Lista de obras - Jorge Ferrer - Dominio Público Uruguay

A Loss-Of-Function Splice Acceptor Variant in IGF2 is Protective for Type 2 Diabetes

artículo científico publicado en 2017

A conditional model reveals that induction of hepatocyte nuclear factor-1alpha in Hnf1alpha-null mutant beta-cells can activate silenced genes postnatally, whereas overexpression is deleterious

scientific journal article

A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element

artículo científico publicado en 2017

A genetic switch in pancreatic beta-cells: implications for differentiation and haploinsufficiency.

artículo científico publicado en 2002

A human pancreatic islet inwardly rectifying potassium channel: cDNA cloning, determination of the genomic structure and genetic variations in Japanese NIDDM patients

A map of open chromatin in human pancreatic islets

artículo científico publicado en 2010

A novel -192c/g mutation in the proximal P2 promoter of the hepatocyte nuclear factor-4 alpha gene (HNF4A) associates with late-onset diabetes.

artículo científico publicado en 2006

Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes

artículo científico publicado en 2013

Argonaute2 mediates compensatory expansion of the pancreatic β cell

artículo científico publicado en 2013

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

artículo científico publicado en 2016

Can Insulin Production Suppress β Cell Growth?

artículo científico publicado en 2016

Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1.

artículo científico publicado en 2013

Cell cycle-dependent differentiation dynamics balances growth and endocrine differentiation in the pancreas

artículo científico publicado en 2015

Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment

artículo científico publicado en 2015

Chromatin immunoprecipitation using isolated islets of Langerhans.

artículo científico publicado en 2003

Cloning of human pancreatic islet large conductance Ca2+-activated K+ channel (hSlo) cDNAs: evidence for high levels of expression in pancreatic islets and identification of a flanking genetic marker

article

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

artículo científico publicado en 2010

Diabetes mellitus in patients with liver cirrhosis

artículo científico publicado en 1994

Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth.

artículo científico publicado en 2007

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

artículo científico publicado en 1997

EuroDia: a beta-cell gene expression resource

artículo científico publicado en 2010

Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity

artículo científico publicado en 2010

Functional targets of the monogenic diabetes transcription factors HNF-1alpha and HNF-4alpha are highly conserved between mice and humans

artículo científico publicado en 2009

GATA6 haploinsufficiency causes pancreatic agenesis in humans

artículo científico publicado en 2011

Gene expression dynamics after murine pancreatitis unveils novel roles for Hnf1α in acinar cell homeostasis.

artículo científico publicado en 2011

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

artículo científico publicado en 2018

Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function

article

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

artículo científico publicado en 2015

Glucose as a Mitogenic Hormone

HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer

artículo científico publicado en 2020

Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets

scientific journal article

Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress

artículo científico publicado en 2011

Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver.

artículo científico publicado en 2009

Hnf1α (MODY3) regulates β-cell-enriched MafA transcription factor expression

artículo científico publicado en 2010

Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas

scientific journal article

Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks

artículo científico publicado en 2016

Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes

article

Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

scientific article published on 28 June 2019

Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes

artículo científico publicado en 2012

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas

artículo científico publicado en 2006

Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.

artículo científico publicado en 2017

Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study

artículo científico publicado en 2018

Lineage fate of ductular reactions in liver injury and carcinogenesis

artículo científico publicado en 2015

Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes

article

Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene

artículo científico publicado en 2007

Mapping open chromatin with formaldehyde-assisted isolation of regulatory elements

artículo científico publicado en 2011

MiR-184 expression is regulated by AMPK in pancreatic islets

artículo científico publicado en 2017

Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain

artículo científico publicado en 2000

Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene

artículo científico publicado en 2021

Neuronatin regulates pancreatic β cell insulin content and secretion

PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression

artículo científico publicado en 2009

Pancreatic Islet GLUT2 Glucose Transporter mRNA and Protein Expression in Humans With and Without NIDDM ⬇️

artículo científico publicado el 1 de diciembre de 1995

Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth

artículo científico publicado en 2009

Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels

artículo científico publicado en 1995

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

artículo científico publicado en 2014

Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming

artículo científico publicado en 2012

Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.

artículo científico publicado en 2018

Putting pancreatic cell plasticity to the test.

artículo científico publicado en 2007

Rare variants identified in the HNF-4α β-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes

article by S. Mitchell et al published 19 July 2002 in Diabetologia

Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

artículo científico publicado en 2018

Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.

