Lista de obras - Rui Moreira - Dominio Público Uruguay

11(th) National Meeting of Organic Chemistry and 4(th) Meeting of Therapeutic Chemistry

artículo científico publicado en 2016

1H NMR spectroscopic identification of protonable sites in cryptolepines with C-11 substituents containing two amino functionalities

scientific article published on 26 February 2012

3-Oxo-β-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling

scientific article published on 20 March 2020

4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.

artículo científico publicado en 2010

A carbamate-based approach to primaquine prodrugs: antimalarial activity, chemical stability and enzymatic activation

artículo científico publicado en 2011

Acyloxymethyl as a drug protecting group. Part 3. Tertiary O-amidomethyl esters of penicillin G: chemical hydrolysis and anti-bacterial activity.

artículo científico publicado en 1996

Acyloxymethyl as a drug protecting group. Part 6

scientific article published on 01 April 2000

Acyloxymethyl as a drug protecting group. Part 7: Tertiary sulfonamidomethyl ester prodrugs of benzylpenicillin: chemical hydrolysis and anti-bacterial activity

artículo científico publicado en 2000

Acyloxymethyl as a drug protecting group: Part 4. The hydrolysis of tertiary amidomethyl ester prodrugs of carboxylic acid agents

scientific article published on 01 November 1997

Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds

artículo científico publicado en 2020

Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media

scientific article published on 01 January 2007

An Overview of Drug Resistance in Protozoal Diseases

scientific article published on 15 November 2019

An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites

artículo científico publicado en 2013

Analytical profiles of "legal highs" containing cathinones available in the area of Lisbon, Portugal

artículo científico publicado en 2014

Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones

artículo científico publicado en 2007

Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine

artículo científico publicado en 2009

Antiplasmodial Drugs in the Gas Phase: A CID and DFT Study of Quinolon-4(1H)-Imine Derivatives

scientific article published on 08 July 2014

Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives

scientific article published on 15 August 2012

Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition

artículo científico publicado en 2009

Aspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathway

artículo científico publicado en 2011

Aza vinyl sulfones: synthesis and evaluation as antiplasmodial agents

artículo científico publicado en 2011

Azaaurones as Potent Antimycobacterial Agents Active against MDR- and XDR-TB

scientific article published on 25 July 2019

Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors

artículo científico publicado en 2008

Biological Evaluation and Mechanistic Studies of Quinolin-(1<i>H</i>)-Imines as a New Chemotype against Leishmaniasis

scientific article published on 17 June 2021

Bis-alkylamine Indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities

artículo científico publicado en 2014

Bis-alkylamine quindolone derivatives as new antimalarial leads

artículo científico publicado en 2010

Bis{(E)-3-[(diethyl-methyl-ammonio)meth-yl]-N-[3-(N,N-dimethyl-sulfamo-yl)-1-methyl-pyridin-4-yl-idene]-4-methoxy-anilinium} tetra-iodide penta-hydrate

artículo científico publicado en 2009

C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: anticancer profile and G-quadruplex stabilization

artículo científico publicado en 2010

Characterizing the dynamics and ligand-specific interactions in the human leukocyte elastase through molecular dynamics simulations.

artículo científico publicado en 2011

Chemical Variations on the p53 Reactivation Theme

artículo científico publicado en 2016

Cleavage of tertiary amidomethyl ester prodrugs of carboxylic acids by rat liver homogenates.

artículo científico publicado en 1999

Clickable 4-Oxo-β-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes.

artículo científico publicado en 2016

Comparative analysis of in vitro rat liver metabolism of the antimalarial primaquine and a derived imidazoquine

artículo científico publicado en 2012

Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ellipticine, olivacine, cryptolepine and a synthetic cryptolepine analog.

artículo científico publicado en 2012

Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity

artículo científico publicado en 2008

Crystallization and Preliminary Diffraction Studies of Porcine Pancreatic Elastase in Complex with a Novel Inhibitor

artículo científico publicado en 2007

Cyclization-activated prodrugs.

artículo científico publicado en 2007

Cyclization-activated prodrugs. Synthesis, reactivity and toxicity of dipeptide esters of paracetamol

artículo científico publicado en 2005

Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations.

