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Lista de obras de Robert Newton

A Holy Grail of asthma management: toward understanding how long-acting beta(2)-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids

artículo científico publicado en 2007

A bronchoprotective role for in a murine model of lipopolysaccharide-induced airways inflammation

artículo científico publicado en 2018

Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A.

artículo científico publicado en 2001

Adenovirus-mediated delivery and expression of a cAMP-dependent protein kinase inhibitor gene to BEAS-2B epithelial cells abolishes the anti-inflammatory effects of rolipram, salbutamol, and prostaglandin E2: a comparison with H-89.

artículo científico publicado en 2004

Alternate COX-2 Transcripts Are Differentially Regulated: Implications for Post-Transcriptional Control

article

An MspI polymorphism at the DXS11 locus.

artículo científico publicado en 1992

An analysis of glucocorticoid receptor-mediated gene expression in BEAS-2B human airway epithelial cells identifies distinct, ligand-directed, transcription profiles with implications for asthma therapeutics

artículo científico publicado en 2015

An inhaled dose of budesonide induces genes involved in transcription and signaling in the human airways: enhancement of anti- and proinflammatory effector genes.

artículo científico publicado en 2016

Analysis of Transcription Factor Activation: NFκB as a Regulator of Inflammatory Genes in Epithelial Cells

artículo científico publicado en 2000

Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids

artículo científico publicado en 2006

Anti-inflammatory and relaxatory effects of prostaglandin E2 in myometrial smooth muscle

artículo científico publicado en 2006

Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms.

artículo científico publicado en 2004

Anti-inflammatory glucocorticoids: changing concepts

artículo científico publicado en 2013

Ceramide Induction of COX-2 and PGE2 in Pulmonary A549 Cells Does Not Involve Activation of NF-κB

article

Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide.

artículo científico publicado en 2012

Corticosteroids and β₂-agonists upregulate mitogen-activated protein kinase phosphatase 1: in vitro mechanisms

artículo científico publicado en 2012

Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors.

artículo científico publicado en 2003

Cytokine induction of cytosolic phospholipase A2 and cyclooxygenase-2 mRNA is suppressed by glucocorticoids in human epithelial cells

artículo científico publicado en 1997

Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting β(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands

artículo científico publicado en 2015

DUSP1 Maintains IRF1 and Leads to Increased Expression of IRF1-dependent Genes: A MECHANISM PROMOTING GLUCOCORTICOID INSENSITIVITY.

artículo científico publicado en 2016

Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells

scientific article published in Journal of Biological Chemistry

Differential Regulation of Cyclo-Oxygenase-1 and Cyclo-Oxygenase-2 Gene Expression by Lipopolysaccharide Treatmentin vivoin the Rat

article

Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E release.

artículo científico publicado en 2004

Differential regulation of cytokine expression after allergen exposure of sensitized rats by cyclosporin A and corticosteroids: Relationship to bronchial hyperresponsiveness

article

Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes.

artículo científico publicado en 2004

E-ring 8-isoprostanes are agonists at EP2- and EP4-prostanoid receptors on human airway smooth muscle cells and regulate the release of colony-stimulating factors by activating cAMP-dependent protein kinase

artículo científico publicado en 2004

Effect of beta2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A.

artículo científico publicado en 2008

Effect of bradykinin, TGF-beta1, IL-1beta, and hypoxia on COX-2 expression in pulmonary artery smooth muscle cells.

artículo científico publicado en 2002

Effect of dexamethasone on interleukin-1beta-(IL-1beta)-induced nuclear factor-kappaB (NF-kappaB) and kappaB-dependent transcription in epithelial cells.

artículo científico publicado en 1998

Eicosanoid mediator expression in mononuclear and polymorphonuclear cells in normal subjects and patients with atopic asthma and cystic fibrosis

artículo científico publicado en 1996

Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action

artículo científico publicado en 2010

Evidence for a second receptor for prostacyclin on human airway epithelial cells that mediates inhibition of CXCL9 and CXCL10 release.

