículo científico publicado en 2006

Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism

artículo científico publicado en 2017

Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors.

artículo científico publicado en 2008

Hepatitis C virus proteins activate NRF2/ARE pathway by distinct ROS-dependent and independent mechanisms in HUH7 cells.

artículo científico publicado en 2011

Hepatitis C virus: The role of N-glycosylation sites of viral genotype 1b proteins for formation of viral particles in insect and mammalian cells.

artículo científico publicado en 2016

Human herpes simplex virus: life cycle and development of inhibitors

artículo científico publicado en 2014

Hydrophobic-core PEGylated graft copolymer-stabilized nanoparticles composed of insoluble non-nucleoside reverse transcriptase inhibitors exhibit strong anti-HIV activity

artículo científico publicado en 2016

Hydroxylamine derivatives for regulation of spermine and spermidine metabolism.

artículo científico

Immunogenic properties of reverse transcriptase of HIV type 1 assessed by DNA and protein immunization of rabbits

scientific article published on 01 September 2000

Inhibition of the helicase activity of the HCV NS3 protein by symmetrical dimeric bis-benzimidazoles ⬇️

artículo científico publicado el 14 de julio de 2011

Interaction of tRNA-derivatives and oligonucleotide primers with AZT-resistant mutants of HIV-1 reverse transcriptase.

artículo científico publicado en 1998

Interactions of the HIV-1 reverse transcriptase 'AZT-resistant' mutant with substrates and AZT-TP.

artículo científico publicado en 1993

Isolation of the regulatory subunit of pig-brain histone kinase by affinity chromatography on cyclic-AMP-containing adsorbent

artículo científico publicado en 1974

Low-molecular-weight regulators of biogenic polyamine metabolism affect cytokine production and expression of hepatitis С virus proteins in Huh7.5 human hepatocarcinoma cells

artículo científico publicado en 2017

Lys631 residue in the active site of the bacteriophage T7 RNA polymerase. Affinity labeling and site-directed mutagenesis ⬇️

artículo científico publicado el 14 de febrero de 1991

Mapping of T7 RNA polymerase active site with novel reagents - oligonucleotides with reactive dialdehyde groups

article

Methylated polyamines as research tools

artículo científico publicado en 2011

Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity

artículo científico publicado en 2016

Modulation of Cell Death Pathways by Hepatitis C Virus Proteins in Huh7.5 Hepatoma Cells.

artículo científico publicado en 2017

Multisubunit RNA polymerases melt only a single DNA base pair downstream of the active site.

artículo científico

Mutant T7 RNA polymerase is capable of catalyzing DNA primer extension reaction

artículo científico publicado en 1998

Mutants of T7 RNA polymerase that are able to synthesize both RNA and DNA

artículo científico publicado en 1995

Mutations conferring drug resistance affect eukaryotic expression of HIV type 1 reverse transcriptase.

artículo científico publicado en 2004

N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase.

artículo científico publicado en 2013

New non-nucleoside inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

artículo científico publicado en 2004

Novel 5-substituted derivatives of 2'-deoxy-6-azauridine with antibacterial activity

scientific article published on 21 February 2019

Oligonucleotides Containing Disaccharide Nucleosides: Synthesis, Physicochemical, and Substrate Properties

artículo científico publicado en 2003

On the Reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines: Unexpected Degradation of P-C-P Bridge

artículo científico publicado en 2017

On the functional role of the Tyr-639 residue of bacteriophage T7 RNA polymerase

artículo científico publicado en 1992

Oxidative Stress during HIV Infection: Mechanisms and Consequences

artículo científico publicado en 2016

Oxidative stress induced by HIV-1 reverse transcriptase modulates the enzyme's performance in gene immunization.

artículo científico publicado en 2013

Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

artículo científico publicado en 2016

Phosphoramidate derivatives of acyclovir: synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro.

artículo científico publicado en 2012

Physico-chemical principles of cAMP-dependent protein phosphorylation. Catalysis of phosphoryl group transfer to nucleophilic agents

artículo científico publicado en 1984

Potent cross-reactive immune response against the wild-type and drug-resistant forms of HIV reverse transcriptase after the chimeric gene immunization.

artículo científico publicado en 2010

Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6.

artículo científico publicado en 2015

Random mutagenesis of the gene for bacteriophage T7 RNA polymerase

scientific article published on 01 April 1993

Recent studies of T7 RNA polymerase mechanism

artículo científico publicado en 1998

Reverse transcriptase-based DNA vaccines against drug-resistant HIV-1 tested in a mouse model.

artículo científico publicado en 2004

Role of a histidine residue in the active site of cyclic AMP-dependent histone kinase ⬇️

artículo científico publicado el 1 de diciembre de 1976

Scaffold hopping: exploration of acetanilide-containing uracil analogues as potential NNRTIs

artículo científico publicado en 2015

Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytes.