artículo científico publicado en 2013

Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties

artículo científico publicado en 2015

Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy

artículo científico publicado en 2011

Design of Modular G-quadruplex Ligands.

artículo científico publicado en 2018

Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials

artículo científico publicado en 2011

Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors

artículo científico publicado en 2001

Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials

artículo científico publicado en 2009

Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase

artículo científico publicado en 2005

Diazaborines as New Inhibitors of Human Neutrophil Elastase

scientific article published on 06 July 2018

Dipeptide derivatives of AZT: synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity

artículo científico publicado en 2008

Dipeptide derivatives of primaquine as transmission-blocking antimalarials: effect of aliphatic side-chain acylation on the gametocytocidal activity and on the formation of carboxyprimaquine in rat liver homogenates

artículo científico publicado en 1999

Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum

artículo científico publicado en 2006

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation.

artículo científico publicado en 2016

Discovery of new heterocycles with activity against human neutrophile elastase based on a boron promoted one-pot assembly reaction

artículo científico publicado en 2013

Dopamine- and tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design.

artículo científico publicado en 2009

Drug discovery in tuberculosis. New drug targets and antimycobacterial agents.

artículo científico publicado en 2018

Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug

artículo científico publicado en 2012

Effect of synthesized inhibitors on babesipain-1, a new cysteine protease from the bovine piroplasm Babesia bigemina

artículo científico publicado en 2010

Electrospray ionization mass spectrometry as a valuable tool in the characterization of novel primaquine peptidomimetic derivatives

artículo científico publicado en 2009

Electrospray ionization-ion trap mass spectrometry study of PQAAPro and PQProAA mimetic derivatives of the antimalarial primaquine

artículo científico publicado en 2008

Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

artículo científico publicado en 2015

Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity

artículo científico publicado en 2010

Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability

artículo científico publicado en 2018

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype

artículo científico publicado en 2015

Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits.

artículo científico publicado en 2013

Five-membered iminocyclitol α-glucosidase inhibitors: synthetic, biological screening and in silico studies.

artículo científico publicado en 2013

Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds

artículo científico publicado en 2013

Four-Component Assembly of Chiral N–B Heterocycles with a Natural Product-Like Framework

scientific article published on 08 February 2012

From hybrid compounds to targeted drug delivery in antimalarial therapy

artículo científico

Half-Sandwich Cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype

scientific article published on 24 August 2020

Harnessing Protein-Ligand Interaction Fingerprints to Predict New Scaffolds of RIPK1 Inhibitors

artículo científico publicado en 2022

Identification of new antimalarial leads by use of virtual screening against cytochrome bc₁.

artículo científico publicado en 2011

Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials

artículo científico publicado en 2005

Imidazolidin-4-one peptidomimetic derivatives of primaquine: synthesis and antimalarial activity

artículo científico publicado en 2008

Imidazoquines as antimalarial and antipneumocystis agents

scientific article published on December 2009

Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies

artículo científico publicado en 2011

Indolo[3,2-c]quinoline G-quadruplex stabilizers: a structural analysis of binding to the human telomeric G-quadruplex

artículo científico publicado en 2015

Indoloquinolines as scaffolds for drug discovery.

artículo científico publicado en 2010

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines.

artículo científico publicado en 2015

Kinetics and mechanism of hydrolysis of N-acyloxymethyl derivatives of azetidin-2-one

artículo científico publicado en 2004

Malaria combination therapies: advantages and shortcomings.

artículo científico publicado en 2008

Metabolism of primaquine by liver homogenate fractions. Evidence for monoamine oxidase and cytochrome P450 involvement in the oxidative deamination of primaquine to carboxyprimaquine

artículo científico publicado en 1999

Michael acceptors as cysteine protease inhibitors.

artículo científico publicado en 2007

N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases

artículo científico publicado en 2012

N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity

artículo científico publicado en 2015

Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: potent, non-cytotoxic, antiapoptotic agents.