artículo científico publicado en 2010

Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta

artículo científico publicado en 1997

Evidence for post-transcriptional regulation of interleukin-5 by dexamethasone

artículo científico publicado en 2003

Exclusion mapping of the gene for X-linked neural tube defects in an Icelandic family

article

Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour

artículo científico publicado en 2006

Expression of COX-2 by normal and reactive astrocytes in the adult rat central nervous system

artículo científico publicado en 1999

Expression of cyclooxygenase types 1 and 2 in human fetal membranes at term

article

GM-CSF expression in pulmonary epithelial cells is regulated negatively by posttranscriptional mechanisms

artículo científico publicado en 2001

GS-5759, a Bifunctional β2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action: Effects on Gene Expression in Human Airway Epithelial Cells

artículo científico publicado en 2016

Glucocorticoid and cytokine crosstalk: Feedback, feedforward, and co-regulatory interactions determine repression or resistance

artículo científico publicado en 2017

Glucocorticoid inhibition of granulocyte macrophage-colony-stimulating factor from T cells is independent of control by nuclear factor-kappaB and conserved lymphokine element 0.

artículo científico publicado en 2003

Glucocorticoid repression of inflammatory gene expression shows differential responsiveness by transactivation- and transrepression-dependent mechanisms

artículo científico publicado en 2013

Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells

artículo científico publicado en 2019

Glucocorticoids inhibit IL-1beta-induced GM-CSF expression at multiple levels: roles for the ERK pathway and repression by MKP-1.

artículo científico publicado en 2010

Harnessing the clinical efficacy of phosphodiesterase 4 inhibitors in inflammatory lung diseases: dual-selective phosphodiesterase inhibitors and novel combination therapies

artículo científico publicado en 2011

How phosphodiesterase 4 inhibitors work in patients with chronic obstructive pulmonary disease of the severe, bronchitic, frequent exacerbator phenotype

artículo científico

Human labour is associated with nuclear factor-kappaB activity which mediates cyclo-oxygenase-2 expression and is involved with the 'functional progesterone withdrawal'.

artículo científico publicado en 2001

Human rhinovirus infection enhances airway epithelial cell production of growth factors involved in airway remodeling

artículo científico publicado en 2008

Human rhinovirus infection up-regulates MMP-9 production in airway epithelial cells via NF-{kappa}B.

artículo científico publicado en 2009

ICAM-1 expression is highly NF-kappaB-dependent in A549 cells. No role for ERK and p38 MAPK.

artículo científico publicado en 2004

IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase.

artículo científico publicado en 2003

Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma

artículo científico publicado en 2005

IkappaBalpha degradation and nuclear factor-kappaB DNA binding are insufficient for interleukin-1beta and tumor necrosis factor-alpha-induced kappaB-dependent transcription. Requirement for an additional activation pathway

artículo científico publicado en 1998

Induction of phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonists. Potential role in beta2-adrenoreceptor desensitization

artículo científico publicado en 1998

Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells.

artículo científico publicado en 2013

Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists.

artículo científico publicado en 2011

Inhibition of ABCC4 potentiates combination beta agonist and glucocorticoid responses in human airway epithelial cells.

artículo científico publicado en 2017

Inhibition of NF-kappaB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK.

artículo científico publicado en 2009

Inhibitors of p38 mitogen-activated protein kinase: potential as anti-inflammatory agents in asthma?

artículo científico publicado en 2003

Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding

artículo científico publicado en 2004

Localization of a mutant gene for cleft palate and ankyloglossia in an X-linked Icelandic family.

artículo científico publicado en 1991

Long-acting beta2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells

artículo científico publicado en 2007

Long-acting β2-agonists promote glucocorticoid-mediated repression of NF-κB by enhancing expression of the feedback regulator TNFAIP3.

artículo científico publicado en 2016

Modulation of transcriptional responses by poly(I:C) and human rhinovirus: effect of long-acting β₂-adrenoceptor agonists.

artículo científico publicado en 2013

NF-kappa B involvement in IL-1 beta-induction of GM-CSF and COX-2: inhibition by glucocorticoids does not require I-kappa B.

artículo científico publicado en 1997

NF-kappaB and AP-1 are required for cyclo-oxygenase 2 gene expression in amnion epithelial cell line (WISH).

artículo científico publicado en 2000

Negative Feed-forward Control of Tumor Necrosis Factor (TNF) by Tristetraprolin (ZFP36) Is Limited by the Mitogen-activated Protein Kinase Phosphatase, Dual-specificity Phosphatase 1 (DUSP1): IMPLICATIONS FOR REGULATION BY GLUCOCORTICOIDS.

artículo científico publicado en 2015

Nitric oxide inhibits IFN regulatory factor 1 and nuclear factor-kappaB pathways in rhinovirus-infected epithelial cells

artículo científico publicado en 2009

Novel RFLPs and microsatellite repeats increase informativity at four loci mapping to Xq22-q25

scientific article published on 01 February 1994

Nuclear factor-kappaB does not mediate the inhibitory effects of dexamethasone on granulocyte-macrophage colony-stimulating factor expression.