artículo científico publicado en 2014

Specific features of HIV-1 integrase inhibition by bisphosphonate derivatives

artículo científico publicado en 2013

Studies on the Mechanism of Action of Histone Kinase Dependent on Adenosine 3':5'-Monophosphate. Evidence for Involvement of Histidine and Lysine Residues in the Phosphotransferase Reaction ⬇️

artículo científico publicado el 15 de noviembre de 1977

Studies on the mechanism of action of the histone kinase dependent on adenosine 3',5'-monophosphate. Fast kinetics of histone H1 phosphorylation.

artículo científico publicado en 1983

Studies on the mechanism of action of the histone kinase dependent on adenosine 3',5'-monophosphate. Interaction of ATP with the catalytic subunit of the pig-brain enzyme: application of the quenched-flow technique.

artículo científico publicado en 1981

Studies on the mechanism of action of the histone kinase dependent on adenosine 3',5'-monophosphate. Investigation of protein-protein interaction by electron spin-resonance spectroscopy and stopped-flow methods

artículo científico publicado en 1983

Substrate properties of C'-methyl UTP derivatives in T7 RNA polymerase reactions. Evidence for N-type NTP conformation

artículo científico publicado en 1997

Synthesis and anti-HIV properties of new carbamate prodrugs of AZT.

artículo científico publicado en 2012

Synthesis and biological characterization of novel charge-deficient spermine analogues.

artículo científico publicado en 2010

Synthesis and biological properties of pyrimidine 4'-fluoro nucleosides and 4'-fluoro uridine 5'-O-triphospate

artículo científico publicado en 2010

Synthesis and evaluation of C-5 modified 2'-deoxyuridine monophosphates as inhibitors of M. tuberculosis thymidylate synthase.

artículo científico publicado en 2015

Synthesis of mixed ribo/deoxyribopolynucleotides by mutant T7 RNA polymerase

artículo científico publicado en 1998

Targeted mutagenesis identifies Asp-569 as a catalytically critical residue in T7 RNA polymerase

artículo científico publicado en 1995

The studies of cooperative regions in T7 RNA polymerase.

artículo científico publicado en 1994

The synthesis and antituberculosis activity of 5'-nor carbocyclic uracil derivatives.

artículo científico publicado en 2012

The synthesis of ψ-(2-aryl-1,3-dioxolan-2-yl) alkyl derivatives of purines and their activity towards HIV reverse transcriptase

artículo científico publicado en 2015

The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism.

artículo científico publicado en 2011

Tyr-571 is involved in the T7 RNA polymerase binding to its promoter

artículo científico publicado en 1993

Versatile synthesis of oxime-containing acyclic nucleoside phosphonates--synthetic solutions and antiviral activity

artículo científico publicado en 2015

[Novel metabolically stable functionally-active mimetic of spermidine]

artículo científico publicado en 2011

[Role of N-linked glycans in HCV glycoprotein E1 in the folding of structural proteins and formation viral particles].

artículo científico publicado en 2013

Lista de obras de Sergey N. Kochetkov

1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus.

5-Arylaminouracil Derivatives: New Inhibitors of Mycobacterium tuberculosis

A new antiviral: chimeric 3TC-AZT phosphonate efficiently inhibits HIV-1 in human tissues ex vivo.

Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication.

Benzohydroxamic acids as potent and selective anti-HCV agents.

Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus.

Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells.

DNA-encoding enzymatically active HIV-1 reverse transcriptase, but not the inactive mutant, confers resistance to experimental HIV-1 challenge.

Determination of binding parameters of cyclic AMP and its analogs to cyclic AMP-dependent protein kinase by the fluorescent probe method ⬇️

Determination of the melting site of the DNA duplex in the active center of bacterial RNA-polymerase by fluorescence quenching technique.

Dual-targeted anti-TB/anti-HIV heterodimers

Effect of Hepatitis C virus proteins on the production of proinflammatory and profibrotic cytokines in Huh7.5 human hepatoma cells

Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.

Enantioselective Synthesis of (R)- and (S)-3-Methylspermidines

Enzymatic activity of thymidine kinase of herpes simlex virus strain resistant to H-phosphonates of Acv

Evaluation of the antiprotozoan properties of 5'-norcarbocyclic pyrimidine nucleosides.

Gene immunization may induce secondary antibodies reacting with DNA.

HCV and oxidative stress in the liver.

HCV core protein uses multiple mechanisms to induce oxidative stress in human hepatoma Huh7 cells.

HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist

Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1

Hepatitis C Virus RNA-Dependent RNA Polymerase Is Regulated by Cysteine S-Glutathionylation

Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system.

Hepatitis C virus RNA-dependent RNA polymerase: study on the inhibition mechanism by pyrogallol derivatives.

Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism

Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors.

Hepatitis C virus proteins activate NRF2/ARE pathway by distinct ROS-dependent and independent mechanisms in HUH7 cells.

Hepatitis C virus: The role of N-glycosylation sites of viral genotype 1b proteins for formation of viral particles in insect and mammalian cells.

