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Lista de obras de Andrew H. Sims

A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity.

artículo científico publicado en 2014

A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk

artículo científico publicado en 2010

Accurate Prediction and Validation of Response to Endocrine Therapy in Breast Cancer

artículo científico publicado en 2015

Accurate prediction of response to endocrine therapy in breast cancer patients: current and future biomarkers

artículo científico publicado en 2016

Adaptation to AI Therapy in Breast Cancer Can Induce Dynamic Alterations in ER Activity Resulting in Estrogen-Independent Metastatic Tumors

artículo científico publicado en 2016

An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer

artículo científico publicado en 2011

Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity

artículo científico publicado en 2015

Approaches towards expression profiling the response to treatment

artículo científico publicado en 2008

Biomarkers of dietary energy restriction in women at increased risk of breast cancer.

artículo científico publicado en 2009

Breast cancer gene expression datasets do not reflect the disease at the population level

artículo científico publicado en 2020

Changes in PIK3CA mutation status are not associated with recurrence, metastatic disease or progression in endocrine-treated breast cancer.

artículo científico publicado en 2014

Correcting for intra-experiment variation in Illumina BeadChip data is necessary to generate robust gene-expression profiles

artículo científico publicado en 2010

Correction: An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast Cancer

artículo científico publicado en 2011

Correction: An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast Cancer

Correction: An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast Cancer

Correction: An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast Cancer

Correction: An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast Cancer.

artículo científico publicado en 2011

Current treatment trends and the need for better predictive tools in the management of ductal carcinoma in situ of the breast

artículo científico publicado en 2017

Cyclin D1, Id1 and EMT in breast cancer

artículo científico publicado en 2011

Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response

artículo científico publicado en 2014

Defining the molecular response to trastuzumab, pertuzumab and combination therapy in ovarian cancer.

artículo científico publicado en 2012

Differential expression of store-operated calcium- and proliferation-related genes in hepatocellular carcinoma cells following TRPC1 ion channel silencing

artículo científico publicado en 2016

Direct integration of intensity-level data from Affymetrix and Illumina microarrays improves statistical power for robust reanalysis

artículo científico publicado en 2012

Down-regulation of the oncogene cyclin D1 increases migratory capacity in breast cancer and is linked to unfavorable prognostic features

artículo científico publicado en 2010

Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer.

artículo científico publicado en 2010

Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue

artículo científico publicado en 2006

Effects of oestrogen on gene expression in the epithelium and stroma of the normal human breast

article

Engineering a synthetic cell panel to identify signalling components reprogrammed by the cell growth regulator anterior gradient-2.

artículo científico publicado en 2014

Enhanced response rate to pegylated liposomal doxorubicin in high grade serous ovarian carcinomas harbouring BRCA1 and BRCA2 aberrations.

artículo científico publicado en 2018

Epigenome-wide SRC-1–Mediated Gene Silencing Represses Cellular Differentiation in Advanced Breast Cancer

article

Estrogen Receptor Pathway Activity Score to Predict Clinical Response or Resistance to Neoadjuvant Endocrine Therapy in Primary Breast Cancer

artículo científico publicado en 2019

Evaluation of Gene Expression Data From Cybrids and Tumours Highlights Elevated NDRG1-Driven Proliferation in Triple-Negative Breast Cancer

artículo científico publicado en 2020

Exercise Window Trial in Newly Diagnosed Breast Cancer-Letter

scientific article published on 01 December 2019

FRMD4A upregulation in human squamous cell carcinoma promotes tumor growth and metastasis and is associated with poor prognosis

artículo científico publicado en 2012

Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer.

artículo científico publicado en 2012

Functional Transcription Factor Target Networks Illuminate Control of Epithelial Remodelling

scientific article published on 30 September 2020

GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment

artículo científico publicado en 2017

Gene expression profiling of response to mTOR inhibitor everolimus in pre-operatively treated post-menopausal women with oestrogen receptor-positive breast cancer

artículo científico publicado en 2010

Gene expression profiling reveals biological pathways responsible for phenotypic heterogeneity between UK and Sri Lankan oral squamous cell carcinomas

artículo científico publicado en 2015

Glutamic protease distribution is limited to filamentous fungi

artículo científico publicado en 2004

GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines

artículo científico publicado en 2011

High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic?

artículo científico publicado en 2006

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy

artículo científico publicado en 2016

ImSig: A resource for the identification and quantification of immune signatures in blood and tissue transcriptomics data

Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors

artículo científico publicado en 2018

Increased STAT1 signaling in endocrine-resistant breast cancer

artículo científico publicado en 2014

Intermittent energy restriction induces changes in breast gene expression and systemic metabolism

artículo científico publicado en 2016

Isolation of four pepsin-like protease genes from Aspergillus niger and analysis of the effect of disruptions on heterologous laccase expression

artículo científico publicado en 2007

KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals

artículo científico publicado en 2012

Kindlin-1 promotes pulmonary breast cancer metastasis

artículo científico publicado en 2018

Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance

artículo científico publicado en 2015

Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: A role for PIP4K2B in the regulation of E-cadherin expression

scientific article published on 14 October 2013

MCL-1 is a prognostic indicator and drug target in breast cancer

artículo científico publicado en 2018

MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures.

artículo científico publicado en 2015

Mechanisms of Disease: prediction and prevention of breast cancer--cellular and molecular interactions

artículo científico publicado en 2005

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

scientific article published on 01 November 2019

Modelling genetic and clinical heterogeneity in epithelial ovarian cancers.

artículo científico publicado en 2011

Modulation of strain-specific differences in gene expression by cannabinoid type 2 receptor deficiency

artículo científico publicado en 2013

Molecular Changes in Lobular Breast Cancers in Response to Endocrine Therapy

artículo científico publicado en 2014

Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumours

scientific article published on 07 January 2019

Monocytes and macrophages, implications for breast cancer migration and stem cell-like activity and treatment

artículo científico publicado en 2015

Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen

artículo científico

Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth

artículo científico publicado en 2017

Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity

artículo científico publicado en 2015

On-treatment biomarkers can improve prediction of response to neoadjuvant chemotherapy in breast cancer

artículo científico publicado en 2019

Origins of breast cancer subtypes and therapeutic implications

artículo científico publicado en 2007

PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer

article

PIK3CA genotype and a PIK3CA mutation-related gene signature and response to everolimus and letrozole in estrogen receptor positive breast cancer

artículo científico publicado en 2013

Pharmacological inhibition of the IKKε/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer

scientific article published on 18 February 2019

Regulation of breast cancer induced bone disease by cancer-specific IKKβ.

artículo científico publicado en 2018

Relative impact of key sources of systematic noise in Affymetrix and Illumina gene-expression microarray experiments

artículo científico publicado en 2011

Sprouty 2 is an independent prognostic factor in breast cancer and may be useful in stratifying patients for trastuzumab therapy

artículo científico publicado en 2011

T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity

artículo científico publicado en 2020

TPD52 and NFKB1 gene expression levels correlate with G2 chromosomal radiosensitivity in lymphocytes of women with and at risk of hereditary breast cancer

artículo científico publicado en 2007

Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

artículo científico publicado en 2020

Targeting of Rac GTPases blocks the spread of intact human breast cancer.

artículo científico publicado en 2012

The G Protein-Coupled Estrogen Receptor (GPER) Expression Correlates with Pro-Metastatic Pathways in ER-Negative Breast Cancer: A Bioinformatics Analysis

scientific article published on 04 March 2020

The T box transcription factor TBX2 promotes epithelial-mesenchymal transition and invasion of normal and malignant breast epithelial cells

artículo científico publicado en 2012

The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers

artículo científico publicado en 2010

The origin of estrogen receptor alpha-positive and alpha-negative breast cancer

artículo científico publicado en 2008

The removal of multiplicative, systematic bias allows integration of breast cancer gene expression datasets - improving meta-analysis and prediction of prognosis

artículo científico publicado en 2008

Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns

artículo científico publicado en 2012

Transcript and protein profiling identifies signaling, growth arrest, apoptosis, and NF-κB survival signatures following GNRH receptor activation

artículo científico publicado en 2013

Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer.

artículo científico publicado en 2011

Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo

artículo científico publicado en 2005

Trastuzumab and pertuzumab produce changes in morphology and estrogen receptor signaling in ovarian cancer xenografts revealing new treatment strategies.

artículo científico publicado en 2011

Tumour sampling method can significantly influence gene expression profiles derived from neoadjuvant window studies

artículo científico publicado en 2016

Unlocking the transcriptomic potential of formalin-fixed paraffin embedded clinical tissues: comparison of gene expression profiling approaches

artículo científico publicado en 2020

Use of expressed sequence tag analysis and cDNA microarrays of the filamentous fungus Aspergillus nidulans

artículo científico publicado en 2004

Use of microarray analysis to investigate EMT gene signatures

artículo científico publicado en 2013

WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel

artículo científico publicado en 2017

Wnt pathway activity in breast cancer sub-types and stem-like cells

artículo científico publicado en 2013

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