artículo científico publicado en 2004

PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappaB-dependent proinflammatory activation of alveolar epithelial cells.

artículo científico publicado en 2008

Pharmacological strategies for improving the efficacy and therapeutic ratio of glucocorticoids in inflammatory lung diseases.

artículo científico publicado en 2009

Phorbol ester-stimulated NF-kappaB-dependent transcription: roles for isoforms of novel protein kinase C.

artículo científico publicado en 2008

Polymorphic dinucleotide repeat at the DXS3 locus

artículo científico publicado en 1991

Potential mechanisms to explain how LABAs and PDE4 inhibitors enhance the clinical efficacy of glucocorticoids in inflammatory lung diseases

artículo científico publicado en 2015

Potentiation of NF-kappaB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells

artículo científico publicado en 2007

Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte colony-stimulating factor

artículo científico publicado en 2005

Prostanoid receptors of the EP4-subtype mediate gene expression changes in human airway epithelial cells with potential anti-inflammatory activity

artículo científico publicado en 2020

Protective Roles for RGS2 in a Mouse Model of House Dust Mite-Induced Airway Inflammation.

artículo científico publicado en 2017

Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone.

artículo científico publicado en 2002

Regulation of tristetraprolin expression by interleukin-1 beta and dexamethasone in human pulmonary epithelial cells: roles for nuclear factor-kappa B and p38 mitogen-activated protein kinase

artículo científico publicado en 2009

Regulators of G-Protein Signaling as Asthma Therapy?

artículo científico publicado en 2018

Repression of Cyclooxygenase-2 and Prostaglandin E2Release by Dexamethasone Occurs by Transcriptional and Post-transcriptional Mechanisms Involving Loss of Polyadenylated mRNA

scientific article published in Journal of Biological Chemistry

Repression of Inflammatory Gene Expression in Human Pulmonary Epithelial Cells by Small-Molecule I B Kinase Inhibitors

article

Repression of transcription by the glucocorticoid receptor: A parsimonious model for the genomics era

artículo científico publicado en 2021

Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasone

artículo científico publicado en 2012

Roles for the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, in feedback control of inflammatory gene expression and repression by dexamethasone.

artículo científico publicado en 2014

Selective prostacyclin receptor agonism augments glucocorticoid-induced gene expression in human bronchial epithelial cells.

artículo científico publicado en 2009

Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor?

artículo científico publicado en 2007

Stimulus-Specific Inhibition of IL-5 by cAMP-Elevating Agents and IL-10 Reveals Differential Mechanisms of Action

artículo científico publicado en 2000

Superinduction of COX-2 mRNA by cycloheximide and interleukin-1beta involves increased transcription and correlates with increased NF-kappaB and JNK activation

artículo científico publicado en 1997

Superiority of combined phosphodiesterase PDE3/PDE4 inhibition over PDE4 inhibition alone on glucocorticoid- and long-acting β2-adrenoceptor agonist-induced gene expression in human airway epithelial cells.

artículo científico publicado en 2014

TGFbeta1 allele association with asthma severity

artículo científico publicado en 2001

The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes.

artículo científico publicado en 2000

The Onset of Labor Alters Corticotropin-Releasing Hormone Type 1 Receptor Variant Expression in Human Myometrium: Putative Role of Interleukin-1β

artículo científico publicado en 2007

The Relative Abundance of Type 1 to Type 2 Cyclo-oxygenase mRNA in Human Amnion at Term

artículo científico publicado en 1994

The long-acting β2 -adrenoceptor agonist, indacaterol, enhances glucocorticoid receptor-mediated transcription in human airway epithelial cells in a gene- and agonist-dependent manner

artículo científico publicado en 2015

The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-gamma-stimulated human bronchial epithelial cells

artículo científico publicado en 2007

Transcriptome-level interactions between budesonide and formoterol provide insight into the mechanism of action of ICS/LABA combination therapy in asthma

artículo científico publicado en 2020

Two RFLPs at the D12S51 locus

artículo científico publicado el 11 de enero de 1991

Understanding how long-acting β2 -adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids in asthma - an update

artículo científico publicado en 2016

Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells.

artículo científico publicado en 2005

β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids

artículo científico publicado en 2011