Human herpes simplex virus: life cycle and development of inhibitors

Hydrophobic-core PEGylated graft copolymer-stabilized nanoparticles composed of insoluble non-nucleoside reverse transcriptase inhibitors exhibit strong anti-HIV activity

Hydroxylamine derivatives for regulation of spermine and spermidine metabolism.

Immunogenic properties of reverse transcriptase of HIV type 1 assessed by DNA and protein immunization of rabbits

Inhibition of the helicase activity of the HCV NS3 protein by symmetrical dimeric bis-benzimidazoles ⬇️

Interaction of tRNA-derivatives and oligonucleotide primers with AZT-resistant mutants of HIV-1 reverse transcriptase.

Interactions of the HIV-1 reverse transcriptase 'AZT-resistant' mutant with substrates and AZT-TP.

Isolation of the regulatory subunit of pig-brain histone kinase by affinity chromatography on cyclic-AMP-containing adsorbent

Low-molecular-weight regulators of biogenic polyamine metabolism affect cytokine production and expression of hepatitis С virus proteins in Huh7.5 human hepatocarcinoma cells

Lys631 residue in the active site of the bacteriophage T7 RNA polymerase. Affinity labeling and site-directed mutagenesis ⬇️

Mapping of T7 RNA polymerase active site with novel reagents - oligonucleotides with reactive dialdehyde groups

Methylated polyamines as research tools

Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity

Modulation of Cell Death Pathways by Hepatitis C Virus Proteins in Huh7.5 Hepatoma Cells.

Multisubunit RNA polymerases melt only a single DNA base pair downstream of the active site.

Mutant T7 RNA polymerase is capable of catalyzing DNA primer extension reaction

Mutants of T7 RNA polymerase that are able to synthesize both RNA and DNA

Mutations conferring drug resistance affect eukaryotic expression of HIV type 1 reverse transcriptase.

N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase.

New non-nucleoside inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

Novel 5-substituted derivatives of 2'-deoxy-6-azauridine with antibacterial activity

Oligonucleotides Containing Disaccharide Nucleosides: Synthesis, Physicochemical, and Substrate Properties

On the Reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines: Unexpected Degradation of P-C-P Bridge

On the functional role of the Tyr-639 residue of bacteriophage T7 RNA polymerase

Oxidative Stress during HIV Infection: Mechanisms and Consequences

Oxidative stress induced by HIV-1 reverse transcriptase modulates the enzyme's performance in gene immunization.

Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

Phosphoramidate derivatives of acyclovir: synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro.

Physico-chemical principles of cAMP-dependent protein phosphorylation. Catalysis of phosphoryl group transfer to nucleophilic agents

Potent cross-reactive immune response against the wild-type and drug-resistant forms of HIV reverse transcriptase after the chimeric gene immunization.

Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6.

Random mutagenesis of the gene for bacteriophage T7 RNA polymerase

Recent studies of T7 RNA polymerase mechanism

Reverse transcriptase-based DNA vaccines against drug-resistant HIV-1 tested in a mouse model.

Role of a histidine residue in the active site of cyclic AMP-dependent histone kinase ⬇️

Scaffold hopping: exploration of acetanilide-containing uracil analogues as potential NNRTIs

Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytes.

Specific features of HIV-1 integrase inhibition by bisphosphonate derivatives

Studies on the Mechanism of Action of Histone Kinase Dependent on Adenosine 3':5'-Monophosphate. Evidence for Involvement of Histidine and Lysine Residues in the Phosphotransferase Reaction ⬇️

Studies on the mechanism of action of the histone kinase dependent on adenosine 3',5'-monophosphate. Fast kinetics of histone H1 phosphorylation.

Studies on the mechanism of action of the histone kinase dependent on adenosine 3',5'-monophosphate. Interaction of ATP with the catalytic subunit of the pig-brain enzyme: application of the quenched-flow technique.

Studies on the mechanism of action of the histone kinase dependent on adenosine 3',5'-monophosphate. Investigation of protein-protein interaction by electron spin-resonance spectroscopy and stopped-flow methods

Substrate properties of C'-methyl UTP derivatives in T7 RNA polymerase reactions. Evidence for N-type NTP conformation

Synthesis and anti-HIV properties of new carbamate prodrugs of AZT.

Synthesis and biological characterization of novel charge-deficient spermine analogues.

Synthesis and biological properties of pyrimidine 4'-fluoro nucleosides and 4'-fluoro uridine 5'-O-triphospate

Synthesis and evaluation of C-5 modified 2'-deoxyuridine monophosphates as inhibitors of M. tuberculosis thymidylate synthase.

Synthesis of mixed ribo/deoxyribopolynucleotides by mutant T7 RNA polymerase

Targeted mutagenesis identifies Asp-569 as a catalytically critical residue in T7 RNA polymerase

The studies of cooperative regions in T7 RNA polymerase.

The synthesis and antituberculosis activity of 5'-nor carbocyclic uracil derivatives.