artículo científico publicado en 2013

Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis

artículo científico publicado en 2010

Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells

artículo científico publicado en 2001

Removing the brakes on cell identity.

artículo científico publicado en 2011

Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult β cells

artículo científico publicado en 2012

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.

artículo científico publicado en 2014

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors

artículo científico publicado en 2015

TIGER: The gene expression regulatory variation landscape of human pancreatic islets

artículo científico publicado en 2021

Targeted deficiency of the transcriptional activator Hnf1alpha alters subnuclear positioning of its genomic targets

artículo científico publicado en 2008

The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice

artículo científico publicado en 2015

The Transcription Factor ERG Regulates Super-Enhancers Associated With an Endothelial-Specific Gene Expression Program

article

The cis-regulatory switchboard of pancreatic ductal cancer

artículo científico publicado en 2016

The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis

artículo científico publicado en 2013

The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse

scientific journal article

Transcriptional enhancers: functional insights and role in human disease

artículo científico publicado en 2015

Transcriptional networks controlling pancreatic development and beta cell function.

artículo científico publicado en 2004

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

artículo científico publicado en 2013

matchSCore: Matching Single-Cell Phenotypes Across Tools and Experiments

βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function

artículo científico publicado en 2016

Lista de obras de Jorge Ferrer

A Loss-Of-Function Splice Acceptor Variant in IGF2 is Protective for Type 2 Diabetes

A conditional model reveals that induction of hepatocyte nuclear factor-1alpha in Hnf1alpha-null mutant beta-cells can activate silenced genes postnatally, whereas overexpression is deleterious

A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element

A genetic switch in pancreatic beta-cells: implications for differentiation and haploinsufficiency.

A human pancreatic islet inwardly rectifying potassium channel: cDNA cloning, determination of the genomic structure and genetic variations in Japanese NIDDM patients

A map of open chromatin in human pancreatic islets

A novel -192c/g mutation in the proximal P2 promoter of the hepatocyte nuclear factor-4 alpha gene (HNF4A) associates with late-onset diabetes.

Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes

Argonaute2 mediates compensatory expansion of the pancreatic β cell

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

Can Insulin Production Suppress β Cell Growth?

Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1.

Cell cycle-dependent differentiation dynamics balances growth and endocrine differentiation in the pancreas

Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment

Chromatin immunoprecipitation using isolated islets of Langerhans.

Cloning of human pancreatic islet large conductance Ca2+-activated K+ channel (hSlo) cDNAs: evidence for high levels of expression in pancreatic islets and identification of a flanking genetic marker

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

Diabetes mellitus in patients with liver cirrhosis

Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth.

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

EuroDia: a beta-cell gene expression resource

Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity

Functional targets of the monogenic diabetes transcription factors HNF-1alpha and HNF-4alpha are highly conserved between mice and humans

GATA6 haploinsufficiency causes pancreatic agenesis in humans

Gene expression dynamics after murine pancreatitis unveils novel roles for Hnf1α in acinar cell homeostasis.

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Glucose as a Mitogenic Hormone

HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer

Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets

Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress

Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver.

Hnf1α (MODY3) regulates β-cell-enriched MafA transcription factor expression

Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas

Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks

Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes

Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas

Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.

Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study

Lineage fate of ductular reactions in liver injury and carcinogenesis

Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes

Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene

Mapping open chromatin with formaldehyde-assisted isolation of regulatory elements

MiR-184 expression is regulated by AMPK in pancreatic islets

Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain

Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene

Neuronatin regulates pancreatic β cell insulin content and secretion

PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression

Pancreatic Islet GLUT2 Glucose Transporter mRNA and Protein Expression in Humans With and Without NIDDM ⬇️

Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth

Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming

Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.

Putting pancreatic cell plasticity to the test.

Rare variants identified in the HNF-4α β-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes

Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.

Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis

Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells

Removing the brakes on cell identity.

Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult β cells

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors

TIGER: The gene expression regulatory variation landscape of human pancreatic islets

Targeted deficiency of the transcriptional activator Hnf1alpha alters subnuclear positioning of its genomic targets

The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice

The Transcription Factor ERG Regulates Super-Enhancers Associated With an Endothelial-Specific Gene Expression Program

The cis-regulatory switchboard of pancreatic ductal cancer

The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis

The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse

Transcriptional enhancers: functional insights and role in human disease

Transcriptional networks controlling pancreatic development and beta cell function.

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

matchSCore: Matching Single-Cell Phenotypes Across Tools and Experiments

βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function