artículo científico publicado en 2009

New Hope in the Fight Against Malaria? ⬇️

artículo científico publicado el 1 de enero de 2011

Novel 3+1 mixed-ligand Technetium-99m complexes carrying dipeptides as monodentate ligands

artículo científico publicado en 2004

Novel anti-plasmodial hits identified by virtual screening of the ZINC database

artículo científico publicado en 2013

Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities

artículo científico publicado en 2013

Novel potent metallocenes against liver stage malaria

artículo científico publicado en 2011

Novel squaramides with in vitro liver stage antiplasmodial activity

artículo científico publicado en 2016

Optimization of O3-acyl kojic acid derivatives as potent and selective human neutrophil elastase inhibitors

artículo científico publicado en 2013

PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity

Peptidomimetic and organometallic derivatives of primaquine active against Leishmania infantum

artículo científico publicado en 2012

Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions

artículo científico publicado en 2019

Phthalimidomethyl as a drug pro-moiety. Probing its reactivity

scientific article published on 01 April 1998

Primaquine dipeptide derivatives bearing an imidazolidin-4-one moiety at the N-terminus as potential antimalarial prodrugs

artículo científico publicado en 2009

Primaquine revisited six decades after its discovery

artículo científico publicado en 2008

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

artículo científico publicado en 2016

Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity.

artículo científico publicado en 2014

Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria

artículo científico publicado en 2013

Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-diones.

artículo científico publicado en 2009

Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons

artículo científico publicado en 2021

Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties

artículo científico publicado en 2017

Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents

artículo científico publicado en 2013

Squaric acid: a valuable scaffold for developing antimalarials?

article published in 2012

Stabilization of porcine pancreatic elastase crystals by glutaraldehyde cross-linking

artículo científico publicado en 2015

Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance.

artículo científico publicado en 2018

Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability

artículo científico publicado en 2013

Structure based virtual screening for discovery of novel human neutrophil elastase inhibitors

Structure-activity relationships for dipeptide prodrugs of acyclovir: implications for prodrug design

artículo científico publicado en 2008

Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents

artículo científico publicado en 2013

Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study.

artículo científico publicado en 2010

Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains.

artículo científico publicado en 2013

Synthesis, stability and in vitro dermal evaluation of aminocarbonyloxymethyl esters as prodrugs of carboxylic acid agents.

artículo científico publicado en 2002

Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase

artículo científico publicado en 2010

Synthetic condensed 1,4-naphthoquinone derivative shifts neural stem cell differentiation by regulating redox state

artículo científico publicado en 2012

Targeting COPD: advances on low‐molecular‐weight inhibitors of human neutrophil elastase ⬇️

artículo científico publicado el 16 de junio de 2011

Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference?

artículo científico publicado en 2016

Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability

scientific article published on 22 March 2019

Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal ⬇️

artículo científico publicado el 21 de diciembre de 2011

Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids.

artículo científico publicado en 2015

Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials

artículo científico publicado en 2014

The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors

artículo científico publicado en 2007

The Bsmoc group as a novel scaffold for the design of irreversible inhibitors of cysteine proteases

artículo científico publicado en 2006

The efficiency of C-4 substituents in activating the beta-lactam scaffold towards serine proteases and hydroxide ion

artículo científico publicado en 2007

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

scientific article published on 08 July 2013

Unanticipated acyloxymethylation of sumatriptan indole nitrogen atom and its implications in prodrug design

artículo científico publicado en 2008

Unanticipated stereoselectivity in the reaction of primaquine alpha-aminoamides with substituted benzaldehydes: a computational and experimental study

artículo científico publicado en 2007

Lista de obras de Rui Moreira

11(th) National Meeting of Organic Chemistry and 4(th) Meeting of Therapeutic Chemistry

1H NMR spectroscopic identification of protonable sites in cryptolepines with C-11 substituents containing two amino functionalities

3-Oxo-β-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling

4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.

A carbamate-based approach to primaquine prodrugs: antimalarial activity, chemical stability and enzymatic activation

Acyloxymethyl as a drug protecting group. Part 3. Tertiary O-amidomethyl esters of penicillin G: chemical hydrolysis and anti-bacterial activity.

Acyloxymethyl as a drug protecting group. Part 6

Acyloxymethyl as a drug protecting group. Part 7: Tertiary sulfonamidomethyl ester prodrugs of benzylpenicillin: chemical hydrolysis and anti-bacterial activity

Acyloxymethyl as a drug protecting group: Part 4. The hydrolysis of tertiary amidomethyl ester prodrugs of carboxylic acid agents

Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds

Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media

An Overview of Drug Resistance in Protozoal Diseases

An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites

Analytical profiles of "legal highs" containing cathinones available in the area of Lisbon, Portugal

Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones

Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine

Antiplasmodial Drugs in the Gas Phase: A CID and DFT Study of Quinolon-4(1H)-Imine Derivatives

Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives

Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition

Aspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathway

Aza vinyl sulfones: synthesis and evaluation as antiplasmodial agents

Azaaurones as Potent Antimycobacterial Agents Active against MDR- and XDR-TB

Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors

Biological Evaluation and Mechanistic Studies of Quinolin-(1<i>H</i>)-Imines as a New Chemotype against Leishmaniasis

Bis-alkylamine Indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities

Bis-alkylamine quindolone derivatives as new antimalarial leads

Bis{(E)-3-[(diethyl-methyl-ammonio)meth-yl]-N-[3-(N,N-dimethyl-sulfamo-yl)-1-methyl-pyridin-4-yl-idene]-4-methoxy-anilinium} tetra-iodide penta-hydrate

C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: anticancer profile and G-quadruplex stabilization

Characterizing the dynamics and ligand-specific interactions in the human leukocyte elastase through molecular dynamics simulations.

Chemical Variations on the p53 Reactivation Theme

Cleavage of tertiary amidomethyl ester prodrugs of carboxylic acids by rat liver homogenates.

Clickable 4-Oxo-β-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes.

Comparative analysis of in vitro rat liver metabolism of the antimalarial primaquine and a derived imidazoquine

Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ellipticine, olivacine, cryptolepine and a synthetic cryptolepine analog.

Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity

Crystallization and Preliminary Diffraction Studies of Porcine Pancreatic Elastase in Complex with a Novel Inhibitor

Cyclization-activated prodrugs.

Cyclization-activated prodrugs. Synthesis, reactivity and toxicity of dipeptide esters of paracetamol

Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations.

Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties

Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy

Design of Modular G-quadruplex Ligands.

Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials

Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors

Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials

Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase

Diazaborines as New Inhibitors of Human Neutrophil Elastase

Dipeptide derivatives of AZT: synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity

Dipeptide derivatives of primaquine as transmission-blocking antimalarials: effect of aliphatic side-chain acylation on the gametocytocidal activity and on the formation of carboxyprimaquine in rat liver homogenates

Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation.

Discovery of new heterocycles with activity against human neutrophile elastase based on a boron promoted one-pot assembly reaction

Dopamine- and tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design.

Drug discovery in tuberculosis. New drug targets and antimycobacterial agents.

Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug

Effect of synthesized inhibitors on babesipain-1, a new cysteine protease from the bovine piroplasm Babesia bigemina

Electrospray ionization mass spectrometry as a valuable tool in the characterization of novel primaquine peptidomimetic derivatives

Electrospray ionization-ion trap mass spectrometry study of PQAAPro and PQProAA mimetic derivatives of the antimalarial primaquine

Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity

Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype

Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits.

Five-membered iminocyclitol α-glucosidase inhibitors: synthetic, biological screening and in silico studies.

Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds

Four-Component Assembly of Chiral N–B Heterocycles with a Natural Product-Like Framework

From hybrid compounds to targeted drug delivery in antimalarial therapy

Half-Sandwich Cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype

Harnessing Protein-Ligand Interaction Fingerprints to Predict New Scaffolds of RIPK1 Inhibitors

Identification of new antimalarial leads by use of virtual screening against cytochrome bc₁.

Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials

Imidazolidin-4-one peptidomimetic derivatives of primaquine: synthesis and antimalarial activity

Imidazoquines as antimalarial and antipneumocystis agents

Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies

Indolo[3,2-c]quinoline G-quadruplex stabilizers: a structural analysis of binding to the human telomeric G-quadruplex

Indoloquinolines as scaffolds for drug discovery.

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines.

Kinetics and mechanism of hydrolysis of N-acyloxymethyl derivatives of azetidin-2-one

Malaria combination therapies: advantages and shortcomings.